The DOI matches its Crossref record; 276 of the 277 references it cites were found in a registry or an index.
Histone methylation: a dynamic mark in health, disease and inheritance
Open accessAbstract
Organisms require an appropriate balance of stability and reversibility in gene expression programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation is integral to this dynamic control. Post-translational modification of histones by methylation is an important and widespread type of chromatin modification that is known to influence biological processes in the context of development and cellular responses. To evaluate how histone methylation contributes to stable or reversible control, we provide a broad overview of how histone methylation is regulated and leads to biological outcomes. The importance of appropriately maintaining or reprogramming histone methylation is illustrated by its links to disease and ageing and possibly to transmission of traits across generations.
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Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
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Metadata
- Authors
- Greer, E. L., & Shi, Y.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Shi, Yang
- Venue
- Nature Reviews Genetics
- Published
- 2012-04-03
- Volume
- 13
- Issue
- 5
- Pages
- 343-357
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC4073795
- OpenAlex
- W2009858080
- Cited by
- 2,241
- References
- 277
- Citations by year
- 2026: 95 · 2025: 195 · 2024: 173 · 2023: 175 · 2022: 175 · 2021: 167 · 2020: 178 · 2019: 165 · 2018: 164 · 2017: 157 · 2016: 158 · 2015: 149 · 2014: 147 · 2013: 104 · 2012: 38
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (NCI118487)
- National Cancer Institute (R01CA118487)
- National Institute of General Medical Sciences (GM058012, R01GM071004, R01GM058012, GM071004)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- histone methylation, epigenetic regulation, chromatin modification, gene expression regulation, cell identity, development (biology), disease, aging, heredity (biology), transgenerational epigenetic inheritance, histone demethylation
- MeSH terms
- Histone Methyltransferases, Animals, Caenorhabditis, Drosophila, Female, Histones, Humans, Male, Methylation, Neoplasms, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Epigenesis, Genetic, Mice, Rats, Histone Demethylases
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