Cited by 1,040Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and CancerImmune Response and Inflammation

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Nutrient sensing and inflammation in metabolic diseases

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Hotamisligil, Gökhan S., Erbay, Ebru·2008·Nature Reviews Immunology

DOI 10.1038/nri2449PMC PMC2814543

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Abstract

The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.

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Authors: Hotamisligil, G. S., & Erbay, E.
Affiliations: Harvard University (US)
ORCID: Erbay, Ebru
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-12
Volume: 8
Issue: 12
Pages: 923-934
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2449
PMC: PMC2814543
OpenAlex: W2138816083
Cited by: 1,040
References: 119
Citations by year: 2026: 31 · 2025: 35 · 2024: 45 · 2023: 30 · 2022: 51 · 2021: 63 · 2020: 59 · 2019: 64 · 2018: 69 · 2017: 70 · 2016: 77 · 2015: 67 · 2014: 73 · 2013: 74 · 2012: 76
FWCI: 5.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Diabetes Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL065405, HL 65405)
National Institute of Diabetes and Digestive and Kidney Diseases (DK52539, DK64360, R01DK064360, R01DK054017, R56DK064360, R01DK056894, R01DK052539)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: nutrient sensing, inflammation, metabolic disorders, type 2 diabetes, atherosclerosis, immune-metabolic crosstalk, metabolic homeostasis, pathogen sensing, immune pathways, chronic metabolic diseases
MeSH terms: Animals, Energy Metabolism, Homeostasis, Humans, Inflammation, Metabolic Diseases, Nutritional Status, Signal Transduction

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