Tissue-resident memory T cells: local specialists in immune defence

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 5,008

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

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Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861

Immunological memory and protective immunity: understanding their relation

Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157

Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases

Qian, Y., Zhu, Y., Li, Y., & Li, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.624411 · Cited by 14

Innate Immune Regulation of Dermatitis

Abreu, D., & Kim, B. (2021) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2021.04.011 · Cited by 14

A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo

Gondé, H., Demeules, M., Hardet, R., Scarpitta, A., Junge, M., Pinto-Espinoza, C., Varin, R., Koch-Nolte, F., Boyer, O., & Adriouch, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.704408 · Cited by 11

Leukocyte Trafficking in Lymphatic VesselsPreprint

Bauer, A., Tatliadim, H., & Halin, C. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041186 · Cited by 13

Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells

Hu, J. P., Wang, W., Wang, M., Wu, C., Jiao, Y., Li, Y., Zhang, W., Liang, C., Lin, Z., Yu, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1591584 · Cited by 13

C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8+ T cell homeostasis and response to acute liver injury

Niemietz, P. M., Peiseler, M., Kohlhepp, M. S., Horn, P., Matchett, K. P., Wang, Y., Haas, L., Zhang, T., Bruneau, A., Guillot, A., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000757 · Cited by 13

T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells

Wang, L., Mishra, S., Fan, K. K.-H., Quon, S., Li, G., Yu, B., Liao, W., Liu, Y., Zhang, X., Qiu, Y., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114258 · Cited by 13

CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis

Ai, S., Arutyunov, A., Liu, J., Hill, J. D., Jiang, X., & Klein, R. S. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03309-y · Cited by 12

Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections

Budimir, N., Martin, M. D., Hartwig, S. M., Legge, K. L., Badovinac, V. P., & Harty, J. T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00040 · Cited by 12

Can Patrolling Liver-Resident T Cells Control Human Malaria Parasite Development?

Walk, J., Stok, J. E., & Sauerwein, R. W. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.01.002 · Cited by 12

Tissue-resident lymphocytes: weaponized sentinels at barrier surfaces

Belz, G. T., Denman, R., Seillet, C., & Jacquelot, N. (2020) · F1000Research · doi:10.12688/f1000research.25234.1 · Cited by 12

Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors

Dosset, M., Joseph, E. L. M., Vargas, T. R., & Apétoh, L. (2020) · Cells · doi:10.3390/cells9071727 · Cited by 12

Pathogenic helper T cells

Hirahara, K., Aoki, A., & Nakayama, T. (2021) · Allergology International · doi:10.1016/j.alit.2021.02.001 · Cited by 13

Tissue-Resident Memory-Like CD8+ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion

Yu, S., Lao, S., Yang, B., & Wu, C. Y. (2021) · Journal of Immunology Research · doi:10.1155/2021/6643808 · Cited by 12

Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet+ Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs

Elfaki, Y., Yang, J., Boehme, J. D., Schultz, K., Bruder, D., Falk, C. S., Huehn, J., & Floess, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147522 · Cited by 12

cDC1 Dependent Accumulation of Memory T Cells Is Required for Chronic Autoimmune Inflammation in Murine Testis

Jing, Y., Cao, M., Zhang, B., Long, X., & Wang, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.651860 · Cited by 12

Malignant and Benign T Cells Constituting Cutaneous T-Cell Lymphoma

Nakai, S., Kiyohara, E., & Watanabe, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312933 · Cited by 13

Comprehensive analysis of the immune pattern of T cell subsets in chronic myeloid leukemia before and after TKI treatment

Yao, D., Lai, J., Lu, Y., Zhong, J., Zha, X., Huang, X., Liu, L., Zeng, X., Chen, S., Weng, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1078118 · Cited by 12

Tumor-specific memory CD8+ T cells are strictly resident in draining lymph nodes during tumorigenesis

Liu, Q., Ran, L., Yue, Z., Su, X., Wang, L., Wen, S., Lei, S., Yang, X., Zhang, Y., Hu, J., et al. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00986-2 · Cited by 12

T cell control of SARS-CoV-2: When, which, and where?

Diniz, M. O., Maini, M. K., & Swadling, L. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101828 · Cited by 12

Role of Dietary Metabolites in Regulating the Host Immune Response in Gastrointestinal Disease

Zaatari, M. E., & Kao, J. Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00051 · Cited by 12

Mycobacterium tuberculosisRv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy

Li, J., Shen, J., Lao, S., Li, X., Liu, J., & Wu, C. Y. (2017) · Clinical Science · doi:10.1042/cs20170205 · Cited by 12

Human T cell immune surveillance: Phenotypic, functional and migratory heterogeneity for tailored immune responses

Zielinski, C. E. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.08.001 · Cited by 13

The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?

Peng, C., & Jameson, S. C. (2020) · International Immunology · doi:10.1093/intimm/dxaa045 · Cited by 12

Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8+ T Cells

Stein, J. V., Ruef, N., & Wissmann, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626019 · Cited by 12

Tissue resident memory T cells inhabit the deep human conjunctiva

Arnous, R., Arshad, S., Sandgren, K. J., Cunningham, A. L., Carnt, N. A., & White, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-09886-3 · Cited by 14

Eavesdropping on the conversation between immune cells and the skin epithelium

Bukhari, S., Mertz, A. F., & Naik, S. (2019) · International Immunology · doi:10.1093/intimm/dxy088 · Cited by 12

Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines?Preprint

Rappuoli, R., Siena, E., & Finco, O. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029256 · Cited by 13

Broad-spectrum vaccine via combined immunization routes triggers potent immunity to SARS-CoV-2 and its variants

Xing, M., Wang, Y., Wang, X., Liu, J., Dai, W., Hu, G., He, F., Zhao, Q., Li, Y., Sun, L., et al. (2023) · Journal of Virology · doi:10.1128/jvi.00724-23 · Cited by 12

Targeting CD8+ T cells in cardiovascular diseases: current options and therapeutic perspectives

Al-Rifai, R., Duval, V., Santos‐Zas, I., Guyon, T., Chetrit, L., Tanchot, C., Cochain, C., Zernecke, A., Vocanson, M., Bensaïd, B., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf098 · Cited by 11

Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma

Csizmar, C. M., & Ansell, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073302 · Cited by 13

Tissue-resident T cells in hepatitis B: A new target for cure?

Bolte, F. J., & Rehermann, B. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170842 · Cited by 11

Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes

Takeda, Y., Kobayashi, S., Kitakaze, M., Yamada, D., Akita, H., Asai, A., Konno, M., Arai, T., Kitagawa, T., Ofusa, K., et al. (2020) · Cells · doi:10.3390/cells9071645 · Cited by 11

Intrapulmonary Vaccination Induces Long-lasting and Effective Pulmonary Immunity Against Staphylococcus aureus Pneumonia

Fan, X., Li, N., Xu, M., Yang, D., & Wang, B. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab012 · Cited by 11

Immune Responses to Varicella-Zoster Virus Vaccines

Levin, M. J., & Weinberg, A. (2021) · Current topics in microbiology and immunology · doi:10.1007/82_2021_245 · Cited by 11

Immune profile analysis of peripheral blood and tumors of lung cancer patients treated with immune checkpoint inhibitors

Ichiki, Y., Fukuyama, T., Ueno, M., Kanasaki, Y., Goto, H., Takahashi, M., Mikami, S., Kobayashi, N., Nakanishi, K., Hayashi, S., et al. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-421 · Cited by 11

Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system

Truchetet, M., & Pradeu, T. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.02.013 · Cited by 12

Changes of CD103-expressing pulmonary CD4+ and CD8+ T cells in S. japonicum infected C57BL/6 mice

Zhao, Y., Yang, Q., Jin, C., Feng, Y., Xie, S., Xie, H., Qi, Y., Qiu, H., Chen, H., Tao, A., et al. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4633-8 · Cited by 10

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespanPreprint

Reiné, J., Carniel, B. F., Solórzano, C., Mitsi, E., Pojar, S., Nikolaou, E., German, E. L., Hyder-Wright, A. D., Hill, H. C., Hales, C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/576744 · Cited by 10

Preventive Treatment with PD-1 Antibody Increases Tissue-resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis

Xiao, Z., Yan, R., Liu, H., Huang, X., Liang, Z., An, G., & Ge, Y. (2023) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-23-0196 · Cited by 10

Bladder tumor ILC1s undergo Th17‐like differentiation in human bladder cancer

Mukherjee, N. Z., Ji, N., Tan, X., Lin, C., Rios, E. M., Chen, C., Huang, T. H. ‐., & Svatek, R. S. (2021) · Cancer Medicine · doi:10.1002/cam4.4243 · Cited by 10

CD103 blockade impair anti-CTLA-4 immunotherapy in oral cancer

Xiao, Y., Mao, L., Yang, Q., Wang, S., Wu, Z., Wan, S., Zhang, M.-J., & Sun, Z. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2023.106331 · Cited by 10

Dietary Fat Inflames CD4 + T Cell Memory in Obesity

Chapman, N. M., & Chi, H. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.012 · Cited by 10

Biosafety Level 3 setup for multiphoton microscopy in vivo

Barlerin, D., Bessière, G., Domingues, J. D. S., Schuette, M., Feuillet, C., & Peixoto, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-00702-x · Cited by 10

Tissue issues

Shacklett, B. L., Ferre, A. L., & Kiniry, B. E. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000530 · Cited by 10

Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection

Lambert, E. E., Buisman, A., & van Els, C. A. C. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_405 · Cited by 10

Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control

Hoji, A., Popescu, I., Pipeling, M. R., Shah, P. D., Winters, S. A., & McDyer, J. F. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900399 · Cited by 9

Live mucosal vaccination stimulates potent protection via varied CD4+ and CD8+ T cell subsets against wild-type Brucella melitensis 16M challenge

Goodwin, Z. I., Yang, X., Hoffman, C. A., & Pascual, D. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.995327 · Cited by 10

Control of pathogens and microbiota by innate lymphoid cells

Cording, S., Medvedovic, J., Lécuyer, E., Aychek, T., & Eberl, G. (2018) · Microbes and Infection · doi:10.1016/j.micinf.2018.05.003 · Cited by 10

Resident memory T cells show that it is never too late to change your ways

Gratz, I. K., & Campbell, D. (2020) · Nature Immunology · doi:10.1038/s41590-020-0637-1 · Cited by 10

Tissue‐resident memory T cells in immunotherapy and immune‐related adverse events by immune checkpoint inhibitor

Xiong, H., & Shen, Z. (2024) · International Journal of Cancer · doi:10.1002/ijc.34940 · Cited by 9

Tissue-resident memory T-cell expressions and their prognostic role in head and neck squamous cell carcinoma: a systematic review and meta-analysis

Ali, A., Bari, M. F., Arshad, S., Wahid, M., Safdar, J., Anwar, K., & Farooqui, W. A. (2025) · BMC Cancer · doi:10.1186/s12885-025-13764-2 · Cited by 12

Perivascular Tertiary Lymphoid Structures in Autoimmune Disease

Goronzy, J. J., & Weyand, C. M. (2025) · Immunological Reviews · doi:10.1111/imr.70047 · Cited by 9

Hydrogel-Based Vaccines: A Promising Approach for Cancer Immunotherapy

Zhang, W.-Q., Zhang, Q., Cai, J., He, J., Xu, Z., Chen, X., & Chen, G. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s526305 · Cited by 9

Tissue-Resident Memory T Cells in Rheumatoid Immune Diseases: Pathogenic Mechanisms and Therapeutic Strategies

Tian, Y., Zhang, J., Wu, L., Zhang, C., Zheng, F., Yang, Y., Lu, G., & Xie, D. (2025) · Biomedicines · doi:10.3390/biomedicines13122945 · Cited by 12

Tumor-Infiltrating Lymphocyte-Based Risk Score for Predicting Prognosis in Gastric Cancer

Xie, S., Mo, P., Li, N., Cai, W., Ruan, J., Ye, J., & Mao, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.522015 · Cited by 9

Clonal expansion of CD4+CD8+ T cells in an adult patient with Mycoplasma pneumoniae-associated Erythema multiforme majus

Volkers, S. M., Meisel, C., Terhorst‐Molawi, D., Burbach, G. J., Schürmann, D., Suttorp, N., & Sander, L. E. (2021) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-021-00520-x · Cited by 9

CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus

Lee, W., Kingstad-Bakke, B. A., Kedl, R. M., Kawaoka, Y., & Suresh, M. (2021) · Journal of Virology · doi:10.1128/jvi.00530-21 · Cited by 9

The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling

Williams, M. E. K., Hardnett, F. P., Sheth, A. N., Wein, A. N., Li, Z.-R. T., Radzio‐Basu, J., Dinh, C. T., Haddad, L. B., Collins, E. M. B., Ofotokun, I., et al. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.10.002 · Cited by 9

Type 1/17 CD103 + CD4 + nasal‐resident memory T cells in non‐eosinophilic chronic rhinosinusitis with nasal polyps

Rha, M., Kim, G., Lee, S., Jung, C. M., Lee, Y., Noh, H. E., Jeong, Y., Cho, H., & Kim, C. (2024) · Allergy · doi:10.1111/all.16094 · Cited by 9

Gut-tropic T cells and extra-intestinal autoimmune diseases

Wu, Y., Wang, Q., Jia, S., Lu, Q., & Zhao, M. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103544 · Cited by 10

Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection

Lopez, C. E., Zacharias, Z. R., Ross, K. A., Narasimhan, B., Waldschmidt, T. J., & Legge, K. L. (2024) · npj Vaccines · doi:10.1038/s41541-024-00883-3 · Cited by 9

Cross-Presentation of Skin-Targeted Recombinant Adeno-associated Virus 2/1 Transgene Induces Potent Resident Memory CD8 + T Cell Responses

Gross, D., Ghenassia, A., Bartolo, L., Urbain, D., Benkhelifa‐Ziyyat, S., Lorain, S., Davoust, J. M., & Chappert, P. (2018) · Journal of Virology · doi:10.1128/jvi.01334-18 · Cited by 10

Role of MAIT cells in metabolic diseases

Toubal, A., & Lehuen, A. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.014 · Cited by 10

Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma

Willemsen, M., Tio, D., Krebbers, G., Kasiem, F. R., Jaspars, E. H., Matos, T. R., Bekkenk, M. W., Bakker, W. J., & Luiten, R. M. (2022) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000002184 · Cited by 10

Phenotypic and functional characterizations of CD8+ T cell populations in malignant pleural effusion

Zhang, Y., Li, W., Zhai, J., Jin, Y., Zhang, L., & Chen, C. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113212 · Cited by 8

Protection Induced by Oral Vaccination with a Recombinant Yersinia pseudotuberculosis Delivering Yersinia pestis LcrV and F1 Antigens in Mice and Rats against Pneumonic Plague

Majumder, S., Olson, R. M., Singh, A., Wang, X., Li, P., Kittana, H., Anderson, P. E., Anderson, D. M., & Sun, W. (2022) · Infection and Immunity · doi:10.1128/iai.00165-22 · Cited by 9

Distinct T cell subsets in adipose tissue are associated with obesity

Haugstøyl, M. E., Cornillet, M., Strand, K., Stiglund, N., Sun, D., Lawrence‐Archer, L., Hjellestad, I. D., Sparrelid, E., Busch, C., Hjelmesaeth, J. S., et al. (2022) · European Journal of Immunology · doi:10.1002/eji.202249990 · Cited by 9

Type-specific L1 virus-like particle-mediated protection of horses from experimental bovine papillomavirus 1-induced pseudo-sarcoid formation is long-lasting

Harnacker, J., Hainisch, E. K., Shafti‐Keramat, S., Kirnbauer, R., & Brandt, S. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000791 · Cited by 9

Tissue-Resident Lymphocytes: Implications in Immunotherapy for Hepatocellular Carcinoma

Han, J. W., & Yoon, S. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010232 · Cited by 9

Monocyte-Derived Dendritic Cells (moDCs) Differentiate into Bcl6+ Mature moDCs to Promote Cyclic di-GMP Vaccine Adjuvant–Induced Memory TH Cells in the Lung

Mansouri, S., Katikaneni, D. S., Gogoi, H., & Jin, L. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001347 · Cited by 9

Revisiting T Cells in Chronic Rhinosinusitis

Moon, S., & Rha, M. (2024) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2024.16.6.585 · Cited by 9

The dual role of TIGIT in regulatory and effector T cells in chronic liver disease

Bozward, A. G., Davies, S. P., Fiancette, R., Wootton, G. E., Faustini, S. E., Kwok, H. F., Richardson, N., Morris, S. M., Kayani, K., Middleton, G., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101405 · Cited by 8

Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis

Stecher, C., Bischl, R., Schmid-Böse, A., Ferstl, S., Potzmann, E., Frank, M., Braun, N., Farlik, M., Flavell, R. A., & Herndler‐Brandstetter, D. (2025) · Nature Communications · doi:10.1038/s41467-025-61231-0 · Cited by 8

Multiomics analysis reveals the genetic and epigenetic features of high-risk NK cell–type chronic active EBV infection

Akazawa, R., Mikami, T., Yamada, M., Kato, I., Kubota, H., Saida, S., Uchihara, Y., Ishikawa, Y., Kamitori, T., Tasaka, K., et al. (2025) · Blood · doi:10.1182/blood.2024026805 · Cited by 10

Preventive Immunology for Livestock and Zoonotic Infectious Diseases in the One Health Era: From Mechanistic Insights to Innovative Interventions

Marzouk, E., & Alajaji, A. I. (2025) · Veterinary Sciences · doi:10.3390/vetsci12101014 · Cited by 14

Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4 + T cells

Kiuchi, M., Nemoto, M., Yagyu, H., Aoki, A., Iwamura, C., Sugimoto, H., Masuo, Y., Morita, H., Ma, S., Okuno, Y., et al. (2025) · Science · doi:10.1126/science.adp0714 · Cited by 9

Antigen-Specific Tissue-Resident Memory T Cells in the Respiratory System Were Generated following Intranasal Vaccination of Mice with BCG

Wu, Q., Kang, S., Huang, J., Wan, S., Yang, B., & Wu, C. Y. (2021) · Journal of Immunology Research · doi:10.1155/2021/6660379 · Cited by 10

Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment

Bonni, S., Brindley, D. N., Chamberlain, M. D., Baghbadorani, N. D., Freywald, A., Hemmings, D. G., Hombach‐Klonisch, S., Klonisch, T. C., Raouf, A., Shemanko, C. S., et al. (2024) · Cancers · doi:10.3390/cancers16050911 · Cited by 12

Immunomodulatory Plant Natural Products as Therapeutics against Inflammatory Skin Diseases

Kumar, N. S., Reddy, N., Kumar, H. M. S., & Vemireddy, S. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266277952240223120435 · Cited by 10

EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma

Li, Z., Lin, X., Yang, Y., Tian, M. L., Zhang, L., Huang, F., Xiao, W., Wei, Z., & Tian, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-88126-w · Cited by 8

Engineering optimal vaccination strategies: effects of physical properties of the delivery system on functions

Zhu, G., Yang, Y., & Sun, T. (2022) · Biomaterials Science · doi:10.1039/d2bm00011c · Cited by 8

HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts

Jazayeri, S. D., Kuo, P., Leggatt, G. R., & Frazer, I. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00524 · Cited by 8

Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

Hu, C., Liu, W., Xu, N., Huang, A., Zhang, Z., Fan, M., Ruan, G., Wang, Y., Xi, T., & Xing, Y. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1830719 · Cited by 8

Robust induction of TRMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses

Lin, P., Liang, C.-Y., Yao, B., Chen, H., Pan, C.-F., Wu, L., Lin, Y.-H., Hsu, Y.-S., Liu, Y.-H., Chen, P., et al. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.03.010 · Cited by 8

An RNA checkpoint that keeps immunological memory at bay

Kontoyiannis, D. L. (2018) · Nature Immunology · doi:10.1038/s41590-018-0168-1 · Cited by 8

Innate phase production of IFN-γ by memory and effector T cells expressing early activation marker CD69 during infection with Cryptococcus deneoformans in the lungs

Miyahara, A., Umeki, A., Sato, K., Nomura, T., Yamamoto, H., Miyasaka, T., Tanno, D., Matsumoto, I., Zong, T., Kagesawa, T., et al. (2024) · Infection and Immunity · doi:10.1128/iai.00024-24 · Cited by 7

IL-12 mRNA-LNP promotes dermal resident memory CD4+ T cell development

Zabala-Peñafiel, A., Lombana, C., Alameh, M., Sacramento, L. A., Mou, Z., Phan, A. T., Aunins, E., Tam, Y. K., Uzonna, J. E., Weissman, D., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01213-x · Cited by 8

CD103+CD8+ tissue‐resident memory T lymphocytes of melanoma boost anti‐tumour immunity and predict immunotherapy outcomes

Zhang, T., Song, J., Li, Y., Shen, K., Xuan, J., Gao, Y., Lu, L., Pang, Z., Wang, L., Yang, Y., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70464 · Cited by 7

T cell-mediated SIV dissemination into the CNS: a single-cell transcriptomic analysis

Xu, X., Niu, M., Lamberty, B. G., Emanuel, K. M., Estrella, L. D., & Fox, H. S. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03543-y · Cited by 6

Skin immunity and inflammation: cellular interactions and communication

Narayanan, D., Sim, S.-L., & Kumari, S. (2025) · Clinical & Translational Immunology · doi:10.1002/cti2.70053 · Cited by 10

The Immunopathogenesis of uveitis

Han, J., Harper, J., Copland, D. A., & Maghsoudlou, P. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1717056 · Cited by 7

Tissue-Resident T Cells in Chronic Relapsing–Remitting Intestinal Disorders

de Albuquerque, J. B., Mueller, C., & Gungor, B. (2021) · Cells · doi:10.3390/cells10081882 · Cited by 7

The thin line between conventional dendritic cells (cDCs) and group 3 innate lymphoid cells (ILC3s) in the gut

Antonova, A. U., Fachi, J. L., Gilfillan, S., & Colonna, M. (2022) · International Immunology · doi:10.1093/intimm/dxac054 · Cited by 8

Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies

Wan, S., Zhao, E., Freeman, D., Weissinger, D., Krantz, B. A., Werba, G., Khanna, L. G., Siolas, D., Oberstein, P. E., Chattopadhyay, P. K., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1067352 · Cited by 7

Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease

Matthe, D. M., Dinkel, M., Schmid, B., Vogler, T., Neurath, M. F., Poeck, H., Neufert, C. F., Büttner-Herold, M. J., & Hildner, K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253514 · Cited by 7

GITR differentially affects lung effector T cell subpopulations during influenza virus infection

Chu, K.-L., Batista, N. V., Girard, M., Law, J. C., & Watts, T. H. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ab1219-254r · Cited by 7

Airway delivery of both a BCG prime and adenoviral boost drives CD4 and CD8 T cells into the lung tissue parenchyma

Kaveh, D. A., García‐Pelayo, M. C., Bull, N. C., Sánchez-Cordón, P. J., Spiropoulos, J., & Hogarth, P. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-75734-x · Cited by 7

Impaired antibacterial response of liver sinusoidal Vγ9+Vδ2+ T cells in patients with chronic liver disease

Rha, M., Han, J. W., Koh, J., Lee, H. S., Kim, J. H., Cho, K., Kim, S. I., Kim, M. S., Lee, J. G., Park, S., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-322182 · Cited by 7

Gut tissue‐resident memory T cells in coeliac disease

Sollid, L. M. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13120 · Cited by 7

The Multifaceted Role of Tissue-Resident Memory T Cells

Christo, S. N., Park, S. L., Mueller, S. N., & Mackay, L. K. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-020220 · Cited by 148

Tissue‐resident memory T cells

Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 215

Editors' Picks

(2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.494

Tissue‐resident memory T (T RM ) cells: Front‐line workers of the immune system

Osman, M., Park, S. L., & Mackay, L. K. (2023) · European Journal of Immunology · doi:10.1002/eji.202250060 · Cited by 20

Anti-viral protective capacity of tissue resident memory T cells

Paik, D. H., & Färber, D. L. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.09.006 · Cited by 53