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Tissue-resident memory T cells: local specialists in immune defence
Abstract
T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional immunity. In recent years, there has been considerable progress in our understanding of tissue-resident T cell development and function, revealing mechanisms for enhanced protective immunity that have the potential to influence rational vaccine design. This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.
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“tissue resident memory T cells (Trm) cells are non-circulating T cells that form the first line of defence against reinfection in tissues [281-283].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [281]
In the citing paper
“Accordingly, the physiologically quite diverse parenchyma of tissues can drive a tissue-specific phenotype of Trm [281].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [281]
In the citing paper
“CD8 Trm cells in epithelial and neuronal tissues can also express CD103 (Figure 20), which is the α-chain of the αEβ7 integrin [281].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [281]
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Metadata
- Authors
- Mueller, S. N., & Mackay, L. K.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Mueller, Scott N.
- Mackay, Laura K.
- Venue
- Nature Reviews Immunology
- Published
- 2015-12-21
- Volume
- 16
- Issue
- 2
- Pages
- 79-89
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2273021913
- Cited by
- 1,006
- References
- 106
- Citations by year
- 2026: 70 · 2025: 87 · 2024: 88 · 2023: 91 · 2022: 100 · 2021: 122 · 2020: 118 · 2019: 102 · 2018: 109 · 2017: 83 · 2016: 34
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- tissue-resident memory T cells, regional immunity, memory T cell differentiation, T cell migration, infection immunity, tumor immunology, vaccine design
- MeSH terms
- Cell Differentiation, Humans, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets
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