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T-bet: a bridge between innate and adaptive immunity
Open accessAbstract
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet.
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Citations
Cites
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“T-bet induction promotes expression of IL-12 receptor, which then shifts Th1 differentiation into a primarily IL-12 driven process (Lazarevic et al., 2013).”
BackgroundPleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation
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“The association of Jmjd3 with Brg1 has been reported to be important for the function of T-bet, a transcription factor essential for the differentiation of T helper 1 (Th1) effector CD4 T cells [79], and for their expression of the prototypical Th1 cytokine interferon g (IFNg) [75]; similar Jmjd3– Brg1 interactions co…”
BackgroundReview of Rosai-Dorfman Disease: New Insights into the Pathogenesis of This Rare Disorder
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“TBX21 encodes for the transcription factor T-bet, which coordinates multiple aspects of both cellular and humoral immune responses [12,29].”
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“CD4+T cells (TH1)— TH1 CD4+T cells are driven by IL-12 activation of Stat4 and T-bet transcription factors on naïve T cells [175, 176] that induces and up-regulates IFN γ [177].”
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“In fact, Tbet is the master regulator of Th1 cells, whereas Foxp3 controls the development and the function of regulatory T cells, while it inhibits the expression of some Tbet-induced factors, as for example IFNg and IL-2.”
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“ILC1s require the transcription factor T-bet for their development and both cNK cells and ILC1s constitutively express this protein (Lazarevic et al., 2013).”
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Bozorgmehr, N., Okoye, I., Oyegbami, O., Xu, L., Fontaine, A., Cox-Kennett, N., Larratt, L. M., Hnatiuk, M., Fagarasanu, A. D., Brandwein, J. M., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002189 · Cited by 53
Transcriptional regulation of adaptive and innate lymphoid lineage specification
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Self-citationA Review of Immunomodulatory Effects of Fluoroquinolones
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“These alterations facilitate the production of effector cytokines, including IFN-γ, TNF-α, and IL-2, and inhibit the production of other CD4 T+ cell subsets and cytokines, such as IL-10 or IL-4 (Lazarevic et al. 2013).”
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“3 Promotion of the macrophage-induced adaptive immune response towards Th2 prowound healing phenotype Newly recruited adaptive immune cells known as T cells are activated via antigen presentation by macrophages or dendritic cells (Lazarevic et al., 2013).”
BackgroundA STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells
Ciucci, T., Vacchio, M. S., & Bosselut, R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711160114 · Cited by 48
“While neither T-bet nor Eomes are expressed in resting T cells, they are upregulated in differentiating Th1 and Tc1 effectors, in which they sustain production of IFNγ and cytotoxic molecules (2, 8, 9).”
BackgroundGlista-Baker, E. E., Taylor-Just, A. J., Sayers, B. C., Thompson, E. A., & Bonner, J. C. (2014) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-11-7 · Cited by 49
“In addition, innate lymphoid cells (ILCs) are a newly described type of cell that share many functional attributes with effector T cell subsets [10].”
BackgroundInfluentialAkhter, W., Nakhle, J., Vaillant, L., Garcin, G., Saout, C. L., Simon, M., Crozet, C., Djouad, F., Jørgensen, C., Vignais, M., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03219-x · Cited by 51
“T-bet is upregulated upon antigen encounter and drives the expression of multiple genes involved in Th1 effector differentiation and in particular IFNγ [61].”
BackgroundExploring the immune response, tolerance and resistance in proliferative kidney disease of salmonids
Bailey, C., Strepparava, N., Wahli, T., & Segner, H. E. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.09.015 · Cited by 47
T helper 2 differentiation is necessary for development of lymphedema
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“As such, the absence of T-bet results in a deficiency of Th1 cells and, ultimately, the failure to activate antimicrobial mechanisms against a variety of pathogens.(13,15) This has been demonstrated by Finotto et al, who showed that mice possessing a targeted mutation for T-bet have markedly reduced IFN-g levels and d…”
Shimizu, K., Sato, Y., Kawamura, M., Nakazato, H., Watanabe, T., Ohara, O., & Fujii, S. (2019) · Communications Biology · doi:10.1038/s42003-019-0389-3 · Cited by 45
Transcription factor-driven regulation of ILC1 and ILC3
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“Not surprisingly, Tbet (TBX21), the lineage-defining transcription factor for Th1 cells [60], was one of the most significantly upregulated transcripts in survivors 3–10 DPI in this study.”
BackgroundDevelopment and Function of Effector Regulatory T Cells
Teh, P. P., Vasanthakumar, A., & Kallies, A. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.08.005 · Cited by 42
HIV infection: focus on the innate immune cells
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“The clonogenic common lymphoid progenitor (CLP) originates ILCs (innate lymphoid cells), B and T lymphocytes, accordingly to the transcriptional factors stimulated [143, 144].”
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“Naive Th cells differentiate into Th1 cells when they are induced to express the transcription factor T-bet, which occurs upon exposure to IFN-g and interleukin (IL)-12 (Lazarevic et al., 2013).”
BackgroundGutjahr, A., Papagno, L., Nicoli, F., Lamoureux, A., Vernejoul, F., Lioux, T., Emma Gostick, D., Price, D. A., Tiraby, G., Pérouzel, É., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602131 · Cited by 43
“A similar pattern was observed with the transcription factor T-bet, which regulates TH1 cells and the synthesis of IFN-g and granzyme B in CD8 T cells (22).”
MethodKang, J., & Malhotra, N. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112025 · Cited by 44
“In other ILC1s, T-bet, not EOMES, drives IFN-γ production.”
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Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1
Renrick, A. N., Thounaojam, M. C., de Aquino, M. T. P., Chaudhuri, E., Pandhare, J., Dash, C., & Shanker, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.607044 · Cited by 43
“SHIP1 inhibits PI3K signaling leading to a reduction in mTOR signaling and ultimately decreasing T-bet.”
BackgroundInfluentialGenetic variants alter T-bet binding and gene expression in mucosal inflammatory disease
Soderquest, K., Hertweck, A., Giambartolomei, C., Henderson, S. R., Mohamed, R., Goldberg, R., Perucha, E., Franke, L., Herrero, J., Plagnol, V., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006587 · Cited by 44
“That T-bet binding sites are associated with mucosal autoimmune disease, but not with RA or psoriasis is somewhat surprising, because all of these diseases have been linked to aberrant Th1 responses [2].”
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“modulation of Toll-like receptor 2 expression and T-cell homing to proinflammatory sites acting on CXCR3 expression.(43) On the other hand, only few genes become substantially modulated in both hippocampus and PFC of the 12-month SNI”
BackgroundHeim, L., Chiriac, M. T., Kachler, K., Mitsch, S., 杨祖钦, Koelle, J., Kharwadkar, R., Geppert, C.-I., Tausche, P., Hohenberger, K., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859738 · Cited by 43
T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis
Zimmermann, J., Kühl, A. A., Weber, M., Grün, J. R., Löffler, J., Haftmann, C., Riedel, R., Maschmeyer, P., Lehmann, K., Westendorf, K., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.5 · Cited by 41
T-bet promotes potent antitumor activity of CD4+ CAR T cells
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Zhao, S., Shen, W., Yu, J., & Wang, L. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0820-6 · Cited by 41
“Background: The Th1 cell-specific transcription factor TBX21 functions as a regulator of expression of a Th1 cytokine, interferon gamma (IFN-γ).”
InfluentialTranscriptional regulation of CD4+ TH cells that mediate tissue inflammation
Loo, T. T., Gao, Y., & Lazarevic, V. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ri0418-152rr · Cited by 43
Self-citationDNX-2401: an investigational drug for the treatment of recurrent glioblastoma
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Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions
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“In addition, transcription factor t-bet plays a pivotal role in the differentiation Th1 and Tc1 cells, which help to kill cancer cells [46].”
BackgroundMendoza, A., Yewdell, W. T., Hoyos, B. E., Schizas, M., Bou-Puerto, R., Michaels, A. J., Brown, C. C., Chaudhuri, J., & Rudensky, A. Y. (2021) · Science Immunology · doi:10.1126/sciimmunol.abi4710 · Cited by 38
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“The production of IFN-g in the CNS tissues of T-bet mice is somewhat unexpected, as the T-bet transcription factor controls the production of IFN-g in many cells of the innate and adaptive immune systems (39).”
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Venturutti, L., & Melnick, A. M. (2020) · Blood · doi:10.1182/blood.2020005857 · Cited by 39
Testicular Diffuse Large B-Cell Lymphoma—Clinical, Molecular, and Immunological Features
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Mendelian susceptibility to mycobacterial diseases: state of the art
Noma, K., Mizoguchi, Y., Tsumura, M., & Okada, S. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.03.004 · Cited by 41
Dendritic Cells and B Cells: Unexpected Partners in Th2 Development
León, B., Ballesteros‐Tato, A., & Lund, F. E. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400149 · Cited by 35
“For example, IL-12–producing mature DCs induce expression of the Th1 lineage–specifying transcription factor, T-bet, in the primed CD4 T cells, and this DC-dependent signal is required to induce full Th1 development (8).”
BackgroundInfluentialZhao, R., Cheng, L., Jiang, Z.-W., Wei, X.-R., Li, B.-H., Wu, Q., Wang, S., Lin, S.-M., Long, Y., Zhang, X.-C., et al. (2018) · Oncoimmunology · doi:10.1080/2162402x.2018.1509173 · Cited by 34
“To explore the mechanisms underlying the synergistic effect of CD28 and DAP10, we focused on the two transcription factors, T-bet and Eomesodermin(Eomes), which are master transcriptional regulators in T cells and meditated their effector function or memory differentiatio.(31,32) We firstly detected the”
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T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection
López-Yglesias, A. H., Burger, E., Araujo, A. M., Martin, A. T., & Yarovinsky, F. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.102 · Cited by 35
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Hope, J. L., Stairiker, C. J., Bae, E., Otero, D. C., & Bradley, L. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01595 · Cited by 38
miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
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“In addition, T-bet acts as a selective repressor of transcriptional pathways associated with type I IFNs subsequent to IFN-γ-induced signaling [44,45].”
BackgroundThe Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes
Clark, M., Kroger, C. J., Qi, K., & Tisch, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615371 · Cited by 37
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O’Donnell, H., & McSorley, S. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00621 · Cited by 34
“For example, while T-bet is considered to be a master transcriptional regulator of IFNγ production, in natural killer (NK) cells and CD8 T cells Eomes is able to make up for the loss of T-bet, while in CD4 T cells T-bet signaling is required (30).”
BackgroundBächle, S. M., Malone, D. F. G., Buggert, M., Karlsson, A. C., Isberg, P., Biague, A. J., Norrgren, H., Medstrand, P., Moll, M., Sandberg, J. K., et al. (2016) · AIDS · doi:10.1097/qad.0000000000001147 · Cited by 33
Eomes Expression Defines Group 1 Innate Lymphoid Cells During Metastasis in Human and Mouse
Verma, R., Er, J. Z., Pu, R. W., Mohamed, J. S., Soo, R. A., Mithiran, H., Tam, J. K. C., & Ding, J. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01190 · Cited by 35
“While T-bet is expressed on both ILC1s and NK cells (37), Eomes is seemingly expressed only on murine NK cells (9), thus making it a more reliable marker to differentiate ILC1s from NK cells (11, 38, 39).”
BackgroundBadeaux, M. D., Rolig, A. S., Agnello, G., Enzler, D., Kasiewicz, M. J., Priddy, L., Wiggins, J. F., Muir, A., Sullivan, M. R., Cleef, J. V., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0317 · Cited by 35
“Differences in CD8þ T-cell memory and exhaustion were measured based upon KLRG1þPD-1hi subpopulations, and differences in short-term memory cells were measured by T-betþEomes subpopulations (36); however, by 17 days after treatment, these subsets were unchanged across treatment groups (Supplementary Fig.”
MethodInghirami, G., Chan, W. C., & Pileri, S. A. (2014) · Immunological Reviews · doi:10.1111/imr.12248 · Cited by 33
“GATA3 (274) is expressed in normal Th2 cells and is important in their differentiation and proliferation, while TBX21 regulates Th1 cell polarization and the differentiation and function of CD8 cytotoxic cells (275, 276).”
BackgroundRestraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis
Cui, K.-R., Chen, Z.-J., Cao, Y.-Q., Liu, S., Ren, G., Hu, G.-Q., Fang, D.-F., Wei, D., Liu, C.-Y., Zhu, J., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.006 · Cited by 30
Linking obesity with type 2 diabetes: the role of T-bet
Sutherland, A. P. R., Wali, J. A., & Thomas, H. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s51432 · Cited by 34
“This is achieved by promoting the differentiation of multiple immune cell lineages that contribute to cell-mediated immunity and by suppressing the function of counterregulatory lineages.(64,65) T-bet is required for the development of optimal CD8+ T cell responses, where it transactivates the expression of IFNγ and c…”
BackgroundHeterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+T cells
Jung, K., Ha, J.-H., Kim, J., Kim, J.-A., Kim, Y., Kim, Y., & Kim, Y. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1438800 · Cited by 31
“mainly T-bet and eomesodermin (Eomes) through the signal transducer and activator of transcription 4 (STAT4) pathway.(6) Strong IL12-STAT4 signaling upregulates T-bet expression in effector CD8C T cells, leading to their subsequent differentiation into SLECs.”
BackgroundOtsuka, T., Nishida, S., Shibahara, T., Temizoz, B., Hamaguchi, M., Shiroyama, T., Kimura, K. B., Miyake, K., Hirata, H., Mizuno, Y., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09818-4 · Cited by 31
“T-bet expression represents the differentiation of cytotoxic CD8+ T cells because these cells require T-bet for IFN-γ and granzyme B production [30, 31].”
BackgroundHartana, C. A., Bergman, E. A., Zirakzadeh, A. A., Krantz, D., Winerdal, M. E., Winerdal, M., Johansson, M., Alamdari, F. I., Jakubczyk, T., Glise, H., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200079 · Cited by 32
Moy, A. P., Murali, M. R., & Nazarian, R. M. (2016) · Journal of Cutaneous Pathology · doi:10.1111/cup.12673 · Cited by 30
Pacella, I., Cammarata, I., Focaccetti, C., Miacci, S., Gulino, A., Tripodo, C., Ravà, M., Barnaba, V., & Piconese, S. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0713 · Cited by 31
“In several settings of chronic antigen exposure including cancer, Tbet effector memory CD8þ T cells have been recognized as a heterogeneous population that can be further differentiated, on the basis of Eomes expression, into Tbet Eomes short-term memory precursors, which can give rise to fully differentiated Tbet Eom…”
BackgroundSato, K., Yamamoto, H., Nomura, T., Kasamatsu, J., Miyasaka, T., Tanno, D., Matsumoto, I., Kagesawa, T., Miyahara, A., Zong, T., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901238 · Cited by 29
“The expression of IL-12Rb2 is reported to be increased on Th1 cells and these innate immune lymphocytes upon stimulation with IFN-g (62).”
BackgroundGil-Farina, I., Di Scala, M., Salido, E., López-Franco, E., Rodríguez-García, E., Blasi, M., Merino, J., Aldabe, R., Prieto, J., & Gonzalez-Aseguinolaza, G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600228 · Cited by 30
“The seemingly contradictory result regarding the upregulation of GATA3 and a decrease of Th2 cytokines could be explained by a redistribution of GATA3 from Th2-specific genes to T-bet binding sites upon interaction with T-bet as recently described (21, 22).”
BackgroundNK cells regulate CXCR2+ neutrophil recruitment during acute lung injury
Hoegl, S., Ehrentraut, H., Brodsky, K. S., Victorino, F., Golden‐Mason, L., Eltzschig, H. K., & McNamee, E. N. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0516-227r · Cited by 30
The Regulatory T-cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis
Yang, C., Huang, X., Fung, E., Liu, J., & Lan, H.-Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-01515-8 · Cited by 30
G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment
Sumida, H., & Cyster, J. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00660 · Cited by 30
Bowles, A. C., Wise, R. M., Gerstein, B. Y., Thomas, R. C., Ogelman, R., Manayan, R. C., & Bunnell, B. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1099-3 · Cited by 30
Lee, Y. S., Yeo, I. J., Kim, K. C., Han, S., & Hong, J. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01379 · Cited by 29
“T-bet is critical associated with TREM-1 expression, and it expressed in various immune cells (39, 58).”
Yang, M., Sun, L., Han, J., Zheng, C., Liang, H., Zhu, J., & Jin, T. (2019) · Molecular Brain · doi:10.1186/s13041-019-0532-6 · Cited by 32
“Th1 cells express the transcription factor T-bet that acts as a positive regulator to promote IFN-γ production [134].”
BackgroundThelen, B., Schipperges, V., Knörlein, P., Hummel, J. F., Arnold, F., Kupferschmid, L., Klose, C. S. N., Arnold, S. J., Boerries, M., & Tanriver, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1058267 · Cited by 29
“Frontiers in Immunology 07 receptors and thusmight have a great impact on trafficking of T cells (29).”
BackgroundExpression of T-bet, Eomesodermin and GATA-3 in porcine αβ T cells
Rodríguez-Gómez, I. M., Talker, S. C., Käser, T., Stadler, M., Hammer, S. E., Saalmüller, A., & Gerner, W. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.02.022 · Cited by 29
Dhume, K., Finn, C. M., Strutt, T. M., Sell, S., & McKinstry, K. K. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0183-z · Cited by 29
Ravi, A., Umapathy, S., & Pan, I. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01609-2 · Cited by 34
“This underscores the role of T-bet in linking adaptive and innate immune responses (Lazarevic et al. 2013).”
Mori, H., Kubo, M., Kai, M., Yamada, M., Kurata, K., Kawaji, H., Kaneshiro, K., Osako, T., Nishimura, R., Arima, N., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05256-2 · Cited by 28
Yang, Q., He, Y., Zhang, Q., Mi, Q., & Zhou, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01199 · Cited by 28
“Transcription factor T-bet (encoded by Tbx21) is an immunecell-specific member of the T-box family of transcription factors, which is best known for its role in T helper (Th)1-cell differentiation, but now recognized as having an important role in many cells of the adaptive and innate immune systems (3).”
Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells
Iwata, S., Zhang, M., He, H., Trimova, G., Hajime, M., Miyazaki, Y., Ohkubo, N., Kanda, Y. S., Todoroki, Y., Miyata, H., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.593103 · Cited by 29
Hope, J. L., Stairiker, C. J., Spantidea, P. I., Gracias, D. T., Carey, A. J., Fike, A. J., van Meurs, M., Brouwers-Haspels, I., Rijsbergen, L. C., Fraietta, J. A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01696 · Cited by 27
Recent advances in immune therapies for gastric cancer
Olnes, M. J., & Martinson, H. A. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00310-y · Cited by 28
Azari, H., Karimi, E., Shekari, M., Tahmasebi, A., Nikpoor, A. R., Negahi, A. A., Sanadgol, N., & Mousavi, P. (2021) · Epigenomics · doi:10.2217/epi-2021-0296 · Cited by 26
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
Dwyer, G. K., Mathews, L. R., Villegas, J. A., Lucas, A., de Peredo, A. G., Blazar, B. R., Girard, J., Poholek, A. C., Luther, S. A., Shlomchik, W. D., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci150927 · Cited by 26
“The process of Th1 differentiation involves 2 phases of Tbet expression, a first phase stimulated by TCR engagement and IFN-γ , and a second, IL-12–enforced phase (23).”
Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines
Piconese, S., & Barnaba, V. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-15774-0_2 · Cited by 27
“At later phases of immune responses, CD4 T cells fully polarized into Th1 effectors, expressing high levels of T-bet, partially lose their competence for IL-2 production (Lazarevic et al. 2013).”
BackgroundThe Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis: A Meta-Analysis
Lai, N., Zhang, S., Wang, J., Zhang, J., Wang, C., Gao, C., & Li, X. (2019) · Journal of Immunology Research · doi:10.1155/2019/1058738 · Cited by 27
TCR-signaling events in cellular metabolism and specialization
Chisolm, D. A., & Weinmann, A. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00292 · Cited by 26
Q fever immunology: the quest for a safe and effective vaccine
Sam, G., Stenos, J., Graves, S., & Rehm, B. H. A. (2023) · npj Vaccines · doi:10.1038/s41541-023-00727-6 · Cited by 26
“T-bet is required by DCs for the production of IFN-γ , TNF-α , and activation of antigen-speci fi c T cells 73,74 .”
BackgroundGrant, N. L., Maiello, P. A., Klein, E. C., Lin, P. L., Borish, H. J., Tomko, J. A., Frye, L. J., White, A. G., Kirschner, D. E., Mattila, J. T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110826 · Cited by 26
“…diseases, including TB, revealing its critical function in controlling infection through production of pro-inflammatory mediators, T cell trafficking, and inhibition of other T cell fates (Pritchard et al., 2019; Szabo et al., 2000; Sullivan et al., 2005; Lazarevic et al., 2013; Lord et al., 2005).”
Metadata
- Authors
- Lazarevic, V., Glimcher, L. H., & Lord, G. M.
- Affiliations
- National Institutes of Health (US)
- Weill Cornell Medicine (US)
- King's College London (GB)
- Corresponding author
- Glimcher, Laurie H.
- Venue
- Nature Reviews Immunology
- Published
- 2013-10-11
- Volume
- 13
- Issue
- 11
- Pages
- 777-789
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC6290922
- OpenAlex
- W2055897422
- Cited by
- 486
- References
- 107
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 26 · 2023: 34 · 2022: 40 · 2021: 41 · 2020: 42 · 2019: 36 · 2018: 50 · 2017: 47 · 2016: 48 · 2015: 32 · 2014: 30 · 2013: 2
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (WT088747MA)
- British Heart Foundation (PG/12/36/29444)
- National Institutes of Health
- U.S. Public Health Service (P01NSO38037)
- Medical Research Council (MR/J006742/1)
- National Cancer Institute (R01CA112663, CA112663, ZIABC011431)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- T-bet, transcription factors, innate immunity, adaptive immunity, memory CD8+ T cells, B cells, innate lymphoid cells, dendritic cells, natural killer cells, type 1 immune response, transcriptional regulatory networks, immune cell development
- MeSH terms
- T-bet Transcription Factor, Animals, B-Lymphocytes, Humans, Immunity, Innate, Immunologic Memory, T-Lymphocyte Subsets, T-Box Domain Proteins, Adaptive Immunity
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