Cited by 4,672MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

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The widespread regulation of microRNA biogenesis, function and decay

Krol, Jacek, Loedige, Inga, Filipowicz, Witold·2010·Nature Reviews Genetics

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Abstract

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.

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DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
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A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
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Retracted: A subfamily of RNA‐binding DEAD‐box proteins acts as an estrogen receptor α coactivator through the N‐terminal activation domain (AF‐1) with an RNA coactivator, SRA
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RETRACTED: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor
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MicroRNAs: Target Recognition and Regulatory Functions
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Self-citation
Origins and Mechanisms of miRNAs and siRNAs
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Edbauer, D. et al. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 65, 373–384 (2010). · DOI · Paper page

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Authors: Krol, J., Loedige, I., & Filipowicz, W.
Affiliations: Friedrich Miescher Institute (CH)
Corresponding author: Filipowicz, Witold
ORCID: Loedige, Inga
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2010-07-27
Volume: 11
Issue: 9
Pages: 597-610
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2843
OpenAlex: W2059357290
Cited by: 4,672
References: 182
Citations by year: 2026: 93 · 2025: 172 · 2024: 267 · 2023: 256 · 2022: 372 · 2021: 330 · 2020: 336 · 2019: 309 · 2018: 308 · 2017: 347 · 2016: 328 · 2015: 321 · 2014: 386 · 2013: 297 · 2012: 325
FWCI: 22.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Novartis Foundation
Friedrich Miescher Institute for Biomedical Research
Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: microRNA biogenesis, microRNA function, post-transcriptional regulation, RNA-protein interactions, protein-protein interaction
MeSH terms: Animals, Gene Expression Regulation, Humans, RNA Stability, MicroRNAs

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The widespread regulation of microRNA biogenesis, function and decay

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