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The widespread regulation of microRNA biogenesis, function and decay
Abstract
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.
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“Ago proteins (namely, Ago1 and Ago2) are the core components of miRNA-silencing complexes (Krol et al., 2010), and this powerful technique allows for sequencing of both the miRNAs and the mRNA target regions to which they bind.”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Krol et al., 2010
In the citing paper
“During the past decade, microRNAs (miRNAs; ∼19–22 nucleotides) have emerged as key posttranscriptional regulators of gene expression, having been implicated in nearly all biological processes (Krol et al., 2010).”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Krol et al., 2010
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4 retracted
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Metadata
- Authors
- Krol, J., Loedige, I., & Filipowicz, W.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Filipowicz, Witold
- ORCID
- Loedige, Inga
- Venue
- Nature Reviews Genetics
- Published
- 2010-07-27
- Volume
- 11
- Issue
- 9
- Pages
- 597-610
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2059357290
- Cited by
- 4,672
- References
- 182
- Citations by year
- 2026: 93 · 2025: 172 · 2024: 267 · 2023: 256 · 2022: 372 · 2021: 330 · 2020: 336 · 2019: 309 · 2018: 308 · 2017: 347 · 2016: 328 · 2015: 321 · 2014: 386 · 2013: 297 · 2012: 325
- FWCI
- 22.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novartis Foundation
- Friedrich Miescher Institute for Biomedical Research
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- microRNA biogenesis, microRNA function, post-transcriptional regulation, RNA-protein interactions, protein-protein interaction
- MeSH terms
- Animals, Gene Expression Regulation, Humans, RNA Stability, MicroRNAs
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