Cited by 2,339MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, Eric, Izaurralde, Elisa·2011·Nature Reviews Genetics

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Abstract

Despite their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs. Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA abundance, whereas the reverse was thought to be true in plants. Now, however, it is clear that microRNAs can induce mRNA degradation in animals and, conversely, translational repression in plants. Recent studies have made important advances in elucidating the relative contributions of these two different modes of target regulation by microRNAs. They have also shed light on the specific mechanisms of target silencing, which, although it differs fundamentally between plants and animals, shares some common features between the two kingdoms.

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Authors: Huntzinger, E., & Izaurralde, E.
Affiliations: Max Planck Institute for Developmental Biology (DE)
Max Planck Society (DE)
Corresponding author: Izaurralde, Elisa
ORCID: Huntzinger, Eric
Izaurralde, Elisa
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2011-01-18
Volume: 12
Issue: 2
Pages: 99-110
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2936
OpenAlex: W2010461414
Cited by: 2,339
References: 86
Citations by year: 2026: 60 · 2025: 100 · 2024: 98 · 2023: 118 · 2022: 140 · 2021: 158 · 2020: 144 · 2019: 141 · 2018: 145 · 2017: 178 · 2016: 170 · 2015: 189 · 2014: 210 · 2013: 195 · 2012: 199
FWCI: 16.27
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Funders: Ministry of Economy, Trade and Industry
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: microRNA, gene silencing, protein synthesis inhibition, mRNA degradation, post-transcriptional regulation, microRNA target regulation, plant microRNAs
MeSH terms: Animals, Humans, Models, Genetic, Protein Biosynthesis, Gene Silencing, RNA Stability, MicroRNAs

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

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