Nutrient sensing and inflammation in metabolic diseases

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245

Obesity alters gut microbial ecology

Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H., & Amer, S. A. K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052734 · Cited by 259

Muscle atrophy in patients with Type 2 Diabetes Mellitus: roles of inflammatory pathways, physical activity and exercise.

Perry, B. D., Caldow, M. K., Brennan‐Speranza, T. C., Sbaraglia, M., Jerums, G., GARNHAM, A. P., Wong, C. Y., Levinger, P., Haq, M. A. U., Hare, D. L., et al. (2016) · PubMed · Cited by 239

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

Yang, X., Wang, X., Liu, D., Yu, L., Xue, B., & Shi, H. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1293 · Cited by 243

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

Singer, K., DelProposto, J. L., Morris, D. L., Zamarron, B. F., Mergian, T. A., Maley, N., Cho, K. W., Geletka, L. M., Subbaiah, P., Muir, L. A., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.005 · Cited by 243

Obesity in pregnancy: prevalence and metabolic consequences

Huda, S. S., Brodie, L. E., & Sattar, N. A. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2009.09.006 · Cited by 246

Leaky gut and diabetes mellitus: what is the link?

de Kort, S., Keszthelyi, D., & Masclee, A. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00845.x · Cited by 235

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Meydani, S. N., Das, S. K., Pieper, C. F., Lewis, M. R., Klein, S., Dixit, V. D., Gupta, A. K., Villareal, D. T., Bhapkar, M., Huang, M., et al. (2016) · Aging · doi:10.18632/aging.100994 · Cited by 228

Shared dysregulated pathways lead to Parkinson's disease and diabetes

Santiago, J. A., & Potashkin, J. A. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.01.002 · Cited by 232

Physical Attractiveness: An Adaptationist Perspective

Sugiyama, L. S. (2015) · Wiley eBooks · doi:10.1002/9781119125563.evpsych112 · Cited by 224

Type 2 diabetes as a disease of ectopic fat?

Sattar, N. A., & Gill, J. M. R. (2014) · BMC Medicine · doi:10.1186/s12916-014-0123-4 · Cited by 223

Biologically active isoquinoline alkaloids covering 2014–2018

Shang, X., Yang, C., Morris-Natschke, S. L., Li, J., Yin, X., Liu, Y., Guo, X., Peng, J., Goto, M., Zhang, J., et al. (2020) · Medicinal Research Reviews · doi:10.1002/med.21703 · Cited by 219

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Lindholm, D., Korhonen, L., Eriksson, O., & Kõks, S. (2017) · Front. Cell Dev. Biol. · doi:10.3389/fcell.2017.00048 · Cited by 198

Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target

Gothai, S., Ganesan, P., Park, S., Fakurazi, S., Choi, D., & Arulselvan, P. (2016) · Nutrients · doi:10.3390/nu8080461 · Cited by 226

The intestinal microbiota: its role in health and disease

Biedermann, L., & Rogler, G. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-014-2476-2 · Cited by 227

Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease

Zhao, G., Jiang, D.-S., & Li, H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.030 · Cited by 218

The intestinal microbiota and obesity

Kallus, S. J., & Brandt, L. J. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823711fd · Cited by 210

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

Tang, Y., Zhang, M. J., Hellmann, J. L., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2012) · Diabetes · doi:10.2337/db12-0684 · Cited by 207

Anti-obesity therapy: from rainbow pills to polyagonists

Müller, T. D., Clemmensen, C., Finan, B., DiMarchi, R. D., & Tschöp, M. H. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014803 · Cited by 199

Gut microbiome and metabolic syndrome

Mazidi, M., Rezaie, P., Kengne, A. P., Ghayour‐Mobarhan, M., & Ferns, G. A. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.024 · Cited by 199

The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows

Sordillo, L. M., & Mavangira, V. (2014) · Animal Production Science · doi:10.1071/an14503 · Cited by 195

Prevalence of Metabolic Syndrome Among Hispanics/Latinos of Diverse Background: The Hispanic Community Health Study/Study of Latinos

HEISS, G. M., Snyder, M., Teng, Y., Schneiderman, N., Llabre, M. M., Cowie, C. C., Carnethon, M. R., Kaplan, R. C., Giachello, A. L. M., Gallo, L. C., et al. (2014) · Diabetes Care · doi:10.2337/dc13-2505 · Cited by 199

Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions

Ghigliotti, G., Barisione, C., Garibaldi, S., Fabbi, P., Brunelli, C., Spallarossa, P., Altieri, P., Rosa, G., Spinella, G., Palombo, D., et al. (2014) · Inflammation · doi:10.1007/s10753-014-9914-1 · Cited by 205

Interactions of Metabolism, Inflammation, and Reproductive Tract Health in the Postpartum Period in Dairy Cattle

LeBlanc, S. J. (2012) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2012.02109.x · Cited by 200

Related actions of probiotics and antibiotics on gut microbiota and weight modification

Angelakis, E., Merhej, V., & Raoult, D. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70179-8 · Cited by 190

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Amen, O. M., Sarker, S. D., Ghildyal, R., & Arya, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00977 · Cited by 190

Metabolic syndrome, Mediterranean diet, and polyphenols: Evidence and perspectives

Finicelli, M., Squillaro, T., Cristo, F. D., Salle, A. D., Melone, M. A. B., Galderisi, U., & Peluso, G. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27506 · Cited by 196

Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease

Xu, L., Kitade, H., Ni, Y., & Ota, T. (2015) · Biomolecules · doi:10.3390/biom5031563 · Cited by 190

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

Spite, M. R., Hellmann, J. L., Tang, Y., Mathis, S., Kosuri, M., Bhatnagar, A., Jala, V. R., & Haribabu, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100196 · Cited by 182

Evaluation of adhesion capacity, cell surface traits and immunomodulatory activity of presumptive probiotic Lactobacillus strains

Kotzamanidis, C., Kourelis, A., LITOPOULOU‐TZANETAKI, E., Tzanetakis, N., & Yiangou, M. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.04.004 · Cited by 174

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

Youm, Y., Adijiang, A., Vandanmagsar, B., Burk, D. H., Ravussin, A., & Dixit, V. D. (2011) · Endocrinology · doi:10.1210/en.2011-1326 · Cited by 187

Gene-environment interactions in chronic inflammatory disease

Renz, H., von Mutius, E., Brandtzæg, P., Cookson, W., Autenrieth, I. B., & Haller, D. (2011) · Nature Immunology · doi:10.1038/ni0411-273 · Cited by 172

Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans

Shivers, R. P., Kooistra, T., Chu, S. W. L., Pagano, D. J., & Kim, D. H. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.09.001 · Cited by 166

Potential role of F ox O 1 and m TORC 1 in the pathogenesis of W estern diet‐induced acne

Melnik, B. C., & Zouboulis, C. C. (2013) · Experimental Dermatology · doi:10.1111/exd.12142 · Cited by 164

Mechanisms of obesity and related pathology: linking immune responses to metabolic stress

Karalis, K. P., Giannogonas, P., Kodela, E., Koutmani, Y., Zoumakis, M., & Teli, T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07304.x · Cited by 163

Global, regional and national epidemiology and prevalence of child stunting, wasting and underweight in low- and middle-income countries, 2006–2018

Ssentongo, P., Ssentongo, A. E., Ba, D. M., Ericson, J. E., Na, M., Gao, X., Fronterrè, C., Chinchilli, V. M., & Schiff, S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-84302-w · Cited by 187

Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study

Xu, B., Wu, Q., La, R., Lu, L., Abdu, F. A., Yin, G., Zhang, W., Ding, W., Ling, Y., He, Z., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02251-w · Cited by 179

Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure

Šoškić, S., Dobutović, B. D., Sudar-Milovanovic, E. M., Obradovic, M. M., Nikolić, D., Djordjevic, J. D., Radak, D. J., Mikhailidis, D. P., & Isenović, E. R. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010153 · Cited by 158

Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression

Golia, M. T., Poggini, S., Alboni, S., Garofalo, S., Albanese, N. C., Viglione, A., Ajmone‐Cat, M. A., St-Pierre, A., Brunello, N., Limatola, C., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.003 · Cited by 161

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

Mihaylova, M. M., Sabatini, D. M., & Yilmaz, Ö. H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.008 · Cited by 158

Branched‐chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view

Bifari, F., & Nisoli, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13624 · Cited by 158

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

Mokarram, P., Albokashy, M., Zarghooni, M., Moosavi, M. A., Sepehri, Z., Chen, Q. M., Hudecki, A., Sargazi, A., Alizadeh, J., Moghadam, A. R., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1290751 · Cited by 150

Cross-talk between adipose tissue and vasculature: role of adiponectin

Li, F. Y. L., Cheng, K. K. Y., Lam, K. S. L., Vanhoutte, P. M., & Xu, A. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02216.x · Cited by 155

Obesity and the risk and prognosis of gallstone disease and pancreatitis

Bonfrate, L., Wang, D. Q.-H., Garruti, G., & Portincasa, P. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.013 · Cited by 125

Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals

Pietzner, M., Kaul, A., Henning, A., Kastenmüller, G., Artati, A., Lerch, M. M., Adamski, J., Nauck, M. A., & Friedrich, N. (2017) · BMC Medicine · doi:10.1186/s12916-017-0974-6 · Cited by 152

Palmitoylethanolamide in CNS health and disease

Raso, G. M., Russo, R., Calignano, A., & Meli, R. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.05.006 · Cited by 153

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease

Steinberg, G. R., & Schertzer, J. D. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.11 · Cited by 150

Reproductive tract inflammatory disease in postpartum dairy cows

LeBlanc, S. J. (2014) · animal · doi:10.1017/s1751731114000524 · Cited by 151

Toll-like receptors, inflammation, metabolism and obesity

Fresno, M., Álvarez, R., & Cuesta, N. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2011.562514 · Cited by 150

Metabolic stress drives sympathetic neuropathy within the liver

Liu, K., Yang, L., Wang, G., Liu, J., Zhao, X., Wang, Y., Li, J., & Yang, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.012 · Cited by 146

Reproductive tract defense and disease in postpartum dairy cows

LeBlanc, S. J., Osawa, T., & Dubuc, J. (2011) · Theriogenology · doi:10.1016/j.theriogenology.2011.07.017 · Cited by 146

C5aR and C3aR antagonists each inhibit diet‐induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Lim, J., Iyer, A., Suen, J. Y., Seow, V., Reid, R. C., Brown, L., & Fairlie, D. P. (2012) · The FASEB Journal · doi:10.1096/fj.12-220582 · Cited by 146

Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis

Depner, C. M., Philbrick, K. A., & Jump, D. Β. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171322 · Cited by 147

Role of selenium-containing proteins in T-cell and macrophage function

Carlson, B. A., Yoo, M., Shrimali, R. K., Irons, R., Gladyshev, V. N., Hatfield, D. L., & Park, J. M. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000176x · Cited by 143

Pharmacological Actions and Underlying Mechanisms of Catechin: A Review

Baranwal, A., Aggarwal, P., Rai, A., & Kumar, N. (2021) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557521666210902162120 · Cited by 143

Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

A-González, N., & Castrillo, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.015 · Cited by 139

Gut Microbiota in Obesity and Undernutrition

de Clercq, N. C., Groen, A. K., Romijn, J. A., & Nieuwdorp, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012914 · Cited by 140

Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice

Feng, B., Jiao, P., Nie, Y., Kim, T., Jun, D., van Rooijen, N., Yang, Z., & Xu, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024358 · Cited by 145

Nuclear Receptors and Inflammation Control: Molecular Mechanisms and Pathophysiological Relevance

Huang, W. J. M., & Glass, C. K. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191189 · Cited by 142

Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation

Logue, J., Murray, H. M., Welsh, P. I., Shepherd, J., Packard, C. J., Macfarlane, P. W., Cobbe, S. M., Ford, I., & Sattar, N. A. (2011) · Heart · doi:10.1136/hrt.2010.211201 · Cited by 139

Endoplasmic Reticulum Stress in Age-Related Macular Degeneration: Trigger for Neovascularization

Salminen, A., Kauppinen, A., Hyttinen, J. M. T., Toropainen, E., & Kaarniranta, K. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00070 · Cited by 141

Role of Innate Immune Response in Non-Alcoholic Fatty Liver Disease: Metabolic Complications and Therapeutic Tools

Meli, R., Mattace Raso, G., & Calignano, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00177 · Cited by 137

Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation

Sampey, B. P., Freemerman, A. J., Zhang, J., Kuan, P. F., Galanko, J. A., O’Connell, T. M., Ilkayeva, O., Muehlbauer, M. J., Stevens, R. D., Newgard, C. B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038812 · Cited by 135

Adipose tissue in obesity and obstructive sleep apnoea

Bonsignore, M. R., McNicholas, W. T., Montserrat, J. M., & Eckel, J. (2011) · European Respiratory Journal · doi:10.1183/09031936.00047010 · Cited by 141

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

Wood, L. G., Li, Q., Scott, H. A., Rutting, S., Berthon, B. S., Gibson, P. G., Hansbro, P. M., Williams, E. J., Horvat, J. C., Simpson, J. L., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.04.037 · Cited by 137

High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE−/− mice

Chan, Y. K., Brar, M. S., Kirjavainen, P. V., Chen, Y., Jiao, P., Li, D., Leung, F. C.-C., & El-Nezami, H. S. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0883-4 · Cited by 138

Endoplasmic reticulum stress in cerebral ischemia

Xin, Q., Ji, B., Cheng, B., Wang, C., Liu, H., Chen, X., Chen, J., & Bai, B. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.02.001 · Cited by 133

Diabetes and Sepsis: Risk, Recurrence, and Ruination

Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 141

Inflammatory phenotypes in the intestine of poultry: not all inflammation is created equal

Kogut, M. H., Genovese, K. J., Swaggerty, C. L., He, H., & Broom, L. J. (2018) · Poultry Science · doi:10.3382/ps/pey087 · Cited by 136

Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis

Xiang, M., Wang, P., Wang, A., Zhang, X., Zhang, Y., Zhang, P., Mei, F., Chen, M., & Li, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.002 · Cited by 133

Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease

Xu, A., & Vanhoutte, P. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00765.2011 · Cited by 130

The major pre- and postmenopausal estrogens play opposing roles in obesity-driven mammary inflammation and breast cancer development

Qureshi, R., Picon-Ruiz, M., Aurrekoetxea-Rodriguez, I., Nunes de Paiva, V., D’Amico, M., Yoon, H., Radhakrishnan, R., Morata-Tarifa, C., Ince, T., Lippman, M. E., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.008 · Cited by 127

Early life events influence whole-of-life metabolic health via gut microflora and gut permeability

Kerr, C. A., Grice, D. M., Tran, C. D., Bauer, D. C., Li, D., Hendry, P. L., & Hannan, G. N. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.837863 · Cited by 129

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice

Hosoi, T., Yokoyama, S., Matsuo, S., Akira, S., & Ozawa, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012537 · Cited by 124

Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes

Goto, T., Naknukool, S., Yoshitake, R., Hanafusa, Y., Tokiwa, S., Li, Y., Sakamoto, T., Nitta, T., Kim, M., Takahashi, N., et al. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.001 · Cited by 127

The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats

Maric, T., Woodside, B. C., & Luheshi, G. N. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.011 · Cited by 123

Role and function of macrophages in the metabolic syndrome

Bhargava, P., & Lee, C. (2012) · Biochemical Journal · doi:10.1042/bj20111708 · Cited by 117

Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice

Charbonneau, A., & Marette, A. (2010) · Diabetes · doi:10.2337/db09-1238 · Cited by 116

Modulation of microglia polarization dynamics during diabetic retinopathy in db / db mice

Arroba, A. I., Alcalde‐Estévez, E., García‐Ramírez, M., Cazzoni, D., de la Villa, P., Sánchez‐Fernández, E. M., Mellet, C. O., Fernández, J. M. G., Hernández, C., Simó, R., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.024 · Cited by 115

Modulation of microglia in the retina: new insights into diabetic retinopathy

Arroba, A. I., & Valverde, Á. M. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-0984-z · Cited by 113

The role of interleukin-6 in glucose homeostasis and lipid metabolism

Lehrskov, L. L., & Christensen, R. H. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00747-2 · Cited by 114

Chemokine Systems Link Obesity to Insulin Resistance

Ota, T. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.3.165 · Cited by 114

Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism

Massafra, V., & van Mil, S. W. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.003 · Cited by 115

The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity

Johnston‐Cox, H., Koupenova, M., Yang, D., Corkey, B. E., Gokce, N., Farb, M. G., LeBrasseur, N. K., & Ravid, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040584 · Cited by 116

Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial

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Low-grade systemic inflammation and the development of metabolic diseases: From the molecular evidence to the clinical practice

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