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Human CD8+ T-cell differentiation in response to viruses
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“Late-stage differentiated effector memory CD4+ and CD8+ T cells accumulate with ageing and many are specific for latent Herpes viruses, especially Cytomegalovirus (CMV) (van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“These CMV-specific T cells exhibit a late-stage differentiated phenotype, including loss of co-stimulatory molecules (e.g., CD27 and CD28) and cell-surface proteins associated with homing to lymphoid tissue (e.g., CD62L and CCR7) (Appay et al. 2008; van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“Further, these cells re-express CD45RA in combination with markers often stated to reflect “senescence” such as CD57 and KLRG1 (Appay et al. 2008; van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“From an evolutionary perspective, there may be an advantage to having an accumulation of late-stage differentiated T cells, assuming few are senescent/functionally exhausted, and considering that many will be specific for viruses such as CMV that require constant immune-surveillance (van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
In the citing paper
“Generally, it is TEMRA cells that become dysfunctional (Fulop et al. 2013; van Lier et al. 2003)”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003
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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
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Kaech, S. M., & Wherry, E. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.007 · Cited by 646
Blackwell, J. M., Jamieson, S. E., & Burgner, D. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00048-08 · Cited by 520
Metadata
- Authors
- van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Nature Reviews Immunology
- Published
- 2003-12
- Volume
- 3
- Issue
- 12
- Pages
- 931-939
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2105579166
- Cited by
- 297
- References
- 104
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 7 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 16 · 2014: 13 · 2013: 17 · 2012: 14
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- CD8+ T cells, T cell differentiation, viral infection, T cell development, latent viruses, T cell heterogeneity, acute viral infection, antiviral immunity
- MeSH terms
- Animals, Cell Differentiation, Humans, Immunologic Memory, Lymphocyte Activation, Viruses, T-Lymphocyte Subsets, Virus Latency, CD8-Positive T-Lymphocytes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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