Cited by 1,559Vitamin D Research StudiesT-cell and B-cell ImmunologyImmune Response and Inflammation

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Vitamin effects on the immune system: vitamins A and D take centre stage

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Mora, J. Rodrigo, Iwata, Makoto, von Andrian, Ulrich H.·2008·Nature Reviews Immunology

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Abstract

Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.

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Authors: Mora, J. R., Iwata, M., & von Andrian, U. H.
Affiliations: Harvard University (US)
Tokushima Bunri University (JP)
Corresponding author: Mora, J. Rodrigo
ORCID: Mora, J. Rodrigo
Iwata, Makoto
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-09
Volume: 8
Issue: 9
Pages: 685-698
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2378
PMC: PMC2906676
OpenAlex: W2018938924
Cited by: 1,559
References: 170
Citations by year: 2026: 46 · 2025: 84 · 2024: 81 · 2023: 75 · 2022: 98 · 2021: 118 · 2020: 123 · 2019: 69 · 2018: 87 · 2017: 88 · 2016: 86 · 2015: 115 · 2014: 89 · 2013: 100 · 2012: 91
FWCI: 8.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 56949, P01HL056949)
National Institute of Allergy and Infectious Diseases (R01AI072252, AI061663, R01AI069259, R01AI061663, AI072252, AI-069259)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 43351, P30DK043351)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 42689, P30AR042689)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: vitamins, vitamin A, vitamin D, immune regulation, lymphocyte activation, T helper cell differentiation, lymphocyte homing, antibody isotypes, immune-mediated diseases, autoimmunity, inflammation, immunomodulatory therapy
MeSH terms: Animals, Humans, Immune System, Immunotherapy, Lymphocytes, Vitamin A, Vitamin D, Vitamins

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Vitamin effects on the immune system: vitamins A and D take centre stage

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