Hope vs hype: where are we in type 1 diabetes?
Open accessAbstract
Much progress has been made in type 1 diabetes research. Biological replacement of islet function has been achieved with pancreas transplantation and with islet transplantation. In the future, human embryonic stem cells and/or induced pluripotent stem cells may offer a potentially unlimited source of cells for islet replacement. Another potential strategy is to induce robust beta cell replication so that regeneration of islets can be achieved. Immune interventions are being studied with the hope of arresting the type 1 diabetes disease process to either prevent the disease or help preserve beta cell function. Mechanical replacement of islet cell function involves the use of glucose sensor-controlled insulin infusion systems. As all of these avenues are pursued, headlines often overstate the case, thus hyping any given advance, which provides enormous hope for patients and families seeking a cure for type 1 diabetes. Often, however, it is an animal study or a pilot trial that is being described. The reality is that translation to successful trials in human beings may not be readily achievable. This article discusses both the hype and the hopes in type 1 diabetes research.
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Survival and patient health have improved considerably, particularly in the past 25 years.
“Although survival and patient health have improved considerably, particularly in the past 25 years, a cure for type 1 diabetes remains elusive.1,2”
From Type 1 diabetes (2018) · cites this paper as [2]
The Pancreas transplantation section (page unavailable) reports better 10-year survival for patients receiving a combined pancreas–kidney transplant than for those receiving a kidney transplant alone, and describes improving transplant outcomes. It does not establish that survival and health improved considerably for people with type 1 diabetes generally, particularly over the past 25 years. (LLM, conf=0.82)
Experimental — accuracy not yet measuredA cure for type 1 diabetes remains elusive.
“a cure for type 1 diabetes remains elusive.1,2”
From Type 1 diabetes (2018) · cites this paper as [2]
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- Authors
- Skyler, J. S.
- Affiliations
- University of Miami (US)
- Corresponding author
- Skyler, Jay S.
- ORCID
- Skyler, Jay S.
- Venue
- Diabetologia
- Published
- 2017-12-23
- Volume
- 61
- Issue
- 3
- Pages
- 509-516
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2776088746
- Cited by
- 51
- References
- 68
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 11 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 8
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Research Institute Foundation (n/a)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, islet transplantation, pancreas transplantation, beta cell regeneration, human embryonic stem cells, induced pluripotent stem cells, immune intervention, research hype, translational research, disease prevention
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Humans, Insulin Infusion Systems, Islets of Langerhans Transplantation, Stem Cell Transplantation
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