The DOI matches its Crossref record; 146 of the 148 references it cites were found in a registry or an index.
Genomic views of STAT function in CD4+ T helper cell differentiation
Open accessAbstract
Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The appropriate differentiation of these CD4+ T-cell subsets requires activation of transcription factors, including signal transducers and activators of transcription (STATs) [11].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Next-generation DNA sequencing
Shendure, J., & Ji, H. (2008) · Nature Biotechnology · doi:10.1038/nbt1486 · Cited by 4,509
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Flagged first, then by citations
2 of the 148 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Danoy, P. et al. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet. 6, e1001195 (2010). · DOI
Cited by
Sorted by citations
Items 101–200 of 295
Zhang, Z., Jyoti, A., Balakrishnan, B., Williams, M. A., Singh, S., Chugani, D. C., & Kannan, S. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.013 · Cited by 40
The importance of co‐stimulation in the orchestration of T helper cell differentiation
Coquet, J. M., Rausch, L., & Borst, J. G. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.45 · Cited by 43
G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils
Nguyen-Jackson, H. T., Li, H. S., Zhang, H., Ohashi, E., & Watowich, S. S. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312126 · Cited by 43
Sun, J., Du, Y., Song, Q., Jing, N., Guan, P., Guo, J., Wang, X., Yang, J., & Zhao, C. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy174 · Cited by 40
Epigenomics and the Microbiota
Alenghat, T. (2014) · Toxicologic Pathology · doi:10.1177/0192623314553805 · Cited by 42
Skullcapflavone II Suppresses TNF-α/IFN-γ-Induced TARC, MDC, and CTSS Production in HaCaT Cells
Lee, H., Lee, D. H., Oh, J., & Chung, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126428 · Cited by 38
Kohal, R., Bisht, P., Gupta, G. D., & Verma, S. K. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.107095 · Cited by 37
Epistasis and immunity: the role of genetic interactions in autoimmune diseases
Rose, A. M., & Bell, L. C. K. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03623.x · Cited by 40
ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
Mele, F., Basso, C., Leoni, C., Aschenbrenner, D., Becattini, S., Latorre, D., Lanzavecchia, A., Sallusto, F., & Monticelli, S. (2015) · Nature Communications · doi:10.1038/ncomms7431 · Cited by 36
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells
Majri-Morrison, S. S., Fritz, J. M., Villarino, A. V., Zheng, L., Kanellopoulou, C., Chaigne-Delalande, B., Grönholm, J., Niemela, J. E., Afzali, B., Biancalana, M., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701133 · Cited by 36
Self-citationIL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer
Timperi, E., Focaccetti, C., Gallerano, D., Panetta, M., Spada, S., Gallo, E., Visca, P., Venuta, F., Diso, D., Prelaj, A., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1328337 · Cited by 35
Regulation of T helper cell differentiation by interferon regulatory factor family members
Zhang, R., Chen, K., Peng, L., & Xiong, H. (2012) · Immunologic Research · doi:10.1007/s12026-012-8328-0 · Cited by 33
STAT3-mediated epigenetic silencing of FOXP3 in LADA T cells is regulated through HDAC5 and DNMT1
Hou, C., Zhong, Y., Wang, Z., Zhao, M., Huang, G., Ouyang, L., Li, Y., Lu, Q., & Zhou, Z. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.12.001 · Cited by 34
Campos-Parra, A. D., Pérez-Quintanilla, M., Martínez-Gutiérrez, A. D., Pérez‐Montiel, D., Coronel-Martínez, J. A., Millán-Catalán, O., de León, D. F. C., & Pérez‐Plasencia, C. (2022) · Current Oncology · doi:10.3390/curroncol29070372 · Cited by 33
Duan, X., Sun, P., Lan, Y., Shen, C., Zhang, X., Hou, S., Chen, J., Ma, B., Xia, Y., & Su, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00701 · Cited by 32
Liu, S., Cao, Y., Cui, K., Ren, G., Zhao, T., Wang, X., Wei, D., Chen, Z., Gurram, R. K., Liu, C., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.018 · Cited by 34
Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions
Chalmin, F., Humblin, É., Ghiringhelli, F., & Végran, F. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.07.002 · Cited by 33
Chromatin organizer SATB1 is an important determinant of T‐cell differentiation
Burute, M., Gottimukkala, K., & Galande, S. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2012.28 · Cited by 34
Han, K., Meadows, A. M., Rodman, M. J., Russo, A. C., Sharma, R., Singh, K., Hassanzadeh, S., Dagur, P. K., Huffstutler, R. D., Krause, F. N., et al. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae006 · Cited by 31
Lee, H., Willi, M., Shin, H. Y., Liu, C., & Hennighausen, L. G. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky891 · Cited by 29
Choi, J., Choi, B. K., Kim, J. S., Lee, J.-W., Park, H. A., Ryu, H. W., Lee, S. U., Hwang, K. W., Yun, W.-K., Kim, H.-C., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0167098 · Cited by 30
Transcription factors and CD 4 T cells seeking identity: masters, minions, setters and spikers
Vahedi, G., Kanno, Y., Sartorelli, V., & O’Shea, J. J. (2013) · Immunology · doi:10.1111/imm.12113 · Cited by 30
Self-citationInhibition of ROCK activity regulates the balance of Th1, Th17 and Treg cells in myasthenia gravis
Song, J., Xi, J., Yu, W., Yan, C., Luo, S.-S., Zhou, L., Zhu, W., Lu, J., Dong, Q., Xiao, B., et al. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.05.006 · Cited by 30
Wang, X., Liao, X., Yu, T., Gong, Y., Zhang, L., Huang, J., Yang, C., Han, C., Yu, L., Zhu, G., et al. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4862 · Cited by 31
Integrating non-coding RNAs in JAK-STAT regulatory networks
Witte, S. J., & Muljo, S. A. (2014) · JAK-STAT · doi:10.4161/jkst.28055 · Cited by 31
Posttranscriptional regulation of T helper cell fate decisions
Hoefig, K. P., & Heissmeyer, V. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708075 · Cited by 31
Transcriptional Enhancers in the Regulation of T Cell Differentiation
Nguyen, M. L. T., Jones, S. A., Prier, J. E., & Russ, B. E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00462 · Cited by 28
Borzouei, S., Sheikh, V., Ghasemi, M., Zamani, A., Telikani, Z., Zareighane, Z., Salehi, I., Mozayanimonfared, A., Amirzargar, M. A., & Behzad, M. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0144 · Cited by 29
Expression profile and prognostic values of STAT family members in non-small cell lung cancer.
Yang, M., Chen, H., Zhou, L., Chen, K., & Su, F. (2019) · Europe PMC (PubMed Central) · Cited by 29
JunB Is Critical for Survival of T Helper Cells
Hsieh, T.-H., Sasaki, D., Taira, N., Chien, H.-C., Sarkar, S., Seto, Y., Miyagi, M., & Ishikawa, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901030 · Cited by 29
Double sword role of EZH2 in leukemia
Safaei, S., Baradaran, B., Hagh, M. F., Alivand, M. R., Talebi, M., Gharibi, T., & Solali, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.059 · Cited by 29
Min, H.-K., Choi, J., Lee, S.-Y., Seo, H.-B., Jung, K., Na, H. S., Ryu, J., Kwok, S., Cho, M., & Park, S. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1774-x · Cited by 28
Klinke, D. J., Cheng, N., & Chambers, E. S. (2012) · Science Signaling · doi:10.1126/scisignal.2002657 · Cited by 28
Lee, H. G., Cho, N., Jeong, A. J., Li, Y.-C., Rhie, S.-J., Choi, J. S., Lee, K. H., Kim, Y. S., Kim, Y.-N., Kim, M., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.384 · Cited by 28
Epigenetic dynamics during CD4+ T cells lineage commitment
Rodríguez, R. M. A., López‐Larrea, C., & Suárez-Álvarez, B. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.04.020 · Cited by 29
Epigenetics of T cells regulated by Polycomb/Trithorax molecules
Onodera, A., & Nakayama, T. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.03.001 · Cited by 27
Pertovaara, M., Silvennoinen, O., & Isomäki, P. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12614 · Cited by 26
Bhaskaran, N., Liu, Z., Saravanamuthu, S. S., Yan, C., Hu, Y., Dong, L., Zelenka, P. S., Zheng, L., Bletsos, V., Harris, R. F., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00184 · Cited by 25
Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Golden, G. J., Wu, V. H., Hamilton, J. T., Amses, K. R., Shapiro, M. R., Japp, A. S., Liu, C., Pampena, M. B., Kuri-Cervantes, L., Knox, J. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59626-0 · Cited by 27
Epigenetic regulation of T helper cells and intestinal pathogenicity
Hagihara, Y., Yoshimatsu, Y., Mikami, Y., Takada, Y., Mizuno, S., & Kanai∥, T. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00732-9 · Cited by 25
Recent Advances in the Role of Arid5a in Immune Diseases and Cancer
Nyati, K. K., & Kishimoto, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.827611 · Cited by 25
Lee, G., Park, J., Lee, H., Kim, K. S., Park, J. H., Kyung, S. Y., Kim, H. S., Yang, H. O., & Jung, B. H. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154818 · Cited by 25
Determinants of the extent and duration of STAT3 signaling
Groner, B. (2012) · JAK-STAT · doi:10.4161/jkst.21469 · Cited by 24
Nishioka, C., Ikezoe, T., Yang, J., & Yokoyama, A. (2016) · Leukemia Research · doi:10.1016/j.leukres.2016.03.012 · Cited by 25
Regulatory mechanisms that control T‐follicular helper and T‐helper 1 cell flexibility
Weinmann, A. S. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.49 · Cited by 24
Estrogenic bias in T-Lymphocyte biology: Implications for cardiovascular disease
Rosenzweig, R., Gupta, S., Kumar, V., Gumina, R. J., & Bansal, S. S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105606 · Cited by 24
Rebhahn, J. A., Deng, N., Gaurav Sharma, A., Livingstone, A. M., Huang, S., & Mosmann, T. R. (2014) · European Journal of Immunology · doi:10.1002/eji.201444645 · Cited by 26
Pasteurella multocida Toxin Manipulates T Cell Differentiation
Hildebrand, D., Heeg, K. M., & Kubatzky, K. F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01273 · Cited by 22
Zare, F., Dehghan-Manshadi, M., & Mirshafiey, A. (2016) · Reumatismo · doi:10.4081/reumatismo.2015.851 · Cited by 22
Common and different roles of IL-4 and IL-13 in skin allergy and clinical implications
Roesner, L. M., Zeitvogel, J., & Heratizadeh, A. (2019) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000553 · Cited by 22
Zhang, Y., Li, C. R., Li, S., Lu, Y., Du, S., Zeng, X., Chen, X., & Chen, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/3427053 · Cited by 22
Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H. Y., & Chang, A. L. S. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.09.011 · Cited by 22
Rendón‐Serna, N., Londoño, L. A. C., Velásquez‐Lopera, M. M., & Bermudez‐Muñoz, M. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15451 · Cited by 21
Dectin-1-activated dendritic cells: A potent Th9 cell inducer for tumor immunotherapy
Chen, J., Zhao, Y., Chu, X., Lu, Y., Wang, S., & Yi, Q. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1238558 · Cited by 21
Jahangard, L., & Behzad, M. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577250 · Cited by 20
Kim, B., Yoon, B. R., Kim, E. K., Noh, K. H., Kwon, S., Yi, E. H., Lee, H. G., Choi, J. S., Kang, S. W., Park, I., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.03.018 · Cited by 20
IL-27 and IL-27-producing CD4+ T cells in human tuberculous pleural effusion
Xia, H., Ye, Z., Zhou, Q., You, W.-J., Cui, A., Wang, X., Zhai, K., Jin, X.-G., Tong, Z.-H., & Shi, H. (2014) · Tuberculosis · doi:10.1016/j.tube.2014.07.003 · Cited by 19
Chu, K., Lin, S., & Chiang, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615868 · Cited by 19
Eva, M. M., Yuki, K. E., Dauphinee, S. M., Schwartzentruber, J., Pyzik, M., Paquet, M., Lathrop, M. G., Majewski, J., Vidal, S. M., & Malo, D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301370 · Cited by 17
Rundquist, O., Nestor, C. E., Jenmalm, M. C., Hellberg, S., & Gustafsson, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.835625 · Cited by 17
Manoochehrabadi, S., Arsang‐Jang, S., Mazdeh, M., Inoko, H., Sayad, A., & Taheri, M. N. (2018) · Human Antibodies · doi:10.3233/hab-180352 · Cited by 17
González‐Serna, D., Shi, C., Kerick, M., Hankinson, J., Ding, J., McGovern, A., Tutino, M., Villanueva-Martín, G., Ortego‐Centeno, N., Callejas-Rubio, J. L., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42396 · Cited by 19
The Evolving View of IL-17-Mediated Immunity in Defense Against Mucocutaneous Candidiasis in Humans
Soltész, B., Tóth, B., Sarkadi, A. K., Erdös, M., & Maródi, L. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2015.1049345 · Cited by 18
Sarkar, I., Davies, R., Aarebrot, A. K., Solberg, S. M., Petrovic, A., Joshi, A. M., Bergum, B., Brun, J. G., Hammenfors, D., Jonsson, R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.854183 · Cited by 16
Roles for Helper T Cell Lineage-Specifying Transcription Factors in Cellular Specialization
Weinmann, A. S. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800147-9.00006-6 · Cited by 16
Zeng, X., Willi, M., Shin, H. Y., Hennighausen, L. G., & Wang, C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.079 · Cited by 16
MicroRNA‐181a restricts human γδ T cell differentiation by targeting Map3k2 and Notch2
Gordino, G., Costa-Pereira, S., Corredeira, P., Alves, P., Costa, L., Gomes, A. Q., Silva‐Santos, B., & Ribot, J. C. (2021) · EMBO Reports · doi:10.15252/embr.202052234 · Cited by 16
Systems-level identification of key transcription factors in immune cell specification
Liu, C., Omilusik, K. D., Toma, C., Kurd, N. S., Chang, J. T., Goldrath, A. W., & Wang, W. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010116 · Cited by 15
Kushak, R. I., Sengupta, A., & Winter, H. S. (2021) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15052 · Cited by 16
Khokhar, M., & Purohit, P. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2364586 · Cited by 14
MiR-29b interacts with IFN-γ and induces DNA hypomethylation in CD4+ T cells of oral lichen planus
Zhang, J., Chen, G.-Y., Wang, F., & Zhou, G. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.252 · Cited by 14
Zhao, Y., Zhang, Z., Lei, W., Wei, Y. Z., Ma, R., Wen, Y., Wei, F., Fan, J., Yang, X., Chen, L., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.648293 · Cited by 14
Ghosh, S., Mukherjee, S., Sengupta, A., Chowdhury, S., Sarkar, S., Keswani, T., & Bhattacharyya, A. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.11.005 · Cited by 14
Won, T., Lee, Y., Hyung, K. E., Yang, E., Sohn, U. D., Min, H. Y., Lee, D. I., Park, S., & Hwang, K. W. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.03.001 · Cited by 14
Iyer, A. K., Liu, J., Gallo, R. M., Kaplan, M. H., & Brutkiewicz, R. R. (2015) · Immunology · doi:10.1111/imm.12521 · Cited by 14
The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation
Tolomeo, M., & Cascio, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189123 · Cited by 15
Wu, Y., Zhao, X., Cui, J., Guo, Y., Zheng, X., Zhang, Y., Niu, M., Li, Z., Wen, S., & Gao, W. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.52915 · Cited by 14
Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity
Waugh, K. A., Leach, S. M., & Slansky, J. E. (2015) · Vaccines · doi:10.3390/vaccines3030771 · Cited by 14
Nagy, Z. S., Ross, J. A., Rodriguez, G., Bálint, B. L., Széles, L., Nagy, L., & Kirken, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057326 · Cited by 13
Liang, Y., Xu, W., Yang, X., Fang, X., Liu, Y., Ni, J., Qiu, L., Peng, H., Cen, H., Leng, R., et al. (2014) · Autoimmunity · doi:10.3109/08916934.2013.873415 · Cited by 13
Lu, Y., Lin, H., Zhai, K., Wang, X., Zhou, Q., & Shi, H. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0097-y · Cited by 13
The Involvement of Calpain in CD4+ T Helper Cell Bias in Multple Sclerosis
Trager, N. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000153 · Cited by 13
Groner, B., & Hennighausen, L. G. (2012) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2012-0010 · Cited by 12
Deciphering the developmental trajectory of tissue-resident Foxp3+ regulatory T cells
Alvarez, F., Liu, Z., Bay, A., & Piccirillo, C. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331846 · Cited by 12
Wu, S., Jiang, J., Wang, D., Lin, D., Lin, M., Chen, P., Chen, J., Zhang, H., Wang, Y., Chen, X., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111218 · Cited by 12
Hoang, T. H., Zhao, Y., Lam, Y., Piekos, S. C., Han, Y.-C., Reilly, C., Joshi, P., Hong, S.-H., Sung, C. O., Giardina, C. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45304-x · Cited by 12
Decreased circulating Th22 and Th17 cells in patients with aplastic anemia
Lu, T., Liu, Y., Li, P., Yu, S., Huang, X., Ma, D., & Ji, C. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.07.031 · Cited by 11
Shimojima, Y., Matsuda, M., Ishii, W., Kishida, D., & Sekijima, Y. (2017) · Autoimmunity · doi:10.1080/08916934.2017.1405942 · Cited by 11
Mensink, M., Schrama, E., Cuadrado, E., van den Biggelaar, M., Amsen, D., de Kivit, S., & Borst, J. G. (2022) · Scientific Reports · doi:10.1038/s41598-022-23515-z · Cited by 10
CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders
Picavet, L. W., Samat, A. A. K., Calis, J. J. A., Nijhuis, L., Scholman, R. C., Mokrý, M., Tough, D. F., Prinjha, R. K., Vastert, S. J., & van Loosdregt, J. (2024) · Biomedicines · doi:10.3390/biomedicines12061344 · Cited by 10
Connelly, T. M., Koltun, W. A., Berg, A. S., Hegarty, J. P., Brinton, D. L., Deiling, S. M., Poritz, L. S., & Stewart, D. B. (2013) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0b013e31829de128 · Cited by 10
LASSIM—A network inference toolbox for genome-wide mechanistic modeling
Magnusson, R., Mariotti, G. P., Köpsén, M., Lövfors, W., Gawel, D. R., Jörnsten, R. J., Linde, J., Nordling, T. E. M., Nyman, E., Schulze, S., et al. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005608 · Cited by 10
Lamprianidou, E., Kordella, C., Kazachenka, A., Zoulia, E., Bernard, E., Filia, A., Laidou, S., Garantziotis, P., Vassilakopoulos, T. P., Papageorgiou, S. G., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020002351 · Cited by 9
A Novel STAT3 Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease
Deng, M., Li, Y., Li, Y., Mao, X., Ke, H., Liang, W., Lei, X., Lau, Y., & Mao, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.866638 · Cited by 9
Cheng, C., Liang, S., Yue, K., Wu, N., Li, Z., Dong, T., Dong, X., Ling, M., Jiang, Q., Liu, J., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216730 · Cited by 9
From a gene-centric to whole-proteome view of differentiation of T helper cell subsets
Lönnberg, T., Chen, Z. J., & Lahesmaa, R. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt033 · Cited by 9
Self-citationDebuisson, D., Mari, N., Denanglaire, S., Léo, O., & Andris, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084415 · Cited by 9
Ko, J. S., Jeong, D., Koh, J., Jung, H., Jung, K. C., Jeon, Y. K., Kim, H. Y., Yi, E. C., Lee, H., Lee, C., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102374118 · Cited by 8
Zhao, X., Wang, L., Lin, H., Wang, J., Fu, J., Zhu, D., & Xu, W. (2022) · PubMed Central · doi:10.22074/cellj.2022.7907 · Cited by 8
Askari, M., Jahangard, L., Zamani, A., Haghighi, M., Salehi, I., Zareighane, Z., Solgi, G., Shahbazi, R., & Behzad, M. (2019) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2019-0010 · Cited by 8
Metadata
- Authors
- O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y.
- Affiliations
- Åbo Akademi University (FI)
- National Institutes of Health (US)
- Venue
- Nature Reviews Immunology
- Published
- 2011-03-25
- Volume
- 11
- Issue
- 4
- Pages
- 239-250
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3070307
- OpenAlex
- W2055082742
- Cited by
- 295
- References
- 148
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 24 · 2018: 27 · 2017: 15 · 2016: 19 · 2015: 25 · 2014: 27 · 2013: 36 · 2012: 26
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041159)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT proteins, cytokine signaling, epigenetic regulation, gene expression regulation, transcriptional repression, autoimmune disease, genome-wide association study
- MeSH terms
- Animals, Autoimmune Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Deficiency Syndromes, Lymphocyte Activation, Nucleosomes, Signal Transduction, Cytokines, Sequence Analysis, DNA, Genomics, STAT Transcription Factors, Mice, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
