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Inhibition of human mast cell activation with the novel selective adenosine A2B receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)22Abbreviations: cAMP, cyclic, AMP; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; DPSPX, 1,3-dipropyl-8-p-sulfophenylxanthine; FBS, fetal bovine serum; IB-MECA, N6 -(3-iodobenzyl)-N-methyl-5′-carbamoyladenosine; IL-8, interleukin-8; IPDX, 3-isobutyl-8-pyr,5rolidinoxanthine; NECA, 5′-N-ethylcarboxamidoadenosine; PDE, 3′,5′-cyclic nucleotide phosphodiesterase; SAR, structure-activity relationship.

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