Cited by 2,339MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, Eric, Izaurralde, Elisa·2011·Nature Reviews Genetics

Open this paper in CoChat — free account

Abstract

Despite their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs. Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA abundance, whereas the reverse was thought to be true in plants. Now, however, it is clear that microRNAs can induce mRNA degradation in animals and, conversely, translational repression in plants. Recent studies have made important advances in elucidating the relative contributions of these two different modes of target regulation by microRNAs. They have also shed light on the specific mechanisms of target silencing, which, although it differs fundamentally between plants and animals, shares some common features between the two kingdoms.

Integrity signals

Registry

Crossref · 10.1038/nrg2936

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Untitled work
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Origins and Mechanisms of miRNAs and siRNAs
Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,161
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429

Show all 86 references

Sorted by citations

Items 601–700 of 1,005

Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex
Hennig, J., Wang, I., Sonntag, M., Gabel, F., & Sattler, M. (2013) · Journal of Biomolecular NMR · doi:10.1007/s10858-013-9719-9 · Cited by 53
Circulating Levels of miR‐133a Predict the Regression Potential of Left Ventricular Hypertrophy After Valve Replacement Surgery in Patients With Aortic Stenosis
García, R., Villar, A. V., Cobo, M., Llano, M., Martín‐Durán, R., Hurlé, M. A., & Nistal, J. F. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000211 · Cited by 53
MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1
Wang, L., Jiang, C., Li, D., Ge, X. Q., Shi, Z., Li, C.-Y., Liu, X., Yin, Y., Zhen, L., Liu, L.-Z., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6545 · Cited by 53
MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway
Hao, J., Zhang, L., Cong, G., Ren, L., & Hao, L. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2469-8 · Cited by 55
Developing microRNA Therapeutics: Approaching the Unique Complexities
Jackson, A. L., & Levin, A. A. (2012) · Nucleic Acid Therapeutics · doi:10.1089/nat.2012.0356 · Cited by 53
Translation regulation gets its ‘omics’ moment
Kuersten, S., Radek, A. J., Vogel, C., & Penalva, L. O. F. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1173 · Cited by 55
Small RNAs: a new frontier in mosquito biology
Lucas, K. J., Myles, K. M., & Raikhel, A. S. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.04.003 · Cited by 55
MicroRNA Target Identification—Experimental Approaches
Martínez-Sánchez, A., & Murphy, C. L. (2013) · Biology · doi:10.3390/biology2010189 · Cited by 56
The Emerging Roles of MicroRNAs in the Pathogenesis of Frontotemporal Dementia–Amyotrophic Lateral Sclerosis (FTD-ALS) Spectrum Disorders
Gascon, E., & Gao, F. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2013.876021 · Cited by 54
miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
Duan, K., GE, Y.-C., Zhang, X. Y., WU, S.-Y., Feng, J.-S., CHEN, S.-L., Zhang, L., Yuan, Z.-H., & FU, C.-H. (2015) · Oncology Letters · doi:10.3892/ol.2015.3645 · Cited by 52
Male Germline Control of Transposable Elements1
Bao, J., & Yan, W. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.095463 · Cited by 55
MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression
Maurel, M., Dejeans, N., Taouji, S., Chevet, É., & Grosset, C. F. (2013) · RNA · doi:10.1261/rna.036483.112 · Cited by 55
Genome-Wide Identification of MicroRNAs in Leaves and the Developing Head of Four Durum Genotypes during Water Deficit Stress
Liu, H., Searle, I. R., Watson‐Haigh, N. S., Baumann, U., Mather, D. E., Able, A. J., & Able, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142799 · Cited by 52
Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells
Yeh, D.-W., Chen, Y.-S., Lai, C.-Y., Liu, Y.-L., Lu, C.-H., Lo, J., Chen, L., Hsu, L.-C., Luo, Y., Xiang, R., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.147 · Cited by 52
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Xue, H., Tu, Y.-H., Ma, T., Wen, T., Yang, T., Xue, L., Cai, M.-W., Wang, F.-X., & Guan, M.-Y. (2019) · Bone · doi:10.1016/j.bone.2019.03.035 · Cited by 49
Host microRNAs and exosomes that modulate influenza virus infection
Zheng, B., Zhou, J., & Wang, H. (2020) · Virus Research · doi:10.1016/j.virusres.2020.197885 · Cited by 54
Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading
Brosnan, C. A., Palmer, A., & Zuryn, S. (2021) · Nature Communications · doi:10.1038/s41467-021-22503-7 · Cited by 56
Differential microRNA Profiles and Their Functional Implications in Different Immunogenetic Subsets of Chronic Lymphocytic Leukemia
Papakonstantinou, N., Ntoufa, S., Chartomatsidou, E., Papadopoulos, G. L., Hatzigeorgiou, A. G., Anagnostopoulos, Α., Chlichlia, K., Ghia, P., Muzio, M., Belessi, C., et al. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00005 · Cited by 52
The role of miRNA in plant–virus interaction: a review
Ademe, A., & Tenkegna, T. A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06290-4 · Cited by 51
MicroRNAs in Cancer: From Gene Expression Regulation to the Metastatic Niche Reprogramming
Semina, E. V., Rysenkova, K. D., Troyanovskiy, K. E., Shmakova, A., & Rubina, K. A. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921070014 · Cited by 50
MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development
Dehghan, Z., Mohammadi‐Yeganeh, S., Rezaee, D., & Salehi, M. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.08.008 · Cited by 51
Current Understanding of Exosomal MicroRNAs in Glioma Immune Regulation and Therapeutic Responses
Peng, J., Liang, Q., Xu, Z., Cai, Y., Peng, B., Li, J., Zhang, W.-Q., Kang, F., Hong, Q., Yan, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.813747 · Cited by 51
Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)
Gupta, A., Nagilla, P., Le, H.-S., Bunney, C., Zych, C., Thalamuthu, A., Bar‐Joseph, Z., Mathavan, S., & Ayyavoo, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022730 · Cited by 51
Retracted
Human micro RNA hsa‐mi R ‐1231 suppresses hepatitis B virus replication by targeting core m RNA
Kohno, T., Tsuge, M., Murakami, E., Hiraga, N., Abe, H., Miki, D., Imamura, M., Ochi, H., Hayes, C. N., & Chayama, K. (2014) · Journal of Viral Hepatitis · doi:10.1111/jvh.12240 · Cited by 51
GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons
Ho, V. M., Dallalzadeh, L. O., Karathanasis, N., Keleş, M. F., Vangala, S., Grogan, T., Poirazi, P., & Martin, K. C. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.04.006 · Cited by 52
STAT3 regulation of and by microRNAs in development and disease
Haghikia, A., Ricke‐Hoch, M., Stapel, B., & Hilfiker‐Kleiner, D. (2012) · JAK-STAT · doi:10.4161/jkst.19573 · Cited by 52
MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells
Cardinali, B., Cappella, M., Provenzano, C., García-Manteiga, J. M., Lazarević, D., Cittaro, D., Martelli, F., & Falcone, G. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.10 · Cited by 51
The emerging roles of MicroRNAs in autism spectrum disorders
Fregeac, J., Colleaux, L., & Nguyen, L. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.018 · Cited by 52
A mixed antagonistic/synergistic miRNA repression model enables accurate predictions of multi-input miRNA sensor activity
Gam, J. J., Babb, J. W., & Weiss, R. (2018) · Nature Communications · doi:10.1038/s41467-018-04575-0 · Cited by 52
HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia–Lymphoma
Yamagishi, M., Fujikawa, D., Watanabe, T., & Uchimaru, K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01686 · Cited by 51
MicroRNAs and Mesenchymal Stem Cells
Collino, F., Bruno, S., Deregibus, M. C., Tetta, C., & Camussi, G. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386015-6.00033-0 · Cited by 52
Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts
Guo, X., Ma, Z., Du, B., Li, T., Li, W., Xu, L., He, J., & Kang, L. (2018) · Nature Communications · doi:10.1038/s41467-018-03437-z · Cited by 50
Identification and characterisation of microRNAs and their target genes in phosphate-starved Nicotiana benthamiana by small RNA deep sequencing and 5’RACE analysis
Huen, A., Bally, J., & Smith, P. M. C. (2018) · BMC Genomics · doi:10.1186/s12864-018-5258-9 · Cited by 50
Towards understanding sex differences in autism spectrum disorders
Leow, K. Q., Tonta, M. A., Lü, J., Coleman, H. A., & Parkington, H. C. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148877 · Cited by 58
MicroRNA‐122 Overexpression Promotes Hepatic Differentiation of Human Adipose Tissue‐Derived Stem Cells
Davoodian, N., Lotfi, A. S., Soleimani, M., & Mowla, S. J. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24822 · Cited by 52
MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells
Tsuyama, J., Bunt, J., Richards, L. J., Iwanari, H., Mochizuki, Y., Hamakubo, T., Shimazaki, T., & Okano, H. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.06.006 · Cited by 50
MAPK and JAK/STAT pathways targeted by miR-23a and miR-23b in prostate cancer: computational and in vitro approaches
Aghaee‐Bakhtiari, S. H., Arefian, E., Naderi, M., Noorbakhsh, F., Nodouzi, V., Asgari, M., Fard‐Esfahani, P., Mahdian, R., & Soleimani, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-3057-3 · Cited by 50
MicroRNA159 Can Act as a Switch or Tuning MicroRNA Independently of Its Abundance in Arabidopsis
Alonso-Peral, M. M., Sun, C., & Millar, A. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034751 · Cited by 50
Complex Degradation Processes Lead to Non-Exponential Decay Patterns and Age-Dependent Decay Rates of Messenger RNA
Deneke, C., Lipowsky, R., & Valleriani, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055442 · Cited by 50
Oncogenic cAMP responsive element binding protein 1 is overexpressed upon loss of tumor suppressive miR-10b-5p and miR-363-3p in renal cancer
Li, Y., CHEN, D., Li, Y., Lu, J., Liu, J., SU, Z., Qi, Z., Shi, M., Jiang, Z., Ni, L., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.4579 · Cited by 50
Role of Dicer and the miRNA system in neuronal plasticity and brain function
Fiorenza, A., & Barco, Á. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.05.001 · Cited by 50
MiR-582-5p/miR-590-5p targeted CREB1/CREB5–NF-κB signaling and caused opioid-induced immunosuppression in human monocytes
Long, X., Li, Y., Qiu, S., Liu, J., He, L., & Peng, Y. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.4 · Cited by 50
Is There a Role for Genomics in the Management of Hypertension?
Burrello, J., Monticone, S., Buffolo, F., Tetti, M., Veglio, F., Williams, T. A., & Mulatero, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061131 · Cited by 50
mi RNA ‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation
Hoey, C., Ray, J., Jeon, J., Huang, X., Taeb, S., Ylanko, J., Andrews, D. W., Boutros, P. C., & Liu, S. K. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12328 · Cited by 50
miRNA Dysregulation in the Development of Non-Alcoholic Fatty Liver Disease and the Related Disorders Type 2 Diabetes Mellitus and Cardiovascular Disease
López‐Pastor, A. R., Infante‐Menéndez, J., Escribano, Ó., & Gómez‐Hernández, A. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.527059 · Cited by 53
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes
Mesirca, P., Nakao, S., Nissen, S. D., Forte, G., Anderson, C., Trussell, T., Li, J., Cox, C., Zi, M., Logantha, S. J. R. J., et al. (2021) · Circulation Research · doi:10.1161/circresaha.119.316386 · Cited by 52
Endogenous miRNA-Activated DNA Nanomachine for Intracellular miRNA Imaging and Gene Silencing
Li, L., Ren, Y., Wen, X., Guo, Q., Wang, J., Li, S., Yang, M. J., & Wang, K. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02907 · Cited by 50
Regulation and different functions of the animal microRNA‐induced silencing complex
Frédérick, P., & Simard, M. J. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1701 · Cited by 51
Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis
Barter, M. J., & Young, D. A. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0353-z · Cited by 50
Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia
Hayder, H., Shan, Y., Chen, Y., O’Brien, J. A., & Peng, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.995462 · Cited by 50
Cellular functions of the microprocessor
Macías, S., Cordiner, R. A., & Cáceres, J. F. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130011 · Cited by 49
Variability in vascular smooth muscle cell stretch-induced responses in 2D culture
Mantella, L. E., Quan, A., & Verma, S. (2015) · Vascular Cell · doi:10.1186/s13221-015-0032-0 · Cited by 49
Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis
Espinosa‐Díez, C., Fierro‐Fernández, M., Sánchez-Gómez, F. J., Rodríguez‐Pascual, F., Alique, M., Ruiz‐Ortega, M., Beraza, N., Martínez‐Chantar, M. L., Fernandez-Hernando, C. F., & Lamas, S. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6025 · Cited by 49
miR-155 targets Caspase-3 mRNA in activated macrophages
Santis, R. D., Liepelt, A., Mossanen, J. C., Dueck, A., Simons, N., Mohs, A., Trautwein, C., Meister, G., Marx, G., Ostareck‐Lederer, A., et al. (2015) · RNA Biology · doi:10.1080/15476286.2015.1109768 · Cited by 49
MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis
Li, M., He, X., Zhang, Z., Li, S., Ren, L., Cao, R., Feng, Y., Ji, Y.-L., Zhao, Y., & Shi, R.-H. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i11.3245 · Cited by 49
mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO1
Arribas‐Hernández, L., Kielpinski, L. J., & Brodersen, P. (2016) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.00231 · Cited by 51
Epigenetics and type 1 diabetes: mechanisms and translational applications
Zullo, A., Sommese, L., Nicoletti, G., Donatelli, F., Mancini, F. P., & Claudio Napoli, A. (2017) · Translational research · doi:10.1016/j.trsl.2017.05.002 · Cited by 49
Discovery of microRNAs associated with the antiviral immune response of Atlantic cod macrophages
Eslamloo, K., Inkpen, S. M., Rise, M. L., & Andreassen, R. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.11.015 · Cited by 49
MicroRNA-216b-5p Functions as a Tumor-suppressive RNA by Targeting TPT1 in Pancreatic Cancer Cells
You, Y., Tan, J., Gong, Y., Dai, H., Chen, H., Xu, X., Yang, A., Zhang, Y., & Bie, P. (2017) · Journal of Cancer · doi:10.7150/jca.18931 · Cited by 49
Computational annotation of miRNA transcription start sites
Wang, S., Talukder, A., Cha, M., Li, X., & Hu, H. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbz178 · Cited by 48
Subgenomic analysis of microRNAs in polyploid wheat
Kantar, M., Akpınar, B. A., Valárik, M., Lucas, S. J., Doležel, J., Hernández, P., & Budak, H. (2012) · Functional & Integrative Genomics · doi:10.1007/s10142-012-0285-0 · Cited by 48
miR-326 Is Downstream of Sonic Hedgehog Signaling and Regulates the Expression of Gli2 and Smoothened
Jiang, Z., Cushing, L., Ai, X., & Lü, J. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0127oc · Cited by 49
MicroRNAs in the kidney: novel biomarkers of acute kidney injury.
Aguado-Fraile, E., Ramos, E., Conde, E., Rodríguez, M., Liaño, F., & García‐Bermejo, L. (2013) · PubMed · doi:10.3265/nefrologia.pre2013.aug.12198 · Cited by 48
Regulation of vascular endothelial growth factor in prostate cancer
de Brot, S., Ntekim, A., Cardenas, R. P., James, V. H., Allegrucci, C., Heery, D. M., Bates, D. O., Ødum, N., Persson, J. L., & Mongan, N. P. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0123 · Cited by 48
microRNAs in Mitochondria: An Unexplored Niche
Borralho, P. M., Rodrigues, C. M. P., & Steer, C. J. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22380-3_3 · Cited by 49
Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma
Cinegaglia, N., Andrade, S. C. S., Tokár, T., Pinheiro, M., Severino, F. E., de Oliveira, R. A., Hasimoto, É. N., Catâneo, D. C., Catâneo, A. J. M., Defaveri, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8713 · Cited by 48
Expression Profiling of IncRNAs, miRNAs, and mRNAs and Their Differential Expression in Leiomyoma Using Next-Generation RNA Sequencing
Chuang, T., & Khorram, O. (2017) · Reproductive Sciences · doi:10.1177/1933719117711265 · Cited by 49
MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7
Liu, M., Wu, H., Wang, S., Pang, P., Jin, S., Sun, C., & Liu, F. (2017) · Gene · doi:10.1016/j.gene.2017.12.049 · Cited by 48
Genetic Programming of Hypertension
Ahn, S.-Y., & Gupta, C. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00285 · Cited by 48
MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila
Goodwin, P. R., Meng, A., Moore, J. K., Hobin, M., Fulga, T. A., Vactor, D. V., & Griffith, L. C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.078 · Cited by 48
Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes
Sommese, L., Benincasa, G., Lanza, M., Sorriento, A., Schiano, C., Lucchese, R., Alfano, R., Nicoletti, G. F., & Claudio Napoli, A. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.08.012 · Cited by 48
Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo
Guo, W., & Wang, Y. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03020-9 · Cited by 49
Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk
Kim, J., Lee, J., Oh, J. H., Chang, H. J., Sohn, D. K., Kwon, O., Shin, A., & Kim, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39747-5 · Cited by 48
MicroRNAs as Biomarkers and Therapeutic Targets in Inflammation- and Ischemia-Reperfusion-Related Acute Renal Injury
Wu, Y.-L., Li, H., Chen, H.-H., & Lin, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186738 · Cited by 49
Association of exosomal microRNAs in human ovarian follicular fluid with oocyte quality
Zhang, D., Lv, J., Tang, R., Feng, Y., Zhao, Y., Fei, X., Chian, R., & Xie, Q. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.11.058 · Cited by 47
The hitchhikers’ guide to RNA sequencing and functional analysis
Chen, J.-W., Shrestha, L., Green, G. A., Leier, A., & Marquez‐Lago, T. T. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbac529 · Cited by 53
Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs
Mačvanin, M., Gluvic, Z. M., Radovanović, J., Essack, M., Gao, X., & Isenović, E. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1124613 · Cited by 47
Transcriptional regulation of co-expressed microRNA target genes
Wang, Y., Li, X., & Hu, H. (2011) · Genomics · doi:10.1016/j.ygeno.2011.09.004 · Cited by 47
Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model
Jalvy, S., Maurel, M., Majo, V., Pierre, N., Chabas, S., Combe, C., Rosenbaum, J., Sagliocco, F. A., & Grosset, C. F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr843 · Cited by 52
ZNF281/ZBP-99: a new player in epithelial–mesenchymal transition, stemness, and cancer
Hahn, S., & Hermeking, H. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1160-3 · Cited by 47
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease
Araldi, E., Chamorro-Jorganes, A., Solingen, C. V., Fernandez-Hernando, C. F., & Suárez, Y. (2015) · Current Vascular Pharmacology · doi:10.2174/15701611113119990012 · Cited by 47
Nucleolin Mediates MicroRNA-directed CSF-1 mRNA Deadenylation but Increases Translation of CSF-1 mRNA
Woo, H.-H., Baker, T., László, C., & Chambers, S. K. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.025288 · Cited by 47
MicroRNA-10a Influences Osteoblast Differentiation and Angiogenesis by Regulating β-Catenin Expression
Li, J., Zhang, Y., Zhao, Q., Wang, J., & He, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000438576 · Cited by 47
Comparative analysis of the small RNA transcriptomes of miiuy croaker revealed microRNA-mediated regulation of TLR signaling pathway response to Vibrio anguillarum infection
Xu, G., Han, J., & Xu, T. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.03.011 · Cited by 47
Cotranslational microRNA mediated messenger RNA destabilization
Tat, T. T., Maroney, P. A., Chamnongpol, S., Coller, J., & Nilsen, T. W. (2016) · eLife · doi:10.7554/elife.12880 · Cited by 50
MicroRNA-mediated interactions between host and hepatitis C virus
Li, H. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i4.1487 · Cited by 47
fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: Lessons from DROSHA
Kim, B., & Kim, V. N. (2018) · Methods · doi:10.1016/j.ymeth.2018.06.004 · Cited by 51
Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis
Xu, J., Sun, J., Ho, P. Y., Luo, Z., Ma, W., Zhao, W., Rathod, S., Fernandez, C. A., Venkataramanan, R., Xie, W., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.04.025 · Cited by 47
Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed
Dávalos, A., Henriques, R., Latasa, M. J., Laparra, M., & Coca, M. A. (2019) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2019.en-1688 · Cited by 50
Identification of a Plasma MicroRNA Profile Associated With Venous Thrombosis
Rodriguez-Rius, A., López, S., Martínez-Pérez, Á., Souto, J. C., & Soria, J. M. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314092 · Cited by 47
CRISPR/Cas12a mediated knock-in of the Polled Celtic variant to produce a polled genotype in dairy cattle
Schuster, F., Aldag, P., Frenzel, A., Hadeler, K., Lucas‐Hahn, A., Niemann, H., & Petersen, B. (2020) · Scientific Reports · doi:10.1038/s41598-020-70531-y · Cited by 50
Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72 -associated frontotemporal dementia and amyotrophic lateral sclerosis
Kmetzsch, V., Anquetil, V., Saracino, D., Rinaldi, D., Camuzat, A., Gareau, T., Jornéa, L., Forlani, S., Couratier, P., Wallon, D., et al. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324647 · Cited by 50
miRNAs cooperate in apoptosis regulation during C. elegans developmentPreprint
Sherrard, R., Luehr, S., Holzkamp, H., McJunkin, K., Memar, N., & Conradt, B. (2017) · Genes & Development · doi:10.1101/gad.288555.116 · Cited by 51
Small molecule chemical probes of microRNA function
Velagapudi, S. P., Vummidi, B. R., & Disney, M. D. (2015) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.10.024 · Cited by 46
The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy
Szostak, J., Gorący, A., Durys, D., Dec, P., Modrzejewski, A., & Pawlik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076214 · Cited by 46
RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting
Sherman, J. H., Munyikwa, T. R. I., Chan, S. Y., Petrick, J. S., Witwer, K. W., & Choudhuri, S. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.09.001 · Cited by 46
MicroRNAs in cardiovascular ageing
Seeger, T., & Boon, R. A. (2015) · The Journal of Physiology · doi:10.1113/jp270557 · Cited by 48
EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma
Li, Z., Chen, X., Li, L., Liu, S., Yang, L., Ma, X., Tang, M., Bode, A. M., Dong, Z., Sun, L., et al. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.007 · Cited by 46
MiR-506 inhibits PRRSV replication in MARC-145 cells via CD151
Wu, J., Peng, X., Zhou, A., Qiao, M., Wu, H., Xiao, H., Liu, G., Zheng, X., Zhang, S., & Mei, S. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2103-6 · Cited by 46
miR-28-5p Promotes Chromosomal Instability in VHL -Associated Cancers by Inhibiting Mad2 Translation
Hell, M. P., Thoma, C. R., Fankhauser, N., Christinat, Y., Weber, T. C., & Krek, W. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2041 · Cited by 48

Authors: Huntzinger, E., & Izaurralde, E.
Affiliations: Max Planck Institute for Developmental Biology (DE)
Max Planck Society (DE)
Corresponding author: Izaurralde, Elisa
ORCID: Huntzinger, Eric
Izaurralde, Elisa
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2011-01-18
Volume: 12
Issue: 2
Pages: 99-110
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2936
OpenAlex: W2010461414
Cited by: 2,339
References: 86
Citations by year: 2026: 60 · 2025: 100 · 2024: 98 · 2023: 118 · 2022: 140 · 2021: 158 · 2020: 144 · 2019: 141 · 2018: 145 · 2017: 178 · 2016: 170 · 2015: 189 · 2014: 210 · 2013: 195 · 2012: 199
FWCI: 16.27
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Funders: Ministry of Economy, Trade and Industry
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: microRNA, gene silencing, protein synthesis inhibition, mRNA degradation, post-transcriptional regulation, microRNA target regulation, plant microRNAs
MeSH terms: Animals, Humans, Models, Genetic, Protein Biosynthesis, Gene Silencing, RNA Stability, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks