Cited by 1,559Vitamin D Research StudiesT-cell and B-cell ImmunologyImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Vitamin effects on the immune system: vitamins A and D take centre stage

Open access

Mora, J. Rodrigo, Iwata, Makoto, von Andrian, Ulrich H.·2008·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri2378

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Vitamin D Deficiency
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Jung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880
Self-citation
Retinoic acid imprints gut-homing specificity on T cells
Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541
Self-citation
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Manel, N., Unutmaz, D., & Littman, D. R. (2008) · Nature Immunology · doi:10.1038/ni.1610 · Cited by 1,328

Flagged first, then by citations

Show all 170 references

Sorted by citations

Items 401–500 of 1,000

Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial
Shirazi, K. M., Nikniaz, Z., Shirazi, A. M., & Rohani, M. (2018) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.09.026 · Cited by 48
The bile acid‐activated retinoic acid response in dendritic cells is involved in food allergen sensitization
Wu, R., Yuan, X., Li, X., Ma, N., Jiang, H., Tang, H., Xu, G., Liu, Z., & Zhang, Z. (2021) · Allergy · doi:10.1111/all.15039 · Cited by 48
MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors
Amini, A., Pang, D., Hackstein, C.-P., & Klenerman, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584521 · Cited by 49
Impact of serum vitamin D level on risk of bladder cancer: a systemic review and meta-analysis
Liao, Y., Huang, J., Qiu, M., & Ma, Z. (2014) · Tumor Biology · doi:10.1007/s13277-014-2728-9 · Cited by 47
Maternal diet and its influence on the development of allergic disease
Miles, E. A., & Calder, P. C. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12453 · Cited by 49
Vitamin D-1α-hydroxylase and vitamin D-24-hydroxylase mRNA studies in chickens
Shanmugasundaram, R., & Selvaraj, R. K. (2012) · Poultry Science · doi:10.3382/ps.2011-02129 · Cited by 47
Immunological function of vitamin D during human pregnancy
Ji, J., Muyayalo, K. P., Zhang, Y., Hu, X., & Liao, A. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12716 · Cited by 47
Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease
Bauset, C., Gisbert-Ferrándiz, L., & Cosín‐Roger, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040622 · Cited by 50
Angiotensin‐converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection
Tan, H. W., Xu, Y., & Lau, A. T. Y. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2122 · Cited by 47
Vitamin D Improves Cognitive Function and Modulates Th17/Treg Cell Balance After Hepatectomy in Mice
Tian, A., Ma, H., Cao, X., Zhang, R., Wang, X., & Bin-yang, W. (2014) · Inflammation · doi:10.1007/s10753-014-9956-4 · Cited by 47
Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases
Bernardo, D., Chaparro, M., & Gisbert, J. P. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700931 · Cited by 46
Taking a bite out of nutrition and arbovirus infection
Weger‐Lucarelli, J., Auerswald, H., Vignuzzi, M., Dussart, P., & Karlsson, E. A. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006247 · Cited by 46
Beneficial Effects of Vitamin D Treatment in an Obese Mouse Model of Non-Alcoholic Steatohepatitis
Jahn, D., Dorbath, D., Kircher, S., Nier, A., Bergheim, I., Lenaerts, K., Hermanns, H. M., & Geier, A. (2019) · Nutrients · doi:10.3390/nu11010077 · Cited by 46
Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables
Pacifico, L., Osborn, J. F., Bonci, E., Pierimarchi, P., & Chiesa, C. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557518666181025153712 · Cited by 47
Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism
Zafalon, R. V. A., Risolia, L. W., Pedrinelli, V., Vendramini, T. H. A., Rodrigues, R. B. A., Amaral, A. R., Kogika, M. M., & Brunetto, M. A. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13259 · Cited by 46
Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation
Porcu, G., Serone, E., Nardis, V. D., Giandomenico, D. D., Lucisano, G., Scardapane, M., Poma, A. M., & Ragnini‐Wilson, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144550 · Cited by 46
Understanding the role of vitamin A and its precursors in the immune system
Gürbüz, M., & Aktaç, Ş. (2022) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2021.10.002 · Cited by 47
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
Rode, A. K. O., Buus, T. B., Mraz, V., Al-Jaberi, F. A. H., Lopez, D. V., Ford, S. L., Hennen, S., Eliasen, I. P., Klewe, I. V., Gharehdaghi, L., et al. (2022) · Cells · doi:10.3390/cells11162587 · Cited by 45
The effect of cigarette smoking on vitamin D level and depression in male patients with acute ischemic stroke
Ren, W., Gu, Y., Zhu, L., Wang, L., Chang, Y., Yan, M., Han, B., & He, J. (2015) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2015.09.006 · Cited by 46
Vitamin D—update for the pediatric rheumatologists
Vojinović, J., & Cimaz, R. (2015) · Pediatric Rheumatology · doi:10.1186/s12969-015-0017-9 · Cited by 45
Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
Jeyakumar, S. M., & Vajreswari, A. (2015) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.156554 · Cited by 45
The Influence of Nutrients on Inflammatory Bowel Diseases
Jarmakiewicz-Czaja, S., Piątek, D., & Filip, R. (2020) · Journal of Nutrition and Metabolism · doi:10.1155/2020/2894169 · Cited by 45
Malnutrition and Dietary Habits Alter the Immune System Which May Consequently Influence SARS-CoV-2 Virulence: A Review
Foolchand, A., Ghazi, T., & Chuturgoon, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052654 · Cited by 46
Respiratory Tract Epithelial Cells Express Retinaldehyde Dehydrogenase ALDH1A and Enhance IgA Production by Stimulated B Cells in the Presence of Vitamin A
Rudraraju, R., Jones, B. G., Surman, S. L., Sealy, R. E., Thomas, P. G., & Hurwitz, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086554 · Cited by 45
Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review
Roche, F. C., & Harris-Tryon, T. A. (2021) · Nutrients · doi:10.3390/nu13020302 · Cited by 44
Parasite Infections in Multiple Sclerosis Modulate Immune Responses through a Retinoic Acid–Dependent Pathway
Correale, J. D., & Farez, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301110 · Cited by 48
Effects of vitamin A and D receptor gene polymorphisms/haplotypes on immune responses to measles vaccine
Ovsyannikova, I. G., Haralambieva, I. H., Vierkant, R. A., O’Byrne, M. M., Jacobson, R. M., & Poland, G. A. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32834df186 · Cited by 44
Vitamin D receptor binds to the ε germline gene promoter and exhibits transrepressive activity
Milovanović, M., Heine, G., Hallatschek, W., Opitz, B., Radbruch, A., & Worm, M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.020 · Cited by 44
Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia
Faulkner, J., Cornelius, D. C., Amaral, L. M., Harmon, A. C., Cunningham, M., Darby, M. M., Ibrahim, T., Thomas, D. S., Herse, F., Wallukat, G., et al. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00388.2015 · Cited by 44
Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture
Ragab, D., Soliman, D., Samaha, D. Y., & Yassin, A. (2016) · Cytokine · doi:10.1016/j.cyto.2016.05.024 · Cited by 44
Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease
Mitson‐Salazar, A., & Prussin, C. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00165 · Cited by 44
Vitamin D high doses supplementation could represent a promising alternative to prevent or treat COVID-19 infection
Mansur, J. L., Tajer, C. D., Mariani, J. A., Inserra, F., Ferder, L., & Manucha, W. A. (2020) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2020.11.003 · Cited by 45
The D-side of COVID-19: musculoskeletal benefits of vitamin D and beyond
Tramontana, F., Napoli, N., Fuleihan, G. E., & Strollo, R. (2020) · Endocrine · doi:10.1007/s12020-020-02407-0 · Cited by 43
A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder
Sarohan, A. R., Kızıl, M., İnkaya, A. Ç., Mahmud, S. O., Akram, M., & Çen, O. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110121 · Cited by 44
Vitamin D receptor upregulation in alloreactive human T cells
Joseph, R. W., Bayraktar, U. D., Kim, T. K., John, L. S. S., Popat, U., Khalili, J. S., Molldrem, J. J., Wieder, E., & Komanduri, K. V. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.04.019 · Cited by 43
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species
Krasowski, M. D., Ai, N., Hagey, L. R., Kollitz, E. M., Kullman, S. W., Reschly, E. J., & Ekins, S. (2011) · BMC Biochemistry · doi:10.1186/1471-2091-12-5 · Cited by 43
Vitamin D levels and bone metabolism in C hinese adult patients with inflammatory bowel disease
Tan, B., Pan, L., Lv, H., Li, Y., Wang, O., Xing, X. P., & Qian, J. (2013) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12118 · Cited by 43
Evaluation of Delta-Aminolevulinic Dehydratase Activity, Oxidative Stress Biomarkers, and Vitamin D Levels in Patients with Multiple Sclerosis
Polachini, C. R. N., Spanevello, R. M., Zanini, D., Baldissarelli, J., Pereira, L. B., Schetinger, M. R. C., da Cruz, I. B. M., Assmann, C. E., Bagatini, M. D., & Morsch, V. M. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9584-2 · Cited by 45
The Relationship between Serum Vitamin D and Chronic Rhinosinusitis: A Systematic Review
Stokes, P., & Rimmer, J. (2016) · American Journal of Rhinology and Allergy · doi:10.2500/ajra.2016.30.4267 · Cited by 43
Immunomodulatory Effect of Vitamin D after Allogeneic Stem Cell Transplantation: Results of a Prospective Multicenter Clinical Trial
Caballero‐Velázquez, T., Montero, I., Sanchez-Guijo, F. M., Parody, R., Saldaña, R., Valcárcel, D., López‐Godino, O., Ferra, C. M., Cuesta, M., Carrillo‐Vico, A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0238 · Cited by 43
Microbiota-Dependent Induction of Colonic Cyp27b1 Is Associated With Colonic Inflammation: Implications of Locally Produced 1,25-Dihydroxyvitamin D3 in Inflammatory Regulation in the Colon
Du, J., Wei, X., Ge, X., Chen, Y., & Li, Y. C. (2017) · Endocrinology · doi:10.1210/en.2017-00578 · Cited by 43
Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto's thyroiditis: A double-blind randomized placebo-controlled clinical trial
Anaraki, P. V., Aminorroaya, A., Amini, M., Momeni, F., Feizi, A., Iraj, B., & Tabatabaei, A. (2017) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_1048_16 · Cited by 43
Palliative effects of Moringa olifera ethanolic extract on hemato-immunologic impacts of melamine in rats
Abd‐Elhakim, Y. M., Bohi, K. M. E., Hassan, S. K., Sayed, S. E., & Abdel-Motal, S. M. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.02.020 · Cited by 43
Vitamin D signaling maintains intestinal innate immunity and gut microbiota: potential intervention for metabolic syndrome and NAFLD
Zeng, Y., Luo, M., Pan, L., Chen, Y., Guo, S., Luo, D., Zhu, L., Liu, Y., Pan, L., Xu, S., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00286.2019 · Cited by 43
Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives
Askari, H., Sanadgol, N., Azarnezhad, A., Tajbakhsh, A., Rafiei, H., Safarpour, A. R., Hayat, S. M. G., Raeis-Abdollahi, E., Savardashtaki, A., Ghanbariasad, A., et al. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06008 · Cited by 43
Nutraceuticals in Viral Infections: An Overview of the Immunomodulating Properties
Costagliola, G., Nuzzi, G., Spada, E., Comberiati, P., Verduci, E., & Peroni, D. G. (2021) · Nutrients · doi:10.3390/nu13072410 · Cited by 45
Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment
Pankratz, V. S., Vierkant, R. A., O’Byrne, M. M., Ovsyannikova, I. G., & Poland, G. A. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-48 · Cited by 42
Vitamin A Deficiency Impairs Adaptive B and T Cell Responses to a Prototype Monovalent Attenuated Human Rotavirus Vaccine and Virulent Human Rotavirus Challenge in a Gnotobiotic Piglet Model
Chattha, K. S., Kandasamy, S., Vlasova, A. N., & Saif, L. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082966 · Cited by 42
Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid
Bramos, A., Perrault, D. P., Yang, S. H.-Y., Jung, E., Hong, Y. K., & Wong, A. K. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001525 · Cited by 42
Vitamin D Status and Tooth Loss in Postmenopausal Females: The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study
Pavlesen, S., Mai, X., Wactawski‐Wende, J., LaMonte, M. J., Hovey, K. M., Genco, R. J., & Millen, A. E. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.150733 · Cited by 42
Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo
Zhang, J.-Z., Wang, M., Ding, Y., Gao, F., Feng, Y., Yakeya, B., Wang, P., Wu, X., Hu, F., Xian, J., et al. (2018) · Medicine · doi:10.1097/md.0000000000011506 · Cited by 42
Vitamin A-Deficient Hosts Become Nonsymptomatic Reservoirs of Escherichia coli-Like Enteric Infections
McDaniel, K. L., Restori, K. H., Dodds, J. W., Kennett, M. J., Ross, A. C., & Cantorna, M. T. (2015) · Infection and Immunity · doi:10.1128/iai.00201-15 · Cited by 42
Polymorphism in the Retinoic Acid Metabolizing Enzyme CYP26B1 and the Development of Crohn’s Disease
Fransén, K., Franzèn, P., Magnuson, A., Elmabsout, A. A., Nyhlin, N., Wickbom, A., Curman, B., Törkvist, L., D’Amato, M., Bohr, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072739 · Cited by 41
Maternal effects of carotenoid supplementation in an ornamented cichlid fish
Brown, A., Leonard, H. M., McGraw, K. J., & Clotfelter, E. D. (2013) · Functional Ecology · doi:10.1111/1365-2435.12205 · Cited by 41
Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes
Singh, P. K., van den Berg, P. R., Long, M. D., Vreugdenhil, A., Grieshober, L., Ochs‐Balcom, H. M., Wang, J., Delcambre, S., Heikkinen, S., Carlberg, C., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-3481-4 · Cited by 41
1,25-Dihydroxyvitamin D3 induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study
Agraz‐Cibrián, J. M., Giraldo, D. M., & Inchima, S. U. (2018) · Steroids · doi:10.1016/j.steroids.2018.11.001 · Cited by 41
Network analysis uncovers putative genes affecting resistance to tick infestation in Braford cattle skin
Moré, D. D., Cardoso, F. F., Mudadu, M. A., Malagó, W., Gulias-Gomes, C. C., Sollero, B. P., Ibelli, A. M. G., Coutinho, L. L., & Regitano, L. C. D. A. (2019) · BMC Genomics · doi:10.1186/s12864-019-6360-3 · Cited by 41
Zinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Trials with Micronutrients Supplementation
Wang, M. X., Win, S. S., & Pang, J. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.19-0718 · Cited by 42
RIG-I Is Required for the Inhibition of Measles Virus by Retinoids
Soye, K. J., Trottier, C., Richardson, C. D., Ward, B. J., & Miller, W. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022323 · Cited by 41
Nutrition, dietary guidelines and optimal periodontal health
Krall, E. A. (2011) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00418.x · Cited by 40
Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in Mice
Seiler, K. M., Waye, S. E., Kong, W., Kamimoto, K., Bajinting, A., Goo, W. H., Onufer, E. J., Courtney, C. M., Guo, J., Warner, B. W., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.06.001 · Cited by 41
Enemy or ally? Fasting as an essential regulator of immune responses
Wilhelm, C., Surendar, J., & Karagiannis, F. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.03.007 · Cited by 42
Could Vitamin D Be Effective in Prevention of Preeclampsia?
Poniedziałek‐Czajkowska, E., & Mierzyński, R. (2021) · Nutrients · doi:10.3390/nu13113854 · Cited by 46
Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever
Alagarasu, K., Bachal, R. V., Bhagat, A. B., Shah, P. S., & Dayaraj, C. (2012) · Virology Journal · doi:10.1186/1743-422x-9-86 · Cited by 40
C-Reactive Protein, Lipid-soluble Micronutrients, and Survival in Colorectal Cancer Patients
Cooney, R. V., Chai, W., Franke, A. A., Wilkens, L. R., Kolonel, L. N., & Marchand, L. L. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0199 · Cited by 40
Vitamin Supplementation at the Time of Immunization with a Cold-Adapted Influenza Virus Vaccine Corrects Poor Mucosal Antibody Responses in Mice Deficient for Vitamins A and D
Surman, S. L., Penkert, R. R., Jones, B. G., Sealy, R. E., & Hurwitz, J. L. (2016) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00739-15 · Cited by 40
Antifungal activity of vitamin D3 against Candida albicans in vitro and in vivo
Lei, J., Xiao, W., Zhang, J., Liu, F., Xin, C., Zhou, B., Chen, W., & Song, Z. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127200 · Cited by 39
Vitamin D, exercise, and immune health in athletes: A narrative review
Crescioli, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954994 · Cited by 42
The Role of Microbiota-Derived Vitamins in Immune Homeostasis and Enhancing Cancer Immunotherapy
Gholami, H., Chmiel, J. A., Burton, J. P., & Vareki, S. M. (2023) · Cancers · doi:10.3390/cancers15041300 · Cited by 40
Vitamin D and chronic rhinitis
Abuzeid, W. M., Akbar, N. A., & Zacharek, M. A. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32834eccdb · Cited by 39
VITAMIN D DEFICIENCY IN NEOVASCULAR VERSUS NONNEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Itty, S., Day, S., Lyles, K. W., Stinnett, S. S., Vajzovic, L. M., & Mruthyunjaya, P. (2014) · Retina · doi:10.1097/iae.0000000000000178 · Cited by 39
Skin-derived TSLP systemically expands regulatory T cells
Leichner, T. M., Satake, A., Harrison, V. S., Tanaka, Y., Archambault, A. S., Kim, B., Siracusa, M. C., Leonard, W. J., Naji, A., Wu, G. F., et al. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.01.003 · Cited by 39
Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) — study design and methods of a randomised controlled double-blinded intervention study
Helve, O., Viljakainen, H. T., Holmlund-Suila, E. M., Rosendahl, J., Hauta‐alus, H., Enlund-Cerullo, M., Valkama, S. M., Heinonen, K., Räikkönen, K., Hytinantti, T. K., et al. (2017) · BMC Pediatrics · doi:10.1186/s12887-017-0845-5 · Cited by 39
Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison
Dubey, A., Rose, R. E., Jones, D. R., & Saint‐Jeannet, J. (2018) · genesis · doi:10.1002/dvg.23091 · Cited by 42
Searching for the Transcriptomic Signature of Immune Tolerance Induction—Biomarkers of Safety and Functionality for Tolerogenic Dendritic Cells and Regulatory Macrophages
Navarro‐Barriuso, J., Mansilla, M. J., & Martínez-Cáceres, E. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02062 · Cited by 42
The Effect of Vitamin D Supplementation on Clinical Outcomes for Critically Ill Patients: A Systemic Review and Meta-Analysis of Randomized Clinical Trials
Shen, H., Mei, Y., Zhang, K., & Xu, X. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.664940 · Cited by 39
The Human Cutaneous Chemokine System
McCully, M. L., & Moser, B. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00033 · Cited by 39
Allergic rhinitis and serum 25-hydroxyvitamin D level in Korean adults
Jung, J., Kim, J., Cho, S., Choi, B.-W., Min, K., & Kang, H. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.08.018 · Cited by 38
Retinol binding protein and vitamin D associations with serum antibody isotypes, serum influenza virus-specific neutralizing activities and airway cytokine profiles
Jones, B. G., Oshansky, C. M., Bajracharya, R., Tang, L., Sun, Y., Wong, S., Webby, R. J., Thomas, P. G., & Hurwitz, J. L. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12718 · Cited by 38
Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage
Chen, X., Yin, B., Lian, R., Zhang, T., Zhang, H., Diao, L., Li, Y., Huang, C., De-sheng, L., & Zeng, Y. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12585 · Cited by 38
Serum Folate, Vitamin B-12, Vitamin A, γ-Tocopherol, α-Tocopherol, and Carotenoids Do Not Modify Associations between Cadmium Exposure and Leukocyte Telomere Length in the General US Adult Population
Nomura, S. J. O., Robien, K., & Zota, A. R. (2017) · Journal of Nutrition · doi:10.3945/jn.116.243162 · Cited by 38
Vitamin supplements in the Era of SARS-Cov2 pandemic
Am, C., Benvenuto, A., Lagattolla, V., Teresa, M., Pasquale, D. L., Giuseppe, C., Giovanni, M., Michele, D. P., Ponziano, E., & Benvenuto, M. (2020) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2020.11.2.0114 · Cited by 39
Mega doses of retinol: A possible immunomodulation in Covid‐19 illness in resource‐limited settings
Midha, I. K., Kumar, N., Kumar, A., & Madan, T. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2204 · Cited by 38
Nutrients Interaction with the Immune System.
Noor, S., Piscopo, S., & Gasmi, A. (2021) · PubMed Central · doi:10.22092/ari.2021.356098.1775 · Cited by 39
Mechanistic Insight into the role of Vitamin D and Zinc in Modulating Immunity Against COVID-19: A View from an Immunological Standpoint
Ahsan, N., Imran, M., Mohammed, Y., Anouti, F. A., Khan, M. I., Banerjee, T., Adnan, M., Ashfaq, F., Kieliszek, M., Ashraf, S. A., et al. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03620-4 · Cited by 37
Retinoic acid signaling in development and differentiation commitment and its regulatory topology
Wu, D., Khan, F. A., Zhang, K., Pandupuspitasari, N. S., Negara, W., Guan, K., Sun, F., & Huang, C. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110773 · Cited by 37
Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort Study
Holmgaard, D. B., Mygind, L. H., Titlestad, I. L., Madsen, H., Fruekilde, P. B. N., Pedersen, S. S., & Pedersen, C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053670 · Cited by 37
Serum concentrations of 25-hydroxyvitamin D and immunoglobulins in an older Swiss cohort: results of the Senior Labor Study
Sakem, B., Nock, C., Stanga, Z. G., Medina, P., Nydegger, U. E., Risch, M., & Risch, L. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-176 · Cited by 37
The Mucosal Factors Retinoic Acid and TGF-β1 Induce Phenotypically and Functionally Distinct Dendritic Cell Types
den Hartog, G., van Altena, C., Savelkoul, H. F. J., & van Neerven, R. J. J. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000353243 · Cited by 37
Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice
Lee, G. Y., Park, C. Y., Cha, K. S., Lee, S. E., Pae, M., & Han, S. N. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.004 · Cited by 37
Effect of vitamin D3 on chemokine expression in pulmonary tuberculosis
Selvaraj, P., Harishankar, M., Singh, B. B., Banurekha, V. V., & Jawahar, M. S. (2012) · Cytokine · doi:10.1016/j.cyto.2012.06.238 · Cited by 37
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids
Lamblin, M., Dabbas, B., Spingarn, R., Mendoza‐Sanchez, R., Wang, T. T., An, B., Huang, D. C., Kremer, R. B., White, J. H., & Gleason, J. L. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.03.078 · Cited by 37
Vitamin A – discovery, metabolism, receptor signaling and effects on bone mass and fracture susceptibility
Lerner, U. H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1298851 · Cited by 39
Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription
Tóth, K., Sarang, Z., Scholtz, B., Brázda, P., Ghyselinck, N. B., Chambon, P., Fésüs, L., & Szondy, Z. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.136 · Cited by 38
Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review
Samad, N., Dutta, S., Sodunke, T. E., Fairuz, A., Sapkota, A., Miftah, Z. F., Jahan, I., Sharma, P., Abubakar, A. R., Rowaiye, A. B., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s307333 · Cited by 38
Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis
Bahlool, A. Z., Fattah, S., O’Sullivan, A., Cavanagh, B., MacLoughlin, R. J., Keane, J., O’Sullivan, M. P., & Cryan, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14081745 · Cited by 36
Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy
Fabre-Mersseman, V., Tubiana, R., Papagno, L., Bayard, C., Briceño, O., Fastenackels, S., Dudoit, Y., Rostane, H., Salmon, D., Costagliola, D. G., et al. (2014) · AIDS · doi:10.1097/qad.0000000000000472 · Cited by 36
Prevention of Type 1 Diabetes
Wherrett, D. K., & Daneman, D. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.08.006 · Cited by 36
Intradermal application of vitamin D3 increases migration of CD14+dermal dendritic cells and promotes the development of Foxp3+regulatory T cells
Bakdash, G., Schneider, L. P., van Capel, T. M. M., Kapsenberg, M. L., Teunissen, M. B. M., & de Jong, E. C. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.22918 · Cited by 36
Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis
Eri, R. D., & Chieppa, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00323 · Cited by 36

Authors: Mora, J. R., Iwata, M., & von Andrian, U. H.
Affiliations: Harvard University (US)
Tokushima Bunri University (JP)
Corresponding author: Mora, J. Rodrigo
ORCID: Mora, J. Rodrigo
Iwata, Makoto
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-09
Volume: 8
Issue: 9
Pages: 685-698
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2378
PMC: PMC2906676
OpenAlex: W2018938924
Cited by: 1,559
References: 170
Citations by year: 2026: 46 · 2025: 84 · 2024: 81 · 2023: 75 · 2022: 98 · 2021: 118 · 2020: 123 · 2019: 69 · 2018: 87 · 2017: 88 · 2016: 86 · 2015: 115 · 2014: 89 · 2013: 100 · 2012: 91
FWCI: 8.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 56949, P01HL056949)
National Institute of Allergy and Infectious Diseases (R01AI072252, AI061663, R01AI069259, R01AI061663, AI072252, AI-069259)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 43351, P30DK043351)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 42689, P30AR042689)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: vitamins, vitamin A, vitamin D, immune regulation, lymphocyte activation, T helper cell differentiation, lymphocyte homing, antibody isotypes, immune-mediated diseases, autoimmunity, inflammation, immunomodulatory therapy
MeSH terms: Animals, Humans, Immune System, Immunotherapy, Lymphocytes, Vitamin A, Vitamin D, Vitamins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin effects on the immune system: vitamins A and D take centre stage

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks