The endocannabinoid system links gut microbiota to adipogenesis

An obesity-associated gut microbiome with increased capacity for energy harvest

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Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

A core gut microbiome in obese and lean twins

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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

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Obesity alters gut microbial ecology

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Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

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Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770 · see citing works

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works

Brain monoglyceride lipase participating in endocannabinoid inactivation

Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373 · see citing works

Modulation of anxiety through blockade of anandamide hydrolysis

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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

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Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

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Nutrient sensing and inflammation in metabolic diseases

Hotamisligil, G. S., & Erbay, E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2449 · Cited by 1,040 · see citing works

The role of the gut microbiota in energy metabolism and metabolic disease

Cani, P., & Delzenne, N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168164 · Cited by 974 · see citing works

Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis.

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Targeting the endocannabinoid system: to enhance or reduce?

Marzo, V. D. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2553 · Cited by 798 · see citing works

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

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Activation of the peripheral endocannabinoid system in human obesity

Engeli, S., Böhnke, J., Feldpausch, M., Gorzelniak, K., Janke, J., Bátkai, S., Pacher, P., Harvey-White, J., Luft, F. C., Sharma, A. M., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2838 · Cited by 686 · cited 4× · see citing works

Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

Matias, I., Gonthier, M., Orlando, P., Martiadis, V., PETROCELLIS, L. D., Cervino, C., Petrosino, S., Hoareau, L., Festy, F., Pasquali, R., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2679 · Cited by 654 · see citing works

Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

Blüher, M., Engeli, S., Klöting, N., Berndt, J., Faßhauer, M., Bátkai, S., Pacher, P., Schön, M. R., Jordan, J., & Stümvoll, M. (2006) · Diabetes · doi:10.2337/db06-0812 · Cited by 528 · see citing works

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

Membrez, M., Blancher, F., Jaquet, M., Bibiloni, R., Cani, P. D., Burcelin, R. G., Corthesy, I., Macé, K., & Chou, C. J. (2008) · The FASEB Journal · doi:10.1096/fj.07-102723 · Cited by 493 · see citing works

A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model

Martin, F., Dumas, M., Wang, Y., Legido‐Quigley, C., Yap, I. K. S., Tang, H., Zirah, S., Murphy, G. M., Cloarec, O., Lindon, J. C., et al. (2007) · Molecular Systems Biology · doi:10.1038/msb4100153 · Cited by 471 · see citing works

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

Osei‐Hyiaman, D., Liu, J., Zhou, L., Godlewski, G., Harvey-White, J. D., Jeong, W., Bátkai, S., Marsicano, G., Lutz, B., Buettner, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34827 · Cited by 461 · see citing works

Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor

Cani, P. D., Knauf, C., Iglesias, M. A., Drucker, D. J., Delzenne, N. M., & Burcelin, R. (2006) · Diabetes · doi:10.2337/db05-1360 · Cited by 404 · see citing works

Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men

Côté, M., Matias, I., Lemieux, I., Petrosino, S., Alméras, N., Després, J., & Marzo, V. D. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803539 · Cited by 382 · see citing works

Impaired Preadipocyte Differentiation in Human Abdominal Obesity

Isakson, P., Hammarstedt, A., Gustafson, B., & Smith, U. (2009) · Diabetes · doi:10.2337/db08-1770 · Cited by 369 · see citing works

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

Buettner, C., Muse, E. D., Cheng, A. M., Chen, L., Scherer, T., Pocai, A., Su, K., Cheng, B., Li, X., Harvey-White, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm1775 · Cited by 342 · see citing works

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

Claus, S. P., Tsang, T. M., Wang, Y., Cloarec, O., Skordi, E., Martin, F., Rezzi, S., Ross, A., Kochhar, S., Holmes, E., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.56 · Cited by 334 · see citing works

Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats

Gary‐Bobo, M., Elachouri, G., Gallas, J., Janiak, P., Marini, P., Ravinet‐Trillou, C., Chabbert, M., Cruccioli, N., Pfersdorff, C., Roque, C., et al. (2007) · Hepatology · doi:10.1002/hep.21641 · Cited by 304 · see citing works

Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation

Bouaboula, M., Hilairet, S., Marchand, J., Fajas, L., Fur, G. L., & Casellas, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.032 · Cited by 298 · see citing works

Biosynthesis and inactivation of the endocannabinoid 2‐arachidonoylglycerol in circulating and tumoral macrophages

Marzo, V. D., Bisogno, T., PETROCELLIS, L. D., Melck, D. J., Orlando, P., Wagner, J. A., & Kunos, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00631.x · Cited by 296 · see citing works

Inflammation and impaired adipogenesis in hypertrophic obesity in man

Gustafson, B., Gogg, S., Hedjazifar, S., Jenndahl, L. E., Hammarstedt, A., & Smith, U. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00377.2009 · Cited by 289 · see citing works

Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes

Chung, S., LaPoint, K., Martinez, K., Kennedy, A. J., Sandberg, M. B., & McIntosh, M. (2006) · Endocrinology · doi:10.1210/en.2006-0536 · Cited by 252 · see citing works

Lipopolysaccharide Induces Anandamide Synthesis in Macrophages via CD14/MAPK/Phosphoinositide 3-Kinase/NF-κB Independently of Platelet-activating Factor

Liu, J., Bátkai, S., Pacher, P., Harvey-White, J. D., Wagner, J. A., Cravatt, B. F., Gao, B., & Kunos, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306062200 · Cited by 234 · see citing works

The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium-Dependent Mechanisms

Pagano, C., Pilon, C., Calcagno, A., Urbanet, R., Rossato, M., Milan, G., Bianchi, K., Rizzuto, R., Bernante, P., Federspil, G., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0768 · Cited by 209 · see citing works

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High‐fat Diet

Starowicz, K., Cristino, L., Matias, I., Capasso, R., Racioppi, A., Izzo, A. A., & Marzo, V. D. (2008) · Obesity · doi:10.1038/oby.2007.106 · Cited by 194 · see citing works

Endocannabinoid biosynthesis and inactivation, from simple to complex

Muccioli, G. G. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.03.007 · Cited by 188 · see citing works

Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors

Marzo, V. D., Côté, M.-P., Matias, I., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1178-6 · Cited by 182 · see citing works

Identification of a Novel Endocannabinoid-Hydrolyzing Enzyme Expressed by Microglial Cells

Muccioli, G. G., Xu, C., Odah, E., Cudaback, E., Cisneros, J. A., Lambert, D. M., López-Rodríguez, M. L., Bajjalieh, S., & Stella, N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4830-06.2007 · Cited by 172 · see citing works

Evidence of impaired adipogenesis in insulin resistance

Yang, X., Jansson, P., Nagaev, I., Jack, M. M., Carvalho, E., Sunnerhagen, K. S., Cam, M. C., Cushman, S. W., & Smith, U. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.152 · Cited by 170 · see citing works

Decreased Expression of Adipogenic Genes in Obese Subjects with Type 2 Diabetes

Dubois, S. G., Heilbronn, L. K., Smith, S. R., Albu, J., Kelley, D. E., & Ravussin, É. (2006) · Obesity · doi:10.1038/oby.2006.178 · Cited by 168 · see citing works

Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re‐feeding

Izzo, A. A., Piscitelli, F., Capasso, R., Aviello, G., Romano, B., Borrelli, F., Petrosino, S., & Marzo, V. D. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00183.x · Cited by 165 · see citing works

Lipopolysaccharide Downregulates Fatty Acid Amide Hydrolase Expression and Increases Anandamide Levels in Human Peripheral Lymphocytes

Maccarrone, M., PETROCELLIS, L. D., Bari, M., Fezza, F., Salvati, S., Marzo, V. D., & Finazzi‐Agrò, A. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2500 · Cited by 162 · see citing works

The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Cell Proliferation and Increases Markers of Adipocyte Maturation in Cultured Mouse 3T3 F442A Preadipocytes

Gary‐Bobo, M., Elachouri, G., Scatton, B., Fur, G. L., Oury-Donat, F., & Bensaïd, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.015040 · Cited by 156 · see citing works

Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism

Sheth, P., Santos, N. D., Seth, A., LaRusso, N. F., & Rao, R. K. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00582.2006 · Cited by 144 · see citing works

Inflammation is associated with a decrease of lipogenic factors in omental fat in women

Poulain‐Godefroy, O., Lecœur, C., Pattou, F. N., Frühbeck, G., & Froguel, P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00926.2007 · Cited by 128 · see citing works

Prevention of Hepatic Fibrosis in a Murine Model of Metabolic Syndrome with Nonalcoholic Steatohepatitis

DeLeve, L. D., Wang, X., Kanel, G. C., Atkinson, R., & McCuskey, R. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070720 · Cited by 115 · see citing works

Inflammation in subcutaneous adipose tissue: relationship to adipose cell size

McLaughlin, T., Deng, A., Yee, G., Lamendola, C., Reaven, G., Tsao, P. S., Cushman, S. W., & Sherman, A. (2010) · Diabetologia · doi:10.1007/s00125-009-1496-3 · Cited by 105 · see citing works

The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids

D'Eon, T. M., Pierce, K. A., Roix, J. J., Tyler, A., Chen, H., & Teixeira, S. R. (2008) · Diabetes · doi:10.2337/db07-1186 · Cited by 102 · see citing works

Getting away from glucose: fanning the flames of obesity-induced inflammation

Shoelson, S. E., & Goldfine, A. B. (2009) · Nature Medicine · doi:10.1038/nm0409-373 · Cited by 98 · see citing works

Top‐down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model

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Anti‐inflammatory Effect of Palmitoylethanolamide on Human Adipocytes

Hoareau, L., Buyse, M., Festy, F., Ravanan, P., Gonthier, M., Matias, I., Petrosino, S., Tallet, F., d’Hellencourt, C. L., Césari, M., et al. (2009) · Obesity · doi:10.1038/oby.2008.591 · Cited by 68 · see citing works

Preadipocyte response and impairment of differentiation in an inflammatory environment

Poulain‐Godefroy, O., & Froguel, P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.053 · Cited by 67 · see citing works

Cannabinoid Type 1 Receptor: Another Arrow in the Adipocytes’ Bow

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Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players

Lambert, D. M., & Muccioli, G. G. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f00061 · Cited by 61 · see citing works

Endocannabinoids, Adipose Tissue and Lipid Metabolism

Pagano, C., Rossato, M., & Vettor, R. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01690.x · Cited by 56 · see citing works

Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia–reperfusion injury complicated by endotoxaemia

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An optimized GC–MS method detects nanomolar amounts of anandamide in mouse brain

Muccioli, G. G., & Stella, N. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.09.030 · Cited by 49 · see citing works

Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients

Sarzani, R., Bordicchia, M., Marcucci, P., Bedetta, S., Santini, S., Giovagnoli, A., Scappini, L., Minardi, D., Muzzonigro, G., Dessı̀-Fulgheri, P., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.009 · Cited by 45 · see citing works

Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members

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The dysregulation of the endocannabinoid system in diabesity—a tricky problem

Scherer, T., & Buettner, C. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0459-y · Cited by 32 · see citing works

Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells

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Reduced cannabinoid receptor 1 protein in subcutaneous adipose tissue of obese

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The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Host-gut microbiota metabolic interactions

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Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

Gut microbiome and health: mechanistic insights

de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388 · see citing works

Short-chain fatty acids in control of body weight and insulin sensitivity

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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works

Intestinal permeability – a new target for disease prevention and therapy

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Psychobiotics: A novel class of psychotropic

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