The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Human CD8+ T-cell differentiation in response to viruses
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Late-stage differentiated effector memory CD4+ and CD8+ T cells accumulate with ageing and many are specific for latent Herpes viruses, especially Cytomegalovirus (CMV) (van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“These CMV-specific T cells exhibit a late-stage differentiated phenotype, including loss of co-stimulatory molecules (e.g., CD27 and CD28) and cell-surface proteins associated with homing to lymphoid tissue (e.g., CD62L and CCR7) (Appay et al. 2008; van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“Further, these cells re-express CD45RA in combination with markers often stated to reflect “senescence” such as CD57 and KLRG1 (Appay et al. 2008; van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“From an evolutionary perspective, there may be an advantage to having an accumulation of late-stage differentiated T cells, assuming few are senescent/functionally exhausted, and considering that many will be specific for viruses such as CMV that require constant immune-surveillance (van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“Generally, it is TEMRA cells that become dysfunctional (Fulop et al. 2013; van Lier et al. 2003)”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1×
“Specific CD8 + T cells in acute viral infection With the emergence of tools — in particular MHC CLASS I TETRAMERS loaded with CD8 + T-cell epitopes for relevant viruse”
BackgroundSallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501
Förster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner‐Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,348
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
The lineage decisions of helper T cells
MURPHY, K. M. M., & Reiner, S. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri954 · Cited by 1,690
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
Cited by
Sorted by citations
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
CD28− T cells: their role in the age-associated decline of immune function
Weng, N., Akbar, A. N., & Goronzy, J. J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.013 · Cited by 630
Kaech, S. M., & Wherry, E. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.007 · Cited by 646
Blackwell, J. M., Jamieson, S. E., & Burgner, D. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00048-08 · Cited by 520
Metadata
- Authors
- van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Nature Reviews Immunology
- Published
- 2003-12
- Volume
- 3
- Issue
- 12
- Pages
- 931-939
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2105579166
- Cited by
- 297
- References
- 104
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 7 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 16 · 2014: 13 · 2013: 17 · 2012: 14
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- CD8+ T cells, T cell differentiation, viral infection, T cell development, latent viruses, T cell heterogeneity, acute viral infection, antiviral immunity
- MeSH terms
- Animals, Cell Differentiation, Humans, Immunologic Memory, Lymphocyte Activation, Viruses, T-Lymphocyte Subsets, Virus Latency, CD8-Positive T-Lymphocytes, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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