Cited by 1,136Gut microbiota and healthImmune Response and InflammationT-cell and B-cell Immunology

The DOI matches its Crossref record; 164 of the 167 references it cites were found in a registry or an index.

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, David·2008·Nature reviews. Immunology

Open this paper in CoChat — free account

Abstract

Mucosal surfaces such as the intestinal tract are continuously exposed to both potential pathogens and beneficial commensal microorganisms. This creates a requirement for a homeostatic balance between tolerance and immunity that represents a unique regulatory challenge to the mucosal immune system. Recent findings suggest that intestinal epithelial cells, although once considered a simple physical barrier, are a crucial cell lineage for maintaining intestinal immune homeostasis. This Review discusses recent findings that identify a cardinal role for epithelial cells in sampling the intestinal microenvironment, discriminating pathogenic and commensal microorganisms and influencing the function of antigen-presenting cells and lymphocytes.

Integrity signals

Registry

Crossref · 10.1038/nri2316

Cites

164 of 164 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×
“In addition, the collective genetic material of commensal communities, termed the microbiome and which encompasses at least 500–1000 species, is thought to encode as much as 100 times the number of genes in the human genom”
Background
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,218
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880
The immunological and genetic basis of inflammatory bowel disease
Bouma, G., & Strober, W. (2003) · Nature reviews. Immunology · doi:10.1038/nri1132 · Cited by 1,796
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683
CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,646
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Girardin, S. E., Boneca, I. G., Carneiro, L. A. M., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M., Labigne-Roussel, A., Zäthringer, U., et al. (2003) · Science · doi:10.1126/science.1084677 · Cited by 1,625
Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria
Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584
Anatomical basis of tolerance and immunity to intestinal antigens
Mowat, A. M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1057 · Cited by 1,414
Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression
Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345
Analysis of Intestinal Flora Development in Breast-Fed and Formula-Fed Infants by Using Molecular Identification and Detection Methods
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326
Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311
Regulation and Function of IKK and IKK-Related Kinases
Häcker, H., & Karin, M. (2006) · Science s STKE · doi:10.1126/stke.3572006re13 · Cited by 1,298
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Treiner, E., Duban, L., Bahram, S., Radosavljevic, M., Wanner, V., Tilloy, F., Affaticati, P., Gilfillan, S., & Lantz, O. (2003) · Nature · doi:10.1038/nature01433 · Cited by 1,139
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
Stappenbeck, T. S., Hooper, L. V., & Gordon, J. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202604299 · Cited by 1,095
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077
Immunity, Inflammation, and Allergy in the Gut
MacDonald, T. T., & Monteleone, G. (2005) · Science · doi:10.1126/science.1106442 · Cited by 1,051
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 1,026
Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
Smythies, L. E., Sellers, M. T., Clements, R. H., Mosteller‐Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M., & Smith, P. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200519229 · Cited by 954
Angiogenins: a new class of microbicidal proteins involved in innate immunity
Hooper, L. V., Stappenbeck, T. S., Hong, C. V., & Gordon, J. I. (2003) · Nature Immunology · doi:10.1038/ni888 · Cited by 947
Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer
Karin, M., Lawrence, T., & Nizet, V. (2006) · Cell · doi:10.1016/j.cell.2006.02.016 · Cited by 938
Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
Garrett, W. S., Lord, G. M., Punit, S., Lugo‐Villarino, G., Mazmanian, S. K., Ito, S., Glickman, J. N., & Glimcher, L. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.017 · Cited by 915
Honor thy symbionts
Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 890
Nod-like proteins in immunity, inflammation and disease
Fritz, J. H., Ferrero, R. L., Philpott, D. J., & Girardin, S. E. (2006) · Nature Immunology · doi:10.1038/ni1412 · Cited by 889
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859
Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila
Ryu, J.-H., Kim, S.-H., Lee, H.-Y., Bai, J. Y., Nam, Y., Bae, J., Lee, D. G., Shin, S. C., Ha, E.-M., & Lee, W. (2008) · Science · doi:10.1126/science.1149357 · Cited by 857
Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination
Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., & Madara, J. (2000) · Science · doi:10.1126/science.289.5484.1560 · Cited by 843
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Zhou, B., Comeau, M. R., Smedt, T. D., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D., Aye, T., Campbell, D., & Ziegler, S. F. (2005) · Nature Immunology · doi:10.1038/ni1247 · Cited by 827
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 827
Dendritic cells in intestinal immune regulation
Coombes, J. L., & Powrie, F. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2335 · Cited by 821
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., Nespoli, A., Viale, G., Allavena, P., & Rescigno, M. (2005) · Nature Immunology · doi:10.1038/ni1192 · Cited by 815
Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
Smith, K., McCoy, K. D., & Macpherson, A. J. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.10.002 · Cited by 789
Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B. P., Brewer, A. W., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062211 · Cited by 787
The regulation of IgA class switching
Cerutti, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2322 · Cited by 777
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765
Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases
Tlaskalová‐Hogenová, H., Štëpánková, R., Hudcovic, T., Tučková, L., Cukrowská, B., Lodinová‐Žádníková, R., Kozáková, H., Rossmann, P., Bártová, J., Sokol, D., et al. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.02.005 · Cited by 755
Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing
Maeda, S., Hsu, L.-C., Liu, H., Bankston, L. A., Iimura, M., Kagnoff, M. F., Eckmann, L., & Karin, M. (2005) · Science · doi:10.1126/science.1103685 · Cited by 748
Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL
He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J. S., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 748
Intestinal microflora in early infancy: composition and development
Fanaro, S., Chierici, R., Guerrini, P., & Vigi, V. (2003) · Acta Paediatrica · doi:10.1111/j.1651-2227.2003.tb00646.x · Cited by 738
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., & Fagarasan, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307317101 · Cited by 721
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
Chieppa, M., Rescigno, M., Huang, A. Y.-C., & Germain, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061884 · Cited by 711
Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide
Abreu, M. T., Vora, P., Faure, E., Thomas, L. S., Arnold, E. T., & Arditi, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1609 · Cited by 681
War and peace at mucosal surfaces
Sansonetti, P. J. (2004) · Nature reviews. Immunology · doi:10.1038/nri1499 · Cited by 680
TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation
Liu, Y., Soumelis, V., Watanabe, N., Ito, T., Wang, Y., Malefyt, R. D. W., Omori, M., Zhou, B., & Ziegler, S. F. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141718 · Cited by 659
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
Yoo, J. Y., Omori, M., Gyarmati, D., Zhou, B., Aye, T., Brewer, A. W., Comeau, M. R., Campbell, D., & Ziegler, S. F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041503 · Cited by 612
SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling
Wald, D. N., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L., Towne, J. E., Sims, J. E., Stark, G. R., & Li, X. (2003) · Nature Immunology · doi:10.1038/ni968 · Cited by 606
Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury
Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I., & Stappenbeck, T. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405979102 · Cited by 605
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora
Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., & Honjo, T. (2002) · Science · doi:10.1126/science.1077336 · Cited by 590
TLR Signaling in the Gut in Health and Disease
Abreu, M. T., Fukata, M., & Arditi, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4453 · Cited by 577
Mucosal Dendritic Cells
Iwasaki, A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141634 · Cited by 555
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
Li, M., Hener, P., Zhang, Z., Kato, S., METZGER, D., & Chambon, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604575103 · Cited by 550
Manipulation of host-cell pathways by bacterial pathogens
Bhavsar, A. P., Guttman, J. A., & Finlay, B. B. (2007) · Nature · doi:10.1038/nature06247 · Cited by 534
A role for TSLP in the development of inflammation in an asthma model
Al-Shami, A., Spolski, R. J., Kelly, J., Keane‐Myers, A., & Leonard, W. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050199 · Cited by 515
TLR3- and Th2 Cytokine-Dependent Production of Thymic Stromal Lymphopoietin in Human Airway Epithelial Cells
Kato, A., Favoreto, S., Avila, P. C., & Schleimer, R. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1080 · Cited by 503
Does the microbiota regulate immune responses outside the gut?
Noverr, M. C., & Huffnagle, G. B. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.10.008 · Cited by 499
Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature · doi:10.1038/nature05590 · Cited by 496
Self-citation
The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
Chen, L.-W., Egan, L. J., Li, Z.-W., Greten, F. R., Kagnoff, M. F., & Karin, M. (2003) · Nature Medicine · doi:10.1038/nm849 · Cited by 483
Anti‐inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL‐12 and up‐regulation of IL‐10 production
Säemann, M. D., Böhmig, G. A., Österreicher, C. H., BURTSCHER, H. J., Parolini, O., Diakos, C., Stöckl, J., Hörl, W. H., & Zlabinger, G. J. (2000) · The FASEB Journal · doi:10.1096/fj.00-0359fje · Cited by 482
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
Ízcue, A., Coombes, J. L., & Powrie, F. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00423.x · Cited by 481
Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
Lotz, M., Gütle, D., Walther, S., Ménard, S., Bogdan, C., & Hornef, M. W. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050625 · Cited by 464
Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β
Dignass, A. U., & Podolsky, D. K. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90136-z · Cited by 449
Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier
Neal, M. D., Leaphart, C. L., Levy, R. M., Prince, J. M., Billiar, T. R., Watkins, S. C., Li, J., Çetin, S., Ford, H. R., Schreiber, A. D., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3070 · Cited by 440
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
McAuley, J., Lindén, S. K., Png, C. W., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V., & McGuckin, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26705 · Cited by 437
Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut
Melmed, G., Thomas, L. S., Lee, N., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Zhou, Y., Hu, B., Arditi, M., & Abreu, M. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1406 · Cited by 431
Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?
Sonnenburg, J. L., Angenent, L. T., & Gordon, J. I. (2004) · Nature Immunology · doi:10.1038/ni1079 · Cited by 417
Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells
Iwasaki, A., & Kelsall, B. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4884 · Cited by 410
Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting
Frey, A., Giannasca, K. T., Weltzin, R., Giannasca, P. J., Reggio, H., Lencer, W. I., & Neutra, M. R. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1045 · Cited by 401
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394
Toll-Like Receptor 4 Signaling by Intestinal Microbes Influences Susceptibility to Food Allergy
Bashir, M. E. H., Louie, S., Shi, H. N., & Nagler‐Anderson, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6978 · Cited by 392
MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection
Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R. P., & Pamer, E. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070563 · Cited by 385
Pathogenicity islands: a molecular toolbox for bacterial virulence
Gal‐Mor, O., & Finlay, B. B. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00794.x · Cited by 383
Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR
Penders, J., Vink, C., Driessen, C., London, N. H. H. J., Thijs, C. T., & Stobberingh, E. E. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.11.052 · Cited by 380
Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
Kaliński, P., Vieira, P. L., Schuitemaker, J. H. N., de Jong, E. C., & Kapsenberg, M. L. (2001) · Blood · doi:10.1182/blood.v97.11.3466 · Cited by 362
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.010 · Cited by 354
Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB
Lee, H., & Ziegler, S. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607305104 · Cited by 338
The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
Xiao, H. Q., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D. D., Altuntas, C. Z., Wald, D. N., Ma, C., Zhou, H., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.012 · Cited by 331
Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
Uehara, A., Fujimoto, Y., Fukase, K., & Takada, H. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.02.007 · Cited by 330
Anti-Inflammatory Effect of Lactobacillus casei on Shigella -Infected Human Intestinal Epithelial Cells
Tien, M.-T., Girardin, S. E., Regnault, B., Bourhis, L. L., Dillies, M., Coppée, J., Bourdet‐Sicard, R., Sansonetti, P. J., & Pédron, T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1228 · Cited by 323
Immunoglobulin transport across polarized epithelial cells
Rojas, R. E., & Apodaca, G. L. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm972 · Cited by 309
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI
Xu, W., He, B., Chiu, A., Chadburn, A., Shan, M., Buldys, M., Ding, A. H., Knowles, D. M., Santini, P. A., & Cerutti, A. (2007) · Nature Immunology · doi:10.1038/ni1434 · Cited by 305
Mucosal immunoglobulins
Woof, J. M., & Mestecky, J. F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00290.x · Cited by 292
Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera.
Bland, P. W., & Warren, L. G. (1986) · PubMed · Cited by 290
Antigen processing and presentation by intestinal epithelial cells – polarity and complexity
Hershberg, R. M., & Mayer, L. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01575-3 · Cited by 289
Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.
Liu, L. M., & MacPherson, G. G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.5.1299 · Cited by 287
Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
Macpherson, A. J., Geuking, M. B., & McCoy, K. D. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02159.x · Cited by 283
Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes
Bogiatzi, S. I., Fernandez, I., Bichet, J.-C., Marloie-Provost, M.-A., Volpe, E., Sastre‐Garau, X., & Soumelis, V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3373 · Cited by 272
Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus.
Umesaki, Y., Setoyama, H., Matsumoto, S., & Okada, Y. (1993) · PubMed Central · Cited by 270
The role of Toll-like receptors and Nod proteins in bacterial infection
Philpott, D. J., & Girardin, S. E. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.012 · Cited by 270
Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury
Brown, S. L., Riehl, T. E., Walker, M. R., Geske, M. J., Doherty, J. M., Stenson, W. F., & Stappenbeck, T. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29159 · Cited by 263
Human thymic stromal lymphopoietin promotes dendritic cell–mediated CD4+ T cell homeostatic expansion
Watanabe, N., Hanabuchi, S., Soumelis, V., Yuan, W., Ho, S., Malefyt, R. D. W., & Liu, Y.-J. (2004) · Nature Immunology · doi:10.1038/ni1048 · Cited by 260
Intestinal inflammation in mice deficient in Tir8 , an inhibitory member of the IL-1 receptor family
Garlanda, C., Riva, F., Polentarutti, N., Buracchi, C., Sironi, M., Bortoli, M. D., Muzio, M., Bergottini, R., Scanziani, E., Vecchi, A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308680101 · Cited by 254
Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
Ziegler, S. F., & Liu, Y.-J. (2006) · Nature Immunology · doi:10.1038/ni1360 · Cited by 234
Immunomodulatory dendritic cells in intestinal lamina propria
Chirdo, F. G., Millington, O. R., Beacock‐Sharp, H., & Mowat, A. M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425882 · Cited by 229
Mucosal CD8α+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties
Bilsborough, J., George, T. C., Norment, A. M., & Viney, J. L. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01606.x · Cited by 225
Early Intestinal Bacterial Colonization and Necrotizing Enterocolitis in Premature Infants: The Putative Role of Clostridium
de la Cochetière, M.-F., Piloquet, H., Robert, C. D., Darmaun, D., Galmiche, J., & Rozé, J. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000134251.45878.d5 · Cited by 224
Murine enterocytes can present soluble antigen to specific class II‐restricted CD4+ T cells
Kaiserlian, D., Vidal, K., & Revillard, J. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190827 · Cited by 206
Genetic and environmental control of salmonella invasion.
Altier, C. (2005) · PubMed · Cited by 192
Transepithelial Pathogen Uptake into the Small Intestinal Lamina Propria
Vallon-Eberhard, A., Landsman, L., Yogev, N., Verrier, B., & Jung, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2465 · Cited by 192
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
Egan, L. J., Eckmann, L., Greten, F. R., Chae, S.-W., Li, Z.-W., Myhre, G. M., Robine, S., Karin, M., & Kagnoff, M. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306734101 · Cited by 192
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
Schilling, J. D., Martin, S. M., Hung, C., Lorenz, R. G., & Hultgren, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0736473100 · Cited by 186
Role of Epithelial Cells in Initiation and Propagation of Intestinal Inflammation. Eliminating the static: tight junction dynamics exposed
Shen, L., & Turner, J. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00439.2005 · Cited by 176
TLR Signaling Mediated by MyD88 Is Required for a Protective Innate Immune Response by Neutrophils to Citrobacter rodentium
Lebeis, S. L., Bommarius, B., Parkos, C. A., Sherman, M. A., & Kalman, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.566 · Cited by 176
Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different
Rimoldi, M., Chieppa, M., Larghi, P., Vulcano, M., Allavena, P., & Rescigno, M. (2005) · Blood · doi:10.1182/blood-2004-11-4321 · Cited by 160
Toll-like receptors and their role in experimental models of microbial infection
Qureshi, S., & Medzhitov, R. (2003) · Genes and Immunity · doi:10.1038/sj.gene.6363937 · Cited by 159
Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease
Kelsall, B. L., & Leon, F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00292.x · Cited by 154
Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response
Fujita, S., Seino, K., Sato, K., Sato, Y., Eizumi, K., Yamashita, N., Taniguchi, M., & Sato, K. (2006) · Blood · doi:10.1182/blood-2005-10-4190 · Cited by 136
MORPHOLOGICAL AND PHYSIOLOGICAL CHARACTERIZATION OF GERMFREE LIFE*
Gordon, H. A. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb53104.x · Cited by 135
Effects of mode of delivery and necrotising enterocolitis on the intestinal microflora in preterm infants
H�llstr�m, M., Eerola, E., Vuento, R., Janas, M., & Tammela, O. K. T. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1146-0 · Cited by 129
Control of intestinal homeostasis by regulatory T cells and dendritic cells
Coombes, J. L., & Maloy, K. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.01.001 · Cited by 127
Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
Arvans, D. L., Vavricka, S. R., Ren, H., Musch, M. W., Kang, L. H., Rocha, F. G., Lucioni, A., Turner, J. R., Alverdy, J. C., & Chang, E. B. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00206.2004 · Cited by 126
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8 , an Inhibitory Member of the Interleukin-1 Receptor Family
Garlanda, C., Riva, F., Veliz, T., Polentarutti, N., Pasqualini, F., Radaelli, E., Sironi, M., Nebuloni, M., Zorini, E. O., Scanziani, E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0560 · Cited by 125
Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine
Brown, N. F., Vallance, B. A., Coombes, B. K., Valdez, Y., Coburn, B. A., & Finlay, B. B. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010032 · Cited by 123
Microbial colonization influences composition and T‐cell receptor Vβ repertoire of intraepithelial lymphocytes in rat intestine
HELGELAND, L., VAAGE, J. T., ROLSTAD, B., MIDTVEDT, T., & BRANDTZAEG, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-783.x · Cited by 122
Cutting Edge: Bacterial Modulation of Epithelial Signaling via Changes in Neddylation of Cullin-1
Collier-Hyams, L. S., Sloane, V. M., Batten, B. C., & Neish, A. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4194 · Cited by 119
The Role of Host Cell Death in Salmonella Infections
Guiney, D. G. (2005) · Springer eBooks · doi:10.1007/3-540-27320-4_6 · Cited by 117
Spontaneous and Continuous Cyclooxygenase-2-Dependent Prostaglandin E2 Production by Stromal Cells in the Murine Small Intestine Lamina Propria: Directing the Tone of the Intestinal Immune Response
Newberry, R. D., McDonough, J. S., Stenson, W. F., & Lorenz, R. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4465 · Cited by 110
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development
Astrakhan, A., Omori, M., Nguyen, T., Becker-Herman, S., Iseki, M., Aye, T., Hudkins, K. L., Dooley, J., Farr, A. G., Alpers, C. E., et al. (2007) · Nature Immunology · doi:10.1038/ni1452 · Cited by 105
M Cells in Antigen Sampling in Mucosal Tissues
Neutra, M. R. (1999) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59951-4_2 · Cited by 89
Host Antimicrobial Defence Peptides in Human Disease
Agerberth, B., & Gudmundsson, G. H. (2006) · Springer eBooks · doi:10.1007/3-540-29916-5_3 · Cited by 88
Differential regulation of B7 mRNA in enterocytes and lymphoid cells.
Sanderson, I. R., Ouellette, A. J., Carter, E. A., Walker, W. A., & Harmatz, P. (1993) · PubMed Central · Cited by 84
Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract
Niess, J. H., & Reinecker, H. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000181710.96904.58 · Cited by 80
Dendritic cells at the host-pathogen interface
Colonna, M., Pulendran, B., & Iwasaki, A. (2006) · Nature Immunology · doi:10.1038/ni0206-117 · Cited by 77
Intestinal Epithelial Cells Control Dendritic Cell Function
Rimoldi, M., Chieppa, M., Vulcano, M., Allavena, P., & Rescigno, M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1309.009 · Cited by 61
A Bone Marrow-Derived APC in the Gut-Associated Lymphoid Tissue Captures Oral Antigens and Presents Them to Both CD4+ and CD8+ T Cells
Blanas, E., Davey, G. M., Carbone, F., & Heath, W. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.2890 · Cited by 58
Intestinal epithelial barrier and mucosal immunity
Sato, A., & Iwasaki, A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5037-z · Cited by 53
Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12
Osterloh, A., Veit, A., Gessner, A., Fleischer, B., & Breloer, M. (2008) · International Immunology · doi:10.1093/intimm/dxn003 · Cited by 53
Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells
Laudański, K., De, A. K., & Miller‐Graziano, C. L. (2007) · European Journal of Immunology · doi:10.1002/eji.200636993 · Cited by 51
Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes
Luo, X., Zuo, X., Zhang, B., Song, L., Wei, X., Zhou, Y., & Xiao, X. (2008) · Cell Stress and Chaperones · doi:10.1007/s12192-008-0036-2 · Cited by 48
Uptake and presentation of antigen to T cells by primary colonic epithelial cells in normal and diseased states
Telega, G. W., Baumgart, D. C., & Carding, S. R. (2000) · Gastroenterology · doi:10.1053/gast.2000.20168 · Cited by 47
Validation of 16S rDNA sequencing in microdissected bowel biopsies from Crohn's disease patients to assess bacterial flora diversity
Hertogh, G. D., Aerssens, J., Hoogt, R. D., Peeters, P., Verhasselt, P., Eyken, P. V., Ectors, N., Vermeire, S., Rutgeerts, P., Coulie, B. J., et al. (2006) · The Journal of Pathology · doi:10.1002/path.2006 · Cited by 44
How do DCs interact with intestinal antigens?
Milling, S. W. F., Cousins, L., & MacPherson, G. G. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.010 · Cited by 38
Uptake of Antigens from the Intestine by Dendritic Cells
MacPherson, G. G., Milling, S. W. F., Yrlid, U., Cousins, L., Turnbull, E. L., & Huang, F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1309.010 · Cited by 37
Bacterial Regulation of Intestinal Immune Responses
MacDonald, T. T., & Gordon, J. N. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.05.012 · Cited by 36
Induction of MHC class II gene products in rat intestinal epithelium during graft-versus-host disease and effects on the immune function of the epithelium.
Bland, P. W., & Whiting, C. V. (1992) · PubMed · Cited by 36
Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-κB for Toll-like receptor- and NOD-dependent activation
Uehara, A., Iwashiro, A., Sato, T., Yokota, S., & Takada, H. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.03.010 · Cited by 35
Essential roles of IL‐12 and dendritic cells but not IL‐23 and macrophages in lupus‐like diseases initiated by cell surface HSP gp96
Dai, J., Liu, B., Cua, D. J., & Li, Z. (2007) · European Journal of Immunology · doi:10.1002/eji.200636643 · Cited by 31
Antigen targeting to MHC class II‐enriched late endosomes in colonic epithelial cells: trafficking of luminal antigens studied in vivo in Crohn's colitis patients
Büning, J., Hundorfean, G., Schmitz, M., Zimmer, K., Ströbel, S., Gebert, A., & Ludwig, D. (2005) · The FASEB Journal · doi:10.1096/fj.05-4807fje · Cited by 28
Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity
Bland, P. W. (1987) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5344-7_25 · Cited by 23

Flagged first, then by citations

3 of the 167 references couldn’t be matched to a known paper.

Sorted by citations

Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
“Finally, detailed analyses of the interactions between epithelial cells and luminal microorganisms, as well as the intricacies of mucosal immune regulation, have also been recently reviewed elsewher”
Background
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,170
Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
Chelakkot, C., Ghim, J., & Ryu, S. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0126-x · Cited by 2,017

See all 1,136

Authors: Artis, D.
Affiliations: University of Pennsylvania (US)
Corresponding author: Artis, David
ORCID: Artis, David
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 8
Issue: 6
Pages: 411-420
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2316
OpenAlex: W2025114863
Cited by: 1,136
References: 167
Citations by year: 2026: 27 · 2025: 33 · 2024: 38 · 2023: 55 · 2022: 61 · 2021: 54 · 2020: 51 · 2019: 52 · 2018: 60 · 2017: 56 · 2016: 58 · 2015: 63 · 2014: 92 · 2013: 85 · 2012: 81
FWCI: 6.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (T32CA009140, T32-CA09140-30)
National Institute of General Medical Sciences (F31-GM82187, F31GM082187)
National Institute of Allergy and Infectious Diseases (AI74878, T32AI007532, R01AI074878, F32-AI72943, F32AI072943, R01AI061570, AI 61570)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: intestinal epithelial cells, commensal bacteria, immune homeostasis, mucosal immunity, host-microbe interactions, epithelial barrier function, antigen presentation, lymphocytes, pathogen discrimination, gut microbiota
MeSH terms: Animals, Bacteria, Gastric Mucosa, Homeostasis, Humans, Intestinal Mucosa

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks