Nutrient sensing and inflammation in metabolic diseases

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245

Obesity alters gut microbial ecology

Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176

Metabolic nuclear receptor signaling and the inflammatory acute phase response

Venteclef, N., Jakobsson, T., Steffensen, K. R., & Treuter, E. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.04.004 · Cited by 99

Diet, Obesity, and Asthma

Wood, L. G. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201702-124aw · Cited by 99

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Peña‐Oyarzún, D., Bravo, R., Díaz‐Vegas, A., Aleman, L., Chiong, M., García, L., Claudia Bambs, S., Troncoso, R., Cifuentes, M., Morselli, E., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.084 · Cited by 108

Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity

West‐Eberhard, M. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809046116 · Cited by 102

Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?

Tsigalou, C., Vallianou, N. G., & Dalamaga, Μ. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00397-8 · Cited by 101

Modulating human aging and age-associated diseases

Fontana, L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.002 · Cited by 99

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.004 · Cited by 97

Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases

Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4688 · Cited by 100

Pancreatic islet inflammation in type 2 diabetes: From α and β cell compensation to dysfunction

Ehses, J. A., Ellingsgaard, H., Böni-Schnetzler, M., & Donath, M. Y. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450903025879 · Cited by 97

Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation

Oh, S., Jekal, J., Jia Liu, B., Kim, J., Park, J., Lee, T., & Jang, K. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202403562 · Cited by 104

Ageing and inflammation – A central role for mitochondria in brain health and disease

Currais, A. J. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.001 · Cited by 97

Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis

Kulkarni, A., Muralidharan, C., May, S. C., Tersey, S. A., & Mirmira, R. G. (2022) · Endocrinology · doi:10.1210/endocr/bqac184 · Cited by 95

Risk factors for pancreatic cancer: underlying mechanisms and potential targets

Kolodecik, T. R., Shugrue, C., Ashat, M., & Thrower, E. C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00415 · Cited by 95

NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet

Pepping, J. K., Freeman, L. R., Gupta, S., Keller, J. N., & Bruce‐Keller, A. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00398.2012 · Cited by 96

Adipose tissue macrophage-derived exosomes induce ferroptosis via glutathione synthesis inhibition by targeting SLC7A11 in obesity-induced cardiac injury

Zhao, X., Si, L., Bian, J., Pan, C., Guo, W., Qin, P., Zhu, W., Xia, Y., Zhang, Q., & Wei, K. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.033 · Cited by 93

Increased Saturated Fatty Acids in Obesity Alter Resolution of Inflammation in Part by Stimulating Prostaglandin Production

Hellmann, J. L., Zhang, M. J., Tang, Y., Rane, M. J., Bhatnagar, A., & Spite, M. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203369 · Cited by 101

Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration

Bae, J., Ricciardi, C. J., Esposito, D., Komarnytsky, S., Hu, P., Curry, B. J., Brown, P. L., Gao, Z., Biggerstaff, J., Chen, J., et al. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00249.2013 · Cited by 100

High-throughput proteomic profiling of the fish liver following bacterial infection

Causey, D. R., Pohl, M., Stead, D., Martín, S., Secombes, C. J., & Macqueen, D. J. (2018) · BMC Genomics · doi:10.1186/s12864-018-5092-0 · Cited by 92

Modulation of immune function in the bovine uterus peripartum

Pascottini, O. B., & LeBlanc, S. J. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.01.042 · Cited by 98

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

Li, P., Zhao, Y., Wu, X., Xia, M., Fang, M., Iwasaki, Y., Sha, J., Chen, Q., Xu, Y., & Shen, A. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr984 · Cited by 91

The pathophysiology of abdominal adipose tissue depots in health and disease

Walker, G. E., Marzullo, P., Ricotti, R., Bona, G., & Prodam, F. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0023 · Cited by 90

Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice

Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yamamoto, S., Hamashima, T., Ishii, Y., Tanaka, M., Suganami, T., Sasahara, M., et al. (2016) · Scientific Reports · doi:10.1038/srep23097 · Cited by 89

Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais

Lainampetch, J., Phienluphon, P. P., Phosat, C., Chumpathat, N., Prangthip, P., Soonthornworasiri, N., Puduang, S., Wechjakwen, N., & Kwanbunjan, K. (2019) · Journal of Diabetes Research · doi:10.1155/2019/9051929 · Cited by 98

Cytokine and growth factor profiling in patients with the metabolic syndrome

Mirhafez, S. R., Pasdar, A., Avan, A., Esmaily, H., Moezzi, A., Mohebati, M., Meshkat, Z., Mehrad‐Majd, H., Eslami, S., Rahimi, H. R., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001038 · Cited by 90

Intestinal Microbiota and Obesity

Blaut, M., & Klaus, S. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_11 · Cited by 91

The Microbiota and Cancer Cachexia

Herremans, K. M., Riner, A. N., Cameron, M. E., & Trevino, J. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246267 · Cited by 89

S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver

Kim, K., Pyo, S., & Um, S. H. (2011) · Hepatology · doi:10.1002/hep.25537 · Cited by 86

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

Sebastian-Valverde, M., & Pasinetti, G. M. (2020) · Cells · doi:10.3390/cells9061552 · Cited by 90

Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis

Pan, X., Kaminga, A. C., Wen, S. W., & Liu, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622438 · Cited by 87

Potential for therapeutic manipulation of the UPR in disease

Park, S. W., & Özcan, U. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0370-z · Cited by 92

Linking the inflammasome to obesity-related disease

Horng, T., & Hotamışlıgil, G. S. (2011) · Nature Medicine · doi:10.1038/nm0211-164 · Cited by 87

Role of Innate Immune Signaling in Non-Alcoholic Fatty Liver Disease

Cai, J., Zhang, X., & Li, H. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.08.003 · Cited by 87

Lymphocytes in the Peritoneum Home to the Omentum and Are Activated by Resident Dendritic Cells

Carlow, D. A., Gold, M. R., & Ziltener, H. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900409 · Cited by 87

The gut microbiota and host innate immunity: Regulators of host metabolism and metabolic diseases in poultry?

Kogut, M. H. (2013) · The Journal of Applied Poultry Research · doi:10.3382/japr.2013-00741 · Cited by 93

Catechin attenuates TNF-α induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes

Cheng, A., Tan, X., Sun, J., Gu, C., Liu, C., & Guo, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217090 · Cited by 88

Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells

Schwager, J., Richard, N., Widmer, F., & Raederstorff, D. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1823-z · Cited by 90

Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis

Burkewitz, K., Feng, G., Dutta, S., Kelley, C. A., Steinbaugh, M. J., Cram, E. J., & Mair, W. B. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108125 · Cited by 86

Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?

Dixit, V. D. (2013) · Diabetes · doi:10.2337/db12-1115 · Cited by 85

Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

Onat, U. İ., Yıldırım, A., Tufanlı, Ö., Çimen, İ., Kocatürk, B., Veli, Z., Hamid, S. M., Shimada, K., Chen, S., Sin, J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.055 · Cited by 84

Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation

Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yanagibashi, T., Ogasawara, M., Yamamoto, S., Imamura, R., Takasaki, I., Hara, H., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900477rr · Cited by 89

Lipopolysaccharide (LPS)-stimulated iNOS Induction Is Increased by Glucosamine under Normal Glucose Conditions but Is Inhibited by Glucosamine under High Glucose Conditions in Macrophage Cells

Hwang, J.-S., Kwon, M.-Y., Kim, K.-H., Lee, Y., Lyoo, I. K., Kim, J. E., Oh, E., & Han, I. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.737940 · Cited by 86

Identification of peptides from edible silkworm pupae (Bombyx mori) protein hydrolysates with antioxidant activity

Cermeño, M., Bascón, C., Amigo‐Benavent, M., Félix, M., & Fitzgerald, R. J. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105052 · Cited by 83

Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia

Chung, S., Ranjan, R., Lee, Y. G., Park, G. Y., Karpurapu, M., Deng, J., Xiao, L., Kim, J., Unterman, T. G., & Christman, J. W. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0514-251r · Cited by 84

Obesity and its associated disease: a role for microbiota?

Tehrani, A. B., Nezami, B. G., Gewirtz, A. T., & Srinivasan, S. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01895.x · Cited by 84

First Evidence for the Anti-inflammatory Activity of Fucoxanthin in High-Fat-Diet-Induced Obesity in Mice and the Antioxidant Functions in PC12 Cells

Tan, C., & Hou, Y. (2013) · Inflammation · doi:10.1007/s10753-013-9757-1 · Cited by 85

Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders

Lu, W., Xu, Y., Shao, X., Gao, F., Li, Y., Hu, J., Zuo, Z., Shao, X., Zhou, L., Zhao, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep12144 · Cited by 82

Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice

Liu, J., Shi, J., Hernandez, R., Li, X., Konchadi, P., Miyake, Y., Chen, Q., Zhou, T., & Zhou, C. (2023) · Environment International · doi:10.1016/j.envint.2023.107769 · Cited by 83

Relationships between Body Fat Distribution, Epicardial Fat and Obstructive Sleep Apnea in Obese Patients with and without Metabolic Syndrome

Lubrano, C., Saponara, M., Bárbaro, G., Specchia, P., Addessi, E., Costantini, D., Tenuta, M., Lorenzo, G. D., Genovesi, G., Donini, L. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047059 · Cited by 81

The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding

Zhang, S. X., Ma, J. H., Bhatta, M., Fliesler, S. J., & Wang, J. J. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.12.001 · Cited by 79

Free fatty acids induce transglutaminase 2‐dependent apoptosis in hepatocytes via ER stress‐stimulated PERK pathways

Kuo, T., Tatsukawa, H., Matsuura, T., Nagatsuma, K., Hirose, S., & Kojima, S. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22833 · Cited by 79

Chronic Parenteral Nutrition Induces Hepatic Inflammation, Steatosis, and Insulin Resistance in Neonatal Pigs1–3

Stoll, B., Horst, D. A., Cui, L., Chang, X., Ellis, K. J., Hadsell, D. L., Suryawan, A., Kurundkar, A., Maheshwari, A., Davis, T. A., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125799 · Cited by 82

Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity

Sears, B., & Ricordi, C. (2010) · Journal of Obesity · doi:10.1155/2011/431985 · Cited by 82

Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

de Souza, C. O., Teixeira, A. A. D. S., de Lima, E. A., Batatinha, H., Gomes, L. M., Carvalho‐Silva, M., Mota, I. T., STRECK, E. L., Hirabara, S. M., & Neto, J. C. R. (2014) · Mediators of Inflammation · doi:10.1155/2014/582197 · Cited by 79

Current and Future Drug Targets in Weight Management

Witkamp, R. F. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0341-1 · Cited by 81

Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors

Chiyonobu, N., Shimada, S., Akiyama, Y., Mogushi, K., Itoh, M., Akahoshi, K., Matsumura, S., Ogawa, K., Ono, H., Mitsunori, Y., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.01.012 · Cited by 78

Dietary inflammatory potential and risk of mortality in metabolically healthy and unhealthy phenotypes among overweight and obese adults

Park, Y., Choi, M. K., Lee, S., Shivappa, N., Han, K., Steck, S. E., Hébert, J. R., Merchant, A. T., & Sandler, D. P. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.002 · Cited by 82

Neuronal Androgen Receptor Regulates Insulin Sensitivity via Suppression of Hypothalamic NF-κB–Mediated PTP1B Expression

Yu, I.-C. I., Lin, H., Liu, N.-C., Sparks, J. D., Yeh, S., Fang, L., Chen, L., & Chang, C. (2012) · Diabetes · doi:10.2337/db12-0135 · Cited by 79

Inhibition of protein kinase R protects against palmitic acid–induced inflammation, oxidative stress, and apoptosis through the JNK/NF‐kB/NLRP3 pathway in cultured H9C2 cardiomyocytes

Mangali, S., Bhat, A., Udumula, M. P., Dhar, I., Sriram, D., & Dhar, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27643 · Cited by 78

Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial

Salden, B. N., Troost, F. J., Wilms, E., Truchado, P., Vilchez-Vargas, R., Pieper, D. H., Jáuregui, R., Marzorati, M., van de Wiele, T., Possemiers, S., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.01.024 · Cited by 77

OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Yang, Y., Li, X., Luan, H. H., Zhang, B., Zhang, K., Nam, J. H., Li, Z., Fu, M., Munk, A., Zhang, D., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916121117 · Cited by 78

Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain

Iwata, M., Ochi, H., Hara, Y., TAGAWA, M., Koga, D., Okawa, A., & Asou, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060706 · Cited by 78

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

Soronen, J., Laurila, P., Naukkarinen, J., Surakka, I. L., Ripatti, S., Jauhiainen, M., Olkkonen, V. M., & Yki‐Järvinen, H. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-9 · Cited by 78

Obesity: a perfect storm for carcinogenesis

Harris, B. H. L., Macaulay, V. M., Harris, D. A., Klenerman, P., Karpe, F., Lord, S., Harris, A. L., & Buffa, F. M. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10046-2 · Cited by 84

Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

Pimentel, G. D., Lira, F. S., Neto, J. C. R., Caris, A. V., Pinheiro, F., Ribeiro, E. B., do Nascimento, C. M. O., & Oyama, L. M. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.04.016 · Cited by 78

Role of caspase-1 in regulation of triglyceride metabolism

Kotas, M. E., Jurczak, M. J., Annicelli, C., Gillum, M. P., Cline, G. W., Shulman, G. I., & Medzhitov, R. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301996110 · Cited by 76

Thyrotropin and Obesity: Increased Adipose Triglyceride Content Through Glycerol-3-Phosphate Acyltransferase 3

Ma, S., Jing, F., Xu, C., Zhou, L., Song, Y., Yu, C., Jiang, D., Gao, L., Li, Y., Guan, Q., et al. (2015) · Scientific Reports · doi:10.1038/srep07633 · Cited by 74

Exercise and Adipose Tissue Macrophages: New Frontiers in Obesity Research?

Goh, J., Goh, K. P., & Abbasi, A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00065 · Cited by 78

Arginine and glutamine supplementation to culture media improves the performance of various channel catfish immune cells

Pohlenz, C., Buentello, A., Mwangi, W., & Gatlin, D. M. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.01.029 · Cited by 73

Cholesterol regulation of receptor‐interacting protein 140 via microRNA‐33 in inflammatory cytokine production

Ho, P.-C., Chang, K.-C., Chuang, Y.-S., & Wei, L.-N. (2011) · The FASEB Journal · doi:10.1096/fj.10-179267 · Cited by 75

A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease

Mori, M. A., Liu, M., Bézy, O., Almind, K., Shapiro, H., Kasif, S., & Kahn, C. R. (2010) · Diabetes · doi:10.2337/db10-0367 · Cited by 74

Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

Koh, J. H., Wang, L., Beaudoin‐Chabot, C., & Thibault, G. (2018) · Journal of Cell Science · doi:10.1242/jcs.217992 · Cited by 73

Metabolomics – a novel window into inflammatory disease

Fitzpatrick, M. A., & Young, S. P. (2013) · Swiss Medical Weekly · doi:10.4414/smw.2013.13743 · Cited by 71

Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance

Nomura, M., Ishii, H., Kawakami, A., & Yoshida, M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00343.2009 · Cited by 70

MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes

Coope, A., Torsoni, A. S., & Velloso, L. A. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-1065 · Cited by 73

Biotin Deficiency Induces Th1- and Th17-Mediated Proinflammatory Responses in Human CD4+ T Lymphocytes via Activation of the mTOR Signaling Pathway

Elahi, A., Sabui, S., Narasappa, N., Agrawal, S., Lambrecht, N. W. G., Agrawal, A., & Said, H. M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701200 · Cited by 70

Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth’s cells in a model of ileitis in mice

Yvon, S., Olier, M., Leveque, M., Jard, G., Tormo, H., Haimoud-Lekhal, D. A., Peter, M., & Eutamène, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1304-z · Cited by 71

Human microflora, probiotics and wound healing

Tsiouris, C. G., & Tsiouri, M. G. (2017) · Wound Medicine · doi:10.1016/j.wndm.2017.09.006 · Cited by 70

Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation

Lettieri‐Barbato, D., Aquilano, K., Baldelli, S., Cannata, S. M., Bernardini, S., Rotilio, G., & Ciriolo, M. R. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.137 · Cited by 70

Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats

Shalaby, M. A., & Saifan, H. Y. (2014) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20140818050741 · Cited by 69

Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFκBp65 signaling in adult offspring

Pimentel, G. D., Lira, F. S., Neto, J. C. R., de Oliveira, J. L., Hachul, A. C. L., Souza, G. I. H., do Carmo, M. D. G. T., dos Santos, R. V. T., de Mello, M. T., Tufik, S., et al. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.12.003 · Cited by 68

Obesity genes and insulin resistance

Belkina, A. C., & Denis, G. V. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32833c5c48 · Cited by 74

Drug Delivery Strategies for the Treatment of Metabolic Diseases

Shi, S., Kong, N., Feng, C., Shajii, A., Bejgrowicz, C., Tao, W., & Farokhzad, O. C. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801655 · Cited by 67

FABP7 upregulation induces a neurotoxic phenotype in astrocytes

Killoy, K. M., Harlan, B. A., Pehar, M., & Vargas, M. R. (2020) · Glia · doi:10.1002/glia.23879 · Cited by 64

Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue

Ronkainen, J., Huusko, T. J., Soininen, R., Mondini, E., Cinti, F., Mäkelä, K. A., Kovalainen, M., Herzig, K., Järvelin, M., Sebert, S. P., et al. (2015) · Scientific Reports · doi:10.1038/srep09233 · Cited by 68

Inhalation of titanium dioxide induces endoplasmic reticulum stress-mediated autophagy and inflammation in mice

Yu, K., Sung, J. H., Lee, S., Kim, J., Kim, S., Cho, W.-Y., Lee, A. Y., Park, S. J., Lim, J., Park, C., et al. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.08.001 · Cited by 66

Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)–Deficient Mice Are Resistant to Diet-Induced Obesity

Feng, B., Jiao, P., Helou, Y. A., Li, Y., He, Q., Walters, M. S., Salomon, A. R., & Xu, H. (2014) · Diabetes · doi:10.2337/db14-0066 · Cited by 66

A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis

Santucci, N. E., D’Attilio, L., Kovalevski, L., Bozza, V. V., Besedovsky, H. O., del Rey, A., Bay, M. L., & Bottasso, O. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026363 · Cited by 66

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

Nakamura, T., Arduini, A., Baccaro, B., Furuhashi, M., & Hotamışlıgil, G. S. (2013) · Diabetes · doi:10.2337/db13-1019 · Cited by 71

Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats

Qiao, J., Li, H., Liu, F.-G., Li, Y., Tian, S., Cao, L., Hu, K., Wu, X., & Miao, M. (2019) · Molecules · doi:10.3390/molecules24162887 · Cited by 65

Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming

Battu, S., Minhas, G., Mishra, A., & Khan, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01719 · Cited by 69

Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice

Yamada, H., Nakajima, T. E., Domon, H., Honda, T., & Yamazaki, K. (2014) · Journal of Periodontal Research · doi:10.1111/jre.12232 · Cited by 65

Obesity and breast cancer

Bakar, D., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90965-5.00006-4 · Cited by 65

Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats

Meriga, B., Parim, B., Chunduri, V. R., Naik, R. R., Nemani, H., Suresh, P., Ganapathy, S., & Uddandrao, V. V. S. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0228-9 · Cited by 64

IL-6 and its role in IgA nephropathy development

Groza, Y., Jemelková, J., Kafkova, L. R., Malý, P., & Raška, M. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.04.001 · Cited by 67

Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion

Cheng, L., Zhao, H., Zhang, W., Liu, B., Liu, Y., Guo, Y., & Nie, L. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.029 · Cited by 64

Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway

Jiang, D., Wang, D., Zhuang, X., Wang, Z., Ni, Y., Chen, S., & Sun, F.-D. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0383-4 · Cited by 65

Nutrient sensing and metabolic changes after methionine deprivation in primary muscle cells of turbot (Scophthalmus maximus L.)

Jiang, H., Bian, F., Zhou, H., Wang, X., Wang, K., Mai, K., & He, G. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.015 · Cited by 64

Omega‐3 fatty acids protect from diet‐induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ‐dependent and PPARγ‐independent actions

Belchior, T., Paschoal, V. A., Magdalon, J., Chimin, P., Farias, T. M., Chaves‐Filho, A. B., Gorjão, R., St.‐Pierre, P., Miyamoto, S., Kang, J. X., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400914 · Cited by 68

Bifidobacteria attenuate the development of metabolic disorders, with inter- and intra-species differences

Zhu, G., Ma, F., Wang, G., Wang, Y., Zhao, J., Zhang, H., & Chen, W. (2018) · Food & Function · doi:10.1039/c8fo00100f · Cited by 63

Association between sleep duration and sleep quality, and metabolic syndrome in Taiwanese police officers

Chang, J.-H., Huang, P.-T., Lin, Y., Lin, C., Lin, C.-M., Shieh, Y., & Lin, Y. (2015) · International Journal of Occupational Medicine and Environmental Health · doi:10.13075/ijomeh.1896.00359 · Cited by 70

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

Iyer, A., Brown, L., Whitehead, J. P., Prins, J. B., & Fairlie, D. P. (2015) · The FASEB Journal · doi:10.1096/fj.15-271155 · Cited by 25

Metabolic Regulation of Inflammation

(2016) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681082271116010008 · Cited by 10

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

Hotamışlıgil, G. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.009 · Cited by 534

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551