Cited by 295Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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Genomic views of STAT function in CD4+ T helper cell differentiation

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O'Shea, John J., Lahesmaa, Riitta, Vahedi, Golnaz, Laurence, Arian, Kanno, Yuka·2011·Nature Reviews Immunology

DOI 10.1038/nri2958PMC PMC3070307

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Abstract

Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.

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Authors: O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y.
Affiliations: Åbo Akademi University (FI)
National Institutes of Health (US)
ORCID: Lahesmaa, Riitta
Vahedi, Golnaz
Laurence, Arian
Kanno, Yuka
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-03-25
Volume: 11
Issue: 4
Pages: 239-250
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2958
PMC: PMC3070307
OpenAlex: W2055082742
Cited by: 295
References: 148
Citations by year: 2026: 7 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 24 · 2018: 27 · 2017: 15 · 2016: 19 · 2015: 25 · 2014: 27 · 2013: 36 · 2012: 26
FWCI: 2.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041159)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: STAT proteins, cytokine signaling, epigenetic regulation, gene expression regulation, transcriptional repression, autoimmune disease, genome-wide association study
MeSH terms: Animals, Autoimmune Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Deficiency Syndromes, Lymphocyte Activation, Nucleosomes, Signal Transduction, Cytokines, Sequence Analysis, DNA, Genomics, STAT Transcription Factors, Mice, Genome-Wide Association Study

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Genomic views of STAT function in CD4+ T helper cell differentiation

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