Cited by 1,006T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Tissue-resident memory T cells: local specialists in immune defence

Mueller, Scott N., Mackay, Laura K.·2016·Nature Reviews Immunology

DOI 10.1038/nri.2015.3

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Abstract

T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional immunity. In recent years, there has been considerable progress in our understanding of tissue-resident T cell development and function, revealing mechanisms for enhanced protective immunity that have the potential to influence rational vaccine design. This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.

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Authors: Mueller, S. N., & Mackay, L. K.
Affiliations: The University of Melbourne (AU)
Corresponding author: Mueller, Scott N.
Mackay, Laura K.
ORCID: Mueller, Scott N.
Mackay, Laura K.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-12-21
Volume: 16
Issue: 2
Pages: 79-89
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2015.3
OpenAlex: W2273021913
Cited by: 1,006
References: 106
Citations by year: 2026: 70 · 2025: 87 · 2024: 88 · 2023: 91 · 2022: 100 · 2021: 122 · 2020: 118 · 2019: 102 · 2018: 109 · 2017: 83 · 2016: 34
FWCI: 7.12
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: tissue-resident memory T cells, regional immunity, memory T cell differentiation, T cell migration, infection immunity, tumor immunology, vaccine design
MeSH terms: Cell Differentiation, Humans, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets

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Tissue-resident memory T cells: local specialists in immune defence

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