B‐1a lymphocytes attenuate insulin resistance
Open accessAbstract
Obesity-associated insulin resistance, a common precursor of type 2 diabetes, is characterized by chronic inflammation of tissues, including visceral adipose tissue (VAT). Here we show that B-1a cells, a subpopulation of B lymphocytes, are novel and important regulators of this process. B-1a cells are reduced in frequency in obese high-fat diet (HFD)-fed mice, and EGFP interleukin-10 (IL-10) reporter mice show marked reductions in anti-inflammatory IL-10 production by B cells in vivo during obesity. In VAT, B-1a cells are the dominant producers of B cell–derived IL-10, contributing nearly half of the expressed IL-10 in vivo. Adoptive transfer of B-1a cells into HFD-fed B cell–deficient mice rapidly improves insulin resistance and glucose tolerance through IL-10 and polyclonal IgM-dependent mechanisms, whereas transfer of B-2 cells worsens metabolic disease. Genetic knockdown of B cell–activating factor (BAFF) in HFD-fed mice or treatment with a B-2 cell–depleting, B-1a cell–sparing anti-BAFF antibody attenuates insulin resistance. These findings establish B-1a cells as a new class of immune regulators that maintain metabolic homeostasis and suggest manipulation of these cells as a potential therapy for insulin resistance.
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In mice fed a high-fat diet, adipose tissue B1 cells ameliorate disease attributable to their production of IL-10 and polyclonal IgM.
“In mice fed an HFD, adipose tissue B1 cells ameliorate disease attributable to their production of IL‐10 and polyclonal IgM( 51 ); however, a role for B1 cells in adipose tissue is yet to be confirmed in humans.”
From The Emerging Role of B Cells in the Pathogenesis of NAFLD (2021) · cites this paper as [51]
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- Authors
- Shen, L., Chng, M. H. Y., Alonso, M. N., Yuan, R., Winer, D. A., & Engleman, E. G.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Stanford Medicine (US)
- University Health Network (CA)
- Corresponding author
- Winer, Daniel A.
- Engleman, Edgar G.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2014-09-22
- Volume
- 64
- Issue
- 2
- Pages
- 593-603
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC4303967
- OpenAlex
- W2105987065
- Cited by
- 109
- References
- 53
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 7
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Diabetes Association (119414, CS-5-12-3886, OG-3-12-3844)
- National Institutes of Health (1R01DK096038)
- Canadian Institutes of Health Research (119414)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- insulin resistance, obesity, type 2 diabetes, visceral adipose tissue, IL-10, BAFF, high-fat diet, glucose tolerance, adoptive transfer, B cell-deficient mice, anti-inflammatory regulation, metabolic homeostasis
- MeSH terms
- Animals, Blood Glucose, Dietary Fats, Female, Gene Expression Regulation, Humans, Immunoglobulin M, Insulin Resistance, Male, Mice, Inbred C57BL, Middle Aged, Obesity, B-Lymphocyte Subsets, Interleukin-10, Glucose Intolerance, Mice
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