Cited by 2,339MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, Eric, Izaurralde, Elisa·2011·Nature Reviews Genetics

Open this paper in CoChat — free account

Abstract

Despite their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs. Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA abundance, whereas the reverse was thought to be true in plants. Now, however, it is clear that microRNAs can induce mRNA degradation in animals and, conversely, translational repression in plants. Recent studies have made important advances in elucidating the relative contributions of these two different modes of target regulation by microRNAs. They have also shed light on the specific mechanisms of target silencing, which, although it differs fundamentally between plants and animals, shares some common features between the two kingdoms.

Integrity signals

Registry

Crossref · 10.1038/nrg2936

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Untitled work
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Origins and Mechanisms of miRNAs and siRNAs
Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,161
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429

Flagged first, then by citations

Show all 86 references

Sorted by citations

Items 801–900 of 1,005

Mechanism of the initiation of mRNA decay: role of eRF3 family G proteins
Hoshino, S.-I. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1133 · Cited by 40
A Three-microRNA Signature Predicts Responses to Platinum-Based Doublet Chemotherapy in Patients with Lung Adenocarcinoma
Saito, M., Shiraishi, K., Matsumoto, K., Schetter, A. J., Ogata‐Kawata, H., Tsuchiya, N., Kunitoh, H., Nokihara, H., WATANABE, S.-I. I., Tsuta, K., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1096 · Cited by 39
Ultra‐Specific Zeptomole MicroRNA Detection by Plasmonic Nanowire Interstice Sensor with Bi‐Temperature Hybridization
Kang, T., Kim, H., Lee, J. M., Lee, H., Choi, Y., Kang, G., Seo, M., Chung, B. H., Jung, Y., & Kim, B. (2014) · Small · doi:10.1002/smll.201400164 · Cited by 39
TGF-β1-miR-200a-PTEN induces epithelial–mesenchymal transition and fibrosis of pancreatic stellate cells
Xu, M., Wang, G., Zhou, H., Cai, J., Li, P., Zhou, M., Lu, Y., Jiang, X., Huang, H., Zhang, Y., et al. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-2988-y · Cited by 39
Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?
Barros, E., & Carvajal, C. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00230 · Cited by 40
Epigenetic regulation of melatonin receptors in neuropsychiatric disorders
Bahna, S. G., & Niles, L. P. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14058 · Cited by 40
Suppression of microRNA-495 alleviates high-glucose-induced retinal ganglion cell apoptosis by regulating Notch/PTEN/Akt signaling
Zhang, X., Yang, Y., & Feng, Z. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.018 · Cited by 39
miRmapper: A Tool for Interpretation of miRNA–mRNA Interaction Networks
da Silveira, W. A., Renaud, L., Simpson, J., Glen, W. B., Hazard, E. S., Chung, D., & Hardiman, G. (2018) · Genes · doi:10.3390/genes9090458 · Cited by 39
Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma
Tu, C., He, J., Qi, L., Ren, X., Zhang, C., Duan, Z., Yang, K., Wang, W., Lu, Q., & Li, Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29754 · Cited by 39
Small Non-Coding-RNA in Gynecological Malignancies
Dwivedi, S. K. D., Rao, G., Dey, A., Mukherjee, P., Wren, J. D., & Bhattacharya, R. (2021) · Cancers · doi:10.3390/cancers13051085 · Cited by 40
Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2
Willkomm, S., Jakob, L., Kramm, K., Graus, V., Neumeier, J., Meister, G., & Grohmann, D. (2022) · Nature Communications · doi:10.1038/s41467-022-31480-4 · Cited by 39
MicroRNA-126 attenuates palmitate-induced apoptosis by targeting TRAF7 in HUVECs
Wáng, Y., Wang, F., Wu, Y., Zuo, L., Zhang, S., Zhou, Q., Wei, W., Wang, Y., & Zhu, H. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2239-4 · Cited by 39
MicroRNA-9 regulates osteoblast differentiation and angiogenesis via the AMPK signaling pathway
Qu, J., Lu, D., Guo, H., Miao, W., Wu, G., & Zhou, M. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2565-1 · Cited by 38
The role of microRNAs in lymphopoiesis
Johanson, T. M., Skinner, J. P. J., Kumar, A., Zhan, Y., Lew, A. M., & Chong, M. M. W. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1606-y · Cited by 39
MicroRNA Profiling of Sendai Virus-Infected A549 Cells Identifies miR-203 as an Interferon-Inducible Regulator of IFIT1/ISG56
Buggele, W. A., & Horvath, C. M. (2013) · Journal of Virology · doi:10.1128/jvi.01064-13 · Cited by 38
Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery
Kneidinger, D., Ibrišimović, M., Lion, T., & Klein, R. (2012) · Antiviral Research · doi:10.1016/j.antiviral.2012.03.011 · Cited by 38
A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method
Ponnusamy, V., Kapellou, O., Yip, E., Evanson, J., Wong, L., Michael-Titus, A. T., Yip, P. K., & Shah, D. K. (2015) · Pediatric Research · doi:10.1038/pr.2015.276 · Cited by 38
MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling
Hyun, J., & Jung, Y. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i29.6652 · Cited by 38
Increased miR-132 level is associated with visual memory dysfunction in patients with depression
Liu, Y., Yang, X. Y., Zhao, L., Zhang, J., Li, T., & Ma, X. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s116287 · Cited by 38
MicroRNAs in injury and repair
Gerlach, C. V., & Vaidya, V. S. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1974-1 · Cited by 38
MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells
Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J., & Xodo, L. E. (2018) · RNA Biology · doi:10.1080/15476286.2018.1526536 · Cited by 38
Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR‐18a‐5p
Zhang, L., Deng, X., Shi, X., & Dong, X. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28172 · Cited by 39
Rapid and efficient generation of GFP ‐knocked‐in Drosophila by the CRISPR ‐Cas9‐mediated genome editing
Kina, H., Yoshitani, T., Hanyu‐Nakamura, K., & Nakamura, A. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12607 · Cited by 38
The Role of miRNAs in Metabolic Diseases
Mačvanin, M., Obradovic, M. M., Zafirovic, S. S., Stanimirović, J., & Isenović, E. R. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220801161536 · Cited by 40
Sample‐to‐answer salivary miRNA testing: New frontiers in point‐of‐care diagnostic technologies
Zhang, Z., Liu, T., Dong, M., Ahamed, M. A., & Guan, W. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1969 · Cited by 37
Recent advances in investigation of circRNA/lncRNA-miRNA-mRNA networks through RNA sequencing data analysis
Gao, Y., Takenaka, K., Xu, S.-M., Cheng, Y., & Janitz, M. (2025) · Briefings in Functional Genomics · doi:10.1093/bfgp/elaf005 · Cited by 41
Control of mRNA turnover: Implication of cytoplasmic RNA granules
Adjibade, P., & Mazrouï, R. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.05.013 · Cited by 41
miR-224 overexpression is a strong and independent prognosticator of short-term relapse and poor overall survival in colorectal adenocarcinoma
Adamopoulos, P. G., Kontos, C. K., Rapti, S.-M., Papadopoulos, I. N., & Scorilas, A. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2775 · Cited by 37
MicroRNA involvement in esophageal carcinogenesis
David, S., & Meltzer, S. J. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.006 · Cited by 37
Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs
Tardito, D., Mallei, A., & Popoli, M. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.749237 · Cited by 37
miR-430 regulates oriented cell division during neural tube development in zebrafish
Takacs, C. M., & Giráldez, A. J. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.11.016 · Cited by 38
The role of microRNAs and nanoparticles in ovarian cancer: a review
Kafshdooz, L., Pourfathi, H., Akbarzadeh, A., Kafshdooz, T., Razban, Z., Sheervalilou, R., Sadr, N. E., Khalilov, R. I., Saghfi, S., Kavetskyy, T. S., et al. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1454931 · Cited by 37
MiRNA-27b Regulates Angiogenesis by Targeting AMPK in Mouse Ischemic Stroke Model
Yuan, Y., Zhang, Z., Wang, Z., & Liu, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.11.041 · Cited by 37
MiR-223 promotes oral squamous cell carcinoma proliferation and migration by regulating FBXW7
Jiang, L., lv, L., Liu, X., Jiang, X., Yin, Q., Hao, Y., & Xiao, L. (2019) · Cancer Biomarkers · doi:10.3233/cbm-181877 · Cited by 37
miR-454-3p exerts tumor-suppressive functions by down-regulation of NFATc2 in glioblastoma
Zuo, J., Yu, H., Xie, P., Liu, W., Wang, K., & Ni, H. (2019) · Gene · doi:10.1016/j.gene.2019.06.008 · Cited by 37
Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters
Park, M. S., Araya-Secchi, R. R., Brackbill, J. A., Phan, H., Kehling, A. C., El-Wahab, E. W. A., Dayeh, D. M., Sotomayor, M. M., & Nakanishi, K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.011 · Cited by 37
MicroRNAs in Cancer Treatment-Induced Cardiotoxicity
Pellegrini, L., Sileno, S., D'Agostino, M., Foglio, E., Florio, M. C., Guzzanti, V., Russo, M. A., Limana, F., & Magenta, A. (2020) · Cancers · doi:10.3390/cancers12030704 · Cited by 37
The Influence of Lifestyle Factors on MiRNA Expression and Signal Pathways: A Review
Panìco, A., Tumolo, M. R., Leo, C. G., Donno, A. D., Grassi, T., Bagordo, F., Serio, F., Idolo, A., Masi, R. D., Mincarone, P., et al. (2020) · Epigenomics · doi:10.2217/epi-2020-0289 · Cited by 37
miR-204: Molecular Regulation and Role in Cardiovascular and Renal Diseases
Liu, J., Liu, Y., Wang, F., & Liang, M. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.14536 · Cited by 37
Ordered Heterogeneity in Dual-Ligand Mof to Enable Intense Electrochemiluminescence for Bioassay with DNA Triangular Prism as Signal Switch
Xue, Y.-Q., Liao, N., Li, Y., Liang, W., Yang, X., Zhong, X., & Zhuo, Y. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114713 · Cited by 37
miRNAs and lncRNAs in reproductive development
Li, Z., Zhang, Y., & Chen, Y. (2015) · Plant Science · doi:10.1016/j.plantsci.2015.05.017 · Cited by 37
Differential microRNA expression in the prefrontal cortex of mouse offspring induced by glyphosate exposure during pregnancy and lactation
Ji, H., Xu, L., Wang, Z., Fan, X., & Wu, L. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5669 · Cited by 37
Circulating Level of miR-378 Predicts Left Ventricular Hypertrophy in Patients with Aortic Stenosis
Chen, Z., Li, C., Xu, Y., Li, Y., Yang, H., & Rao, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105702 · Cited by 36
acal is a Long Non-coding RNA in JNK Signaling in Epithelial Shape Changes during Drosophila Dorsal Closure
Ríos‐Barrera, L. D., Gutiérrez-Pérez, I., Domínguez, M., & Riesgo‐Escovar, J. R. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004927 · Cited by 36
Profiling of MicroRNAs Involved in Retinal Degeneration Caused by Selective Müller Cell Ablation
Chung, S. H., Gillies, M. C., Sugiyama, Y., Zhu, L., Lee, S., & Shen, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118949 · Cited by 36
Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB
Antognelli, C., Gambelunghe, A., Muzi, G., & Talesa, V. N. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.026 · Cited by 36
Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection
Gupta, P., Liu, B., Wu, J. Q., Soriano, V., Vispo, E., Carroll, A. P., Goldie, B. J., Cairns, M. J., & Saksena, N. K. (2014) · Virology · doi:10.1016/j.virol.2013.12.026 · Cited by 36
Neurobiological Signatures of Alcohol Dependence Revealed by Protein Profiling
Gorini, G., Roberts, A. J., & Mayfield, R. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082656 · Cited by 37
Cardiovascular RNA Interference Therapy
Poller, W. C., Tank, J., Skurk, C., & Gast, M. (2013) · Circulation Research · doi:10.1161/circresaha.113.301056 · Cited by 37
MicroRNA biogenesis: Epigenetic modifications as another layer of complexity to the microRNA expression regulation
Bhat, S. S., Jarmołowski, A., & Szweykowska-Kulińska, Z. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1370 · Cited by 36
Genome-Wide microRNA Binding Site Variation between Extinct Wild Aurochs and Modern Cattle Identifies Candidate microRNA-Regulated Domestication Genes
Braud, M., Magee, D. A., Park, S. D. E., Sonstegard, T. S., Waters, S. M., MacHugh, D. E., & Spillane, C. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00003 · Cited by 36
Environment-Dependent Genotype-Phenotype Associations in Avian Breeding Time
Gienapp, P., Laine, V. N., Mateman, A. C., van Oers, K., & Visser, M. E. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00102 · Cited by 36
Longer Work/Rest Intervals During High-Intensity Interval Training (HIIT) Lead to Elevated Levels of miR-222 and miR-29c
Schmitz, B., Rolfes, F., Schelleckes, K., Mewes, M., Thorwesten, L., Krüger, M., Klose, A., & Brand, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00395 · Cited by 36
Circulating plasma exosomes in obstructive sleep apnoea and reverse dipping blood pressure
Khalyfa, A., Gozal, D., Chan, W., Andrade, J., & Prasad, B. (2019) · European Respiratory Journal · doi:10.1183/13993003.01072-2019 · Cited by 36
Light Triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana
Choi, S., Ryu, M. Y., Viczián, A., Jung, H. J., Kim, G. M., Arce, A. L., Achkar, N. P., Manavella, P. A., Dolde, U., Wenkel, S., et al. (2019) · Molecular Plant · doi:10.1016/j.molp.2019.10.011 · Cited by 36
Synaptic plasticity and depression: the role of miRNAs dysregulation
Rahmani, S., Kadkhoda, S., & Ghafouri-Fard, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07461-7 · Cited by 35
Advances in the Immune Regulatory Role of Non-Coding RNAs (miRNAs and lncRNAs) in Insect-Pathogen Interactions
Moure, U. A. E., Tan, T., Sha, L., Lu, X., Shao, Z., Yang, G., Wang, Y., & Cui, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856457 · Cited by 36
MicroRNAs in kidney development and disease
Cerqueira, D. M., Tayeb, M. N., & Ho, J. (2022) · JCI Insight · doi:10.1172/jci.insight.158277 · Cited by 38
Exploiting microRNA regulation for genetic engineering
Gentner, B., & Naldini, L. (2012) · Tissue Antigens · doi:10.1111/tan.12002 · Cited by 38
Disruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell–environment interaction genes
Chen, B., Chen, X., Wu, X., Wang, X., Wang, Y., Lin, T., Kurata, J. S., Wu, J., Vonderfecht, S. L., Sun, G., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.09.034 · Cited by 36
miR‐20b regulates expression of proteinase‐activated receptor‐1 (PAR‐1) thrombin receptor in melanoma cells
Saleiban, A., Faxälv, L., Claesson, K., Jönsson, J., & Osman, A. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12217 · Cited by 35
miR-21 functionally interacts with the 3′UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells
Vicinus, B., Rubie, C., Faust, S. K., Frick, V. O., Ghadjar, P., Wagner, M., Graeber, S. M., & Schilling, M. K. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.10.031 · Cited by 36
Changes in mRNA expression precede changes in micro RNA expression in lesional psoriatic skin during treatment with adalimumab
Raaby, L., Langkilde, A., Kjellerup, R. B., Vinter, H., Khatib, S. H., Hjuler, K. F., Johansen, C., & Iversen, L. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13721 · Cited by 35
MicroRNA Screening and the Quest for Biologically Relevant Targets
Eulálio, A., & Mano, M. (2015) · SLAS DISCOVERY · doi:10.1177/1087057115578837 · Cited by 37
Pluripotent Stem Cell-Derived Somatic Stem Cells as Tool to Study the Role of MicroRNAs in Early Human Neural Development
Roese-Koerner, B., Stappert, L., Koch, P., Brüstle, O., & Borghese, L. (2013) · Current Molecular Medicine · doi:10.2174/1566524011313050003 · Cited by 35
Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1
Happel, C., Ramalingam, D., & Ziegelbauer, J. M. (2016) · PLoS Biology · doi:10.1371/journal.pbio.2000998 · Cited by 35
Averrhoa carambola free phenolic extract ameliorates nonalcoholic hepatic steatosis by modulating mircoRNA-34a, mircoRNA-33 and AMPK pathways in leptin receptor-deficient db/db mice
Pang, D., You, L., Zhou, L. M., Li, T., Zheng, B., & Liu, R. H. (2017) · Food & Function · doi:10.1039/c7fo00833c · Cited by 35
Differential Regulatory Roles of MicroRNAs in Porcine Intramuscular and Subcutaneous Adipocytes
Xu, K., Miao, J., Huang, X., Peng, Y., Wu, W., & Zhang, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08191 · Cited by 35
Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1
Park, S. J., Choi, S., Kim, G. M., Møller, C., Pai, H., & Yang, S. W. (2021) · Molecular Plant · doi:10.1016/j.molp.2021.01.020 · Cited by 35
Circulating microRNAs
Makarova, J. A., Shkurnikov, M. Y., Turchinovich, A. A., Tonevitsky, A., & Grigoriev, A. I. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915090035 · Cited by 35
Apoptosis-promoting properties of miR-3074-5p in MC3T3-E1 cells under iron overload conditions
Feng, Y., He, P.-Y., Kong, W.-D., Cen, W., Wang, P., Liu, C., Zhang, W., Li, S., & Jiang, J. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00281-w · Cited by 35
Mammalian proteome expansion by stop codon readthrough
Manjunath, L. E., Singh, A., Som, S., & Eswarappa, S. M. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1739 · Cited by 36
Progress and prospects of noncoding RNAs in insects
Li, M., Xiao, H., He, K., & Li, F. (2019) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(18)61976-8 · Cited by 40
Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes
Rizzuti, M., Melzi, V., Gagliardi, D., Resnati, D., Meneri, M., Dioni, L., Masrori, P., Hersmus, N., Poesen, K., Locatelli, M., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04217-1 · Cited by 34
Evidence of Cross-Kingdom Gene Regulation by Plant MicroRNAs and Possible Reasons for Inconsistencies
Xu, T., Zhu, Y., Lin, Z., Lei, J., Li, L., Zhu, W., & Wu, D. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09097 · Cited by 34
Synaptic control of local translation: the plot thickens with new characters
Thomas, M. G., Pascual, M. L., Maschi, D., Luchelli, L., & Boccaccio, G. L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1506-y · Cited by 38
MiR169 and its target PagHAP2-6 regulated by ABA are involved in poplar cambium dormancy
Ding, Q., Zeng, J., & He, X. (2016) · Journal of Plant Physiology · doi:10.1016/j.jplph.2016.03.017 · Cited by 34
Epigenetic aspects of rheumatoid arthritis: contribution of non-coding RNAs
Kolarz, B., & Majdan, M. (2017) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2017.01.003 · Cited by 34
Translational control in plant antiviral immunity
Machado, J. P., Calil, I. P., dos Santos, A. A., & Fontes, E. P. B. (2017) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2016-0092 · Cited by 37
Circular RNAs and exosomes in cancer: a mysterious connection
Hou, J., Jiang, W., Zhu, L., Zhong, S., Zhang, H., Li, J., Zhou, S., Yang, S., He, Y., Wang, D., et al. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1839-y · Cited by 34
Framework Nucleic Acid-Mediated Pull-Down MicroRNA Detection with Hybridization Chain Reaction Amplification
Qu, X., Xiao, M., Li, F., Lai, W., Li, L., Zhou, Y., Lin, C., Li, Q., Ge, Z., Wen, Y., et al. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00278 · Cited by 34
Circular and Micro RNAs from Arabidopsis thaliana Flowers Are Simultaneously Isolated from AGO-IP Libraries
Capelari, É. F., da Fonseca, G. C., Guzmán, F., & Margis, R. (2019) · Plants · doi:10.3390/plants8090302 · Cited by 34
Curcumin Suppresses Osteogenesis by Inducing miR-126a-3p and Subsequently Suppressing the WNT/LRP6 Pathway
Li, H., Yue, L., Xu, H., Li, N., Li, J., Zhang, Z., & Zhao, R. C. (2019) · Aging · doi:10.18632/aging.102232 · Cited by 34
MicroRNA-150-5p promotes cell motility by inhibiting c-Myb-mediated Slug suppression and is a prognostic biomarker for recurrent ovarian cancer
Tung, C.-H., Kuo, L., Huang, M., Wu, Y.-Y., Tsai, Y.-T., Wu, J.-E., Hsu, K., Chen, Y., & Hong, T.-M. (2019) · Oncogene · doi:10.1038/s41388-019-1025-x · Cited by 34
ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia
Shu, Y., Wang, Y., Lv, W.-Q., Peng, D.-Y., Li, J., Zhang, H., Jiang, G.-J., Yang, B.-J., Liu, S., Zhang, J., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1471 · Cited by 34
Role of MicroRNAs in Host Defense against Infectious Bursal Disease Virus (IBDV) Infection: A Hidden Front Line
Li, J., & Zheng, S. J. (2020) · Viruses · doi:10.3390/v12050543 · Cited by 35
Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer
Dittmar, R. L., Liu, S., Tai, M.-C., Rajapakshe, K., Huang, Y., Longton, G., DeCapite, C., Hurd, M. W., Paris, P. L., Kirkwood, K. S., et al. (2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0303 · Cited by 34
Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Codocedo, J. F., Ríos, J. A., Godoy, J. A., & Inestrosa, N. C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9201-7 · Cited by 34
The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy
Smyth, A., Callaghan, B., Willoughby, C. E., & O'Brien, C. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810216 · Cited by 34
Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects
Shang, R., Zhang, F., Xu, B., Xi, H., Zhang, X., Wang, W., & Wu, L. (2015) · Nature Communications · doi:10.1038/ncomms9430 · Cited by 35
Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts
Tan, K., Wang, X., Zhang, Z., Miao, K., Yu, Y., An, L., & Tian, J. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.141051 · Cited by 34
MicroRNA-mediated immune regulation in rheumatic diseases
Lam, I. K. Y., Chow, J. X., Lau, C. S., & Chan, V. S. F. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.044 · Cited by 35
Stress, microRNAs, and stress-related psychiatric disorders: an overview
Musazzi, L., Mingardi, J., Ieraci, A., Barbon, A., & Popoli, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02139-3 · Cited by 35
Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling
Hsu, S., Huang, H., Chou, C., Sun, Y., Hsu, M., & Tsou, A. (2015) · BMC Genomics · doi:10.1186/1471-2164-16-s2-s12 · Cited by 33
The emerging world of small silencing RNAs in protozoan parasites
Atayde, V. D., Tschudi, C., & Ullu, E. (2011) · Trends in Parasitology · doi:10.1016/j.pt.2011.03.002 · Cited by 33
The combination of transcriptomics and informatics identifies pathways targeted by miR-204 during neurogenesis and axon guidance
Conte, I., Merella, S., García-Manteiga, J. M., Migliore, C., Lazarević, D., Carrella, S., Marco-Ferreres, R., Avellino, R., Davidson, N. P., Emmett, W., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku498 · Cited by 33
Role of microRNAs in hepatocellular carcinoma
Xu, H. (2015) · Frontiers in bioscience · doi:10.2741/4358 · Cited by 33
Association of microRNA-155, interleukin 17A, and proteinuria in preeclampsia
Yang, X., Zhang, J., & Ding, Y. (2017) · Medicine · doi:10.1097/md.0000000000006509 · Cited by 34
MiR‐181a inhibits vascular inflammation induced by ox‐LDL via targeting TLR4 in human macrophages
Du, X., Lu, J., & Sha, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26622 · Cited by 33
Role of GW182 protein in the cell
Niaz, S., & Hussain, M. U. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.05.009 · Cited by 33

Authors: Huntzinger, E., & Izaurralde, E.
Affiliations: Max Planck Institute for Developmental Biology (DE)
Max Planck Society (DE)
Corresponding author: Izaurralde, Elisa
ORCID: Huntzinger, Eric
Izaurralde, Elisa
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2011-01-18
Volume: 12
Issue: 2
Pages: 99-110
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2936
OpenAlex: W2010461414
Cited by: 2,339
References: 86
Citations by year: 2026: 60 · 2025: 100 · 2024: 98 · 2023: 118 · 2022: 140 · 2021: 158 · 2020: 144 · 2019: 141 · 2018: 145 · 2017: 178 · 2016: 170 · 2015: 189 · 2014: 210 · 2013: 195 · 2012: 199
FWCI: 16.27
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Funders: Ministry of Economy, Trade and Industry
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: microRNA, gene silencing, protein synthesis inhibition, mRNA degradation, post-transcriptional regulation, microRNA target regulation, plant microRNAs
MeSH terms: Animals, Humans, Models, Genetic, Protein Biosynthesis, Gene Silencing, RNA Stability, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks