Cited by 741Cannabis and Cannabinoid ResearchInflammatory mediators and NSAID effectsNatural Compounds in Disease Treatment

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Cannabinoid-based drugs as anti-inflammatory therapeutics

Klein, Thomas W.·2005·Nature Reviews Immunology

DOI 10.1038/nri1602

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Abstract

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from eating disorders to rabies. However, as newer, more effective drugs were discovered and as the potential for abuse of marijuana was recognized, its use as a therapeutic became restricted, and only recently has its therapeutic potential been re-evaluated. Recent studies in animal models and in humans have produced promising results for the treatment of various disorders - such as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive and anti-inflammatory properties; therefore, on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.

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Authors: Klein, T. W.
Affiliations: University of South Florida (US)
Corresponding author: Klein, Thomas W.
ORCID: Klein, Thomas W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-05
Volume: 5
Issue: 5
Pages: 400-411
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1602
OpenAlex: W2072422429
Cited by: 728
References: 128
Citations by year: 2026: 15 · 2025: 29 · 2024: 25 · 2023: 27 · 2022: 31 · 2021: 46 · 2020: 46 · 2019: 35 · 2018: 26 · 2017: 42 · 2016: 31 · 2015: 33 · 2014: 39 · 2013: 32 · 2012: 32
FWCI: 5.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: anti-inflammatory therapy, chronic inflammatory diseases, immunosuppression, cannabis, obesity, cancer, spasticity, tremor, neuropathology
MeSH terms: Animals, Anti-Inflammatory Agents, Cannabinoids, Cell Movement, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Cytokines, Receptors, Cannabinoid

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