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The SYK tyrosine kinase: a crucial player in diverse biological functions
Open accessAbstract
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.
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“SYK is perhaps best known for the critical role that it plays in mounting protective antifungal immune responses downstream of C-type lectin (CLEC) receptors expressed on innate immune cells (Lionakis et al., 2017; Mocsai et al., 2010).”
From SYK coordinates neuroprotective microglial responses in neurodegenerative disease (2022) · cites this paper as Mocsai et al., 2010
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“However, recent studies indicate that it is also involved in innate immunity and non-immune functions.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [96]
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“Upon ITAM phosphorylation, the SYK tyrosine kinase is recruited to the receptor and its activation leads to downstream phosphorylation events including activation of SHP-1 and RAC (11, 12)”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [11]
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Metadata
- Authors
- Mócsai, A., Ruland, J., & Tybulewicz, V. L. J.
- Affiliations
- Semmelweis University (HU)
- TUM Klinikum (DE)
- National Institute for Medical Research (GB)
- Corresponding author
- Mócsai, Attila
- Venue
- Nature Reviews Immunology
- Published
- 2010-05-14
- Volume
- 10
- Issue
- 6
- Pages
- 387-402
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4782221
- OpenAlex
- W2017341404
- Cited by
- 1,368
- References
- 194
- Citations by year
- 2026: 71 · 2025: 94 · 2024: 107 · 2023: 111 · 2022: 99 · 2021: 100 · 2020: 78 · 2019: 76 · 2018: 75 · 2017: 87 · 2016: 78 · 2015: 70 · 2014: 87 · 2013: 78 · 2012: 84
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Wellcome Trust (087782)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Syk, innate immune recognition, C-type lectin, integrins, NLRP3 inflammasome, osteoclast maturation, bone metabolism, platelet activation, vascular development, cell adhesion, autoimmune disease, B-cell lymphoma, therapeutic target, Drosophila melanogaster
- MeSH terms
- Syk Kinase, Animals, Cell Adhesion, Humans, Protein-Tyrosine Kinases, Receptors, Immunologic, Signal Transduction, Cell Lineage, Intracellular Signaling Peptides and Proteins
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