The DOI matches its Crossref record; 164 of the 167 references it cites were found in a registry or an index.
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
Abstract
Mucosal surfaces such as the intestinal tract are continuously exposed to both potential pathogens and beneficial commensal microorganisms. This creates a requirement for a homeostatic balance between tolerance and immunity that represents a unique regulatory challenge to the mucosal immune system. Recent findings suggest that intestinal epithelial cells, although once considered a simple physical barrier, are a crucial cell lineage for maintaining intestinal immune homeostasis. This Review discusses recent findings that identify a cardinal role for epithelial cells in sampling the intestinal microenvironment, discriminating pathogenic and commensal microorganisms and influencing the function of antigen-presenting cells and lymphocytes.
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“The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.59, 60, 61, 62, 63,64”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [64]
Citations
Cites
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
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The gut microbiota as an environmental factor that regulates fat storage
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Obesity alters gut microbial ecology
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×
“In addition, the collective genetic material of commensal communities, termed the microbiome and which encompasses at least 500–1000 species, is thought to encode as much as 100 times the number of genes in the human genom”
BackgroundPhosphorylation meets ubiquitination: the control of NF-κB activity
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Metagenomic Analysis of the Human Distal Gut Microbiome
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Cited by
Sorted by citations
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
“Finally, detailed analyses of the interactions between epithelial cells and luminal microorganisms, as well as the intricacies of mucosal immune regulation, have also been recently reviewed elsewher”
BackgroundThe inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,170
Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
Chelakkot, C., Ghim, J., & Ryu, S. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0126-x · Cited by 2,017
Metadata
- Authors
- Artis, D.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Artis, David
- ORCID
- Artis, David
- Venue
- Nature reviews. Immunology
- Published
- 2008-06
- Volume
- 8
- Issue
- 6
- Pages
- 411-420
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2025114863
- Cited by
- 1,136
- References
- 167
- Citations by year
- 2026: 27 · 2025: 33 · 2024: 38 · 2023: 55 · 2022: 61 · 2021: 54 · 2020: 51 · 2019: 52 · 2018: 60 · 2017: 56 · 2016: 58 · 2015: 63 · 2014: 92 · 2013: 85 · 2012: 81
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (T32CA009140, T32-CA09140-30)
- National Institute of General Medical Sciences (F31-GM82187, F31GM082187)
- National Institute of Allergy and Infectious Diseases (AI74878, T32AI007532, R01AI074878, F32-AI72943, F32AI072943, R01AI061570, AI 61570)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- intestinal epithelial cells, commensal bacteria, immune homeostasis, mucosal immunity, host-microbe interactions, epithelial barrier function, antigen presentation, lymphocytes, pathogen discrimination, gut microbiota
- MeSH terms
- Animals, Bacteria, Gastric Mucosa, Homeostasis, Humans, Intestinal Mucosa
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