Cited by 704MicroRNA in disease regulationT-cell and B-cell ImmunologyPlant Molecular Biology Research

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MicroRNAs as regulatory elements in immune system logic

Mehta, Arnav, Baltimore, David·2016·Nature Reviews Immunology

DOI 10.1038/nri.2016.40

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Abstract

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate decisions. They act by negatively regulating the expression of key immune development genes, thus contributing important logic elements to the regulatory circuitry. Deletion studies have made it increasingly apparent that they confer robustness to immune cell development, especially under conditions of environmental stress such as infectious challenge and ageing. Aberrant expression of certain miRNAs can lead to pathological consequences, such as autoimmunity and haematological cancers. In this Review, we discuss the mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output, first at the level of haematopoietic stem cells, then in innate and adaptive immune cells. We then discuss the pathological consequences of dysregulation of these miRNAs.

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Authors: Mehta, A., & Baltimore, D.
Affiliations: California Institute of Technology (US)
Corresponding author: Mehta, Arnav
Baltimore, David
ORCID: Mehta, Arnav
Baltimore, David
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2016-04-28
Volume: 16
Issue: 5
Pages: 279-294
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2016.40
OpenAlex: W2343186061
Cited by: 704
References: 259
Citations by year: 2026: 29 · 2025: 55 · 2024: 43 · 2023: 52 · 2022: 84 · 2021: 122 · 2020: 100 · 2019: 67 · 2018: 79 · 2017: 58 · 2016: 14
FWCI: 6.67
Type: journal article
Language: en
Update notices: erratum (2016-05-23)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Cancer Institute (F30CA183220)
National Institute of Allergy and Infectious Diseases (R01AI079243)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, post-transcriptional regulation, immune cell development, hematopoiesis, cell fate determination, hematopoietic stem cells, innate immune cells, adaptive immune cells, autoimmunity, hematologic cancer, aging, infection
MeSH terms: Animals, Cell Differentiation, Disease Susceptibility, Gene Expression Regulation, Hematopoietic Stem Cells, Homeostasis, Humans, Immune System, Immunity, Innate, Autoimmunity, MicroRNAs, Adaptive Immunity, Immunomodulation

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MicroRNAs as regulatory elements in immune system logic

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