Cited by 1,840Immune cells in cancerPhagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

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Monocytes and macrophages: developmental pathways and tissue homeostasis

Ginhoux, Florent, Jung, Steffen·2014·Nature Reviews Immunology

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Abstract

Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies that aim to manipulate these cells will require an in-depth understanding of their origins and the mechanisms that ensure their homeostasis. Recent evidence shows that monocytes do not substantially contribute to most tissue macrophage populations in the steady state or during certain types of inflammation. Rather, most tissue macrophage populations in mice are derived from embryonic precursors, are seeded before birth and can maintain themselves in adults by self-renewal. In this Review, we discuss the evidence that has dramatically changed our understanding of monocyte and macrophage development, and the maintenance of these cells in the steady state.

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Authors: Ginhoux, F., & Jung, S.
Affiliations: Agency for Science, Technology and Research (SG)
Weizmann Institute of Science (IL)
Corresponding author: Ginhoux, Florent
Jung, Steffen
ORCID: Ginhoux, Florent
Jung, Steffen
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2014-05-23
Volume: 14
Issue: 6
Pages: 392-404
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3671
OpenAlex: W2055620105
Cited by: 1,840
References: 123
Citations by year: 2026: 65 · 2025: 135 · 2024: 140 · 2023: 134 · 2022: 160 · 2021: 155 · 2020: 157 · 2019: 181 · 2018: 187 · 2017: 172 · 2016: 160 · 2015: 150 · 2014: 43
FWCI: 17.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: monocytes, tissue macrophages, monocyte development, macrophage ontogeny, tissue homeostasis, self-renewal, inflammation, therapeutic target
MeSH terms: Animals, Birds, Bone Marrow Cells, Dendritic Cells, Hematopoiesis, Homeostasis, Humans, Inflammation, Macrophages, Monocytes, Zebrafish, Mice

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Monocytes and macrophages: developmental pathways and tissue homeostasis

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