Cited by 1,000Cell death mechanisms and regulationNF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

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Regulation of tumour necrosis factor signalling: live or let die

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Brenner, Dirk, Blaser, Heiko, Mak, Tak W.·2015·Nature Reviews Immunology

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Abstract

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders.

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THE UBIQUITIN SYSTEM
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
The ubiquitin code
Komander, D., & Rape, M. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060310-170328 · Cited by 3,679
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Immunotherapy in colorectal cancer: Rationale, challenges and potential
Ganesh, K., Stadler, Z. K., Cercek, A., Mendelsohn, R. B., Shia, J., Segal, N. H., & Diaz, L. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0126-x · Cited by 1,954
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics
Jang, D.-I., Lee, A.-H., Shin, H.-Y., Song, H.-R., Park, J.-H., Kang, T., Lee, S., & Yang, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052719 · Cited by 1,864
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
Kalliolias, G. D., & Ivashkiv, L. B. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.169 · Cited by 1,453
Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,068
TNF and ROS crosstalk in inflammation
Blaser, H., Dostert, C., Mak, T. W., & Brenner, D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.12.002 · Cited by 1,008
Self-citation
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Re, D. P. D., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 994
Necroptosis: Mechanisms and Relevance to Disease
Galluzzi, L., Kepp, O., Chan, F. K.-M., & Kroemer, G. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100247 · Cited by 740
The cytokine network involved in the host immune response to periodontitis
Pan, W., Wang, Q., & Chen, Q. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0064-z · Cited by 740
Converging roles of caspases in inflammasome activation, cell death and innate immunity
Man, S. M., & Kanneganti, T. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.7 · Cited by 717
Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer
Kong, D.-H., Kim, Y., Kim, M. K., Jang, J. Y., & Lee, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041057 · Cited by 710
Acute Pancreatitis: Diagnosis and Treatment
Szatmary, P., Grammatikopoulos, T., Cai, W., Huang, W., Mukherjee, R., Halloran, C. M., Beyer, G., & Sutton, R. (2022) · Drugs · doi:10.1007/s40265-022-01766-4 · Cited by 684
The role of IL-1β and TNF-α in intervertebral disc degeneration
Wang, Y., Che, M., Xin, J., Zheng, Z. J., Li, J., & Zhang, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110660 · Cited by 634
The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond
Dostert, C., Grusdat, M., Letellier, E., & Brenner, D. (2018) · Physiological Reviews · doi:10.1152/physrev.00045.2017 · Cited by 529
Self-citation
Ubiquitin ligases in oncogenic transformation and cancer therapy
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The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses
Ward-Kavanagh, L. K., Lin, W. W., Šedý, J. R., & Ware, C. F. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.019 · Cited by 463
Signaling pathways and targeted therapies for psoriasis
Guo, J., Zhang, H., Lin, W., Lu, L., Su, J., & Chen, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01655-6 · Cited by 489
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
Yin, H., Zhang, X., Yang, P., Zhang, X., Peng, Y., Li, D., Yu, Y., Wu, Y., Wang, Y., Zhang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21514-8 · Cited by 412
TNF activity and T cells
Mehta, A. K., Gracias, D. T., & Croft, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.003 · Cited by 404
TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
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TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration
Yamashita, M., & Passegué, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.019 · Cited by 387
Tumour necrosis factor signalling in health and disease
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Modes of Regulated Cell Death in Cancer
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Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 357
Selected cytokine pathways in rheumatoid arthritis
Noack, M., & Miossec, P. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0619-z · Cited by 313
Cell Death in Liver Diseases: A Review
Shojaie, L., Iorga, A., & Dara, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249682 · Cited by 309
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
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Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilić, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 290
Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects
Gough, P., & Myles, I. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585880 · Cited by 288
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Josephs, S. F., Ichim, T. E., Prince, S. M., Kesari, S., Marincola, F. M., Escobedo, A. R., & Jafri, A. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1611-7 · Cited by 258
Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications
Álvarez, M. M., Liu, J. C., Santiago, G. T., Cha, B.-H., Vishwakarma, A., Ghaemmaghami, A. M., & Khademhosseini, A. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.026 · Cited by 262
Cytosolic DNA Sensing in Organismal Tumor Control
Vanpouille-Box, C., Demaria, S., Formenti, S. C., & Galluzzi, L. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.05.013 · Cited by 250
Role of tumor necrosis factor-alpha in the central nervous system: a focus on autoimmune disorders
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Orzalli, M. H., & Kagan, J. C. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.05.007 · Cited by 241
Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
Park, S. H., Kang, K., Γιαννοπούλου, Ε., Qiao, Y., Kang, K., Kim, G., Park‐Min, K., & Ivashkiv, L. B. (2017) · Nature Immunology · doi:10.1038/ni.3818 · Cited by 247
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Mulay, S. R., Linkermann, A., & Anders, H. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015040405 · Cited by 233
TNF in the liver: targeting a central player in inflammation
Tiegs, G., & Horst, A. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00910-2 · Cited by 231
Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity
Dufva, O., Koski, J., Maliniemi, P., Ianevski, A., Klievink, J., Leitner, J., Pölönen, P., Hohtari, H., Saeed, K., Hannunen, T., et al. (2020) · Blood · doi:10.1182/blood.2019002121 · Cited by 224
TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death
Borghi, A., Verstrepen, L., & Beyaert, R. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.03.009 · Cited by 226
Cytokine-Induced Modulation of Colorectal Cancer
Mager, L. F., Wasmer, M.-H., Rau, T. T., & Krebs, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00096 · Cited by 223
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Remick, B. C., Gaidt, M. M., & Vance, R. E. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-031732 · Cited by 218
TNFα in Liver Fibrosis
Yang, Y. M., & Seki, E. (2015) · Current Pathobiology Reports · doi:10.1007/s40139-015-0093-z · Cited by 203
Apoptotic Pathways and Alzheimer’s Disease: Probing Therapeutic Potential
Sharma, V., Singh, T. G., Singh, S., Garg, N., & Dhiman, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03418-7 · Cited by 201
Death in the intestinal epithelium—basic biology and implications for inflammatory bowel disease
Blander, J. M. (2016) · FEBS Journal · doi:10.1111/febs.13771 · Cited by 197
MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis
Wu, X., Poulsen, K. L., Sanz‐García, C., Huang, E., McMullen, M. R., Roychowdhury, S., Dasarathy, S., & Nagy, L. E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.023 · Cited by 183
Tumor Necrosis Factor-α in Heart Failure: an Updated Review
Schumacher, S. M., & Prasad, S. V. N. (2018) · Current Cardiology Reports · doi:10.1007/s11886-018-1067-7 · Cited by 179
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Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target
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Host pathogen interactions in Helicobacter pylori related gastric cancer
Chmiela, M., Karwowska, Z., Gonciarz, W., Allushi, B., & Stączek, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i9.1521 · Cited by 178
Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy
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A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models
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Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice
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The TNF–TNFR Family of Co-signal Molecules
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Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury
Mu, J., Li, C., Shi, Y., Liu, G., Zou, J., Zhang, D., Jiang, C., Wang, X., He, L., Huang, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29772-w · Cited by 145
The Role of Cytokines in Predicting the Response and Adverse Events Related to Immune Checkpoint Inhibitors
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Nutritional predictors for postoperative short-term and long-term outcomes of patients with gastric cancer
Kanda, M., Mizuno, A., Tanaka, C., Kobayashi, D., Fujiwara, M., Iwata, N., Hayashi, M., Yamada, S., Nakayama, G., Fujii, T., et al. (2016) · Medicine · doi:10.1097/md.0000000000003781 · Cited by 137
Characterisation of extracellular vesicle‐subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure
Dozio, V., & Sanchez, J. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1302705 · Cited by 137
Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
Guo, Z., Zhang, Z., Prajapati, M., & Li, Y. (2021) · Viruses · doi:10.3390/v13091876 · Cited by 141
Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration
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Risk of Herpes Zoster in Individuals on Biologics, Disease-Modifying Antirheumatic Drugs, and/or Corticosteroids for Autoimmune Diseases: A Systematic Review and Meta-Analysis
Marra, F., Lo, E. A., Kalashnikov, V., & Richardson, K. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw205 · Cited by 122
TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
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Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition
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The Role of TNF-α in Alzheimer’s Disease: A Narrative Review
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Cytokine and chemokine regulation of venous thromboembolism
Najem, M. Y., Couturaud, F., & Lemarié, C. A. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14759 · Cited by 117
Acute inflammation regulates neuroregeneration through the NF-κB pathway in olfactory epithelium
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Neuroimmune Communication in Health and Disease
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Preoperative predictors of postoperative complications after gastric cancer resection
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Importance of TNF-alpha and its alterations in the development of cancers
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Authors: Brenner, D., Blaser, H., & Mak, T. W.
Affiliations: Luxembourg Institute of Health (LU)
University Health Network (CA)
Corresponding author: Brenner, Dirk
ORCID: Brenner, Dirk
Mak, Tak W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-05-26
Volume: 15
Issue: 6
Pages: 362-374
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3834
OpenAlex: W1572664742
Cited by: 998
References: 182
Citations by year: 2026: 52 · 2025: 88 · 2024: 81 · 2023: 97 · 2022: 100 · 2021: 112 · 2020: 107 · 2019: 94 · 2018: 96 · 2017: 84 · 2016: 75 · 2015: 11
FWCI: 8.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
Funders: Fonds National de la Recherche Luxembourg
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: TNF-α, cell survival, apoptosis, regulated necrosis, inflammatory diseases, autoimmune disease, arthritis, inflammatory bowel disease, inflammatory cytokines
MeSH terms: Animals, Autoimmune Diseases, Cell Communication, Homeostasis, Humans, Inflammation, Tumor Necrosis Factor-alpha, NF-kappa B, Apoptosis, Membrane Microdomains, Ubiquitination, Activation, Metabolic

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