The DOI matches its Crossref record; 257 of the 259 references it cites were found in a registry or an index.
MicroRNAs as regulatory elements in immune system logic
Abstract
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate decisions. They act by negatively regulating the expression of key immune development genes, thus contributing important logic elements to the regulatory circuitry. Deletion studies have made it increasingly apparent that they confer robustness to immune cell development, especially under conditions of environmental stress such as infectious challenge and ageing. Aberrant expression of certain miRNAs can lead to pathological consequences, such as autoimmunity and haematological cancers. In this Review, we discuss the mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output, first at the level of haematopoietic stem cells, then in innate and adaptive immune cells. We then discuss the pathological consequences of dysregulation of these miRNAs.
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“Both macrophages and granulocytes are called professional phagocytes, and each may be a cellular target for microRNAs, but only macrophages are considered as appropriate for potential experimental transfection [53].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [53]
In the citing paper
“Both macrophages and granulocytes are called professional phagocytes, and each may be a cellular target for microRNAs, but only macrophages are considered as appropriate for potential experimental transfection [53].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [53]
Citations
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Metadata
- Authors
- Mehta, A., & Baltimore, D.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Mehta, Arnav
- Baltimore, David
- Venue
- Nature Reviews Immunology
- Published
- 2016-04-28
- Volume
- 16
- Issue
- 5
- Pages
- 279-294
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2343186061
- Cited by
- 704
- References
- 259
- Citations by year
- 2026: 29 · 2025: 55 · 2024: 43 · 2023: 52 · 2022: 84 · 2021: 122 · 2020: 100 · 2019: 67 · 2018: 79 · 2017: 58 · 2016: 14
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-05-23)
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Cancer Institute (F30CA183220)
- National Institute of Allergy and Infectious Diseases (R01AI079243)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, post-transcriptional regulation, immune cell development, hematopoiesis, cell fate determination, hematopoietic stem cells, innate immune cells, adaptive immune cells, autoimmunity, hematologic cancer, aging, infection
- MeSH terms
- Animals, Cell Differentiation, Disease Susceptibility, Gene Expression Regulation, Hematopoietic Stem Cells, Homeostasis, Humans, Immune System, Immunity, Innate, Autoimmunity, MicroRNAs, Adaptive Immunity, Immunomodulation
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