Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia
Abstract
Hypoxia is a consequence of inadequate oxygen availability. At the cellular level, lowered oxygen concentration activates signal cascades including numerous receptors, ion channels, second messengers, as well as several protein kinases and phosphatases. This, in turn, activates trans‐factors like transcription factors, RNA‐binding proteins and miRNAs, mediating an alteration in gene expression control. Each cell type has its unique constellation of oxygen sensors, couplers and effectors that determine the activation and predominance of several independent hypoxia‐sensitive pathways. Hence, altered gene expression patterns in hypoxia result from a complex regulatory network with multiple divergences and convergences. Although hundreds of genes are activated by transcriptional control in hypoxia, metabolic rate depression, as a consequence of reduced ATP level, causes inhibition of mRNA translation. In a multi‐phase response to hypoxia, global protein synthesis is suppressed, mainly by phosphorylation of eIF2‐alpha by PERK and inhibition of mTOR, causing suppression of 5′‐cap‐dependent mRNA translation. Growing evidence suggests that mRNAs undergo sorting at stress granules, which determines the fate of mRNA as to whether being translated, stored, or degraded. Data indicate that translation is suppressed only at ‘free’ polysomes, but is active at subsets of membrane‐bound ribosomes. The recruitment of specific mRNAs into subcellular compartments seems to be crucial for local mRNA translation in prolonged hypoxia. Furthermore, ribosomes themselves may play a significant role in targeting mRNAs for translation. This review summarizes the multiple facets of the cellular adaptation to hypoxia observed in mammals.
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PERK upregulates ATF4, which along with ATF6 and IRE1 pathways selectively regulates gene expression to assist the cell to tolerate hypoxia.
“It also upregulates the transcription factor ATF4, which along with the ATF6 and IRE1 pathways selectively regulates gene expression to assist the cell to tolerate hypoxia (180, 343, 585).”
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“These adaptations include increased amino acid transporter activity and enzyme expression to boost the concentration of glutathione, the principal intracellular antioxidant, stimulation of hematopoiesis, and upregulation of the angiogenic growth factor VEGF.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [180]
Cites
1 retracted
Lee, M. Y., Hwang, J.-T., Lee, H., Jung, S., Kang, I., Chi, S.-G., Kim, S. S., & Ha, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306104200 · Cited by 235 · see citing works
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works
(2008) · doi:10.1038/nrg2290 · Cited by 5,199 · see citing works
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177 · see citing works
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature · doi:10.1038/16729 · Cited by 3,310 · see citing works
Kim, D.-H., Sarbassov, D., Ali, S. M., King, J. E., Latek, R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,135 · see citing works
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617 · see citing works
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585 · see citing works
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103 · see citing works
Oxygen sensing by HIF hydroxylases
Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works
Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953 · see citing works
The economics of ribosome biosynthesis in yeast
Warner, J. R. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01460-7 · Cited by 1,933 · see citing works
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911 · see citing works
Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 1,751 · see citing works
The PI3K‒PDK1 connection: more than just a road to PKB
Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,632 · see citing works
HIF‐1α is required for solid tumor formation and embryonic vascularization
Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545 · see citing works
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545 · see citing works
Messenger-RNA-binding proteins and the messages they carry
Dreyfuss, G., Kim, V. N., & Kataoka, N. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm760 · Cited by 1,469 · see citing works
(2000) · PubMed · Cited by 1,445 · see citing works
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
Baldwin, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11991 · Cited by 1,427 · see citing works
Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works
Lev, S., Moreno, H., Martinez, R., Canoll, P., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., & Schlessinger, J. (1995) · Nature · doi:10.1038/376737a0 · Cited by 1,381 · see citing works
Translational control in stress and apoptosis
Holčı́k, M., & Sonenberg, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1618 · Cited by 1,366 · see citing works
Initiation of translation in prokaryotes and eukaryotes
Kozak, M. (1999) · Gene · doi:10.1016/s0378-1119(99)00210-3 · Cited by 1,364 · see citing works
Jang, S. K., Kräusslich, H., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C., & Wimmer, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2636-2643.1988 · Cited by 1,363 · see citing works
P bodies and the control of mRNA translation and degradation
Parker, R., & Sheth, U. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.011 · Cited by 1,335 · see citing works
Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress
Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332 · see citing works
RNA regulons: coordination of post-transcriptional events
Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works
Kedersha, N., Gupta, M., Li, W., Miller, I. J., & Anderson, P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.7.1431 · Cited by 1,260 · see citing works
Oxygen sensing and molecular adaptation to hypoxia
Bunn, H. F., & Poyton, R. Ο. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.3.839 · Cited by 1,185 · see citing works
Erythropoietin: structure, control of production, and function
JELKMANN, W. E. B. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.449 · Cited by 1,167 · see citing works
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · see citing works
Wenger, R. H. (2002) · The FASEB Journal · doi:10.1096/fj.01-0944rev · Cited by 1,135 · see citing works
Hochachka, P. W., Buck, L. T., Doll, C. J., & Land, S. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9493 · Cited by 1,105 · see citing works
Kristiansen, T. Z., Navarro, J. D., Amanchy, R., Kristiansen, T. Z., Jonnalagadda, C. K., Surendranath, V., Niranjan, V., Muthusamy, B., Gandhi, T. K. B., Gronborg, M., et al. (2003) · Genome Research · doi:10.1101/gr.1680803 · Cited by 1,078 · see citing works
Molecular mechanisms of translational control
Gebauer, F., & Hentze, M. W. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1488 · Cited by 991 · see citing works
Anderson, P., & Kedersha, N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512082 · Cited by 984 · see citing works
Internal ribosome entry sites in eukaryotic mRNA moleculesPreprint
Hellen, C. U. T., & Sarnow, P. (2001) · Genes & Development · doi:10.1101/gad.891101 · Cited by 977 · see citing works
Modulation of Akt kinase activity by binding to Hsp90
Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967 · see citing works
Mammalian TOR: a homeostatic ATP sensor
Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001) · Science · doi:10.1126/science.1063518 · Cited by 962 · see citing works
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942 · see citing works
Semenza, G. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00518-9 · Cited by 935 · see citing works
A hierarchy of ATP-consuming processes in mammalian cells
Buttgereit, F., & Brand, M. D. (1995) · Biochemical Journal · doi:10.1042/bj3120163 · Cited by 929 · see citing works
Gingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885 · see citing works
5′-Nucleotidase: molecular structure and functional aspects
Zimmermann, H. (1992) · Biochemical Journal · doi:10.1042/bj2850345 · Cited by 880 · see citing works
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862 · see citing works
Bolster, D. R., Crozier, S. J., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200171200 · Cited by 851 · see citing works
AMP-Activated Protein Kinase – Development of the Energy Sensor Concept
Hardie, D. G., Hawley, S. A., & Scott, J. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108944 · Cited by 813 · see citing works
Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism.
Ježek, P., & Hlavatá, L. (2005) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2005.05.013 · Cited by 771 · see citing works
Detection and Characterization of Tumor Hypoxia Using pO <sub>2</sub> Histography
Vaupel, P., Höckel, M., & Mayer, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1628 · Cited by 728 · see citing works
Brunn, G. J., Williams, J. M., Sabers, C. J., Wiederrecht, G., Lawrence, J. C., & Abraham, R. T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00911.x · Cited by 723 · see citing works
Gene-Specific Regulation by General Translation Factors
Dever, T. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00642-6 · Cited by 720 · see citing works
Sitkovsky, M. V., Lukashev, D. E., Apasov, S. G., Kojima, H., Koshiba, M., Caldwell, C. C., Ohta, A., & Thiel, M. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104731 · Cited by 697 · see citing works
Metabolic rate depression in animals: transcriptional and translational controls
Storey, K. B., & Storey, J. M. (2004) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793103006195 · Cited by 696 · see citing works
Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, J. A., Sonenberg, N., Koromilas, A. E., & Wouters, B. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7405-7416.2002 · Cited by 688 · see citing works
Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes
Duranteau, J., Chandel, N. S., Kulisz, A., Shao, Z., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11619 · Cited by 679 · see citing works
MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia
Zhong, H., Lv, Q., Ye, W., Wong, C.-K. A., Cai, G., Gu, D., Ji, Y., Zhao, C., Wang, J., Yang, B. B., et al. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000116 · Cited by 653 · see citing works
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy
Ushio‐Fukai, M., & Nakamura, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.044 · Cited by 651 · see citing works
Peroxynitrite reactions and formation in mitochondria
Radí, R., Cassina, A., Hodara, R., Quijano, C., & Castro, L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01111-5 · Cited by 635 · see citing works
Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia
Levy, A. P., Levy, N. S., & Goldberg, M. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2746 · Cited by 629 · see citing works
Kedersha, N., Chen, S., Farny, N. G., Li, W., Miller, I. J., Stahl, J., & Anderson, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-05-0221 · Cited by 624 · see citing works
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
Jefferies, H. B. J., Reinhard, C., Kozma, S. C., & Thomas, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4441 · Cited by 623 · see citing works
Schieke, S. M., Phillips, D., McCoy, J. P., Aponte, A. M., Shen, R.-F., Balaban, R. S., & Finkel, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603536200 · Cited by 623 · see citing works
Hypoxia-induced energy stress regulates mRNA translation and cell growth
Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.010 · Cited by 607 · see citing works
Cowan, K. J., & Storey, K. B. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00220 · Cited by 594 · see citing works
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress
Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell · doi:10.1016/j.cell.2004.08.025 · Cited by 588 · see citing works
Structure and function of adenosine receptors and their genes
Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583 · see citing works
Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Günzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192342099 · Cited by 561 · see citing works
(2001) · PubMed · Cited by 557 · see citing works
Cellular Mechanism of Oxygen Sensing
López‐Barneo, J., Pardal, R., & Ortega‐Sáenz, P. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.259 · Cited by 546 · see citing works
Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during Hypoxia
Thompson, L. F., Eltzschig, H. K., Ibla, J. C., Wiele, C. J. V. D., Resta, R., Morote–Garcia, J. C., & Colgan, S. P. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040915 · Cited by 544 · see citing works
Brazil, D. P., Park, J., & Hemmings, B. A. (2002) · Cell · doi:10.1016/s0092-8674(02)01083-8 · Cited by 537 · see citing works
The power of the 3′ UTR: translational control and development.
Kuersten, S., & Goodwin, E. B. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1125 · Cited by 530 · see citing works
Potter, C. J., Huang, H., & Xu, T. (2001) · Cell · doi:10.1016/s0092-8674(01)00333-6 · Cited by 522 · see citing works
ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies.
Seino, S. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.337 · Cited by 521 · see citing works
Signalling to translation: How signal transduction pathways control the protein synthetic machinery
Proud, C. G. (2007) · Biochemical Journal · doi:10.1042/bj20070024 · Cited by 520 · see citing works
Iron Metabolism and the IRE/IRP Regulatory System: An Update
Pantopoulos, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.001 · Cited by 505 · see citing works
CONTROL OF TRANSLATION INITIATION IN ANIMALS
Gray, N. K., & Wickens, M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.399 · Cited by 500 · see citing works
Mazure, N. M., Chen, E. Y., Laderoute, K. R., & Giaccia, A. J. (1997) · Blood · doi:10.1182/blood.v90.9.3322 · Cited by 498 · see citing works
Acute Oxygen-Sensing Mechanisms
Weir, Ε. K., López‐Barneo, J., Buckler, K. J., & Archer, S. L. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050002 · Cited by 489 · see citing works
Regulation of protein synthesis in mammalian cells
Fan, H., & Penman, S. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90091-4 · Cited by 479 · see citing works
Ellisen, L. W., Ramsayer, K. D., Johannessen, C. M., Yang, A., Beppu, H., Minda, K., Oliner, J. D., McKeon, F., & Haber, D. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00706-2 · Cited by 474 · see citing works
Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase
Ushio‐Fukai, M., & Alexander, R. W. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000044378.09409.b5 · Cited by 473 · see citing works
Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212770200 · Cited by 463 · see citing works
Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival
Wang, X., McCullough, K. D., Franke, T. F., & Holbrook, N. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14624 · Cited by 461 · see citing works
Eukaryotic mRNPs May Represent Posttranscriptional Operons
Keene, J. D., & Tenenbaum, S. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00559-2 · Cited by 457 · see citing works
Hung, S.-C., Pochampally, R. R., Chen, S.-C., Hsu, S.-C., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0686 · Cited by 457 · see citing works
McEwen, E. L., Kedersha, N., Song, B., Scheuner, D. L., Gilks, N., Han, A., Chen, J.-J., Anderson, P., & Kaufman, R. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412882200 · Cited by 448 · see citing works
Messenger RNA regulation: to translate or to degrade
Shyu, A., Wilkinson, M., & van Hoof, A. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601977 · Cited by 447 · see citing works
Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress
Blais, J. D., Filippenko, V., Bi, M., Harding, H. P., Ron, D., Koumenis, C., Wouters, B. G., & Bell, J. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7469-7482.2004 · Cited by 447 · see citing works
Fatica, A., & Tollervey, D. W. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00336-8 · Cited by 446 · see citing works
Horman, S., Browne, G., Krause, U., Patel, J., Vertommen, D., Bertrand, L., Lavoinne, A., Hue, L., Proud, C. G., & Rider, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01077-1 · Cited by 440 · see citing works
Cardioprotection by Ecto-5′-Nucleotidase (CD73) and A 2B Adenosine Receptors
Eckle, T. D. L. G., Krahn, T., Grenz, A., Köhler, D., Mittelbronn, M. G. A., Ledent, C. A., Jacobson, M. A., Oßwald, H., Thompson, L. F., Unertl, K. E., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.669697 · Cited by 437 · see citing works
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB
Frede, S., Stockmann, C., Freitag, P., & Fandrey, J. (2006) · Biochemical Journal · doi:10.1042/bj20051839 · Cited by 436 · see citing works
Bruick, R. K. (2003) · Genes & Development · doi:10.1101/gad.1145503 · Cited by 435 · see citing works
BelAiba, R. S., Bonello, S., Zähringer, C., Schmidt, S., Hess, J., Kietzmann, T., & Görlach, A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-04-0391 · Cited by 423 · see citing works
Archer, S. L., Souil, E., Dinh‐Xuan, A. T., Schremmer, B., Mercier, J., Yaagoubi, A. E., Nguyen-Huu, L., Reeve, H. L., & Hampl, V. (1998) · Journal of Clinical Investigation · doi:10.1172/jci333 · Cited by 403 · see citing works
Anderson, M. T., Staal, F. J. T., Gitler, C., Herzenberg, L. A., & Herzenberg, L. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11527 · Cited by 401 · see citing works
The role of the 5′ untranslated region of an mRNA in translation regulation during development
van der Velden, A. W., & Thomas, A. A. M. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00134-4 · Cited by 397 · see citing works
Functional Specificity among Ribosomal Proteins Regulates Gene Expression
Komili, S., Farny, N. G., Roth, F. P., & Silver, P. A. (2007) · Cell · doi:10.1016/j.cell.2007.08.037 · Cited by 390 · see citing works
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Giaccia, A. J., Simon, M. C., & Johnson, R. (2004) · Genes & Development · doi:10.1101/gad.1243304 · Cited by 380 · see citing works
Anderson, P., & Kedersha, N. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.16.3227 · Cited by 376 · see citing works
Effect of γ-butyrobetaine on fatty liver in juvenile visceral steatosis mice
Higashi, Y., Yokogawa, K., Takeuchi, N., Tamai, I., Nomura, M., Hashimoto, N., Hayakawa, J.-I., Miyamoto, K., & Tsuji, A. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011775631 · Cited by 373 · see citing works
HIF hydroxylation and the mammalian oxygen-sensing pathway
Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318181 · Cited by 365 · see citing works
Koritzinsky, M., Magagnin, M. G., van den Beucken, T., Seigneuric, R., Savelkouls, K. G. M., Dostie, J., Pyronnet, S., Kaufman, R. J., Weppler, S. A., Voncken, J. W., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600998 · Cited by 364 · see citing works
HIF hydroxylation and the mammalian oxygen-sensing pathway
Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18181 · Cited by 363 · see citing works
Downregulation of Cellular Metabolism During Environmental Stress: Mechanisms and Implications
Hand, S. C., & Hardewig, I. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.002543 · Cited by 354 · see citing works
Terada, N., Patel, H. R., Takase, K., Kohno, K., Nairn, A. C., & Gelfand, E. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11477 · Cited by 353 · see citing works
Eukaryotic initiation factor eIF2
Kimball, S. R. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00128-9 · Cited by 344 · see citing works
Fontana, J. T., Fulton, D. J., Chen, Y., Fairchild, T. A., McCabe, T. J. D., Fujita, N., Tsuruo, T., & Sessa, W. C. (2002) · Circulation Research · doi:10.1161/01.res.0000016837.26733.be · Cited by 340 · see citing works
Reiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 338 · see citing works
Lang, K. J. D., Kappel, A., & Goodall, G. J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0017 · Cited by 314 · see citing works
Lahiri, S., Roy, A., Baby, S. M., Hoshi, T., Semenza, G. L., & Prabhakar, N. R. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.07.001 · Cited by 312 · see citing works
Baird, S. D., Turcotte, M., Korneluk, R. G., & Holčı́k, M. (2006) · RNA · doi:10.1261/rna.157806 · Cited by 306 · see citing works
Ca2+-dependent regulation in neuronal gene expression
Bito, H., Deisseroth, K. A., & Tsien, R. W. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80072-4 · Cited by 300 · see citing works
Mitochondria and cellular oxygen sensing in the HIF pathway
Taylor, C. T. (2008) · Biochemical Journal · doi:10.1042/bj20071249 · Cited by 298 · see citing works
Blais, J. D., Addison, C., Edge, R. E., Falls, T. J., Zhao, H., Wary, K. K., Koumenis, C., Harding, H. P., Ron, D., Holčı́k, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-06 · Cited by 295 · see citing works
Re‐programming of translation following cell stress allows IRES‐mediated translation to predominate
Spriggs, K. A., Stoneley, M., Bushell, M., & Willis, A. E. (2007) · Biology of the Cell · doi:10.1042/bc20070098 · Cited by 292 · see citing works
Kimball, S. R., Horetsky, R. L., Ron, D., Jefferson, L. S., & Harding, H. P. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00314.2002 · Cited by 291 · see citing works
Stiehl, D. P., JELKMANN, W. E. B., Wenger, R. H., & Hellwig‐Bürgel, T. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02247-0 · Cited by 285 · see citing works
Stress-Responsive Protein Kinases in Redox-Regulated Apoptosis Signaling
Matsuzawa, A., & Ichijo, H. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.472 · Cited by 283 · see citing works
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α
Galbán, S., Kuwano, Y., Pullmann, R., Martindale, J. L., Kim, H. H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J. O., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-07 · Cited by 279 · see citing works
A microRNA component of the hypoxic response
Kulshreshtha, R., Davuluri, R. V., Calin, G. A., & Ivan, M. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402310 · Cited by 273 · see citing works
Regulation of Angiogenesis by Hypoxia and Hypoxia‐Inducible Factors
Hickey, M. M., & Simon, M. C. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)76007-0 · Cited by 268 · see citing works
mTOR integrates amino acid- and energy-sensing pathways
Tokunaga, C., Yoshino, K., & Yonezawa, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.07.019 · Cited by 268 · see citing works
Kline, D. D., Peng, Y., Manalo, D. J., Semenza, G. L., & Prabhakar, N. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022634199 · Cited by 263 · see citing works
Kanichai, M., Ferguson, D., Prendergast, P. J., & Campbell, V. A. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21446 · Cited by 262 · see citing works
Akiri, G., Nahari, D., Finkelstein, Y., Le, S., Elroy‐Stein, O., & Levi, B.-Z. (1998) · Oncogene · doi:10.1038/sj.onc.1202019 · Cited by 261 · see citing works
Gnaiger, E., Méndez, G., & Hand, S. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11080 · Cited by 261 · see citing works
The ribosome filter hypothesis
Mauro, V. P., & Edelman, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192442499 · Cited by 260 · see citing works
Mitchell, S. A., Spriggs, K. A., Coldwell, M. J., Jackson, R. J., & Willis, A. E. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00093-5 · Cited by 259 · see citing works
Abdelmohsen, K., Kuwano, Y., Kim, H. H., & Gorospe, M. (2008) · Biological Chemistry · doi:10.1515/bc.2008.022 · Cited by 258 · see citing works
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
Sarbassov, D. D., & Sabatini, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506096200 · Cited by 248 · see citing works
Jung, S., Yang, W. K., Kim, J., Kim, H. S., Kim, E. J., Yun, H., Park, H., Kim, S. S., Choe, W., Kang, I., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn032 · Cited by 246 · see citing works
Searching for regulatory elements in human noncoding sequences
Duret, L., & Bücher, P. (1997) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(97)80058-9 · Cited by 245 · see citing works
Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
Fandrey, J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00577.2003 · Cited by 243 · see citing works
Evans, J. R., Mitchell, S. A., Spriggs, K. A., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206645 · Cited by 233 · see citing works
Connolly, E., Braunstein, S., Formenti, S., & Schneider, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3955-3965.2006 · Cited by 233 · see citing works
Translational control: the cancer connection
Clemens, M. J., & Bommer, U. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00127-7 · Cited by 220 · see citing works
Hyde, R. J., Cass, C. E., Young, J. D., & Baldwin, J. D. S. A. (2001) · Molecular Membrane Biology · doi:10.1080/09687680118799 · Cited by 214 · see citing works
mRNA Stability and the Control of Gene Expression: Implications for Human Disease
Hollams, E. M., Giles, K. M., Thomson, A. M., & Leedman, P. J. (2002) · Neurochemical Research · doi:10.1023/a:1020992418511 · Cited by 210 · see citing works
Compernolle, V. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.07.003 · Cited by 209 · see citing works
Tourrière, H., Gallouzi, I., Chébli, K., Capony, J. P., Mouaikel, J., van der Geer, P., & Tazi, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7747-7760.2001 · Cited by 207 · see citing works
Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene
Norris, M. L., & Millhorn, D. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23774 · Cited by 201 · see citing works
Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body
Cross, A. R., HENDERSON, L. M., Jones, O. T. G., Delpiano, M. A., Hentschel, J., & Acker, H. (1990) · Biochemical Journal · doi:10.1042/bj2720743 · Cited by 201 · see citing works
miRNAs Get an Early Start on Translational Silencing
Meister, G. (2007) · Cell · doi:10.1016/j.cell.2007.09.021 · Cited by 200 · see citing works
Alternative mechanisms of initiating translation of mammalian mRNAs
Jackson, R. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051231 · Cited by 200 · see citing works
Goldberg, M., Gaut, C., & Bunn, H. F. (1991) · Blood · doi:10.1182/blood.v77.2.271.271 · Cited by 199 · see citing works
Vaux, E. C., Metzen, E., Yeates, K. M., & Ratcliffe, P. J. (2001) · Blood · doi:10.1182/blood.v98.2.296 · Cited by 198 · see citing works
Growth regulation of the vascular system: an emerging role for adenosine
Adair, T. H. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00840.2004 · Cited by 193 · see citing works
Waypa, G. B., Guzy, R., Mungai, P. T., Mack, M. M., Marks, J. D., Roe, M. W., & Schumacker, P. T. (2006) · Circulation Research · doi:10.1161/01.res.0000247068.75808.3f · Cited by 191 · see citing works
Lee, S.-W., Berger, S. J., Martinović, S., Paša-Tolić, L., Anderson, G., Shen, Y.-F., Zhao, R., & Smith, R. D. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.082119899 · Cited by 188 · see citing works
Comerford, K. M., Leonard, M. O., Karhausen, J., Carey, R., Colgan, S. P., & Taylor, C. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337412100 · Cited by 185 · see citing works
Kim, J. H., Paek, K. Y., Choi, K., Kim, T., Hahm, B., Kim, K., & Jang, S. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.708-720.2003 · Cited by 183 · see citing works
Palacios‐Callender, M., Quintero, M., Hollis, V., Springett, R., & Moncada, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401723101 · Cited by 181 · see citing works
Selective Activation of p38α and p38γ by Hypoxia
Conrad, P., Rust, R. T., Han, J., Millhorn, D. E., & Beitner‐Johnson, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23570 · Cited by 177 · see citing works
Suzuma, K., Takahara, N., Suzuma, I., Isshiki, K., Ueki, K., Leitges, M., Aiello, L. P., & King, G. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022644499 · Cited by 170 · see citing works
A second look at cellular mRNA sequences said to function as internal ribosome entry sites
Kozak, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki958 · Cited by 167 · see citing works
Moudgil, R., Michelakis, E. D., & Archer, S. L. (2006) · Microcirculation · doi:10.1080/10739680600930222 · Cited by 167 · see citing works
Regulation of microRNA Expression: the Hypoxic Component
Kulshreshtha, R., Ferracin, M., Negrini, M., Calin, G. A., Davuluri, R. V., & Ivan, M. (2007) · Cell Cycle · doi:10.4161/cc.6.12.4410 · Cited by 165 · see citing works
Leach, R. M., Hill, H. M., Snetkov, V. A., Robertson, T. P., & Ward, J. P. T. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00211.x · Cited by 162 · see citing works
Bonnal, S., Pileur, F., Orsini, C., Parker, F., Pujol, F., Prats, A., & Vagner, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411492200 · Cited by 156 · see citing works
Protective Role of Ecto-5′-Nucleotidase (CD73) in Renal Ischemia
Grenz, A., Zhang, H., Eckle, T. D. L. G., Mittelbronn, M. G. A., Wehrmann, M., Köhle, C., Kloor, D., Thompson, L. F., Oßwald, H., & Eltzschig, H. K. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006101141 · Cited by 155 · see citing works
From factors to mechanisms: translation and translational control in eukaryotes
Preiß, T., & Hentze, M. W. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00005-2 · Cited by 154 · see citing works
Control of the hypoxic response through regulation of mRNA translation
Wouters, B. G., van den Beucken, T., Magagnin, M. G., Koritzinsky, M., Fels, D. R., & Koumenis, C. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.03.009 · Cited by 154 · see citing works
López‐Lastra, M., RIVAS, A., & Barría, M. I. (2005) · Biological Research · doi:10.4067/s0716-97602005000200003 · Cited by 147 · see citing works
Methylation of proteins involved in translation
Polevoda, B. V., & Sherman, F. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05831.x · Cited by 145 · see citing works
Srinivas, V., Leshchinsky, I., Sang, N., King, M. P., Minchenko, О. H., & Caro, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100177200 · Cited by 143 · see citing works
Translational control of gene expression during hypoxia
van den Beucken, T., Koritzinsky, M., & Wouters, B. G. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.7.2972 · Cited by 142 · see citing works
Mitchell, S. A., Spriggs, K. A., Bushell, M., Evans, J. R., Stoneley, M., Quesne, J. L., Spriggs, R. V., & Willis, A. (2005) · Genes & Development · doi:10.1101/gad.339105 · Cited by 142 · see citing works
Beitner‐Johnson, D., & Millhorn, D. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19834 · Cited by 142 · see citing works
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum
Pyhtila, B. M., Zheng, T., Lager, P. J., Keene, J. D., Reedy, M. C., & Nicchitta, C. V. (2008) · RNA · doi:10.1261/rna.721108 · Cited by 141 · see citing works
Yamada, K., & Inagaki, N. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.020 · Cited by 140 · see citing works
Calcium signaling stimulates translation of HIF‐α during hypoxia
Hui, A. S., Bauer, A. L., Striet, J. B., Schnell, P. O., & Czyzyk-Krzeska, M. (2006) · The FASEB Journal · doi:10.1096/fj.05-5086com · Cited by 136 · see citing works
Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma
Kluiver, J. L., van den Berg, A., de Jong, D., Blokzijl, T., Harms, G., Bouwman, E., Jacobs, S. C., Poppema, S., & Kroesen, B. J. (2006) · Oncogene · doi:10.1038/sj.onc.1210147 · Cited by 135 · see citing works
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries
Yuan, X. J., Tod, M. L., Rubin, L. J., et al. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.2.h281 · Cited by 134 · see citing works
Vumbaca, F., Phoenix, K. N., Rodríguez‐Pinto, D., Han, D. K. M., & Claffey, K. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02078-06 · Cited by 129 · see citing works
Shiritova, L. A., W, E. K., R, H. L., & M, E. (2002) · Advances in experimental medicine and biology · doi:10.1007/0-306-46825-5_21 · Cited by 128 · see citing works
Oxygen sensing and oxidant/redox-related pathways
Haddad, J. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.162 · Cited by 122 · see citing works
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts
Klotz, L., Schieke, S. M., Sies, H., & Holbrook, N. J. (2000) · Biochemical Journal · doi:10.1042/bj3520219 · Cited by 121 · see citing works
Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism
Young, R. M., Wang, S.-J., Gordan, J. D., Ji, X., Liebhaber, S. A., & Simon, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710079200 · Cited by 121 · see citing works
Ritzel, A. M. L. N. M. W. L. (2001) · Molecular Membrane Biology · doi:10.1080/09687680118530 · Cited by 120 · see citing works
Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cues
Levine, T. P., & Rabouille, C. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.06.005 · Cited by 117 · see citing works
Ritzel, M. W. L., Ng, A. M. L., Yao, S. Y. M., et al. (2001) · Molecular Membrane Biology · doi:10.1080/09687680010026313 · Cited by 117 · see citing works
Pathophysiology and Clinical effects of Chronic Hypoxia
Pierson, D. J. (2000) · Respiratory Care · doi:10.1177/002013240004500104 · Cited by 114 · see citing works
Christensen, A., Kahn, L. E., & Bourne, C. M. (1987) · American Journal of Anatomy · doi:10.1002/aja.1001780102 · Cited by 114 · see citing works
The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases
Acker, T., Fandrey, J., & Acker, H. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.04.008 · Cited by 112 · see citing works
Efficient Mammalian Protein Synthesis Requires an Intact F-Actin System
Stapulionis, R., Kolli, S., & Deutscher, M. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24980 · Cited by 109 · see citing works
The hypoxic proteome is influenced by gene-specific changes in mRNA translation
Koritzinsky, M., Seigneuric, R., Magagnin, M. G., van den Beucken, T., Lambin, P., & Wouters, B. G. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.036 · Cited by 108 · see citing works
Structural and compositional features of untranslated regions of eukaryotic mRNAs
Pesole, G., Liuni, S., Grillo, G., & Saccone, C. (1997) · Gene · doi:10.1016/s0378-1119(97)00407-1 · Cited by 108 · see citing works
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Surviving hypoxia by modulation of mRNA translation rate
Fähling, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00875.x · Cited by 54 · see citing works
Self-citation
- Authors
- Fähling, M.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Fähling, M.
- ORCID
- Fähling, M.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2009-01-05
- Volume
- 195
- Issue
- 2
- Pages
- 205-230
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W2065309438
- Cited by
- 57
- References
- 283
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 2 · 2013: 8 · 2012: 5
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- hypoxia, cellular oxygen sensing, hypoxia signaling, translational arrest, eIF2α phosphorylation, PERK, mTOR inhibition, stress granules, mRNA translation, membrane-bound ribosomes, local translation, transcriptional regulation, gene expression regulation
- MeSH terms
- Adenosine Triphosphate, Animals, Calcium, Cells, Gene Expression Regulation, Humans, Mammals, Oxygen, Ribosomes, Protein Biosynthesis, Cell Hypoxia, Reactive Oxygen Species, Reactive Nitrogen Species
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