The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Exploring genetic interactions and networks with yeast
Abstract
The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.
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“All of our top hits displayed fitness defects in the presence of caspofungin, indicative of a negative chemical-genetic interaction”
From Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans (2018) · cites this paper as Boone et al., 2007
Citations
Cites
A haplotype map of the human genome
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XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
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Self-citationFunctional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
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A comprehensive two-hybrid analysis to explore the yeast protein interactome
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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
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Research works printed but not linked: 1
- Sprague, G. F. Jr & Thorner, J. W. in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression Vol. 2 (eds Jones, E. W., Pringle, J. R. & Broach, J. R.) 657–744 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1992).
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Gilbert, L. A., Horlbeck, M. A., Adamson, B., Villalta, J. E., Chen, Y., Whitehead, E. H., Guimaraes, C., Panning, B., Ploegh, H. L., Bassik, M. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.029 · Cited by 2,728
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Lehár, J., Krueger, A., Avery, W., Heilbut, A. M., Johansen, L. M., Price, E. R., Rickles, R. J., Short, G. F., Staunton, J. E., Jin, X., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1549 · Cited by 959
Metadata
- Authors
- Boone, C., Bussey, H., & Andrews, B. J.
- Affiliations
- University of Toronto (CA)
- McGill University (CA)
- Corresponding author
- Boone, Charles
- Andrews, Brenda J.
- Venue
- Nature Reviews Genetics
- Published
- 2007-06
- Volume
- 8
- Issue
- 6
- Pages
- 437-449
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2150749732
- Cited by
- 661
- References
- 90
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 20 · 2023: 17 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 37 · 2018: 28 · 2017: 57 · 2016: 27 · 2015: 29 · 2014: 43 · 2013: 41 · 2012: 44
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Genome Canada
- Ontario Genomics Institute
- Canada Research Chairs
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- genetic interactions, genetic interaction networks, Saccharomyces cerevisiae, genetic screen, gene networks, quantitative traits
- MeSH terms
- Algorithms, Chromosome Mapping, Diploidy, Epistasis, Genetic, Genes, Lethal, Models, Genetic, Mutation, Phenotype, Saccharomyces cerevisiae, Genome, Fungal, Gene Deletion, Oligonucleotide Array Sequence Analysis, Genomics, Saccharomyces cerevisiae Proteins
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