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NF-κB at the crossroads of life and death

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Single Nucleotide Polymorphisms in Colitis-Associated Colorectal Cancer: A Current Overview with Emphasis on the Role of the Associated Genes Products

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Ars moriendi: Proteases as sculptors of cellular suicide

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Effects of Azo Dye Adulterated Palm Oil on the Expression of Inflammatory, Functional, Antioxidant Markers and Body Weights in Albino Rats

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Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity‐related hepatic insulin resistance

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Assessment of albumin and overall survival in advanced non-small cell lung cancer patients with anlotinib treatment using generalized additive model: A retrospective cohort study

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Direct Interaction of Minocycline to p47phox Contributes to its Attenuation of TNF-α-Mediated Neuronal PC12 Cell Death: Experimental and Simulation Validation

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Signaling pathways associated with interleukins 12 and 23 and epigenetic mechanism of sequential-specific regulation of expression of related genes by miRNAs as molecular markers for assessing the potential of anti-cytokine therapies

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Single Nucleotide Polymorphisms and Post-operative Complications Following Major Gastrointestinal Surgery: a Systematic Review and Meta-analysis

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The expression pattern of membranous TNF-α is distinct from its intracellular form in breast cancer-draining lymph nodes

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Efeitos agudos e crônicos do exercício físico aeróbio em pacientes com arterite de Takayasu

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Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1Preprint

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Disruption of oncogenic MCL-1-BAX/BAK interaction using integrase inhibitors: insights from a molecular docking and dynamic exploration

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Evaluation of Polystyrene Nanoplastics Induced Cardiotoxicity Under Different Dietary Patterns in Mice

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Unmasking Hemophagocytic Lymphohistiocytosis After Minimal Tumor Necrosis Factor-Alpha (TNF-α) Blockade: An Interplay of Contributing Elements

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Systemic Immune Remodeling in Breast Cancer: Selective Enrichment of TNFR2+ Circulating Lymphocytes in Breast Cancer

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Unlocking the potential of TNF: From biologic agents to small-molecule inhibitors

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Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics

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SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

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The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death

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TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

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Research Progress and Application Prospects of Myogenic Factors Involved in Bone and Fat Formation

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Phytochemical Profiling and Anticancer Potential of Fagonia cretica L. Extracts on Liver Cancer (HepG2) Cells using In vitro and In silico Approaches

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Exploration of some medicinal plants for peptic ulcer disease: In-silico approach for wound management

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Methionine enkephalin upregulates the immune function of RAW264.7 cells to inhibit the infection of Nelson Bay orthoreoviruses

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Toxicity Impacts of Trace-Level of F-53B in Atmospheric Particles: Implications for Low-Exposure Risk Assessment

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A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation

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Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model

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Therapeutic Synergy of Silibinin‐Loaded Nanogel and Low‐Dose Gamma Radiation in Hepatocellular Carcinoma: Emphasis on EMT, Angiogenesis, and Immune Response

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TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers

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Differential Inflammatory Response to Exhaustive Exercise in Trained and Untrained Individuals: Potential Biomarkers of Training Adaptation

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Isoliquiritigenin alleviates ethanol-induced gastric ulcers by modulating the TNF signaling pathway and targeting IL-6

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Synthesis, ADMET, DFT analysis, molecular docking, and multitarget bioactivity of a 2,5-dihydroxybenzaldehyde Schiff base: Insights into antioxidant, anti-inflammatory, and selective anticancer activity

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Plasmin and sterile inflammation jointly drive fatal embryonic liver degeneration in endothelial chromatin remodeler mutant mice

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Methods to Study the Effect of IKK Inhibition on TNF-Inducing Apoptosis and Necroptosis in Cultured Cells

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Inorganic polyphosphate modulates leukocyte accumulation and vascular endothelial cell permeability and ameliorates cecal ligation and puncture-induced lethality

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Isolation, physicochemical, and structure–function relationship of the hydrophobic variant of Fc-fusion proteins that bind to TNF-α receptor, HS002 and HS002A

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Genetic Knock-out of TNFR1 and TNFR2 in a JAK2-V617F Polycythemia Vera Mouse Model

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Jiedu Huoxue Decoction for Cytokine Storm and Thrombosis in Severe COVID-19: A Combined Bioinformatics and Computational Chemistry Approach

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"Recent Advancement on Experimentally Proven Phytopharmaceuticals that Inhibit Vasculature Development, Cancer Cell Invasion and Metastasis"

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Effect of different types of immunosuppressive therapy on the parameters of TNF receptor expression in patients with rheumatoid arthritis

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Naturally occurring plant-derived sulfonated and sulfated saponins from 1983 to 2024

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Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid

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All-trans retinoic acid exacerbates Stevens-Johnson syndrome and toxic epidermal necrolysis via TNF signaling pathways: A network toxicology, molecular docking, and experimental study

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A Boolean network model for invasive thyroid carcinoma

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Drug-Induced Liver Injury and TNFα Signaling: From In Vivo Understanding to In Vitro Testing Approaches

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Effector Mechanisms and Cellular Outputs

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Paradoxical Inflammation in IBD Patients Treated with Anti-Tumor Necrosis Factor Alpha Therapy

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Tumour necrosis factor (TNF) receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

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Model of Cell Activation through TLR4 and TNFR2 Receptors

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In Silico Screening Anticancer of Six Triterpenoids toward miR-494 and TNF-α Targets

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Assessing Neurotoxicant-Induced Inflammation in the Central Nervous System: Cytokine mRNA with Immunostaining of Microglia Morphology

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The TNF Superfamily

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HIV-1 Envelope Glycoprotein 120 Induced Neuroinflammation Does Not Result in Neurocognitive Impairment in An in vivo Rat Model

Kao, C.-C. A. (2015) · TSpace (University of Toronto) · Cited by 1

Dissection of TLR4-Induced Necroptosis Using Specific Inhibitors of Endocytosis and P38 MAPK

Ariana, A. (2017) · uO Research (University of Ottawa) · doi:10.20381/ruor-20249 · Cited by 1

Diarrheagenic Escherichia coli signaling and interactions with host innate immunity and intestinal microbiota

Wang, G. (2017) · K-State Research Exchange (Kansas State University) · Cited by 1

SARS-CoV-2 Exploits Sexually Dimorphic and Adaptive IFN and TNFa Signaling to Gain Entry into Alveolar EpitheliumPreprint

Wang, Y., Gurrapu, S., Chen, H., Laudato, S., Caggiano, E. G., Jiang, Y., Ling, H., & Giancotti, F. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.23.453505 · Cited by 1

Integrated bioinformatics approach to understand immune-related key genes and pathways in chronic spontaneous urticariaPreprint

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Characterisation of red blood cell Phagocytosis and assessment of nanoparticle uptake by Monocytic cells

Jin, Y. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.208148 · Cited by 1

TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neuronsPreprint

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Longitudinal and large-scale monitoring of transcriptome and RBP-RNA interactome in living cells by engineered protein nanocagesPreprint

Hu, L., Xie, G., Wu, Y., Li, Y., Wan, Z.-L., Li, M., Wang, J., & Wang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.13.642977 · Cited by 1

Circulating extracellular vesicles drive microglial senescence and neurodegeneration in Parkinson’s diseasePreprint

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Roles of apoptosis and necroptosis in the onset of chronic pancreatitis

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Investigating the impact of flavonoid metabolites on endothelial function and vascular inflammation

Warner, E. F. (2016) · UEA Digital Repository (University of East Anglia)

The role of NF-κB signalling in T cell homeostasis and function

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Leukocytapheresis Therapy of Inflammatory Bowel Disease

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Avaliação morfofuncional e expressão gênica de Sirt1 no pulmão de camundongos jovens e idosos expostos ao particulado da exaustão de diesel (DEP)

Júnior, G. R. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2017.tde-11052017-145435

Early growth response genes 2 and 3 are potent inhibitors of T-bet function for interferon gamma production in Tcells

Singh, R. K. (2016)

Nouvelles voies de mort cellulaire des hépatocytes

Filliol, A. A., Seyec, J. L., & Samson, M. (2017)

Effects of an Acute High-Volume Isokinetic Intervention on Circulating Levels of TNF-α and STNFR: Influence of Age

Arroyo, E. (2017) · Journal of International Crisis and Risk Communication Research

Efeito de drogas sintéticas inibidoras do fator de necrose tumoral alfa na artrite reumatoide em ratos

Mendes, M. T. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2017.tde-28102017-113448

Tumor Necrosis Factor Inhibition

Papp, K. A., & Nicholas, M. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-66884-0_13

Citoadesão na imunopatogênese da síndrome do desconforto respiratório agudo associado à malária.

Ortolan, L. D. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-14032018-115444

Regulation of ABCB1 expression and activity in porcine brain endothelial cells

Vergara, P. (2016) · Research Explorer (The University of Manchester)

Expression levels of the apoptosis genes FAS, TNFR2, TRAIL, DR3 and DR4/5 in patients with newly diagnosed chronic lymphatic leukemia before and after treatment with fludarabine, cyclophosphamide and rituximab (FCR)

Захаров, С. Г., Голенков, А. К., Misyurin, V. A., Катаева, Е. В., Baryshnikova, M. A., Chuksina, Y. Y., Mitina, T. A., Трифонова, Е. В., Высоцкая, Л. Л., Chernykh, Y. B., et al. (2018) · Almanac of Clinical Medicine · doi:10.18786/2072-0505-2018-46-8-734-741

Avaliação do efeito terapêutico de plasmídeos vacinais contendo o gene da proteína de estresse térmico de 60kDa de Paracoccidioides brasiliensis na paracoccidioidomicose experimental em camundongos

de Souza, I. E. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2019.tde-20112018-111938

Schwann cells promote spontaneous autoimmune peripheral polyneuropathy

Trout, D. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/qwam-gr80

Sodium salicylate effects on prostate cancer aggressiveness and development of prostate cancer spheroids for drug evaluation

Wang, R. (2019) · Cronfa (Swansea University) · doi:10.23889/suthesis.51919

TNF controls a speed-accuracy tradeoff in the apoptotic decision to restrict viral spreadPreprint

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Immunmodulation im Cholesteatom

Leichtle, A., Draf, C., Ryan, A. F., & Bruchhage, K. (2020) · Laryngo-Rhino-Otologie · doi:10.1055/s-0040-1711889

Effects of Time-Doses and Cycle-Doses of Acute Vibration Exposure on Apoptotic Cell Death and TNF-α Signaling in the Vocal Fold Epithelium

Novaleski, C. K. (2016)

Secondary Analysis of Microarray Data Reveals Immune-Related Key Genes and Pathways in Chronic Spontaneous UrticariaPreprint

Su, W., Huang, B., Guan, Y., Wang, J., Wei, Y., Zhao, Y., Ji, J., & Jiao, Q. (2020) · doi:10.21203/rs.3.rs-35480/v1

TNF Drives AKI-to-CKD Transition Downstream of Proximal Tubule EGFR

Abdelmageed, M. M., Kefaloyianni, E., Arthanarisami, A., Khamissi, F. Z., Atkinson, J. J., & Herrlich, A. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.20213210s1177c

TNFR1 is Upregulated and Mediates Apoptosis in Cumulus Cells of Women With Polycystic Ovarian SyndromePreprint

Jiang, Y., Jiang, R., Zhang, P., Yu, Q., Ba, H., & Jin, L. (2021) · Research Square · doi:10.21203/rs.3.rs-596490/v1

Tumour necrosis factor (TNF) receptor family in GtoPdb v.2021.3

MacEwan, D. J. (2021) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f334/2021.3

Systemic Immunosuppression for the Treatment of Pediatric Uveitis

Chaulk, A. L., Miller, C., Barke, M., Goldberg, B., & Goldberg, A. (2021) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000402

Transcriptome analysis of spliceosome inhibition in human cells

Blackmore, A. B. (2020) · doi:10.22215/etd/2020-14072

Faculty Opinions recommendation of The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair.

Anand, P. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736179682.793588171

Amnion Mesenchymal Cells Modulate Acute Inflammatory Response at the Maternal-Fetal Interface in a TNF-Dependent FashionPreprint

Presicce, P., Cappelletti, M., Morselli, M., Ma, F., Senthamaraikannan, P., Nadel, B. B., Miller, L. A., Pellegrini, M. A., Jobe, A. H., Chougnet, C. A., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4049204

Faculty Opinions recommendation of Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis.

Mecsas, J. C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726840938.793562322

Death Receptors

Krammer, P. H., Pietkiewicz, S., & Lavrik, I. N. (2016) · Wiley eBooks · doi:10.1002/9780470015902.a0021571.pub2

Faculty Opinions recommendation of LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.

McDermott, M., & Jarosz-Griffiths, H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734083403.793555176

sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritisPreprint

Zhao, Y., Xuezhi, Y., Li, S., Zhang, B., Li, S., Wang, X., Wang, Y., Jia, C., Chang, Y., & Wei, W. (2021) · Research Square · doi:10.21203/rs.3.rs-695405/v1

Through the looking glass: trypanosome infections in zebrafish : seeing is believing

Dóró, E. (2019) · doi:10.18174/475570

Targeting Cancer through NF-Kb Pathway with Selected Natural Products (β-Elemene, Puerarin and Gypenosides)

Ahmad, B. I. (2020) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2020.10.001472

A RELAÇÃO DA OBESIDADE COM O APARECIMENTO DA NEOPLASIA DE PRÓSTATA

Alves, E. D. (2022) · Literacia Cientifica Editora & Cursos eBooks · doi:10.53524/lit.edt.978-65-84528-08-6/01

Molecular dissection of BV6 induced sensitization of rhabdomyosarcoma spheroids towards NK cell attack

Särchen, V. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.70951

Unidirectional and multidirectional changes in the expression of membrane-bound TNF receptors on immunocompetent cells in rheumatoid arthritis and bronchial asthma

Alshevskaya, A., Zhukova, J., Lopatnikova, J., Sennikova, J. A., Сергеевна, Ш. Н., Александровна, Ч. О., Сизиков, А. Э., Непомнящих, В. М., Demina, D. V., & Sennikov, S. V. (2022) · Immunologiya · doi:10.33029/0206-4952-2022-43-6-632-642

Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy

Fischer, R., Kontermann, R. E., & Maier, O. (2015) · Antibodies · doi:10.3390/antib4010048 · Cited by 90

Death by TNF: a road to inflammation

Loo, G., & Bertrand, M. J. M. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00792-3 · Cited by 1,035

Tumor Necrosis Factor Signaling Pathways

Rajput, A., & Ware, C. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30048-7 · Cited by 12

The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

Webster, J. D., & Vucic, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00365 · Cited by 324

Tumour necrosis factor (TNF) receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

MacEwan, D. J. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f334/2019.4 · Cited by 1