The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity
Open accessAbstract
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus‐mediated disease. The initial sections focus on seasonal coronaviruses, SARS‐CoV, and MERS‐CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS‐CoV‐2 and COVID‐19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS‐CoV‐2.
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Host genetics contribute to COVID-19 susceptibility and severity.
“suggested that host genetics might contribute to disease susceptibility and severity”
From COVID-19 and the human innate immune system (2021) · cites this paper as Ovsyannikova et al., 2020
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COVID-19 and the human innate immune system
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- Authors
- Ovsyannikova, I. G., Haralambieva, I. H., Crooke, S. N., Poland, G. A., & Kennedy, R. B.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Kennedy, Richard B.
- ORCID
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2020-07
- Volume
- 296
- Issue
- 1
- Pages
- 205-219
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC7404857
- OpenAlex
- W3041470702
- Cited by
- 258
- References
- 179
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 22 · 2023: 48 · 2022: 50 · 2021: 86 · 2020: 18 · 2013: 1
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI132348, AI121054, AI127365)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, host genetics, immune response, HLA genes, genetic polymorphism, disease susceptibility, disease severity, seasonal coronaviruses, SARS-CoV, MERS-CoV, viral genetics
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Humans, Pneumonia, Viral, Coronavirus Infections, Genetic Predisposition to Disease, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Host-Pathogen Interactions, Pandemics, Disease Resistance, Middle East Respiratory Syndrome Coronavirus
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