The DOI matches its Crossref record; 181 of the 182 references it cites were found in a registry or an index.
The widespread regulation of microRNA biogenesis, function and decay
Abstract
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.
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“Ago proteins (namely, Ago1 and Ago2) are the core components of miRNA-silencing complexes (Krol et al., 2010), and this powerful technique allows for sequencing of both the miRNAs and the mRNA target regions to which they bind.”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Krol et al., 2010
In the citing paper
“During the past decade, microRNAs (miRNAs; ∼19–22 nucleotides) have emerged as key posttranscriptional regulators of gene expression, having been implicated in nearly all biological processes (Krol et al., 2010).”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Krol et al., 2010
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4 retracted
Fukuda, T., Yamagata, K., Fujiyama, S., Μatsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1577 · Cited by 452
RetractedA TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Melo, S. A., Ropero, S., Moutinho, C., Aaltonen, L. A., Yamamoto, H., Calin, G. A., Rossi, S., Fernández, A. F., Carneiro, F., Oliveíra, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.317 · Cited by 375
RetractedWatanabe, M., Yanagisawa, J., Kitagawa, H., Takeyama, K., Ogawa, S., Arao, Y., Suzawa, M., Kobayashi, Y., Yano, T., Yoshikawa, H., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1341 · Cited by 267
RetractedRETRACTED: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor
Yamagata, K., Fujiyama, S., Ito, S., Ueda, T., Murata, T., Naitou, M., Takeyama, K., Minami, Y., O’Malley, B. W., & Kato, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.017 · Cited by 197
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Self-citationOrigins and Mechanisms of miRNAs and siRNAs
Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,161
Regulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214
Self-citationSwitching from Repression to Activation: MicroRNAs Can Up-Regulate Translation
Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,911
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873
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1 of the 182 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Edbauer, D. et al. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 65, 373–384 (2010). · DOI · Paper page
Cited by
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Synergic functions of miRNAs determine neuronal fate of adult neural stem cells
Pons-Espinal, M., de Luca, E., Marzi, M. J., Beckervordersandforth, R., Armirotti, A., Nicassio, F., Fabel, K., Kempermann, G., & De Pietri Tonelli, D. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.02.012 · Cited by 59
Multi-omics integration strategies for animal epigenetic studies — A review
Kim, D.-Y., & Kim, J.-M. (2021) · Animal Bioscience · doi:10.5713/ab.21.0042 · Cited by 47
Emerging roles for ncRNAs in alcohol use disorders
Mayfield, R. D. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.004 · Cited by 43
Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential
Gan, H., Lei, Y., Yuan, N., Tang, K., Hao, W., Ma, Q., Wu, M., Zhou, X., Li, X., Huang, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111244 · Cited by 41
Herman, A. B., Anerillas, C., Harris, S. C., Munk, R., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Zhang, Y., Heckenbach, I. J., Scheibye-Knudsen, M., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab538 · Cited by 31
Engineering brain-derived neurotrophic factor mRNA delivery for the treatment of Alzheimer’s disease
Li, H., Cao, Y., Ye, J., Yang, Z., Chen, Q., Liu, X., Zhang, B., Qiao, J., Tang, Q., Yang, H., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143152 · Cited by 32
Lopez-Valenzuela, M., Ramirez, O., Rosas, A., Garcia-Vargas, S., de la Rasilla, M., Lalueza-Fox, C., & Espinosa-Parrilla, Y. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss023 · Cited by 31
Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice
Miao, N., Jin, J., Kim, S.-N., & Sun, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030671 · Cited by 19
Exosomes: Potential Biomarkers and Functions in Head and Neck Squamous Cell Carcinoma
Li, T., Li, J., Wang, H., Zhao, J., Yan, M., He, H., & Yu, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.881794 · Cited by 18
Hu, F., Xu, P., Sun, B., & Xiao, Z. (2017) · Gene · doi:10.1016/j.gene.2017.05.014 · Cited by 9
Montel Hayes, R., Mason, C. E., & Miller, J. J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1671122 · Cited by 5
“…gene expression post-transcriptionally by binding to target messenger RNAs (mRNAs) and suppress translation or promote mRNA degradation (29). miRNAs are both targets and regulators of epigenetic processes since they exist within a feedback loop with DNA methylation and histone modi fi cations (30).”
Metadata
- Authors
- Krol, J., Loedige, I., & Filipowicz, W.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Filipowicz, Witold
- ORCID
- Loedige, Inga
- Venue
- Nature Reviews Genetics
- Published
- 2010-07-27
- Volume
- 11
- Issue
- 9
- Pages
- 597-610
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2059357290
- Cited by
- 4,672
- References
- 182
- Citations by year
- 2026: 93 · 2025: 172 · 2024: 267 · 2023: 256 · 2022: 372 · 2021: 330 · 2020: 336 · 2019: 309 · 2018: 308 · 2017: 347 · 2016: 328 · 2015: 321 · 2014: 386 · 2013: 297 · 2012: 325
- FWCI
- 22.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novartis Foundation
- Friedrich Miescher Institute for Biomedical Research
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- microRNA biogenesis, microRNA function, post-transcriptional regulation, RNA-protein interactions, protein-protein interaction
- MeSH terms
- Animals, Gene Expression Regulation, Humans, RNA Stability, MicroRNAs
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