Cited by 258SARS-CoV-2 and COVID-19 ResearchGenetic Associations and EpidemiologyCOVID-19 Clinical Research Studies

The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity

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Ovsyannikova, Inna G., Haralambieva, Iana H., Crooke, Stephen N., Poland, Gregory A., Kennedy, Richard B.·2020·Immunological Reviews

Abstract

This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus‐mediated disease. The initial sections focus on seasonal coronaviruses, SARS‐CoV, and MERS‐CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS‐CoV‐2 and COVID‐19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS‐CoV‐2.

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Crossref · 10.1111/imr.12897

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  • Host genetics contribute to COVID-19 susceptibility and severity.

    “suggested that host genetics might contribute to disease susceptibility and severity”

    From COVID-19 and the human innate immune system (2021) · cites this paper as Ovsyannikova et al., 2020

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Research works printed but not linked: 2

  1. [78]78. Nguyen A, David JK, Maden SK, et al. Human leukocyte antigen susceptibility map for SARS‐CoV‐2. J Virol. 2020;94(13), e00510–20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. [111]111. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single‐cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019‐nCov. bioRxiv. 2020. [DOI] [PMC free article] [PubMed] [Google Scholar]

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Authors
Ovsyannikova, I. G., Haralambieva, I. H., Crooke, S. N., Poland, G. A., & Kennedy, R. B.
Affiliations
Mayo Clinic (US)
Corresponding author
Kennedy, Richard B.
Venue
Immunological Reviews
Publisher
Wiley
Published
2020-07
Volume
296
Issue
1
Pages
205-219
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W3041470702
Cited by
258
References
179
Citations by year
2026: 10 · 2025: 23 · 2024: 22 · 2023: 48 · 2022: 50 · 2021: 86 · 2020: 18 · 2013: 1
FWCI
2.39
Type
journal article
Language
en
Open access
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI132348, AI121054, AI127365)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
SARS-CoV-2, COVID-19 pandemic, host genetics, immune response, HLA genes, genetic polymorphism, disease susceptibility, disease severity, seasonal coronaviruses, SARS-CoV, MERS-CoV, viral genetics
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Humans, Pneumonia, Viral, Coronavirus Infections, Genetic Predisposition to Disease, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Host-Pathogen Interactions, Pandemics, Disease Resistance, Middle East Respiratory Syndrome Coronavirus

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