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Cited by 783

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Biological principles of microRNA-mediated regulation: shared themes amid diversity

Open access
Flynt, Alex S., Lai, Eric C.·2008·Nature Reviews Genetics

Abstract

Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression. Such themes may reflect some of the inherent advantages of exploiting microRNA control in biological circuits, and provide insight into the consequences of microRNA dysfunction in disease.

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Metadata

Authors
Flynt, A. S., & Lai, E. C.
Venue
Nature Reviews Genetics
Published
2008-11
Volume
9
Issue
11
Pages
831-842
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2080551186
Cited by
783
References
17
FWCI
2.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Biological principles of microRNA-mediated regulation: shared themes amid diversity. https://app.cochat.ai/papers/10.1038/nrg2455
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Flynt, A. S., & Lai, E. C. (2008). Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nature Reviews Genetics. https://doi.org/10.1038/nrg2455

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.