The SYK tyrosine kinase: a crucial player in diverse biological functions

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Davis, R. E., Ngo, V. N., Lenz, G., Tolar, P., Young, R. M., Romesser, P. B., Kohlhammer, H., Lamy, L., Zhao, H., Yang, Y., et al. (2010) · Nature · doi:10.1038/nature08638 · Cited by 1,651

Signalling through C-type lectin receptors: shaping immune responses

Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449

Antigen receptor tail clue

Reth, M. G. (1989) · Nature · doi:10.1038/338383b0 · Cited by 1,430

F c RECEPTOR BIOLOGY

Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191

Dectin-1: a signalling non-TLR pattern-recognition receptor

Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 947

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

Rogers, N. C., Slack, E. M. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L. J., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 897

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

Groß, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T. D., Peschel, C., Förster, I., & Ruland, J. (2006) · Nature · doi:10.1038/nature04926 · Cited by 871

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004) · Nature · doi:10.1038/nature02444 · Cited by 832

A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections

Glocker, E.-O., Hennigs, A., Nabavi, M., Schäffer, A. A., Woellner, C., Salzer, U., Pfeifer, D., Veelken, H., Warnatz, K., Tahami, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810719 · Cited by 800

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Ishikawa, E., Ishikawa, T., Morita, Y. S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., & Yamasaki, S. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091750 · Cited by 794

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martínez, D., Hernanz-Falcón, P., Rosewell, I., & Sousa, C. R. E. (2009) · Nature · doi:10.1038/nature07750 · Cited by 750

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

Friedberg, J. W., Sharman, J. P., Sweetenham, J. W., Johnston, P. B., Vose, J. M., LaCasce, A. S., Schaefer-Cutillo, J., de Vos, S., Sinha, R., Leonard, J. P., et al. (2009) · Blood · doi:10.1182/blood-2009-08-236471 · Cited by 747

Mincle is an ITAM-coupled activating receptor that senses damaged cells

Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K., & Saito, T. (2008) · Nature Immunology · doi:10.1038/ni.1651 · Cited by 740

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Turner, M., Joseph Mee, P., Costello, P. S., Williams, O., Price, A. A., Duddy, L. P., Furlong, M. T., Geahlen, R. L., & Tybulewicz, V. L. J. (1995) · Nature · doi:10.1038/378298a0 · Cited by 612

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

Hise, A. G., Tomalka, J. A., Ganesan, S., Patel, K., Hall, B. A., Brown, G. D., & Fitzgerald, K. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.002 · Cited by 582

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

Kraus, M., Alimzhanov, M. B., Rajewsky, N., & Rajewsky, K. (2004) · Cell · doi:10.1016/j.cell.2004.05.014 · Cited by 573

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Negishi, I., Motoyama, N., Nakayama, K., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A. C., & Loh, D. Y. (1995) · Nature · doi:10.1038/376435a0 · Cited by 554

Syk tyrosine kinase required for mouse viability and B-cell development

Cheng, A. M., Rowley, B., Pao, W., Hayday, A., Bolen, J. B., & Pawson, T. (1995) · Nature · doi:10.1038/378303a0 · Cited by 528

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

Underhill, D. M., Rossnagle, E., Lowell, C. A., & Simmons, R. M. (2005) · Blood · doi:10.1182/blood-2005-03-1239 · Cited by 527

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

Suzuki‐Inoue, K. (2005) · Blood · doi:10.1182/blood-2005-05-1994 · Cited by 523

Involvement of the Snake Toxin Receptor CLEC-2, in Podoplanin-mediated Platelet Activation, by Cancer Cells

Suzuki‐Inoue, K., Kato, Y., Inoue, O., Kaneko, M. K., Mishima, K., Yatomi, Y., Yamazaki, Y., Narimatsu, H., & Ozaki, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702327200 · Cited by 519

R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation

Braselmann, S., Taylor, V., Zhao, H., Wang, S., Sylvain, C., Baluom, M., Qu, K., Herlaar, E., Lau, A., Young, C., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.109058 · Cited by 519

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

Elder, M. E., Lin, D., Clever, J. L., Chan, A. C., Hope, T. J., Weiss, A., & Parslow, T. G. (1994) · Science · doi:10.1126/science.8202712 · Cited by 512

A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages

Crowley, M. T., Costello, P. S., Fitzer-Attas, C. J., Turner, M., Meng, F., Lowell, C., Tybulewicz, V. L. J., & DeFranco, A. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1027 · Cited by 506

Signal transduction by the TCR for antigen

Kane, L. P., Lin, J., & Weiss, A. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00083-2 · Cited by 498

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E. M., Stenger, S., Andersen, P. L., Ruland, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904013 · Cited by 497

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

Chan, A. C., Kadlecek, T. A., Elder, M. E., Filipovich, A. H., Kuo, W.-L., Iwashima, M., Parslow, T. G., & Weiss, A. (1994) · Science · doi:10.1126/science.8202713 · Cited by 492

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Robinson, M. J., Osorio, F., Rosas, M., Freitas, R. P., Schweighoffer, E., Groß, O., Verbeek, J. S., Ruland, J., Tybulewicz, V. L. J., Brown, G. D., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082818 · Cited by 483

Dectin-2 Is a Pattern Recognition Receptor for Fungi That Couples with the Fc Receptor γ Chain to Induce Innate Immune Responses

Sato, K., Yang, X.-L., Yudate, T., Chung, J., Wu, J., Luby‐Phelps, K., Kimberly, R. P., Underhill, D. M., Cruz, P. D., & Ariizumi, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606542200 · Cited by 470

The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

Mócsai, A., Humphrey, M. B., Ziffle, J. V., Hu, Y., Burghardt, A. J., Spusta, S. C., Majumdar, S., Lanier, L. L., Lowell, C. A., & Nakamura, M. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401602101 · Cited by 467

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A. B. H., Phillips, J. H., Pekkarinen, P., et al. (2000) · Nature Genetics · doi:10.1038/77153 · Cited by 460

The Fc receptor γ‐chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

Poole, A. W., Gibbins, J. M., Turner, M., van Vugt, M. J., van de Winkel, J. G. J., Saito, T., Tybulewicz, V. L. J., & Watson, S. P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.9.2333 · Cited by 450

Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling

Bertozzi, C. C., Schmaier, A. A., Mericko, P. A., Hess, P. R., Zou, Z., Chen, M., Chen, C., Xu, B., Lu, M., Zhou, D. D., et al. (2010) · Blood · doi:10.1182/blood-2010-02-270876 · Cited by 437

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

Wells, C. A., Salvage-Jones, J., Li, X., Hitchens, K., Butcher, S., Murray, R. Z., Beckhouse, A. G., Lo, Y.-L.-S., Manzanero, S., Cobbold, C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7404 · Cited by 434

TREM and TREM-like receptors in inflammation and disease

Ford, J. W., & McVicar, D. W. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.009 · Cited by 434

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805177106 · Cited by 425

Syk is required for integrin signaling in neutrophils

Mócsai, A., Zhou, M., Meng, F., Tybulewicz, V. L., & Lowell, C. A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00303-5 · Cited by 421

Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

Abtahian, F., Guerriero, A., Sebzda, E., Lu, M., Zhou, R., Mócsai, A., Meyers, E. E., Huang, B., Jackson, D. G., Ferrari, V. A., et al. (2003) · Science · doi:10.1126/science.1079477 · Cited by 421

CLEC5A is critical for dengue-virus-induced lethal disease

Chen, S.-T., Lin, Y., Huang, M.-T., Wu, M., Cheng, S., Lei, H.-Y., Lee, C., Chiou, T., Wong, C., & Hsieh, S.-L. E. (2008) · Nature · doi:10.1038/nature07013 · Cited by 412

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

Obergfell, A., Eto, K., Mócsai, A., Buensuceso, C. S., Moores, S. L., Brugge, J. S., Lowell, C. A., & Shattil, S. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112113 · Cited by 410

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

Turner, M., Schweighoffer, E., Colucci, F., Santo, J. P. D., & Tybulewicz, V. L. J. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01574-1 · Cited by 400

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

Ruefli-Brasse, A. A., French, D. M., & Dixit, V. M. (2003) · Science · doi:10.1126/science.1090769 · Cited by 384

NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway

Billadeau, D. D., Upshaw, J. L., Schoon, R. A., Dick, C. J., & Leibson, P. J. (2003) · Nature Immunology · doi:10.1038/ni929 · Cited by 376

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L., & Lowell, C. A. (2006) · Nature Immunology · doi:10.1038/ni1407 · Cited by 376

The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils

Kiefer, F., Brumell, J., Al-Alawi, N., Latour, S., Cheng, A., Veillette, A., Grinstein, S., & Pawson, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4209 · Cited by 376

Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells

Goodridge, H. S., Simmons, R. M., & Underhill, D. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3107 · Cited by 365

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Shio, M. T., Eisenbarth, S. C., Savaria, M., Vinet, A. F., Bellemare, M.-J., Harder, K. W., Sutterwala, F. S., Bohle, D. S., Descoteaux, A., Flavell, R. A., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000559 · Cited by 361

The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors

Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S. W., Inui, M., Takai, T., Shibuya, A., Saijo, S., et al. (2007) · Nature Immunology · doi:10.1038/ni1466 · Cited by 360

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

Wakselman, S., Béchade, C., Roumier, A., Bernard, D., Triller, A., & Bessis, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1006-08.2008 · Cited by 351

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

Gaide, O., Favier, B., Legler, D. F., Bonnet, D., Brissoni, B., Valitutti, S., Bron, C., Tschopp, J., & Thome, M. (2002) · Nature Immunology · doi:10.1038/ni830 · Cited by 343

Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve‐week, randomized, placebo‐controlled trial

Weinblatt, M. E., Kavanaugh, A., Burgos‐Vargas, R., Dikranian, A. H., Medrano-Ramírez, G., Morales‐Torres, J., Murphy, F. T., Musser, T. K., Straniero, N., Vicente‐Gonzales, A. V., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23992 · Cited by 343

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Kaifu, T., Nakahara, J., Inui, M., Mishima, K., Momiyama, T., Kaji, M., Sugahara, A., Koito, H., Ujike, A., Nakamura, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16923 · Cited by 342

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+ Dendritic Cells and a Subset of Monocytes

Huysamen, C., Willment, J. A., Dennehy, K. M., & Brown, G. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709923200 · Cited by 337

The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation

Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M. P., Griffiths, E. K., Krawczyk, C. M., Bauer, B., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00148-1 · Cited by 336

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

Rolli, V., Gallwitz, M., Wossning, T., Flemming, A., Schamel, W. W. A., Zürn, C., & Reth, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00739-6 · Cited by 331

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

Coopman, P. J., Do, M. T. H., Barth, M. M., Bowden, E. T., Hayes, A. J., Basyuk, E. I., Blancato, J. K., Vezza, P. R., McLeskey, S. W., Mangeat, P. H., et al. (2000) · Nature · doi:10.1038/35021086 · Cited by 324

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation

Werninghaus, K., Babiak, A., Groß, O., Hölscher, C., Dietrich, H., Agger, E. M., Mages, J., Mócsai, A., Schoenen, H., Finger, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081445 · Cited by 319

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Chen, L., Monti, S., Juszczyński, P., Daley, J. F., Chen, W., Witzig, T. E., Habermann, T. M., Kutok, J. L., & Shipp, M. A. (2007) · Blood · doi:10.1182/blood-2007-07-100115 · Cited by 317

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

Otero, K., Turnbull, I. R., Poliani, P. L., Vermi, W., Cerutti, E., Aoshi, T., Tassi, I., Takai, T., Stanley, S. L., Miller, M., et al. (2009) · Nature Immunology · doi:10.1038/ni.1744 · Cited by 315

ITAM-mediated tonic signalling through pre-BCR and BCR complexes

Monroe, J. G. (2006) · Nature reviews. Immunology · doi:10.1038/nri1808 · Cited by 313

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

Saijo, K., Schmedt, C., Su, I.-H., Karasuyama, H., Lowell, C. A., Reth, M. G., Adachi, T., Patke, A., Santana, A., & Tarakhovsky, A. (2003) · Nature Immunology · doi:10.1038/ni893 · Cited by 307

The Taxonomy of Developmental Control in Caenorhabditis elegans

Ruvkun, G., & Hobert, O. (1998) · Science · doi:10.1126/science.282.5396.2033 · Cited by 305

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

Uhrín, P., Zaujec, J., Breuss, J. M., Olcaydu, D., Chrenek, P., Stockinger, H. S. J., Fuertbauer, E., Moser, M., Haiko, P., Fässler, R., et al. (2010) · Blood · doi:10.1182/blood-2009-04-216069 · Cited by 295

Spleen Tyrosine Kinase Syk Is Necessary for E-Selectin-Induced αLβ2 Integrin-Mediated Rolling on Intercellular Adhesion Molecule-1

Zarbock, A., Lowell, C. A., & Ley, K. F. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.011 · Cited by 292

A requirement for CARMA1 in TCR-induced NF-κB activation

Wang, D., You, Y., Case, S. M., McAllister‐Lucas, L. M., Wang, L., DiStefano, P. S., Núñez, G., Bertin, J., & Lin, X. (2002) · Nature Immunology · doi:10.1038/ni824 · Cited by 291

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.

Costello, P. S., Turner, M., Walters, A. E., Cunningham, C. N., Bauer, P. H., Downward, J., & Tybulewicz, V. L. J. (1996) · PubMed · Cited by 290

Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

Zou, W., Kitaura, H., Reeve, J., Long, F., Tybulewicz, V. L. J., Shattil, S. J., Ginsberg, M. H., Ross, F. P., & Teitelbaum, S. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611083 · Cited by 288

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

Deckert, M., Tartare-Deckert, S., Couture, C., Mustelin, T., & Altman, A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80273-3 · Cited by 285

Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis

Awasaki, T., Tatsumi, R., Takahashi, K., Arai, K., Nakanishi, Y., Ueda, R., & Ito, K. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.027 · Cited by 285

Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma

Streubel, B., Vinatzer, U., Willheim, M., Raderer, M., & Chott, A. (2005) · Leukemia · doi:10.1038/sj.leu.2404045 · Cited by 281

Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dendritic Cells

Ng, G., Sharma, K., Ward, S. M., Desrosiers, M. D., Stephens, L. A., Schoel, W. M., Li, T., Lowell, C. A., Ling, C.-C., Amrein, M. W., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.013 · Cited by 276

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk

Podolanczuk, A. J., Lazarus, A. H., Crow, A. R., Grossbard, E., & Bussel, J. B. (2008) · Blood · doi:10.1182/blood-2008-07-166439 · Cited by 264

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI

Kitaura, J., Song, J., Tsai, M. M., Asai, K., Maeda‐Yamamoto, M., Mócsai, A., Kawakami, Y., Liu, F., Lowell, C. A., Barisas, B. G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735525100 · Cited by 261

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

Fu, J., Gerhardt, H., McDaniel, J. M., Xia, B., Liu, X., Ivanciu, L., Ny, A., Hermans, K., Silasi‐Mansat, R., McGee, S., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36077 · Cited by 246

Negative Regulation of Immunoreceptor Signaling

Veillette, A., Latour, S., & Davidson, D. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.130710 · Cited by 242

Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70

Deindl, S., Kadlecek, T. A., Brdička, T., Cao, X., Weiss, A., & Kuriyan, J. (2007) · Cell · doi:10.1016/j.cell.2007.03.039 · Cited by 240

The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade

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Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

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Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor

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Proteomic and Genetic Approaches Identify Syk as an AML Target

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Erk Kinases Link Pre-B Cell Receptor Signaling to Transcriptional Events Required for Early B Cell Expansion

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An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment

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DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk

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G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.

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Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)

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Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.

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C-type lectin Mincle is an activating receptor for pathogenic fungus

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The Signaling Adapter Protein DAP12 Regulates Multinucleation During Osteoclast Development

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Mac-1 Signaling via Src-Family and Syk Kinases Results in Elastase-Dependent Thrombohemorrhagic Vasculopathy

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The Syk tyrosine kinase: A new negative regulator in tumor growth and progression

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Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

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Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

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CARD9 versus CARMA1 in innate and adaptive immunity

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Syk and Slp-76 Mutant Mice Reveal a Cell-Autonomous Hematopoietic Cell Contribution to Vascular Development

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MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture

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Cutting Edge: Constitutive B Cell Receptor Signaling Is Critical for Basal Growth of B Lymphoma

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Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production

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The N-terminal SH2 Domains of Syk and ZAP-70 Mediate Phosphotyrosine-independent Binding to Integrin β Cytoplasmic Domains

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Genetic deficiency of Syk protects mice from autoantibody‐induced arthritis

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The possible involvement of virus in breast cancer

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Immunoreceptor-like signaling by β2 and β3 integrins

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TCR-Induced Transmembrane Signaling by Peptide/MHC Class II Via Associated Ig-α/β Dimers

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The Syk Kinase SmTK4 of Schistosoma mansoni Is Involved in the Regulation of Spermatogenesis and Oogenesis

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Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors

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Extensive Gene Duplication in the Early Evolution of Animals Before the Parazoan–Eumetazoan Split Demonstrated by G Proteins and Protein Tyrosine Kinases from Sponge and Hydra

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Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

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High dose M‐CSF partially rescues the Dap12−/− osteoclast phenotype

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Roles of the ITAM and PY Motifs of Epstein-Barr Virus Latent Membrane Protein 2A in the Inhibition of Epithelial Cell Differentiation and Activation of β-Catenin Signaling

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Syk Tyrosine Kinase Mediates Epstein-Barr Virus Latent Membrane Protein 2A-induced Cell Migration in Epithelial Cells

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Inhibition of β2 Integrin Receptor and Syk Kinase Signaling in Monocytes by the Src Family Kinase Fgr

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Regulation of Signaling in B Cells through the Phosphorylation of Syk on Linker Region Tyrosines

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The kinase Syk as an adaptor controlling sustained calcium signalling and B‐cell development

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The Vav binding site of the non–receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)–mediated neutrophil migration

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Regulation of Developmental Lymphangiogenesis by Syk+ Leukocytes

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Deregulated Syk inhibits differentiation and induces growth factor–independent proliferation of pre–B cells

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SLP-76 Regulates Fcγ Receptor and Integrin Signaling in Neutrophils

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Characterization of the Kaposi's Sarcoma-Associated Herpesvirus K1 Signalosome

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Immunoreceptor Tyrosine-Based Activation Motif-Dependent Signaling by Kaposi's Sarcoma-Associated Herpesvirus K1 Protein: Effects on Lytic Viral Replication

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Frequent Epigenetic Inactivation of Spleen Tyrosine Kinase Gene in Human Hepatocellular Carcinoma

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Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen

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Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase.

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Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

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Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function

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Transcription Repressor Activity of Spleen Tyrosine Kinase Mediates Breast Tumor Suppression

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T Cell Activation Induced by Novel Gain-of-function Mutants of Syk and ZAP-70

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Appearance and disappearance of Syk family protein-tyrosine kinase genes during metazoan evolution

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