The history of toll-like receptors - redefining innate immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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A Toll-like receptor recognizes bacterial DNA

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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Function and Activation of NF-kappaB in the Immune System

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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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Human gut microbiome: Hopes, threats and promises

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Fever and the thermal regulation of immunity: the immune system feels the heat

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The intestinal microbiota fuelling metabolic inflammation

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Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa

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Structure–function relationships of immunostimulatory polysaccharides: A review

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Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

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The delivery of therapeutic oligonucleotides

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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

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CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

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Converging roles of caspases in inflammasome activation, cell death and innate immunity

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Sepsis: Current Dogma and New Perspectives

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Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

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TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis

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The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

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Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens

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Human Coronaviruses: A Review of Virus–Host Interactions

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The dawn of mRNA vaccines: the COVID-19 case

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Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

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Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update

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Toll-like receptors: Activation, signalling and transcriptional modulation

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Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

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The innate immune function of airway epithelial cells in inflammatory lung disease

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Estrogens, Neuroinflammation, and Neurodegeneration

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Interferons and viruses: an evolutionary arms race of molecular interactions

Hoffmann, H.-H., Schneider, W. M., & Rice, C. M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.004 · Cited by 427

Allergen Immunotherapy in Children User’s Guide

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Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

Mokrá, D., Jošková, M., & Mokrý, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010340 · Cited by 386

Mucosal immunity to pathogenic intestinal bacteria

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IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline

Fu, A. K. Y., Hung, K.-W., Yuen, M. Y. F., Zhou, X., Mak, D. S. Y., Chan, I. C. W., Cheung, T. H., Zhang, B., Fu, W.-Y., Liew, F. Y., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604032113 · Cited by 369

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

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The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

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Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

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Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

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Innate sensing of malaria parasites

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Exotoxins and endotoxins: Inducers of inflammatory cytokines

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Emerging roles of p53 and other tumour-suppressor genes in immune regulation

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The role of extracellular histone in organ injury

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TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

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Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

Wang, L., & He, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967193 · Cited by 334

Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade

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From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses

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Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective

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Exploiting replicative stress to treat cancer

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The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

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Toll-like receptors (TLRs) in aquatic animals: Signaling pathways, expressions and immune responses

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Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

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Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

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Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response

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The lysosome as a command-and-control center for cellular metabolism

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TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases

Luchner, M., Reinke, S., & Milicic, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020142 · Cited by 296

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

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Dysbiosis of gut microbiota in promoting the development of colorectal cancer

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A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

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Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

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Toll-like Receptors in the Vascular System: Sensing the Dangers Within

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Endothelial cells translate pathogen signals into G-CSF–driven emergency granulopoiesis

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Radiation and Inflammation

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Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

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Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

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Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk

Feng, M., Chen, J. Y., Weissman-Tsukamoto, R., Volkmer, J.-P., Ho, P. Y., McKenna, K. M., Cheshier, S. H., Zhang, M., Ring, N. G., Gip, P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424907112 · Cited by 253

Gut microbiota and metabolic syndrome

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Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

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RIP kinases: key decision makers in cell death and innate immunity

Humphries, F., Yang, S., Wang, B., & Moynagh, P. N. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.126 · Cited by 249

Sweeten PAMPs: Role of sugar complexed PAMPs in innate immunity and vaccine biology

Mahla, R. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00248 · Cited by 239

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes

Essuman, K., Summers, D. W., Sasaki, Y., Mao, X. R., Yim, A. K., DiAntonio, A., & Milbrandt, J. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.024 · Cited by 244

Innate immune sensing of coronavirus and viral evasion strategies

Kasuga, Y., Zhu, B., Jang, K., & Yoo, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00602-1 · Cited by 236

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

Heinz, L. X., Lee, J., Kapoor, U., Kartnig, F., Sedlyarov, V., Παπακώστας, Κ., César‐Razquin, A., Essletzbichler, P., Goldmann, U., Stefanovic, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2282-0 · Cited by 233

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

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Innate immune recognition of DNA: A recent history

Dempsey, A., & Bowie, A. (2015) · Virology · doi:10.1016/j.virol.2015.03.013 · Cited by 229

Obesity, diabetes, and the gut microbiome: an updated review

Singer-Englar, T., Barlow, G. M., & Mathur, R. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1543023 · Cited by 224

Tomato receptor FLAGELLIN-SENSING 3 binds flgII-28 and activates the plant immune system

Hind, S. R., Strickler, S. R., Boyle, P. C., Dunham, D., Bao, Z., O’Doherty, I. M., Baccile, J. A., Hoki, J. S., Viox, E. G., Clarke, C. R., et al. (2016) · Nature Plants · doi:10.1038/nplants.2016.128 · Cited by 214

Toll-like receptors and their role in persistent pain

Lacagnina, M. J., Watkins, L. R., & Grace, P. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.006 · Cited by 216

Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

Chang, C.-W., Lee, H., Li, L.-H., Chiau, J. C., Wang, T.-E., Chuang, W.-H., Chen, M., Wang, H.-Y., Shih, S., Liu, C.-Y., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020386 · Cited by 210

The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging

Meyers, A. K., & Zhu, X. (2020) · Cells · doi:10.3390/cells9081808 · Cited by 207

TLR‐mediated activation of NK cells and their role in bacterial/viral immune responses in mammals

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Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism

Chen, T., Li, Q., Wu, J., Wu, Y., Peng, W., Li, H., Wang, J., Tang, X., Peng, Y., & Fu, X. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2233-x · Cited by 202

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

Joosten, L. A. B., Abdollahi‐Roodsaz, S., Dinarello, C. A., O'Neill, L. A. J., & Netea, M. G. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.61 · Cited by 208

Mechanisms of Fever Production and Lysis: Lessons from Experimental LPS Fever

Roth, J., & Blatteis, C. M. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130033 · Cited by 206

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

Dutta, D., Jana, M., Majumder, M., Mondal, S., Roy, A., & Pahan, K. (2021) · Nature Communications · doi:10.1038/s41467-021-25767-1 · Cited by 195

Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants

Bhagchandani, S. H., Johnson, J. A., & Irvine, D. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.013 · Cited by 195

A guide to miRNAs in inflammation and innate immune responses

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Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

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Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

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Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression

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Anti-tumor Activity of Toll-Like Receptor 7 Agonists

Chi, H., Li, C., Zhao, F. S., Zhang, L., Ng, T. B., Jin, G., & Sha, O. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00304 · Cited by 182

ERK1/2 in immune signalling

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Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950

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A dual-action peptide-containing hydrogel targets wound infection and inflammation

Puthia, M., Butrym, M., Petrlová, J., Strömdahl, A., Andersson, M. Å., Kjellström, S., & Schmidtchen, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6601 · Cited by 182

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