Regulation of tumour necrosis factor signalling: live or let die

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840

The ubiquitin code

Komander, D., & Rape, M. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060310-170328 · Cited by 3,679

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046

Signalling pathways of the TNF superfamily: a double-edged sword

Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2/TACE

Zhou, C., Qin, Y., Chen, R., Gao, F., Zhang, J., & Lu, F. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118222 · Cited by 22

The prognostic value of geriatric nutritional risk index in elderly patients with severe community-acquired pneumonia

Wei, L., Xie, H., Li, J., Li, R., Chen, W., Huang, L., Li, X., & Yan, P. (2020) · Medicine · doi:10.1097/md.0000000000022217 · Cited by 22

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

Takigawa, S., Chen, A. B., Nishimura, A., Liu, S., Li, B., Sudo, A., Yokota, H., & Hamamura, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050674 · Cited by 22

Convergent Transcription of Interferon-Stimulated Genes by TNF-A and IFN-A Augments Antiviral Activity against HCV and HEV

Wang, W., Xu, L., Brandsma, J., Wang, Y., Hakim, M. S., Zhou, X., Yin, Y., Fuhler, G. M., van der Laan, L. J. W., van der Woude, C. J., et al. (2016) · Journal of Hepatology · doi:10.1016/s0168-8278(16)00687-5 · Cited by 22

Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model

Luo, S., OuYang, L., Wei, J., Wu, F., Wu, Z., Lei, W., & Yuan, D. (2017) · Korean Journal of Parasitology · doi:10.3347/kjp.2017.55.3.267 · Cited by 22

Genome wide host gene expression analysis in mice experimentally infected with Pasteurella multocida

Priya, G. B., Nagaleekar, V. K., Milton, A. A. P., Saminathan, M., Kumar, A., Sahoo, A. R., Wani, S. A., Kumar, A., Gupta, S. K., Sahoo, A. P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179420 · Cited by 22

Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro

Liu, L., Wei, Z., Fang, R., Li, X., & Li, W. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104315 · Cited by 22

The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets

Verso, L. L., Talbot, G., Morissette, B., Guay, F., Matte, J. J., Farmer, C., Gong, J., Wang, Q., Bissonnette, N., Beaulieu, C., et al. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa208 · Cited by 22

The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration

Kurniawan, H., Nickels, S., Žagare, A., Zuccoli, E., Rosety, I., Gomez‐Giro, G., Glaab, E., & Schwamborn, J. C. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03577-2 · Cited by 21

Inflammation and disease: Modelling and modulation of the inflammatory response to alleviate critical illness

Day, J., Cockrell, C., Namas, R. A., Zamora, R., An, G. C., & Yoram Vodovotz, B. (2018) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2018.08.008 · Cited by 21

Herpes simplex virus 1 ICP6 impedes TNF receptor 1–induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles

Ali, M., Roback, L., & Mocarski, E. S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004651 · Cited by 22

Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection

Morris, D. R., Ansar, M., Ivanciuc, T., Qu, Y., Casola, A., & Garofalo, R. P. (2020) · Viruses · doi:10.3390/v12101176 · Cited by 21

Macrophage Polarization in Chronic Lymphocytic Leukemia: Nurse-Like Cells Are the Caretakers of Leukemic Cells

Mesaros, O., Jimbu, L., Neaga, A., Popescu, C., Berceanu, I., Tomuleasa, C., Fetică, B., & Zdrenghea, M. (2020) · Biomedicines · doi:10.3390/biomedicines8110516 · Cited by 21

Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice

Oliveira, S. R., Dionísio, P. A., Gaspar, M. M., Ferreira, M. B. T., Rodrigues, C. A. B., Gonçalves‐Pereira, R., Estevão, M. S., Perry, M. D. J., Moreira, R., Afonso, C. A. M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105289 · Cited by 21

The Antigastric Cancer Effect of Triptolide is Associated With H19/NF-κB/FLIP Axis

Yuan, W., Huang, J., Hou, S., Li, H., Bie, L., Chen, B., Li, G., Zhou, Y., & Chen, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918588 · Cited by 21

Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart

Wang, J., Tomar, D., Martin, T. G., Dubey, S., Dubey, P. K., Song, J., Landesberg, G. P., McCormick, M. G., Myers, V. D., Merali, S., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.12.013 · Cited by 21

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions

Sharma, S., Singh, N., Turk, A. A., Wan, I., Guttikonda, A., Dong, J. L., Zhang, X., & Opyrchal, M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i13.1815 · Cited by 22

Proinflammatory Cytokines Mediate GPCR Dysfunction

Mohan, M. L., Vasudevan, N. T., & Prasad, S. V. N. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000456 · Cited by 22

Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization

Jo, J.-Y., Im, S. H., Babcock, D. T., Iyer, S. C., Gunawan, F., Cox, D. N., & Galko, M. J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.474 · Cited by 21

Molecular mechanism and therapy application of necrosis during myocardial injury

Xu, T., Ding, W., Tariq, M., Wang, Y., Wan, Q., Li, M., & Wang, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13575 · Cited by 22

Regulation of apoptotic and inflammatory signaling pathways in hepatocellular carcinoma via Caesalpinia gilliesii galactomannan

Megeed, R. M. A., Hamed, A. R., Matloub, A. A., Kadry, M. O., & Abdel‐Hamid, A. Z. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3404-y · Cited by 21

In vitro generation of human monocyte-derived dendritic cells methodological aspects in a comprehensive review

Cechim, G., & Chies, J. A. B. (2019) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201920190310 · Cited by 21

Molecular mechanisms and clinical studies of iguratimod for the treatment of ankylosing spondylitis

Liu, S., Cui, Y., & Zhang, X. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05207-z · Cited by 21

Connecting Immune Cell Infiltration to the Multitasking Microglia Response and TNF Receptor 2 Induction in the Multiple Sclerosis Brain

Veroni, C., Serafini, B., Rosicarelli, B., Fagnani, C., Aloisi, F., & Agresti, C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00190 · Cited by 21

Use of anti-TNF-α therapy in Crohn's disease is associated with increased incidence of multiple sclerosis

Avasarala, J., Guduru, Z., McLouth, C. J., Wilburn, A., Talbert, J., Sutton, P., & Sokola, B. S. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102942 · Cited by 21

Extracellular Matrix-Induced GM-CSF and Hypoxia Promote Immune Control of Mycobacterium tuberculosis in Human In Vitro Granulomas

Arbués, A., Schmidiger, S., Kammuller, M. E., & Portevin, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.727508 · Cited by 20

Cytotoxic activity of anti-mucin 1 chimeric antigen receptor T cells expressing PD-1-CD28 switch receptor against cholangiocarcinoma cells

Supimon, K., Sangsuwannukul, T., Sujjitjoon, J., Chieochansin, T., Junking, M., & Yenchitsomanus, P. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2022.10.006 · Cited by 20

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

Pegoretti, V., Bauer, J., Fischer, R., Paro, I., Douwenga, W., Kontermann, R. E., Pfizenmaier, K., Houben, E., Broux, B., Hellings, N., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02785-y · Cited by 20

Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice

Zhu, Y., Wang, L., Li, J., Zhao, Y., Yu, X., Liu, P., Deng, X.-B., Liu, J., Yang, F., Zhang, Y., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.10.003 · Cited by 21

Pulmonary RNA interference against acute lung injury mediated by mucus- and cell-penetrating nanocomplexes

Zhang, W., Shen, J., Liang, J., Ge, C., Zhou, Y. C., Yin, L., & Ji, Y. I. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.032 · Cited by 20

Hidradenitis Suppurativa: An Understanding of Genetic Factors and Treatment

Chu, Y.-L., & Yu, S. (2024) · Biomedicines · doi:10.3390/biomedicines12020338 · Cited by 20

Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening

Udommethaporn, S., Tencomnao, T., McGowan, E. M., & Boonyaratanakornkit, V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159151 · Cited by 20

Harnessing co-stimulatory TNF receptors for cancer immunotherapy: Current approaches and future opportunities

Waight, J. D., Gombos, R. B., & Wilson, N. S. (2017) · Human Antibodies · doi:10.3233/hab-160308 · Cited by 20

Protective effects of maresin 1 against inflammation in experimentally induced acute pancreatitis and related lung injury

Munir, F., Jamshed, M. B., Shahid, N., Muhammad, S. A., Bhandari, A., & Zhang, Q. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00078.2019 · Cited by 21

The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death

El‐Mesery, M., Rosenthal, T., Rauert‐Wunderlich, H., Schreder, M., Stühmer, T., Leich, E., Schlösser, A., Ehrenschwender, M., Wajant, H., & Siegmund, D. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1860-2 · Cited by 20

Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment

Voskamp, C., Koevoet, W. J. L. M., Somoza, R. A., Caplan, A. I., Lefebvre, V., van Osch, G. J. V. M., & Narcisi, R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00658 · Cited by 20

Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

Sorrentino, A., Menevse, A. N., Michels, T., Volpin, V., Durst, F. C., Sax, J., Xydia, M., Hussein, A., Stamova, S., Spoerl, S., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004258 · Cited by 21

Regulation of Drug-Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses

Morgan, E. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802949-7.00002-x · Cited by 20

Design and synthesis of 1,3-benzothiazinone derivatives as potential anti-inflammatory agents

Li, J., Fan, X., Deng, J., Liang, Y., Ma, S., Lu, Y., Zhang, J., Shi, T., Tan, W., & Wang, Z. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115526 · Cited by 19

Therapeutic potential of TNFR2 agonists: a mechanistic perspective

Chen, Y., Jiang, M., & Chen, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1209188 · Cited by 19

MKL 1 is an epigenetic mediator of TNF ‐α‐induced proinflammatory transcription in macrophages by interacting with ASH 2

Song, M., Fang, F., Dai, X. J., Yu, L., Fang, M., & Xu, Y. (2017) · FEBS Letters · doi:10.1002/1873-3468.12601 · Cited by 20

Tumor necrosis factor-α −308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis

Wang, H., Guo, S., Wan, C., Yang, T., Zeng, N., Wu, Y., Chen, L., Shen, Y., & Wen, F. (2017) · Oncotarget · doi:10.18632/oncotarget.20862 · Cited by 19

Stimulations of the Culture Medium of Activated Microglia and TNF-Alpha on a Scrapie-Infected Cell Line Decrease the Cell Viability and Induce Marked Necroptosis That Also Occurs in the Brains from the Patients of Human Prion Diseases

Ma, Y., Shi, Q., Xiao, K., Wang, J., Chen, C., Gao, L., Gao, C., & Dong, X. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00354 · Cited by 20

Autoantibodies and Cytokines

Khan, W. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.68834 · Cited by 19

Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions

Kuczak, M., Musiał, M., Malarz, K., Rurka, P., Zorębski, E., Musioł, R., Dzida, M., & Mrozek‐Wilczkiewicz, A. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.128160 · Cited by 19

An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice

Javaid, N., Patra, M. C., Cho, D., Batool, M., Kim, Y., Choi, G. M., Kim, M. S., Hahm, D., & Choi, S. (2022) · Science Signaling · doi:10.1126/scisignal.abi8713 · Cited by 19

Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis

Ouahed, J., Griffith, A. E., Collen, L. V., & Snapper, S. B. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad319 · Cited by 18

Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway

Pokharel, S. M., Chiok, K. L., Shil, N. K., Mohanty, I. P., & Bose, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257576 · Cited by 19

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB

Won, M., Park, K. A., Kim, S., Ju, E., Ko, Y. B., Yoo, H. J., Ro, H., Lee, J., Oh, J., Lee, E. G., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00906-9 · Cited by 18

S‐palmitoylation regulates innate immune signaling pathways: molecular mechanisms and targeted therapies

Cai, J., Cui, J., & Wang, L. (2023) · European Journal of Immunology · doi:10.1002/eji.202350476 · Cited by 21

Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling

Gesiorowski, A., Ettich, J., Werner, J., Wittich, C., Pieper, S., Padrini, G., Behnke, K., Floss, D. M., Lang, P. A., Moll, J. M., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105343 · Cited by 18

Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration

Hansman, D., Ma, Y., Thomas, D., Smith, J. R., Casson, R. J., & Peet, D. J. (2024) · Bioscience Reports · doi:10.1042/bsr20231904 · Cited by 18

Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity

Pramanik, S., Harini Devi, M., Chakrabarty, S., Paylar, B., Pradhan, A., Thaker, M., Ayyadhury, S., Manavalan, A., Olsson, P., Pramanik, G., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105834 · Cited by 18

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression

Simon, P. S., Bardhan, K., Chen, M. R., Paschall, A. V., Lu, C., Bollag, R. J., Kong, F.-C., Jin, J., Kong, F., Waller, J. L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8246 · Cited by 18

TNF-αInduced the Enhanced Apoptosis of Mesenchymal Stem Cells in Ankylosing Spondylitis by Overexpressing TRAIL-R2

Liu, Z., Gao, L., Wang, P., Xie, Z., Cen, S., Li, Y., Wu, X., Wang, L., Su, H., Deng, W., et al. (2017) · Stem Cells International · doi:10.1155/2017/4521324 · Cited by 18

miR-181 interacts with signaling adaptor molecule DENN/MADD and enhances TNF-induced cell death

Ghorbani, S., Talebi, F., Ghasemi, S., Jahan‐Abad, A. J., Vojgani, M., & Noorbakhsh, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174368 · Cited by 18

RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway

Li, C.-Z., Jiang, X., Lin, B., Hong, H.-J., Zhu, S., Jiang, L., Wang, X., Tang, N., She, F., & Chen, Y. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s159026 · Cited by 18

Inorganic polyphosphate protects against lipopolysaccharide-induced lethality and tissue injury through regulation of macrophage recruitment

Terashima-Hasegawa, M., Ashino, T., Kawazoe, Y., Shiba, T., Manabe, A., & Numazawa, S. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.017 · Cited by 18

Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology

Li, K. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127717 · Cited by 18

B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor

Yoon, S.-S., & Moon, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137166 · Cited by 18

Electrochemical Nanobiosensors as Point‐of‐Care Testing Solution to Cytokines Measurement Limitations

Pérez, D. J., Patiño, E., & Orozco, J. (2021) · Electroanalysis · doi:10.1002/elan.202100237 · Cited by 18

Network analysis and the impact of Aflibercept on specific mediators of angiogenesis in HUVEC cells

Latifi‐Navid, H., Soheili, Z., Samiei, S., Sadeghi, M., Taghizadeh, S., Pirmardan, E. R., & Ahmadieh, H. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16778 · Cited by 19

Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors

Fang, X., Li, M., Zhang, W., Li, J., & Zhu, T. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.11.012 · Cited by 18

Targeting TNFR2: A Novel Breakthrough in the Treatment of Cancer

Li, M., Zhang, X., Bai, X., & Liang, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.862154 · Cited by 18

Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine

Cao, Q., Mertens, R. T., Sivanathan, K. N., Cai, X., & Xiao, P. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru0322-176r · Cited by 19

Elevation of circulating TNF receptor 2 in cancer: A systematic meta-analysis for its potential as a diagnostic cancer biomarker

Kartikasari, A. E. R., Cassar, E., Razqan, M. A. M., Szydzik, C., Huertas, C. S., Mitchell, A., & Plebanski, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918254 · Cited by 18

TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD

Bikker, R., Christmann, M., Preuß, K., Welz, B., Friesenhagen, J., Dittrich‐Breiholz, O., Huber, R., & Brand, K. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.06.009 · Cited by 18

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling

Siegmund, D., Ehrenschwender, M., & Wajant, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0973-3 · Cited by 18

At The Interface: Small-Molecule Inhibitors of Soluble Cytokines

Raavi, Koehler, A. N., & Vegas, A. J. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00469 · Cited by 18

Fluorescence-Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators

Lo, C. H., Schaaf, T. M., Thomas, D. D., & Sachs, J. N. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1130-2_9 · Cited by 17

Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways

Heluany, C. S., Donate, P. B., Schneider, A. H., Fabris, A. L., Gomes, R. A., Villas-Boas, I. M., Tambourgi, D. V., Silva, T. A., Trossini, G. H. G., Nalesso, G., et al. (2021) · Antioxidants · doi:10.3390/antiox10060929 · Cited by 17

Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Lu, M., Lee, Y., Li, Z., & Lillehoj, H. S. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104374 · Cited by 17

Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor–ligand signaling complex

Zeng, J., Loi, G. W. Z., Saipuljumri, E. N., Duran, M., Silva-García, O., Perez‐Aguilar, J. M., Aguirre, V. M. B., & Lo, C. H. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2308132121 · Cited by 19

Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction

Fan, K., Gökbağ, B., Tang, S., Li, S., Huang, Y., Wang, L., Cheng, L., & Li, L. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae425 · Cited by 17

Monocyte‐Derived Macrophages Induce Alveolar Macrophages Death via TNF‐α in Acute Lung Injury

Xiao, J., Hou, F., Wang, H., Wang, R., Liu, Y., Wu, X., & Xie, L. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.70081 · Cited by 18

Autopsy-proven demyelination associated with infliximab treatment

Bradshaw, M. J., Mobley, B. C., Zwerner, J. P., & Sriram, S. (2016) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000205 · Cited by 17

Systemic delivery of the tumor necrosis factor gene to tumors by a novel dual DNA-nanocomplex in a nanoparticle system

Shukla, V., Dalela, M., Vij, M., Weichselbaum, R. R., Kharbanda, S. M., Ganguli, M., Kufe, D. W., & Singh, H. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.03.004 · Cited by 17

Molluscum Contagiosum Virus MC159 Abrogates cIAP1-NEMO Interactions and Inhibits NEMO Polyubiquitination

Biswas, S., & Shisler, J. L. (2017) · Journal of Virology · doi:10.1128/jvi.00276-17 · Cited by 20

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

Lampl, S., Janas, M. K., Donakonda, S., Brugger, M., Lohr, K., Schneider, A., Manske, K., Sperl, L. E., Klaeger, S., Küster, B., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.06.026 · Cited by 18

FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts

Li, B., Ding, Z., Calbay, O., Li, Y., Li, T., Jin, L., & Huang, S. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00575-x · Cited by 17

Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells

Sulen, A., Gullaksen, S., Bader, L., McClymont, D. W., Skavland, J., Gavasso, S., & Gjertsen, B. T. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.018 · Cited by 17

Manufacture and characterization of anti-inflammatory liposomes from jumbo flying squid ( Dosidicus gigas ) skin phospholipid extraction

Kao, Y.-F., Wu, Y. S., Chou, C., Fu, S., Liu, C., Chai, H., & Chen, Y. (2018) · Food & Function · doi:10.1039/c8fo00767e · Cited by 17

Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling

Zhang, J., Yang, Y., Zhou, S., He, X., Cao, X. D., Wu, C., Hu, H., Qin, J., Wei, G., Wang, H., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0441-3 · Cited by 17

Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis

Deng, Y. L., Sun, Y., Yu, L., Huang, Y., & Chi, P. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02712-0 · Cited by 16

Zafirlukast Is a Promising Scaffold for Selectively Inhibiting TNFR1 Signaling

Vunnam, N., Yang, M., Lo, C. H., Paulson, C. N., Fiers, W. D., Huber, E., Been, M., Ferguson, D. M., & Sachs, J. N. (2023) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.2c00048 · Cited by 16

The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells

Guo, X., Yu, H., Ma, H., Li, H., Li, L., Yan, F., Huang, J., & Li, L. (2023) · The Journal of Toxicological Sciences · doi:10.2131/jts.48.299 · Cited by 16

Targeted Delivery of the Pan‐Inflammasome Inhibitor MM01 as an Alternative Approach to Acute Lung Injury Therapy

García‐Fernández, A., Sancho, M., Garrido, E. M. N., Bisbal, V., Sancenón, F., Martínez‐Máñez, R., & Orzáez, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301577 · Cited by 16

Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells

Inoue, M., Tsuji, Y., Ueno, R., Miyamoto, D., Tanaka, K., Moriyasu, Y., Shibata, S., Okuda, M., Ando, D., Abe, Y., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-40925-9 · Cited by 17

USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells

Gao, B. J., Qiao, Y., Zhu, S., Yang, N., Zou, S.-S., Liu, Y., & Chen, J. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107463 · Cited by 18

A low level of tumor necrosis factor α in tumor microenvironment maintains the self-renewal of glioma stem cells by Vasorin-mediated glycolysis

Zhang, Y., Kang, T., Wang, Y., Song, C., Li, H., Mi, H., Li, Y., Dong, M., Ma, X., Zhu, H., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae147 · Cited by 16

Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition

El-Husseiny, W. M., El‐Sayed, M. A. ‐., El‐Azab, A. S., Alsaif, N. A., Alanazi, M. M., & Abdel‐Aziz, A. A. ‐. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1740695 · Cited by 16

A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice

Kalovyrna, N., Apokotou, O., Boulekou, S., Paouri, E., Boutou, A., & Georgopoulos, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-65378-2 · Cited by 16

ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis

Zeng, T., Gan, J., Liu, Y., Shi, L., Lu, Z., Xue, Y., Xiong, R., Liu, L., Yang, Z., Lin, Y., et al. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00136 · Cited by 16

Discovery of novel indazole-acylsulfonamide hybrids as selective Mcl-1 inhibitors

Wan, Y., Li, Y., Yan, C., Wen, J., & Tang, Z. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104217 · Cited by 16

Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

Cappuccio, L., & Maisse, C. (2020) · Cells · doi:10.3390/cells9122612 · Cited by 17

Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition

Ali, H., Caballero, R. E., Dong, S. X. M., Gajnayaka, N., Vranjkovic, A., Ahmed, D., Iqbal, S., Crawley, A. M., Angel, J. B., Cassol, E., et al. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.4a0220-114rr · Cited by 16

The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma

Takabe, P., Siiskonen, H., Rönkä, A., Kainulainen, K., & Pasonen‐Seppänen, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.811434 · Cited by 16

Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics

Ciuffa, R., Uliana, F., Mannion, J., Mehnert, M., Tenev, T., Marulli, C., Satanowski, A., Keller, L. M. L., Rodilla-Ramírez, P. N., Ori‬‬, A., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117175119 · Cited by 17

Integrating network pharmacology and experimental validation to advance psoriasis treatment: Multi-target mechanistic elucidation of medicinal herbs and natural compounds

Jo, H.-G., Seo, J., Jang, B., Kim, Y., Kim, H., Baek, E., Park, S.-Y., & Lee, D. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103836 · Cited by 15

Gut microbial metabolites in inflammatory bowel disease: immunological mechanisms regulating Treg/Th17 balance and therapeutic potential

Chen, H., Yu, S., Zhang, M., Tian, B., Yang, L., & Lu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1780865 · Cited by 15

Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy

Fischer, R., Kontermann, R. E., & Maier, O. (2015) · Antibodies · doi:10.3390/antib4010048 · Cited by 90

Death by TNF: a road to inflammation

Loo, G., & Bertrand, M. J. M. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00792-3 · Cited by 1,035

Tumor Necrosis Factor Signaling Pathways

Rajput, A., & Ware, C. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30048-7 · Cited by 12

The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

Webster, J. D., & Vucic, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00365 · Cited by 324

Tumour necrosis factor (TNF) receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

MacEwan, D. J. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f334/2019.4 · Cited by 1