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Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
Open accessAbstract
The tumour microenvironment is the primary location in which tumour cells and the host immune system interact. Different immune cell subsets are recruited into the tumour microenvironment via interactions between chemokines and chemokine receptors, and these populations have distinct effects on tumour progression and therapeutic outcomes. In this Review, we focus on the main chemokines that are found in the human tumour microenvironment; we elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology, and we consider how they affect cancer immunity and tumorigenesis. We also discuss the potential of targeting chemokine networks, in combination with other immunotherapies, for the treatment of cancer.
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“Chemokines and their receptors coordinate the trafficking and spatial organization of immune cells within tumors[59], whereas MHC molecules are involved in antigen presentation and subsequent T-cell activation, which are essential for antitumor immune responses[58, 60].”
Metadata
- Authors
- Nagarsheth, N., Wicha, M. S., & Zou, W.
- Venue
- Nature Reviews Immunology
- Published
- 2017-05-30
- Volume
- 17
- Issue
- 9
- Pages
- 559-572
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2617691667
- Cited by
- 2,206
- References
- 35
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- green
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