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Genomic views of STAT function in CD4+ T helper cell differentiation
Open accessAbstract
Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.
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“The appropriate differentiation of these CD4+ T-cell subsets requires activation of transcription factors, including signal transducers and activators of transcription (STATs) [11].”
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2 of the 148 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Danoy, P. et al. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet. 6, e1001195 (2010). · DOI
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Transcriptional control of effector and memory CD8+ T cell differentiation
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JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
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Self-citationMechanisms of Jak/STAT Signaling in Immunity and Disease
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CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm
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Metadata
- Authors
- O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y.
- Affiliations
- Åbo Akademi University (FI)
- National Institutes of Health (US)
- Venue
- Nature Reviews Immunology
- Published
- 2011-03-25
- Volume
- 11
- Issue
- 4
- Pages
- 239-250
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3070307
- OpenAlex
- W2055082742
- Cited by
- 295
- References
- 148
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 24 · 2018: 27 · 2017: 15 · 2016: 19 · 2015: 25 · 2014: 27 · 2013: 36 · 2012: 26
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041159)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT proteins, cytokine signaling, epigenetic regulation, gene expression regulation, transcriptional repression, autoimmune disease, genome-wide association study
- MeSH terms
- Animals, Autoimmune Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Deficiency Syndromes, Lymphocyte Activation, Nucleosomes, Signal Transduction, Cytokines, Sequence Analysis, DNA, Genomics, STAT Transcription Factors, Mice, Genome-Wide Association Study
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