The history of toll-like receptors - redefining innate immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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A Toll-like receptor recognizes bacterial DNA

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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Function and Activation of NF-kappaB in the Immune System

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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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Approaching the asymptote? Evolution and revolution in immunology.Preprint

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Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

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The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

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Unresponsiveness of MyD88-deficient mice to endotoxin.

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Interleukin-1 and interleukin-1 antagonism

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

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A family of human receptors structurally related to Drosophila Toll.

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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

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Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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Recognition of single-stranded RNA viruses by Toll-like receptor 7

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

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The roles of TLRs, RLRs and NLRs in pathogen recognition

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Structure and Function of Lipopolysaccharide Binding Protein

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Oncogenically active MYD88 mutations in human lymphoma

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Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )

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Sequence and specificity of two antibacterial proteins involved in insect immunity

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Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

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Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.10 · Cited by 1,360

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

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The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor

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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

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Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

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Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

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TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,217

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

Lund, J. M., Sato, A., Akira, S., Medzhitov, R. M., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,197

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

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IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

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Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

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Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

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Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

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Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T., Sato, S., Ishii, K. J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., et al. (2004) · Nature Immunology · doi:10.1038/ni1118 · Cited by 1,058

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

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TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

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TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

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A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

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TIRAP: an adapter molecule in the Toll signaling pathway

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Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

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cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

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Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

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Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

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Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

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Control of B-cell responses by Toll-like receptors

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

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Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

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Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

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dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

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Soluble CD14 participates in the response of cells to lipopolysaccharide.

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Drosophila Toll and IL-1 receptor

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Chemische Erforschung von Lipopolysacchariden gramnegativer Bakterien

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Structural Basis of TLR5-Flagellin Recognition and Signaling

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Structures of the Toll-like Receptor Family and Its Ligand Complexes

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Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum.

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The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling

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Recognition and plasma clearance of endotoxin by scavenger receptors

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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8

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Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

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Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

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Dif, a dorsal-related gene that mediates an immune response in Drosophila

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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

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Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

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Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

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Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

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TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

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Maturation of Human Dendritic Cells by Cell Wall Skeleton ofMycobacterium bovisBacillus Calmette-Guerin: Involvement of Toll-Like Receptors

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