Histone methylation: a dynamic mark in health, disease and inheritance

Chromatin modifications and their function

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The language of covalent histone modifications

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Regulation of chromatin by histone modifications

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

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Capturing Chromosome Conformation

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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

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The polycomb group protein EZH2 is involved in progression of prostate cancer

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Histone demethylation by a family of JmjC domain-containing proteins

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Active Genes Are Tri-Methylated at K4 of Histone H3

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

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Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

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Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

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Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

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Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

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SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

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Role of the polycomb protein EED in the propagation of repressive histone marks

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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

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Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

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Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers

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Lamin A-dependent nuclear defects in human aging

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Regulation of Alternative Splicing by Histone Modifications

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Global histone modification patterns predict risk of prostate cancer recurrence

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Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

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Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

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MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

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Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

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Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

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Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation

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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

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The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

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The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

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Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4

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Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain

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Establishment and Maintenance of a Heterochromatin Domain

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ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9Preprint

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JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor

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Histone Methyltransferases Direct Different Degrees of Methylation to Define Distinct Chromatin Domains

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Histone Deimination Antagonizes Arginine Methylation

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Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

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Epigenetics in Alternative Pre-mRNA Splicing

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A histone H3 lysine 27 demethylase regulates animal posterior development

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Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

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Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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SET Domain-containing Protein, G9a, Is a Novel Lysine-preferring Mammalian Histone Methyltransferase with Hyperactivity and Specific Selectivity to Lysines 9 and 27 of Histone H3

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Methylation of histone H3 Lys 4 in coding regions of active genes

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Regulation of MLL1 H3K4 methyltransferase activity by its core components

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Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

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Chromatin structure and the inheritance of epigenetic information

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

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SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

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JMJD6 Is a Histone Arginine Demethylase

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The Paf1 Complex Is Required for Histone H3 Methylation by COMPASS and Dot1p: Linking Transcriptional Elongation to Histone Methylation

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ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation

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Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

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The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases

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Differential chromatin marking of introns and expressed exons by H3K36me3

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Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

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The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3Preprint

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DNA methylation and histone modifications: teaming up to silence genes

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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

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From the editors

(2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2159

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