Phylogenetic Relationships within the Opisthokonta Based on Phylogenomic Analyses of Conserved Single-Copy Protein Domains
Open accessAbstract
Many of the eukaryotic phylogenomic analyses published to date were based on alignments of hundreds to thousands of genes. Frequently, in such analyses, the most realistic evolutionary models currently available are often used to minimize the impact of systematic error. However, controversy remains over whether or not idiosyncratic gene family dynamics (i.e., gene duplications and losses) and incorrect orthology assignments are always appropriately taken into account. In this paper, we present an innovative strategy for overcoming orthology assignment problems. Rather than identifying and eliminating genes with paralogy problems, we have constructed a data set comprised exclusively of conserved single-copy protein domains that, unlike most of the commonly used phylogenomic data sets, should be less confounded by orthology miss-assignments. To evaluate the power of this approach, we performed maximum likelihood and Bayesian analyses to infer the evolutionary relationships within the opisthokonts (which includes Metazoa, Fungi, and related unicellular lineages). We used this approach to test 1) whether Filasterea and Ichthyosporea form a clade, 2) the interrelationships of early-branching metazoans, and 3) the relationships among early-branching fungi. We also assessed the impact of some methods that are known to minimize systematic error, including reducing the distance between the outgroup and ingroup taxa or using the CAT evolutionary model. Overall, our analyses support the Filozoa hypothesis in which Ichthyosporea are the first holozoan lineage to emerge followed by Filasterea, Choanoflagellata, and Metazoa. Blastocladiomycota appears as a lineage separate from Chytridiomycota, although this result is not strongly supported. These results represent independent tests of previous phylogenetic hypotheses, highlighting the importance of sophisticated approaches for orthology assignment in phylogenomic analyses.
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Sebé-Pedrós, A., & Ruiz‐Trillo, I. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.5.12603 · Cited by 26 · see citing works
Self-citationModel-based prediction of sequence alignment quality
Ahola, V., Aittokallio, T. A., Vihinen, M., & Uusipaikka, E. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn414 · Cited by 23 · see citing works
Animals and Their Unicellular Ancestors
Paps, J., & Ruiz‐Trillo, I. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022853 · Cited by 13 · see citing works
Self-citationDo we need many genes for phylogenetic inference?
Aleoshin, V. V., Константинова, А. В., Mikhailov, K. V., Nikitin, M. A., & Petrov, N. B. (2007) · Biochemistry (Moscow) · doi:10.1134/s000629790712005x · Cited by 13 · see citing works
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The Revised Classification of Eukaryotes
Adl, S. M., Simpson, A. G. B., Lane, C. E., Lukeš, J., Bass, D., Bowser, S. S., Brown, M. W., Burki, F., Dunthorn, M., Hampl, V., et al. (2012) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2012.00644.x · Cited by 1,680 · see citing works
EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex
Sancak, Y., Markhard, A. L., Kitami, T., Kovács-Bogdán, E., Kamer, K. J., Udeshi, N. D., Carr, S. A., Chaudhuri, D., Clapham, D. E., Li, A. A., et al. (2013) · Science · doi:10.1126/science.1242993 · Cited by 666 · see citing works
Animal phylogeny and its evolutionary implications
Dunn, C. W., Giribet, G., Edgecombe, G. D., & Hejnol, A. (2014) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-120213-091627 · Cited by 401 · see citing works
Ancient gene linkages support ctenophores as sister to other animals
Schultz, D. T., Haddock, S. H. D., Bredeson, J. V., Green, R. E., Simakov, O., & Rokhsar, D. S. (2023) · Nature · doi:10.1038/s41586-023-05936-6 · Cited by 362 · see citing works
Fungal evolution: diversity, taxonomy and phylogeny of the Fungi
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A genome-scale phylogeny of the kingdom Fungi
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The origin of Metazoa: a unicellular perspective
Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332 · see citing works
Self-citationThe Capsaspora genome reveals a complex unicellular prehistory of animals
Suga, H., Chen, Z., de Mendoza, A., Sebé-Pedrós, A., Brown, M. W., Kramer, E., Carr, M., Kerner, P., Vervoort, M., Sánchez-Pons, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms3325 · Cited by 317 · see citing works
Self-citationDeep metazoan phylogeny: When different genes tell different stories
Nosenko, T., Schreiber, F., Adamska, M., Adamski, M., Eitel, M., Hammel, J., Maldonado, M., Müller, W. E. G., Nickel, M., Schierwater, B., et al. (2013) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2013.01.010 · Cited by 254 · see citing works
Independent evolution of striated muscles in cnidarians and bilaterians
Steinmetz, P. R. H., Kraus, J. E. M., Larroux, C., Hammel, J. U., Amon-Hassenzahl, A., Houliston, E., Wörheide, G., Nickel, M., Degnan, B. M., & Technau, U. (2012) · Nature · doi:10.1038/nature11180 · Cited by 252 · see citing works
NF‐κB: where did it come from and why?
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de Mendoza, A., Sebé-Pedrós, A., Šestak, M. S., Matejčić, M., Torruella, G., Domazet‐Lošo, T., & Ruiz‐Trillo, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311818110 · Cited by 237 · see citing works
Self-citationKarpov, S. A., Mamkaeva, M. A., Aleoshin, V. V., Nassonova, E., Lilje, O., & Gleason, F. H. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00112 · Cited by 230 · see citing works
Phylogenomics Reveals Convergent Evolution of Lifestyles in Close Relatives of Animals and Fungi
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Self-citationCavalier‐Smith, T. (2012) · European Journal of Protistology · doi:10.1016/j.ejop.2012.06.001 · Cited by 204 · see citing works
de Mendoza, A., Sebé-Pedrós, A., & Ruiz‐Trillo, I. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu038 · Cited by 194 · see citing works
Self-citationThe others: our biased perspective of eukaryotic genomes
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Self-citationKocot, K. M., Citarella, M. R., Moroz, L. L., & Halanych, K. M. (2013) · Evolutionary Bioinformatics · doi:10.4137/ebo.s12813 · Cited by 166 · see citing works
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Regulated aggregative multicellularity in a close unicellular relative of metazoa
Sebé-Pedrós, A., Irimia, M., del Campo, J., Parra-Acero, H., Russ, C., Nusbaum, C., Blencowe, B. J., & Ruiz‐Trillo, I. (2013) · eLife · doi:10.7554/elife.01287 · Cited by 171 · see citing works
Self-citationA Phylogenomic Framework to Study the Diversity and Evolution of Stramenopiles (=Heterokonts)
Derelle, R., López‐García, P., Timpano, H., & Moreira, D. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw168 · Cited by 173 · see citing works
Self-citationDynamics of genomic innovation in the unicellular ancestry of animals
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Self-citationThe origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition
Ros-Rocher, N., Pérez-Posada, A., Leger, M. M., & Ruiz‐Trillo, I. (2021) · Open Biology · doi:10.1098/rsob.200359 · Cited by 160 · see citing works
Self-citationEvolution and Classification of Myosins, a Paneukaryotic Whole-Genome Approach
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Self-citationPhylogenomics demonstrates that breviate flagellates are related to opisthokonts and apusomonads
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Self-citationPhylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
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Premetazoan Origin of the Hippo Signaling Pathway
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Self-citationDiversity as opportunity: Insights from 600 million years of AHR evolution
Hahn, M. E., Karchner, S. I., & Merson, R. R. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.02.003 · Cited by 134 · see citing works
Origin and evolution of lysyl oxidases
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Self-citationSuga, H., Dacre, M., de Mendoza, A., Shalchian‐Tabrizi, K., Manning, G., & Ruiz‐Trillo, I. (2012) · Science Signaling · doi:10.1126/scisignal.2002733 · Cited by 121 · see citing works
Self-citationThe ancestral gene repertoire of animal stem cells
Alié, A., Hayashi, T., Sugimura, I., Manuel, M., Sugano, W., Mano, A., Satoh, N., Agata, K., & Funayama, N. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514789112 · Cited by 119 · see citing works
Conserved properties of individual Ca 2+ -binding sites in calmodulin
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Hehenberger, E., Tikhonenkov, D., Kolísko, M., del Campo, J., Esaulov, A., Mylnikov, A. P., & Keeling, P. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.006 · Cited by 99 · see citing works
Cavalier‐Smith, T., Chao, E. E. Y., Snell, E. A., Berney, C., Fiore‐Donno, A. M., & Lewis, R. (2014) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2014.08.012 · Cited by 106 · see citing works
Paps, J., Medina-Chacón, L. A., Marshall, W. L., Suga, H., & Ruiz‐Trillo, I. (2012) · Protist · doi:10.1016/j.protis.2012.09.002 · Cited by 104 · see citing works
Self-citationDevelopment of ichthyosporeans sheds light on the origin of metazoan multicellularity
Suga, H., & Ruiz‐Trillo, I. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.01.009 · Cited by 102 · see citing works
Self-citationFlavonoids and Melanins: A Common Strategy across Two Kingdoms
Carletti, G., Nervo, G., & Cattivelli, L. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9672 · Cited by 91 · see citing works
Mitogenomics at the base of Metazoa
Osigus, H.-J., Eitel, M., Bernt, M., Donath, A., & Schierwater, B. (2013) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2013.07.016 · Cited by 89 · see citing works
Early evolution of the T-box transcription factor family
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Self-citationEukaryotic G Protein Signaling Evolved to Require G Protein–Coupled Receptors for Activation
Bradford, W. S., Buckholz, A. P., Morton, J., Price, C. M., Jones, A. M., & Urano, D. (2013) · Science Signaling · doi:10.1126/scisignal.2003768 · Cited by 77 · see citing works
Convergence of ion channel genome content in early animal evolution
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501195112 · Cited by 76 · see citing works
Tikhonenkov, D. V., Hehenberger, E., Сергеевич, Е. А., Belyakova, O. I., Mazei, Y., Mylnikov, A. P., & Keeling, P. J. (2020) · BMC Biology · doi:10.1186/s12915-020-0762-1 · Cited by 86 · see citing works
The Evolution of the Secreted Regulatory Protein Progranulin
Palfree, R. G. E., Bennett, H. P. J., & Bateman, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133749 · Cited by 70 · see citing works
de Mendoza, A., Suga, H., Permanyer, J., Irimia, M., & Ruiz‐Trillo, I. (2015) · eLife · doi:10.7554/elife.08904 · Cited by 67 · see citing works
Self-citationKatz, L. A., & Grant, J. R. (2014) · Systematic Biology · doi:10.1093/sysbio/syu126 · Cited by 68 · see citing works
Parfrey, L. W., & Lahr, D. J. G. (2013) · BioEssays · doi:10.1002/bies.201200143 · Cited by 66 · see citing works
Exploring the evolutionary history of centrosomes
Azimzadeh, J. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0453 · Cited by 66 · see citing works
Fort, P., & Blangy, A. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx100 · Cited by 58 · see citing works
Fungi on wild seeds and fruits
Perera, R. H. (2020) · Mycosphere · doi:10.5943/mycosphere/11/1/14 · Cited by 65 · see citing works
‘Biogeneric’ developmental processes: drivers of major transitions in animal evolution
Newman, S. A. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0443 · Cited by 65 · see citing works
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss182 · Cited by 64 · see citing works
A family of diatom-like silicon transporters in the siliceous loricate choanoflagellates
Marron, A. O., Alston, M. J., Heavens, D., Akam, M., Caccamo, M., Holland, P. W. H., & Walker, G. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2012.2543 · Cited by 54 · see citing works
Hernandez, A. M., & Ryan, J. F. (2019) · doi:10.1101/729103 · Cited by 52 · see citing works
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Self-citationTikhonenkov, D. V., Mikhailov, K. V., Hehenberger, E., Karpov, S. A., Prokina, K. I., Сергеевич, Е. А., Belyakova, O. I., Mazei, Y., Mylnikov, A. P., Aleoshin, V. V., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.061 · Cited by 47 · see citing works
Ancient dynamin segments capture early stages of host–mitochondrial integration
Purkanti, R., & Thattai, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407163112 · Cited by 51 · see citing works
A Novel Predicted Calcium-Regulated Kinase Family Implicated in Neurological DisordersPreprint
Dudkiewicz, M., Lenart, A., & Pawłowski, K. (2012) · Nature Precedings · doi:10.1371/journal.pone.0066427 · Cited by 45 · see citing works
Genome-scale comparative analysis of gene fusions, gene fissions, and the fungal tree of life
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Vinogradov, S. N., Bailly, X., Smith, D. R., Tinajero‐Trejo, M., Poole, R. K., & Hoogewijs, D. (2013) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/b978-0-12-407693-8.00009-1 · Cited by 49 · see citing works
Evolution and Classification of the T-Box Transcription Factor Family
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Self-citationThe Mitochondrial Genomes of a Myxozoan Genus Kudoa Are Extremely Divergent in Metazoa
Takeuchi, F., Sekizuka, T., Ogasawara, Y., Yokoyama, H., Kamikawa, R., Inagaki, Y., Nozaki, T., Sugita‐Konishi, Y., Ohnishi, T., & Kuroda, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132030 · Cited by 47 · see citing works
Alzayady, K. J., Sebé-Pedrós, A., Chandrasekhar, R., Wang, L., Ruiz‐Trillo, I., & Yule, D. I. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv098 · Cited by 47 · see citing works
Self-citationThe promise and pitfalls of synteny in phylogenomics
Steenwyk, J. L., & King, N. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002632 · Cited by 48 · see citing works
Tracing the evolutionary history of blood cells to the unicellular ancestor of animals
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del Campo, J., Mallo, D., Massana, R., de Vargas, C., Richards, T. A., & Ruiz‐Trillo, I. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12759 · Cited by 45 · see citing works
Self-citationMassive expansion of the calpain gene family in unicellular eukaryotes
Zhao, S., Liang, Z., Demko, V., Wilson, R., Johansen, W., Olsen, O., & Shalchian‐Tabrizi, K. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-193 · Cited by 44 · see citing works
Self-citationEarliest Holozoan Expansion of Phosphotyrosine Signaling
Suga, H., Torruella, G., Burger, G., Brown, M. W., & Ruiz‐Trillo, I. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst241 · Cited by 43 · see citing works
Self-citationMolecular Phylogeny and Ultrastructure of Aphelidium aff. melosirae (Aphelida, Opisthosporidia)
Karpov, S. A., Mamkaeva, M. A., Benzerara, K., Moreira, D., & López‐García, P. (2014) · Protist · doi:10.1016/j.protis.2014.05.003 · Cited by 40 · see citing works
Zhang, L., Chen, F., Zhang, G., Zhang, Y., Niu, S.-C., Xiong, J., Lin, Z., Cheng, Z., & Liu, Z. (2016) · The Plant Journal · doi:10.1111/tpj.13159 · Cited by 40 · see citing works
Step-by-Step Evolution of Telomeres: Lessons from Yeasts
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Grau‐Bové, X., Sebé-Pedrós, A., & Ruiz‐Trillo, I. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt052 · Cited by 39 · see citing works
Self-citationYabuki, A., Ishida, K., & Cavalier‐Smith, T. (2012) · Protist · doi:10.1016/j.protis.2012.04.005 · Cited by 39 · see citing works
Juravel, K., Porras, L., Höhna, S., Pisani, D., & Wörheide, G. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282444 · Cited by 38 · see citing works
Zhang, Y., Li, F., Chen, Y., Wu, H., Meng, Q., & Guan, L. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00367 · Cited by 38 · see citing works
The Origin of Metazoan Multicellularity: A Potential Microbial Black Swan Event
Ruiz-Trillo, I., Kin, K., & Casacuberta, E. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032421-120023 · Cited by 36 · see citing works
Self-citationA taxon-rich and genome-scale phylogeny of Opisthokonta
Liu, H., Steenwyk, J. L., Zhou, X., Schultz, D. T., Kocot, K. M., Shen, X., Rokas, A., & Li, Y. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002794 · Cited by 39 · see citing works
del Campo, E. M., Casano, L. M., & Barreno, E. (2012) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2012.11.013 · Cited by 31 · see citing works
Divergence and ranking of taxa across the kingdoms Animalia, Fungi and Plantae
Samarakoon, M. C. (2016) · Mycosphere · doi:10.5943/mycosphere/7/11/5 · Cited by 31 · see citing works
He, D., Sierra, R., Pawłowski, J., & Baldauf, S. (2016) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2016.04.033 · Cited by 26 · see citing works
Pandey, A., & Braun, E. L. (2020) · Biology · doi:10.3390/biology9040064 · Cited by 30 · see citing works
Nitrile Hydratase Genes Are Present in Multiple Eukaryotic Supergroups
Marron, A. O., Akam, M. E., & Walker, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032867 · Cited by 30 · see citing works
Pittis, A. A., Goh, V., Cebrian-Serrano, A., Wettmarshausen, J., Perocchi, F., & Gabaldón, T. (2020) · Nature Communications · doi:10.1038/s41467-020-17705-4 · Cited by 29 · see citing works
Lai, A. G., Pouchkina-Stantcheva, N. N., Donfrancesco, A. D., Kildisiute, G., Sahu, S., & Aboobaker, A. A. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-0949-4 · Cited by 29 · see citing works
López‐Escardó, D., Grau‐Bové, X., Guillaumet-Adkins, A., Gut, M., Sieracki, M. E., & Ruiz‐Trillo, I. (2017) · Scientific Reports · doi:10.1038/s41598-017-11466-9 · Cited by 28 · see citing works
Self-citationThe early history of the metazoa—a paleontologist’s viewpoint
Zhuravlev, A. Y. (2015) · Biology Bulletin Reviews · doi:10.1134/s2079086415050084 · Cited by 26 · see citing works
Arroyo, A. S., López‐Escardó, D., Kim, E., Ruiz‐Trillo, I., & Najle, S. R. (2018) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2018.00099 · Cited by 26 · see citing works
Self-citationPizarro, D., Divakar, P. K., Grewe, F., Leavitt, S. D., Huang, J., Grande, F. D., Schmitt, I., Wedin, M., Crespo, A., & Lumbsch, H. T. (2018) · Fungal Diversity · doi:10.1007/s13225-018-0407-7 · Cited by 26 · see citing works
Releasing uncurated datasets is essential for reproducible phylogenomics
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Metazoan evolution and diversity of glutamate receptors and their auxiliary subunits
Ramos-Vicente, D., Grant, S. G. N., & Bayés, À. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108640 · Cited by 20 · see citing works
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Self-citationLack of Csk-Mediated Negative Regulation in a Unicellular Src Kinase
Schultheiss, K. P., Suga, H., Ruiz‐Trillo, I., & Miller, W. T. (2012) · Biochemistry · doi:10.1021/bi300965h · Cited by 20 · see citing works
Self-citationFilamentous ascomycete genomes provide insights into Copia retrotransposon diversity in fungi
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Extracellular Matrix Evolution: An Overview
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Phylogenetic and ecological diversity of apusomonads, a lineage of deep‐branching eukaryotes
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Self-citationChang, T., & Stergiopoulos, I. (2015) · FEBS Journal · doi:10.1111/febs.13256 · Cited by 16 · see citing works
What Makes an Animal? The Molecular Quest for the Origin of the Animal Kingdom
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Self-citation
- Authors
- Torruella, G., Derelle, R., Paps, J., Lang, B. F., Roger, A. J., Shalchian-Tabrizi, K., & Ruiz-Trillo, I.
- Affiliations
- Institut de Recerca de la Biodiversitat de la Universitat de Barcelona (ES)
- Barcelona Biomedical Research Park (ES)
- University of Oxford (GB)
- Université de Montréal (CA)
- Dalhousie University (CA)
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-07-18
- Volume
- 29
- Issue
- 2
- Pages
- 531-544
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- PMC
- PMC3350318
- OpenAlex
- W2150623567
- Semantic Scholar
- b16f34159cb1f408e4a2796aed3dd74c788a1ea6
- Cited by
- 169
- References
- 104
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 22 · 2013: 25 · 2012: 16
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Biology and Evolution (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Access at Essex (University of Essex) (acceptedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Harvard University
- Broad Institute
- Institució Catalana de Recerca i Estudis Avançats
- National Institutes of Health
- National Human Genome Research Institute (U54HG003273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Keywords
- Opisthokonta, eukaryotic phylogeny, orthology assignment, paralogy, Ichthyosporea, Choanoflagellata, animals, Blastocladiomycota, Chytridiomycota, systematic errors, cat model
- MeSH terms
- Animals, Bayes Theorem, Fungi, Models, Genetic, Phylogeny, Likelihood Functions, Sequence Alignment, Sequence Analysis, DNA, Protein Structure, Tertiary, Evolution, Molecular, Genomics, Eukaryota
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