Cited by 1,006T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Tissue-resident memory T cells: local specialists in immune defence

Mueller, Scott N., Mackay, Laura K.·2016·Nature Reviews Immunology

DOI 10.1038/nri.2015.3

Open this paper in CoChat — free account

Abstract

T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional immunity. In recent years, there has been considerable progress in our understanding of tissue-resident T cell development and function, revealing mechanisms for enhanced protective immunity that have the potential to influence rational vaccine design. This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.

Integrity signals

Registry

Crossref · 10.1038/nri.2015.3

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 5,008
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor
Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331
Self-citation
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157

Show all 106 references

Sorted by citations

Items 701–800 of 1,000

BMDCs induce the generation of the CD103+CD8+ tissue-resident memory T cell subtype, which amplifies local tumor control in the genital tract
Huang, Y., Zhou, L., Zhang, H., Zhang, L., Xi, X., & Sun, Y. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104502 · Cited by 7
A 33-color panel of phenotypic analysis of murine organ specific immune cells
Yang, S.-Y., Huang, M., Sun, Y., Li, L., Bian, Z.-H., Long, J., & Zhao, Z. (2022) · Journal of Immunological Methods · doi:10.1016/j.jim.2022.113294 · Cited by 7
Pre-existing tumor host immunity characterization in resected non-small cell lung cancer
Rocha, P., Rodrigo‐Calvo, M. T., Moliner, L., Menéndez, S., Masfarré, L., Navarro, N., Rey-Vergara, R. D., Galindo-Campos, M. A., Taus, Á., Giner, M., et al. (2023) · Lung Cancer · doi:10.1016/j.lungcan.2023.107257 · Cited by 8
Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice
Le, P. M., Pal‐Ghosh, S., Menko, A. S., & Stepp, M. A. (2023) · Biomolecules · doi:10.3390/biom13071059 · Cited by 7
Regulation of global CD8+ T‐cell positioning by the actomyosin cytoskeleton
Stein, J. V., & Ruef, N. (2019) · Immunological Reviews · doi:10.1111/imr.12759 · Cited by 7
A single dose of COVID-19 vaccine induces a strong T cell and B cell response in healthcare professionals recovered from SARS-CoV-2 infection
Laranjeira, P., Rodrigues, T., Silva, A., Barbosa, P., Reis, T., Lopes, C., Pinho, A. C. O., Silva, S., Silva, I., Carvalho, A., et al. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00801-8 · Cited by 6
Breaking Immunosuppressive Barriers by Engineered Nanoplatforms for Turning Cold Tumor to Hot
Dong, J., Huang, Y., Zhou, Z., & Sun, M. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200020 · Cited by 7
Poised cell circuits in human skin are activated in diseasePreprint
Reynolds, G., Végh, P., Fletcher, J., Poyner, E. F. M., Stephenson, E., Goh, I., Botting, R. A., Huang, N., Olabi, B., Dubois, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.05.369363 · Cited by 7
Mitophagy drives maldifferentiation of tissue-resident memory T cells in patients with rheumatoid arthritis
Liu, T., Wang, M., Li, L., Wu, T., Ji, H., Zheng, M., Tang, L., Gan, W.-J., Wen, Z., & Yuan, F. (2024) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2024.2420432 · Cited by 6
Tissue-Resident Memory T Cells in Cancer Metastasis Control
Montgomery, T., Master, A. P., Jin, Z., Shi, Q., Lai, Q., Desai, R., Zhang, W., Maharjan, C. K., & Kolb, R. H. (2025) · Cells · doi:10.3390/cells14161297 · Cited by 6
Resident T cells in the healthy and multiple sclerosis brain
Smolders, J., Hsiao, C., Huitinga, I., & Hamann, J. (2026) · Trends in Immunology · doi:10.1016/j.it.2025.12.006 · Cited by 8
Tissue resident memory T cells populate the human uveal tract
Foers, A. D., Reekie, I. R., Wickramasinghe, L. C., Ward, A., Buckley, T. M. W., Attar, M., Aguilar-Munoa, S., Pilapil, Q., Elsayed, M. E. A. A., Pledger, S., et al. (2026) · Scientific Reports · doi:10.1038/s41598-025-33444-2 · Cited by 6
Phenotypic and Immunometabolic Aspects on Stem Cell Memory and Resident Memory CD8+ T Cells
Manna, M. P. L., Azgomi, M. S., Tamburini, B., Badami, G. D., Mohammadnezhad, L., Dieli, F., & Caccamo, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884148 · Cited by 6
Intestinal tissue‐resident memory T cells maintain distinct identity from circulating memory T cells after in vitro restimulation
Beumer‐Chuwonpad, A., Behr, F. M., van Alphen, F. P. J., Kragten, N. A. M., Hoogendijk, A. J., van den Biggelaar, M., & van Gisbergen, K. P. J. M. (2024) · European Journal of Immunology · doi:10.1002/eji.202350873 · Cited by 6
Regulatory B Cells Expressing Granzyme B from Tolerant Renal Transplant Patients: Highly Differentiated B Cells with a Unique Pathway with a Specific Regulatory Profile and Strong Interactions with Immune System Cells
Sailliet, N., Dupuy, A., Brinas, F., Renaudin, K., Colas, L., Kerleau, C., Nguyen, T., Fourgeux, C., Poschmann, J., Gosset, C., et al. (2024) · Cells · doi:10.3390/cells13151287 · Cited by 6
Fighting the enemy within: Systemic immune defense against mucosal Salmonella infection
Nguyen, A. T., & McSorley, S. J. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106930 · Cited by 7
CagA-dependent Hobit + gastric tissue-resident memory T cells confer full protection from Helicobacter pylori reinfection
Gong, R., Huang, B., Ralser, A., Friedrich, V., Mibus, C., Engelsberger, V., Koch, M. R., Skerhut, M., Giese, T., Andrä, I., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-334781 · Cited by 7
Metabolic control of innate-like T cells
Riffelmacher, T., & Kronenberg, M. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01219-5 · Cited by 6
Gutsy memory T cells stand their ground against pathogens
Jensen, I. J., & Färber, D. L. (2022) · Science Immunology · doi:10.1126/sciimmunol.ade7168 · Cited by 6
Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC
Koeck, S., Amann, A., Kern, J., Zwierzina, M., Lorenz, E., Sopper, S., Zwierzina, H., Mildner, F., Sykora, M. M., Sprung, S., et al. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2274130 · Cited by 6
JAML promotes the antitumor role of tumor-resident CD8+ T cells by facilitating their innate-like function in human lung cancer
Hao, Z., Xin, Z., Chen, Y., Shao, Z., Lin, W., Wu, W., Lin, M., Liu, Q., Chen, D., Wu, P., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216839 · Cited by 6
T cell fate mapping and lineage tracing technologies probing clonal aspects underlying the generation of CD8 T cell subsets
Al‐Khabouri, S., & Gerlach, C. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12983 · Cited by 5
Papillomavirus-like Particles in Equine Medicine
Hainisch, E. K., Jindra, C., Kirnbauer, R., & Brandt, S. (2023) · Viruses · doi:10.3390/v15020345 · Cited by 6
Editorial: Bone Marrow T Cells at the Center Stage in Immunological Memory
Rosa, F. D., & Watts, T. H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00596 · Cited by 6
Grand Challenges in Immunological Memory
Mueller, S. N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00385 · Cited by 6
Self-citation
Role of mitotic diffusion barriers in regulating the asymmetric division of activated CD8 T cellsPreprint
Emurla, H., Barral, Y., & Oxenius, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.10.458880 · Cited by 6
Peritoneal immunity in decompensated cirrhosis
Ibidapo-Obe, O., Rooney, M. D., & Bruns, T. (2025) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2025.2565670 · Cited by 5
Glomerular endothelial cells eliminate nicotinamide adenine dinucleotide to instruct CD103 + T cells in human lupus nephritis
Li, J., Liu, M., Ji, H., Lei, J., Su, D., Li, L., Liu, T., Yuan, F., Xu, L., Cao, Q., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2507422122 · Cited by 5
Keeping it local: how CD8 TRMs regulate viral and cancer immunity
Rodrigues, L. C., Bonorino, C., Haubert, A. F., Lins, M. P., Pereira, G. P., Romão, P. R. T., & Rouse, B. T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1618700 · Cited by 5
Metabolic traits of T cells and the implications in autoimmune diseases
Zhou, Y., Zhou, Y., Zhu, Q., Guo, W., & Li, C. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.103989 · Cited by 6
Increased Numbers of CD4 + T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1
Shan, L., Fonville, M., Hoekstra, M., Fronczek, R., Smolders, J., & Swaab, D. F. (2026) · Annals of Neurology · doi:10.1002/ana.78199 · Cited by 6
Lipid nanoparticle composition directs systemic trafficking and tissue-specific T cell immunity after intramuscular injection
Wei, C. Y., Zhu, Y., Lu, X., Goodier, K. D., Yu, D., Liu, X., Choy, J., Calderón, A. T., Su, Y., Ma, J., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-026-01706-7 · Cited by 8
Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery
Pinho, A. C. O., Barbosa, P., Lázaro, A., Tralhão, J. G., Pereira, M. J., Paiva, A. A., Laranjeira, P., & Carvalho, E. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106911 · Cited by 5
Angel and devil: the protective immunity and pathogenic inflammation of tissue resident memory T cells in ulcerative colitis
Wang, X., Zhang, J., Fang, L., & Tang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1518339 · Cited by 6
Novel immune drug combination induces tumour microenvironment remodelling and reduces the dosage of anti-PD-1 antibody
Ozasa, T., Nakajima, M., Tsunedomi, R., Goto, S., Adachi, K., Takahashi, H., Tamada, K., & Nagano, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-87344-6 · Cited by 5
Resident memory T cells in mouse and human
Watanabe, R. (2016) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.39.505 · Cited by 5
T cells in the heterogeneous tumour immune microenvironment of hepatocellular carcinoma: Implications for immune checkpoint inhibitor therapy
Barsch, M., Salié, H., Mesesan, A., & Bengsch, B. (2023) · Liver Cancer International · doi:10.1002/lci2.72 · Cited by 5
Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications
Sato, H., Meng, S., Hara, T., Tsuji, Y., Arao, Y., Sasaki, K., Kobayashi, S., di Luccio, E., Hirotsu, T., Satoh, T., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12061342 · Cited by 5
Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells
Li, J., Zhai, X.-L., & Yu, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1505755 · Cited by 5
The importance of advanced cytometry in defining new immune cell types and functions relevant for the immunopathogenesis of HIV infection
Agrati, C., Biasi, S. D., Fidanza, L., Gibellini, L., Nasi, M., Pinti, M., & Cossarizza, A. (2020) · AIDS · doi:10.1097/qad.0000000000002675 · Cited by 5
Cutting Edge: Influenza-Induced CD11alo Airway CD103+ Tissue Resident Memory T Cells Exhibit Compromised IFN-γ Production after In Vivo TCR Stimulation
van de Wall, S., Crooks, S. D., Varga, S. M., Badovinac, V. P., & Harty, J. T. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200931 · Cited by 5
Concomitant Expression of CD39, CD69, and CD103 Identifies Antitumor CD8+ T Cells in Breast Cancer Implications for Adoptive Cell Therapy
Lama, G. I. G., Noel, G. L., López-Márquez, F. C., González-Galarza, F. F., Hinojosa, A. I. P., Nava‐Rivera, L. E., Willard-Gallo, K. E., & Arguello, J. R. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201025666230901094219 · Cited by 4
Advancement in regional immunity and its clinical implication
Zhou, C., Sun, L., Zhao, L., & Zhang, X. (2017) · Science China Life Sciences · doi:10.1007/s11427-017-9224-6 · Cited by 5
Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design
Shacklett, B. L., Ferre, A. L., & Kiniry, B. E. (2020) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00481-7 · Cited by 6
BACH2-driven tissue resident memory programs promote HIV-1 persistencePreprint
Wei, Y., Ma, H. K., Wong, M. E., Papasavvas, E., Konnikova, L., Tebas, P., Morgenstern, R., Montaner, L. J., & Ho, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.16.628794 · Cited by 5
Regulatory T‐cell‐derived interleukin‐15 shapes cytotoxic T cell memory
Geginat, J., & Granucci, F. (2022) · European Journal of Immunology · doi:10.1002/eji.202250238 · Cited by 4
Intragraft regulatory T cells in the modern era: what can high-dimensional methods tell us about pathways to allograft acceptance?
Bei, K. F., Moshkelgosha, S., Liu, B. J., & Juvet, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1291649 · Cited by 4
Local Power: The Role of Tissue-Resident Immunity in Human Genital Herpes Simplex Virus Reactivation
Zhu, J., & Miner, M. D. (2024) · Viruses · doi:10.3390/v16071019 · Cited by 4
Phenotypic Analysis of Nasal CD69+ CD4+ Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Rha, M., Kim, G., & Lee, S. (2025) · Journal of rhinology · doi:10.18787/jr.2025.00025 · Cited by 4
Natural Ginger-Derived Exosomes as Effective Therapeutics for Glioblastoma
Wang, S., Zhang, D., Zheng, M., Zou, Y., & Shi, B. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c04780 · Cited by 4
Mechanosensing by T cells promotes a tissue-resident memory transcriptional program
Postat, J., Merino, M., Mingarelli, A., Cerf, A., Bhagrath, A., Patel, D., Shen, C., Brodbeck, J., Tirgar, P., Rogers, D., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02581-9 · Cited by 6
Varying Immunizations With Plasmodium Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8+ T Cell Dynamics
Frank, R., Gabel, M., Heiss, K., Mueller, A., & Graw, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01137 · Cited by 5
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine-induced CD4+ TRM in the gastric epithelium.
Tong, J., Chen, S., Gu, X., Zhang, X., Wei, F., & Xing, Y.-Y. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.06.011 · Cited by 2
Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice
Wang, Z., Zhong, M., Chubicka, T., Kinnear, E., Rice, T., Holder, B. S., Kampmann, B., & Tregoning, J. S. (2024) · npj Viruses · doi:10.1038/s44298-024-00073-x · Cited by 4
Macrophage-derived IL-15 imprints peritoneal TRM-like CD8 T cells in cirrhosis and spontaneous bacterial peritonitis
Ibidapo-Obe, O., Stengel, S., Frissen, M., Reißing, J., Große, K., Rooney, M. D., Quickert, S., Nguyen, T.-H., Baumgart, S., Leal-Lassalle, H., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101381 · Cited by 4
A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion
Sottoriva, K., Paik, N. Y., White, Z., Bandara, T., Shao, L., Sano, T., & Pajcini, K. V. (2022) · JCI Insight · doi:10.1172/jci.insight.157015 · Cited by 5
The Memory T Cell “Communication Web” in Context with Gastrointestinal Disorders—How Memory T Cells Affect Their Surroundings and How They Are Influenced by It
Knauss, A., Gabel, M., Neurath, M. F., & Weigmann, B. (2022) · Cells · doi:10.3390/cells11182780 · Cited by 5
Integrated analysis of Helicobacter pylori-related prognostic gene modification patterns in the tumour microenvironment of gastric cancer
Zheng, K., Wang, Y., Wang, J., Wang, C., & Chen, J. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.964203 · Cited by 4
CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity
Lim, Y. S., & Shin, H. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.01.002 · Cited by 4
GM-CSF Promotes the Survival of Peripheral-Derived Myeloid Cells in the Central Nervous System for Pain-Induced Relapse of Neuroinflammation
Matsuyama, S., Yamamoto, R., Murakami, K., Takahashi, N., Nishi, R., Ishii, A., Nio‐Kobayashi, J., Abe, N., Tanaka, K., Jiang, J., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200567 · Cited by 4
Study on Horizon Scanning by Citation Network Analysis and Text Mining: A Focus on Drug Development Related to T Cell Immune Response
Fujii, E., Takata, T., Yamano, H., Honma, M., Shimokawa, M., Sasaki, H., & Shikano, M. (2021) · Therapeutic Innovation & Regulatory Science · doi:10.1007/s43441-021-00351-3 · Cited by 4
PD‐1: always on my mind
Park, S. L., & Mackay, L. K. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.69 · Cited by 4
Self-citation
Perivascular Lymphocyte Clusters Induced by Gastric Subserous Layer Vaccination Mediate Optimal Immunity against Helicobacter through Facilitating Immune Cell Infiltration and Local Antibody Response
Hu, C., Liu, W., Xu, N., Huang, A., Zeng, Z., Luo, S., Zhang, Z., Fan, M., Ye, F., Xi, T., et al. (2020) · Journal of Immunology Research · doi:10.1155/2020/1480281 · Cited by 4
The Liver as a Lymphoid Organ
Lian, Z., & Li, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_2 · Cited by 4
Human CD4 + CD103 + cutaneous resident memory T cells are found in the circulation of healthy subjectsPreprint
Klicznik, M. M., Morawski, P. A., Höllbacher, B., Varkhande, S. R., Motley, S., Kuri-Cervantes, L., Goodwin, E. C., Rosenblum, M. D., Long, S. A., Brachtl, G., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/361758 · Cited by 4
Dendritic cell-mediated responses to secreted Cryptosporidium effectors are required for parasite-specific CD8 + T cell responsesPreprint
Haskins, B. E., Gullicksrud, J. A., Wallbank, B. A., Dumaine, J. E., Guérin, A., Cohn, I. S., O’Dea, K. M., Pardy, R. D., Merolle, M. I., Shallberg, L. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.16.553566 · Cited by 4
Early-life viral infections and asthma: new cells and ideas
Lan, J., McCray, A., Brown, E., & Eddens, T. J. (2025) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001514 · Cited by 3
Best practices in mouse models of skin transplantation
Borges, T. J., Krummey, S. M., & Ford, M. L. (2025) · American Journal of Transplantation · doi:10.1016/j.ajt.2025.09.025 · Cited by 4
Is psoriatic arthritis a dissemination of cutaneous psoriatic TRM cells? Role of tissue-resident memory T cells (TRM) in psoriatic disease
Raychaudhuri, S. P., & Raychaudhuri, S. K. (2025) · Current Opinion in Immunology · doi:10.1016/j.coi.2025.102702 · Cited by 5
A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses
Cheng, C. Y., Sun, J., Lu, C., Yu, Q., He, Y., Wu, B., Ren, D., Ding, S., Zhao, J., & Li, Y. (2025) · Advanced Science · doi:10.1002/advs.202512097 · Cited by 3
Single-cell analysis indicating CCR8 modulates CD8+ tissue-resident memory T cells to attenuates rejection in transplantation
Wang, X., Li, X., Cai, H., Jia, Z., Zhou, X., Ding, R., Song, M., Liu, H., Wang, F., Wu, B., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-32785-2 · Cited by 3
Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions
Ye, H., Wong, A., Chen, X., Sun, W., He, H., Li, X., & Wu, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1781606 · Cited by 5
Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection
Parsa, R., de Assis, H. C., Castro, T. B. R., dos Reis, G. L., Sushil, A., Hartweger, H., Bilate, A. M. B., & Mucida, D. (2026) · Nature Immunology · doi:10.1038/s41590-026-02451-4 · Cited by 5
Tracking spatio-temporal dynamics of early immune responses to an intranasal OMV-based pneumococcal vaccine candidate in mice
Kanwal, S., To, S. V., Uijen, R. F., Roverts, R., van Cranenbroek, B., van Opzeeland, F. J., Joosten, B., van Saparoea, B. V. D. B., de Jongh, C. E. V. D. G., van Rijssen, E., et al. (2026) · npj Vaccines · doi:10.1038/s41541-026-01430-y · Cited by 4
Mucosal Vaccine Development: From Adjuvant Design to Next-Generation Delivery Strategies
Lee, W.-H., & Kim, E. (2026) · Biomedicines · doi:10.3390/biomedicines14051060 · Cited by 5
Mucosal immunity and vaccine development
Hong, W., Alu, A., Zhang, Z., Zhang, Y. L., He, X., Xu, L., Li, M., He, W., & Wang, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02687-4 · Cited by 3
PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice
Tomas, J., Koo, Y., Popoff, D., Gorvel, V. A., Hanniffy, S. B., Gorvel, J., & Mionnet, C. (2021) · Toxins · doi:10.3390/toxins13090632 · Cited by 4
Basic immunology
Chang, C. C.-C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95061-9.00003-5 · Cited by 3
Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children
Meng, L., Yang, Y., He, S., Chen, H., Zhan, Y., Yang, R., Li, Z., Zhu, J., Zhou, J., Li, Y., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03611-9 · Cited by 3
Tissue-Resident Memory T Cells in Tumor Immunity and Immunotherapy of Digestive System Tumors
Cheng, M., Liu, J., Liang, Y., Xu, J., Ma, L., & Liang, J. (2025) · Immunological Investigations · doi:10.1080/08820139.2024.2447780 · Cited by 4
Distinct transcriptomic signatures in pulmonary tissue resident and vascular resident-like T cells in nonhuman primates
Melton, A., Potter, E. L., Penney, T., Krzykwa, C., Rowe, L. A., Goff, K. A., Scheuermann, S. E., Russell‐Lodrigue, K., Melton, H. J., Magnani, D. M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112745 · Cited by 3
Memory T cell formation and phenotype varies across intestinal compartments
Sandford, S., Evrard, M., Burn, T. N., Christo, S. N., Yakou, M. H., Obers, A., Alexandre, Y. O., Mackay, L. K., & Mueller, S. N. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.06.005 · Cited by 3
Self-citation
Some vexations that challenge viral immunology
Rouse, B. T., & Mueller, S. N. (2016) · F1000Research · doi:10.12688/f1000research.8391.1 · Cited by 3
Self-citation
Prediction of response to surgical therapy in nonsegmental vitiligo based on an immunohistochemical cutoff value
Amin, D. I., Bassiouny, D. A., El‐Tahlawi, S., Tawdy, A. E., & Abdellatif, M. (2020) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.4103/jewd.jewd_40_19 · Cited by 3
South Ural state medical University, Department of Dermatovenerology
Letyaeva, O. I. (2020) · CHILDREN INFECTIONS · doi:10.22627/2072-8107-2020-19-3-58-64 · Cited by 3
[Advances in the Study of Tissue-resident Memory T Cells in Lung Cancer].
Tan, S., & Tian, P. (2022) · PubMed · doi:10.3779/j.issn.1009-3419.2022.102.49 · Cited by 3
Tissue-resident, memory CD8+ T cells are effective in clearing intestinal Eimeria falciformis reinfection in mice
Shi, F., Zhang, S., Zhang, N., Yu, Y., Sun, P., Tang, X., Liu, X., & Suo, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1128637 · Cited by 3
Development of modern immunization agent against bovine papillomavirus type 1 infection based on BPV1 L1 recombinant protein
Vráblíková, A., Brezáni, V., Pšikal, I., Fraiberk, M., Šebela, M., Fojtíková, M., Kulich, P., Héžová, R., & Mašek, J. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1116661 · Cited by 3
Crohn’s disease treatment and memory T-cell subset changes: insights from a case series
Chen, Z., Tang, Y.-Y., Sheng, S.-Y., Lu, C.-G., Xu, K.-W., Chen, G.-J., Wang, Y., Gu, Y., Song, X.-M., & Hong, H. (2024) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-23-21 · Cited by 3
The Skinny on Fat Trm Cells
Cheuk, S., & Eidsmo, L. (2017) · Immunity · doi:10.1016/j.immuni.2017.12.003 · Cited by 3
The healing power of painful memories
Naik, S. (2018) · Science · doi:10.1126/science.aat0963 · Cited by 3
The impact of lymphoid memory cells in different ages of COVID-19 patients
Jafari, M., Kolahdooz, H., Mahmoudi, M., Azarnaminy, A. F., Mobasheri, L., & Esmaeili, S. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101503 · Cited by 3
Adaptive immunity
Blanchard, N., Salvioni, A., & Robey, E. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815041-2.00026-8 · Cited by 3
IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)
Олейник, Е. К., Churov, A. V., & Олейник, В. М. (2018) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2018-5-613-620 · Cited by 3
Resident Memory T Cells
Akbaba, H. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90334 · Cited by 4
Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow
Kim, K. H., Choi, A., Kim, S. H., Song, H., Jin, S., Kim, K., Jang, J., Choi, H., & Jung, Y. W. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0137 · Cited by 3
Doctors can fulfil euthanasia request if patient develops dementia, rules Dutch Supreme Court
Sheldon, T. (2020) · BMJ · doi:10.1136/bmj.m1652 · Cited by 3
Influence of testosterone on blood sugar, serum insulin and free fatty acid responses to glucose in normal male dog.
Renauld, A., & Sverdlik, R. C. (1975) · PubMed · Cited by 3
Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancerPreprint
Weeden, C. E., Gayevskiy, V., Trussart, M., Marceaux, C., Ribera, N. T., Batey, D., Teh, C. E., Mitchell, A. J., Antippa, P. N., Leong, T. L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.20.440373 · Cited by 3
Hiding in Plain Sight: CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissuesPreprint
Jarvis, L. B., Howlett, S., Rainbow, D. B., Coppard, V., Ferreira, R. C., Needham, E., Prabhu, A., Alkwai, S., Ellis, L., Georgieva, Z. G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.24.573232 · Cited by 3

Authors: Mueller, S. N., & Mackay, L. K.
Affiliations: The University of Melbourne (AU)
Corresponding author: Mueller, Scott N.
Mackay, Laura K.
ORCID: Mueller, Scott N.
Mackay, Laura K.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-12-21
Volume: 16
Issue: 2
Pages: 79-89
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2015.3
OpenAlex: W2273021913
Cited by: 1,006
References: 106
Citations by year: 2026: 70 · 2025: 87 · 2024: 88 · 2023: 91 · 2022: 100 · 2021: 122 · 2020: 118 · 2019: 102 · 2018: 109 · 2017: 83 · 2016: 34
FWCI: 7.12
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: tissue-resident memory T cells, regional immunity, memory T cell differentiation, T cell migration, infection immunity, tumor immunology, vaccine design
MeSH terms: Cell Differentiation, Humans, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tissue-resident memory T cells: local specialists in immune defence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks