Cited by 1,000Cell death mechanisms and regulationNF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 181 of the 182 references it cites were found in a registry or an index.

Regulation of tumour necrosis factor signalling: live or let die

Open access

Brenner, Dirk, Blaser, Heiko, Mak, Tak W.·2015·Nature Reviews Immunology

Open this paper in CoChat — free account Open PDF

Abstract

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri3834

Cites

181 of 181 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

THE UBIQUITIN SYSTEM
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
The ubiquitin code
Komander, D., & Rape, M. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060310-170328 · Cited by 3,679
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

Flagged first, then by citations

Show all 182 references

1 of the 182 references couldn’t be matched to a known paper.

Sorted by citations

Items 701–800 of 1,000

The reducing effect of TNF-α on carbonic anhydrase III gene expression in colon carcinoma and osteosarcoma cells
Türkoğlu, S. A., Okuyan, D., & KOCKAR, F. T. (2025) · Cytotechnology · doi:10.1007/s10616-025-00815-6 · Cited by 5
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1
Zou, T., Liu, R., Wang, G., Wang, G., Jiang, Z., Wang, C., Wang, W., Cai, M., Zhang, S., Cao, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64939-1 · Cited by 5
PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8 + T cell dysfunction
Wu, K., Luo, L., Liu, Y., Wang, K., Zheng, J., Liang, H., Xu, F., Liu, R., Chang, C., Huang, L., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334562 · Cited by 5
Correlation analysis of lung mucosa-colonizing bacteria with clinical features reveals metastasis-associated bacterial community structure in non-small cell lung cancer patients
Wang, W., Liang, X., Kong, H., Yang, Y. P., Xia, Y., Wang, Q., Xia, A., & Geng, J. (2023) · Respiratory Research · doi:10.1186/s12931-023-02420-7 · Cited by 6
Synthesis of cinnamoyl tethered indoline derivatives with anti-inflammatory and antioxidant activities
Liu, Y., Sun, J., Ran, Y., & Zheng, L. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115936 · Cited by 5
Interleukin-10 induces TNF-driven apoptosis and ROS production in salivary gland cancer cells
Скрипник, М. І., Yatsenko, T., Riabets, O., Salama, Y., Skikevych, M., Osada, T., Tobita, M., Takahashi, S., Hattori, K., & Heissig, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31777 · Cited by 5
Interferon-I modulation and natural products: Unraveling mechanisms and therapeutic potential in severe COVID-19
Song, Y., Lu, J., Qin, P., Chen, H., & Chen, L. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.08.005 · Cited by 5
Effect of Exogenous Melatonin on Performance and Mastitis in Dairy Cows
Li, Y., Cheng, Z., Ma, W., Qiu, Y., Liu, T., Nan, B., Li, M., Sun, L., Liu, W., Yin, H., et al. (2024) · Veterinary Sciences · doi:10.3390/vetsci11090431 · Cited by 5
A systematic approach to identify gaps in neuroimmunology: TNF-α and fear learning deficits, a worked example
Heesbeen, E. J., Bijlsma, E. Y., Risseeuw, T. A., Hessel, E. V. S., & Groenink, L. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.027 · Cited by 5
Death and survival of gut CD4 T cells following HIV-1 infection ex vivo
Mickens, K. L., Dillon, S. M., Guo, K., Thompson, A. N., Barrett, B. S., Wood, C., Kechris, K. J., Santiago, M. L., & Wilson, C. C. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae486 · Cited by 5
Human macrophage response to the emerging enteric pathogen Aeromonas veronii : Inflammation, apoptosis, and downregulation of histones
Naidovski, N., Chong, S. K. T., Liu, F., Riordan, S. M., Wehrhahn, M. C., Yuwono, C., & Zhang, L. (2024) · Virulence · doi:10.1080/21505594.2024.2440554 · Cited by 5
AFM‐Based Deep Learning Decodes Human Macrophage Mechanophenotypes
Chen, J., Wu, H., Yang, W., Li, H., Li, Q., Li, S., Liu, Y., Liu, F., Xu, Y., Chang, Y., et al. (2025) · Small Methods · doi:10.1002/smtd.202500953 · Cited by 5
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion
Levy, S. C., Antunes, L. A. A., de Abreu, J. G. B., Nascimento, J. A. S., Kuntz, A. C., Fialho, W. L. S., Rodrigues, A. S., Teixeira, E. C., Calasans‐Maia, J. D. A., de Araújo, M. C., et al. (2019) · Brazilian Dental Journal · doi:10.1590/0103-6440201902367 · Cited by 5
Activation of GSK3 Prevents Termination of TNF-Induced Signaling
Welz, B., Bikker, R., Hoffmeister, L., Diekmann, M., Christmann, M., Brand, K., & Huber, R. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300806 · Cited by 5
Protective Effect of Citrus Medica limonum Essential Oil against Escherichia coli K99-Induced Intestinal Barrier Injury in Mice
Tang, W., Zhang, Z., Nie, D., Li, Y., Liu, S., & Li, Y. (2023) · Nutrients · doi:10.3390/nu15122697 · Cited by 5
Uncovering the pharmacological mechanism of Shou Tai Wan on recurrent spontaneous abortion: A integrated pharmacology strategy-based research
Yang, K., Zeng, L., Li, Y., Wu, L., Xiang, W., Wu, X., Wang, G., Bao, T., Huang, S., Yu, R., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117589 · Cited by 5
Posttranslational Modifications and Death Receptor Signalling
Micheau, O. (2017) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-56805-8_11 · Cited by 6
Recombinant expression, purification and bioactivity characterization of extracellular domain of human tumor necrosis factor receptor 1
Zhang, C., An, L., Wang, R., Cao, Y. W., Jiang, H., Ouyang, S., Ma, X., & Lu, Y. (2018) · Protein Expression and Purification · doi:10.1016/j.pep.2018.11.002 · Cited by 5
Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision
Eguida, M., & Rognan, D. (2021) · Journal of Cheminformatics · doi:10.1186/s13321-021-00567-3 · Cited by 6
Validation of immunogenic PASD1 peptides against HLA-A*24:02 colorectal cancer
Soh, J. E. C., Abu, N., Sagap, I., Mazlan, L., Yahaya, A., Mustangin, M., Khoo, T. S., Saidin, S., Ishak, M., Mutalib, N. A., et al. (2019) · Immunotherapy · doi:10.2217/imt-2019-0073 · Cited by 5
Innate Immunity in Inflammation
Cignarella, A., & Bolego, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-77658-3_7 · Cited by 5
Switching from TNF-induced inflammation to death signaling
Xu, Q., Choksi, S., & Liu, Z. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1392402 · Cited by 5
Effect of TNFα stimulation on expression of kidney risk inflammatory proteins in human umbilical vein endothelial cells cultured in hyperglycemia
Md Dom, Z. I., Pipino, C., Krolewski, B., O’Neil, K., Satake, E., & Krolewski, A. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-90496-w · Cited by 4
Anti-tumor necrosis factor therapy in the treatment of systemic autoinflammatory diseases: the responses of innate immune cells
Wang, S., Xiao, R., Chen, Y., Ye, Y., He, T., Yang, Y., Chen, X., & Chou, C. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf026 · Cited by 4
Anti-inflammatory and barrier repair mechanisms of active components in Daemonorops draco Bl. for UVB-induced skin damage
Wu, X., Zhang, Y., Yi, F., Geng, Z., Guo, M., Ling, X., Li, J., & Li, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-01289-4 · Cited by 4
Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma
Pang, Q. Y., Novera, W., Koh, L., Chong, Y. K., Lim, S. W., Sim, N. L., Rizzetto, S., Liu, J., Lin, X., Ang, S. Y. L., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf145 · Cited by 4
Modeling of kidney allograft rejection using hiPSC-derived kidney organoids and HLA-mismatched PBMCs: an in vitro co-culture system
Lim, S. W., Cui, S., Fang, X., Na, D.-H., Lee, H., Shin, Y., Kang, H., Oh, E., & Chung, B. H. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05867-7 · Cited by 4
HIV-Induced Apoptosis: Host Defense and Viral Strategy
Chisompola, D., Mwansa, P., Nzobokela, J., Ameka, M., Kirabo, A., Hinton, A. O., Jr., & Masenga, S. K. (2025) · Biology · doi:10.3390/biology14121680 · Cited by 5
Associations between plasma proteins and psychological wellbeing: evidence from over 20 years of the English Longitudinal Study of Ageing
Gong, J., Scholes, S., Cole, S., Zaninotto, P., & Steptoe, A. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03401-6 · Cited by 4
TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma
Dang, T., Chang, Z., Meng, J., Cui, X., Wang, P., & Chai, J. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155728 · Cited by 4
CPT-11 mitigates autoimmune diseases by suppressing effector T cells without affecting long-term anti-tumor immunity
Liang, H., Fan, X., Cheng, H., Ma, X., Sun, Y., Nan, F., Zhou, J., Shu, P., Zhang, W., Zuo, F., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01983-8 · Cited by 4
Soluble Plasma Proteins of Tumor Necrosis Factor and Immunoglobulin Superfamilies Reveal New Insights into Immune Regulation in People with HIV and Opioid Use Disorder
Ghanta, P. P., Dang, C. M., Nelson, C. M., Feaster, D. J., Forrest, D. W., Tookes, H., Pahwa, R. N., Pallikkuth, S., & Pahwa, S. G. (2024) · Vaccines · doi:10.3390/vaccines12050520 · Cited by 4
New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation
Xu, Y., Wang, X., Wang, Y., Guo, L., Zhao, X., Dong, M., Wen, J., Wu, Z., Li, C., Mu, W., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34591 · Cited by 4
Tob negatively regulates NF-κB activation in breast cancer through its association with the TNF receptor complex
Tokumasu, M., Sato, A., Ito-Kureha, T., Yamamoto, M., Ohmine, N., Semba, K., Inoue, J., & Yamamoto, T. S. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00897-6 · Cited by 4
Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies
Altaf, A., Kiran, A., Sarwar, M., Maqbool, T., Sharif, S., Iqbal, H., Farooq, S., Ali, Q., Han, S., & Ahmad, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321445 · Cited by 4
Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway
Yang, Y., Deng, J., Liu, P., He, J., Tan, J., Yu, B., Bai, Y., Luo, F., Xu, J., & Zhang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1525922 · Cited by 4
Analysis of In Silico Properties and In Vitro Immunomodulatory Effects of Seven Synthetic Host Defence Peptides in Gilthead Seabream (Sparus aurata) Leucocytes
Marín-Parra, C., Serna-Duque, J. A., Espinosa‐Ruíz, C., & Esteban, M. Á. (2025) · Marine Biotechnology · doi:10.1007/s10126-025-10488-z · Cited by 4
Sustained secretion of anti‐tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis
Zafir‐Lavie, I., Miari, R., Sherbo, S., Krispel, S., Tal, O., Liran, A., Shatil, T., Badinter, F., Goltsman, H., Shapir, N., et al. (2017) · The Journal of Gene Medicine · doi:10.1002/jgm.2965 · Cited by 4
Preclinical Safety Assessment of 2 Inhaled Single-Domain Antibodies in the Cynomolgus Monkey
Haworth, R., Boyle, M., Edwards, P., Gupta, R., Fagg, R., Karantabias, G., & Price, M. (2020) · Toxicologic Pathology · doi:10.1177/0192623320972387 · Cited by 4
Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular docking
Zhang, H., Xu, Z., Gao, H., & Zhang, Q. (2023) · Biotechnology Letters · doi:10.1007/s10529-023-03359-x · Cited by 4
Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus
Fu, W., Xie, Z., Bai, M., Zhang, Z., Zhao, Y., & Tian, J. (2023) · Proteome Science · doi:10.1186/s12953-023-00205-w · Cited by 4
Facts and Hopes on Neutralization of Protumor Inflammatory Mediators in Cancer Immunotherapy
Olivera, I., Luri‐Rey, C., Teijeira, Á., Eguren‐Santamaría, I., Gomis, G., Palencia, B., Berraondo, P., & Melero, I. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3653 · Cited by 4
The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements
Wu, Y., Li, Y., Wu, T., & Yang, H. (2024) · Cancer Insight · doi:10.58567/ci03020005 · Cited by 4
Therapeutics as Control: Model-Based Control Discovery for Sepsis
An, G. C., Cockrell, C., & Day, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-56510-7_5 · Cited by 4
Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids
Kleijn, K. M. A. D., Straasheijm, K. R., Zuure, W. A., & Martens, G. J. M. (2022) · Biomedicines · doi:10.3390/biomedicines10051025 · Cited by 5
Peran sitokin dalam kerusakan saraf pada penyakit kusta: Tinjuan Pustaka
Darmaputra, I. G. N., & Ganeswari, P. A. D. (2018) · Intisari Sains Medis · doi:10.15562/ism.v9i3.328 · Cited by 4
The potential mechanism of the Ruhao Dashi formula in treating acute pneumonia via network pharmacology and molecular docking
Yi, X.-X., Zhou, H., He, Y. T., Yang, C., Yu, L., Wan, H., & Chen, J. (2023) · Medicine · doi:10.1097/md.0000000000033276 · Cited by 4
Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease
Woo, S., Gandhi, S., Ghincea, A., Saber, T., Lee, C., & Ryu, C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1254904 · Cited by 4
Cancer Stem Cells: An Ever-Hiding Foe
Wilczyński, J. R. (2022) · Experientia supplementum · doi:10.1007/978-3-030-91311-3_8 · Cited by 4
ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells
Lumsden, A. L., Ma, Y., Ashander, L. M., Stempel, A. J., Keating, D. J., Smith, J. R., & Appukuttan, B. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3384-8 · Cited by 4
Suramin protects from cisplatin-induced acute kidney injury.
Dupre, T. V. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2217 · Cited by 4
P2Y12 signaling in muscle satellite cells contributes to masseter muscle contraction-induced pain
Sawada, S., Hitomi, S., Hayashi, Y., Yoshikawa, K., Yagasaki, F., Shinozuka, H., Yonehara, Y., Tsuboi, Y., Iwata, K., & Shinoda, M. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105360 · Cited by 3
Orthogonal Host–Guest Interactions Enable Programming of Protocell Membranes for Cellular High-Order Assembly and Enhanced Immunogenicity
Xiong, S., Mukwaya, V., Yu, X., Zeng, Y., Wang, L., Zhao, W., & Dou, H. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c20476 · Cited by 3
The Importance of TNF-α Signaling – Potential Risk Factor in Neurodegenerative and Cardiovascular Diseases
Marta, B., Białecka, M. A., Machoy‐Mokrzyńska, A., Malinowski, D., & Rać, M. E. (2025) · Archives of Medical Science · doi:10.5114/aoms/201446 · Cited by 3
Effects of Carotenoid Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Ye, X., & Li, Y. (2025) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2024-0256 · Cited by 3
Immunopathology in PMM2-CDG: Defective glycosylation impact in the TNFα -TNFR1 signalling pathway
Pascoal, C., Granjo, P., Kodríková, R., Falcão, M., Santos, A. C. V., Teodoro, I., Pakanová, Z., Nemčovič, M., Mucha, J., Castro‐Caldas, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1655354 · Cited by 3
USP13 depletion sensitizes colorectal cancer cells to necroptosis by destabilizing cIAP2 proteins
Kim, Y. J., Das, T., Park, J., Hwang, I., Kim, E. E., & Song, E. J. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01595-4 · Cited by 3
METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification
He, D., Jiang, X.-K., Guo, G., Ma, J.-F., Chen, J., Zhang, Y., Zhuang, J.-F., Xie, P., & Zhang, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1717319 · Cited by 3
A Case-Based Literature Review of RELA Associated Inflammatory Diseases
Karaçayır, N., Yazol, M., Yayla, E. N. S., Şenol, P. E., Yıldız, Ç., Belder, N., Kutlar, M., Küçükali, B., Acun, B., Yıldırım, D. G., et al. (2026) · Journal of Clinical Immunology · doi:10.1007/s10875-025-01968-x · Cited by 3
Circulating tumor necrosis factor α in deceased donors promotes kidney injury and associates with inferior short- and long-term graft function and survival
Fawaz, S., Hartling, I. G., Michelakis, I., Vaughan, R. H., Ploeg, R. J., Sharples, E. J., Charles, P. D., & Kaisar, M. E. (2026) · American Journal of Transplantation · doi:10.1016/j.ajt.2026.01.023 · Cited by 3
Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells
Ying, C., Wang, D., Zeng, S.-Y., Jin, C.-M., Ying, M., & Hu, X. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01786-w · Cited by 3
Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies
Segués, A., van Duijnhoven, S. M. J., Paradé, M., Driessen-Engels, L., Vukovic, N., Zaiss, D. M. W., Sijts, A. J. A. M., Berraondo, P., & van Elsas, A. (2021) · Journal of Immunological Methods · doi:10.1016/j.jim.2021.113173 · Cited by 3
Correlation of Increased Soluble Tumor Necrosis Factor Receptor 1 with Mortality and Dependence on Treatment in Non-Small-Cell Lung Cancer Patients: A Longitudinal Cohort Study
Hassan, L., Bedir, A., Kraus, F. B., Ostheimer, C., Vordermark, D., Mikolajczyk, R., Seliger, B., & Medenwald, D. (2024) · Cancers · doi:10.3390/cancers16030525 · Cited by 3
Decoy peptides that inhibit TNF signaling by disrupting the TNF homotrimeric oligomer
Javaid, N., Ahmad, S. B., Patra, M. C., & Choi, S. (2024) · FEBS Journal · doi:10.1111/febs.17220 · Cited by 3
Recent advances of small-molecule Mcl-1 inhibitors or degraders as promising anti-cancer agents (2018-present)
Chen, H., Yan, Z., Xiao, C., Tang, Z., & Wan, Y. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118079 · Cited by 5
Cell Injury and Necrosis
d’Avila, J. C., Levin, S., & Radi, Z. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64220-4 · Cited by 3
Autoimmune diseases and ubiquitin system
Oshima, S. (2017) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.40.442 · Cited by 3
Regulated Cell Death
Land, W. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-78655-1_19 · Cited by 3
TNF-TNFR1 Signaling Enhances the Protection Against Neospora caninum Infection
França, F. B. F., Silva, M. V., Silva, M. F., Ramos, E. L. P., Miranda, V. D. S., Mota, C. M., Santiago, F. M., Mineo, J. R., & Mineo, T. W. P. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.789398 · Cited by 3
Programmed cell death and liver diseases
Онищенко, Н. А., Гоникова, З. З., Nikolskaya, A. O., Кирсанова, Л. А., & Sevastianov, V. I. (2022) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2022-1-72-88 · Cited by 3
Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice
Wang, X., Lü, M., Gu, H., Xiao, T., Hu, G., Luo, M., Guo, X., & Xia, Y. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.039 · Cited by 3
Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine
Nedospasov, S. A., Kruglov, A., Tumanov, A. V., Drutskaya, M. S., Astrakhantseva, I. V., & Kuprash, D. V. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924050067 · Cited by 3
The hemostatic activity and Mechanistic roles of glucosyloxybenzyl 2-isobutylmalate extract (BSCE) from Bletilla striata (Thunb.) Rchb.f. in Inhibiting pulmonary hemorrhage
Liu, G., Mu, K., Ran, F., Liu, J., Zhou, L., Peng, L., Guo, F., Liu, Y., Wei, F.-D., Zhu, L.-L., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38203 · Cited by 3
TNF-induced chronic inflammation does not affect tumorigenesis driven by p53 loss
Lacey, D. C., Strasser, A., & Bouillet, P. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.470 · Cited by 3
Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs)
Land, W. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-78655-1_14 · Cited by 3
Active Human and Murine Tumor Necrosis Factor α Cytokines Produced from Silkworm Baculovirus Expression System
Ebihara, T., Xu, J. C., Tonooka, Y., Nagasato, T., Kakino, K., Masuda, A., Minamihata, K., Kamiya, N., Nakatake, H., Chieda, Y., et al. (2021) · Insects · doi:10.3390/insects12060517 · Cited by 3
Immunopathogenesis of erythema nodosum leprosum
Indah, M. S., & Karmila, I. G. A. A. D. (2021) · Intisari Sains Medis · doi:10.15562/ism.v12i3.1134 · Cited by 3
Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules
Emadi, A., Tomasz Lipniacki, B., Levchenko, A., & Abdi, A. (2023) · Biology · doi:10.3390/biology12121461 · Cited by 3
Evolution of Small-Molecule Immunology Research—Changes Since CMC II
Dhar, T. G. M., & Dyckman, A. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12401-1 · Cited by 3
Monitoring RIPK1 Phosphorylation in the TNFR1 Signaling Complex
Priem, D., Dondelinger, Y., & Bertrand, M. J. M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8754-2_17 · Cited by 4
Hematopoietic Stem Cell Stress and Regeneration
Termini, C. M., & Chute, J. P. (2020) · Current Stem Cell Reports · doi:10.1007/s40778-020-00181-3 · Cited by 5
As a matter of fat: Emerging roles of lipid‐sensitive E3 ubiquitin ligases
Gawden‐Bone, C. M., Lehner, P. J., & Volkmar, N. (2023) · BioEssays · doi:10.1002/bies.202300139 · Cited by 2
Traditional Chinese Herbal Medicine: Therapeutic Potential in Chronic Obstructive Pulmonary Disease
Shi, Q., Liu, X., Shengbu, M., Jiaqiu, S., & Lai, X. (2024) · Natural Product Communications · doi:10.1177/1934578x241293922 · Cited by 2
Streptococcal pyrogenic exotoxin a induces regulatory T cells via TNF-α-TNFR2 signaling
Lu, C., Ma, J., Lin, M.-C., Wu, C.-J., Kuo, C.-Y., Chiang-Ni, C., & Kuo, M. (2025) · Medical Microbiology and Immunology · doi:10.1007/s00430-025-00835-1 · Cited by 2
Potential disease-related risk of saccharin in ovarian cancer: An integrative multi-evidence analysis
Song, Y. S., Yang, H., Wang, Y., Lin, C., & Wang, X. (2025) · Reproductive Toxicology · doi:10.1016/j.reprotox.2025.109044 · Cited by 2
Exploring potential targets and molecular mechanisms of traumatic brain injury exacerbated by Benzo(a)pyrene via network toxicology and molecular dynamics simulation
Hu, H., Hu, Y., Wan, S., Wang, Q., & Li, H. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10109-4 · Cited by 2
Decoding necrosome assembly: harmonizing signal amplification and attenuation through optimal RIP3 stoichiometry
Li, X., Cao, Y., Xu, F., Zhang, Y., Kong, Y., Lan, C., Zhu, R., Lin, C., Zhong, C., Liu, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67098-5 · Cited by 2
Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death
Kawamura, K., Ono, K., Mishima, E., Hashizume, O., Conrad, M., Miki, H., & Funato, Y. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116964 · Cited by 2
What we thought we knew about TNF—And what we now must re-learn
Nilsson, A. R. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102827 · Cited by 2
Fabrication of Electrospun PCL/PEO Microfibers with Fe 3 O 4 Nanoparticles for Magnetic Hyperthermia: Immunocompatibility Assessment Using CD14+ Monocytes, CD4+ and CD8+ T Cells, and CD56+ NK Cells In Vitro
Radoń, A., Deręgowska, A., Ciuraszkiewicz, A., Hawełek, Ł., Spałek, H., Warski, T., Hudecki, A., Łukowiec, D., Piotrowski, P., Krogul-Sobczak, A., et al. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c02218 · Cited by 2
Ginger-derived nanoparticles targeting NF-κB mediated inflammatory pathways: a systematic review of in vitro and in vivo evidence
Wirattami, A. T., Handono, K., Handoko, E., & Nugrahenny, D. (2026) · Future Science OA · doi:10.1080/20565623.2026.2657522 · Cited by 2
Receptor interacting protein 1 knockdown induces cell death in liver cancer by suppressing STAT3/ATR activation in a p53-dependent manner.
Jung, S.-Y., Park, J., Jeong, J., Song, K., Ahn, J., Hwang, S., Kim, J., Park, J.-K., Lim, D., & Song, J. Y. (2022) · PubMed Central · Cited by 2
The Role of TNF-α in Rheumatoid Arthritis
Feng, T. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v36i.6210 · Cited by 2
Albicanol antagonizes PFF-induced mitochondrial damage and reduces inflammatory factors by regulating innate immunity
Xuan, L., Guo, J., Xia, D., Li, L., Wang, D., & Chang, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115014 · Cited by 2
Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment
Gong, B., Jia, W., Zhou, Y., Xu, Y., Ya, W., & Gao, H. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300061 · Cited by 2
Soluble B7 and TNF family in colorectal cancer: Serum level, prognostic and treatment value
Monfared, M. S., Nazmi, S., Parhizkar, F., & Jafari, D. (2025) · Human Immunology · doi:10.1016/j.humimm.2025.111232 · Cited by 2
The cancer-associated SF3B1K700E spliceosome mutation confers enhanced sensitivity to BV-6-induced cytotoxicity
Roets, L. E., Blayney, J. K., McMillan, H. P., Preston, P. J., Mutch, A., Mills, K., Savage, K. I., & Lappin, K. M. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07790-y · Cited by 2
Biopharmaceutical molecules
Benyahia, B., Brumano, L. P., Pessoa, A., & da Silva, F. V. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-444-64301-8.00002-0 · Cited by 2
Role of trigeminal ganglion satellite glial cells in masseter muscle pain hypersensitivity
Sawada, S., Hitomi, S., Hayashi, Y., Shinozuka, H., Yonehara, Y., Iwata, K., & Shinoda, M. (2024) · Journal of Oral Biosciences · doi:10.1016/j.job.2024.100596 · Cited by 2
Cellular Inflammatory Responses
Land, W. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-78655-1_22 · Cited by 2

Authors: Brenner, D., Blaser, H., & Mak, T. W.
Affiliations: Luxembourg Institute of Health (LU)
University Health Network (CA)
Corresponding author: Brenner, Dirk
ORCID: Brenner, Dirk
Mak, Tak W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-05-26
Volume: 15
Issue: 6
Pages: 362-374
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3834
OpenAlex: W1572664742
Cited by: 998
References: 182
Citations by year: 2026: 52 · 2025: 88 · 2024: 81 · 2023: 97 · 2022: 100 · 2021: 112 · 2020: 107 · 2019: 94 · 2018: 96 · 2017: 84 · 2016: 75 · 2015: 11
FWCI: 8.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
Funders: Fonds National de la Recherche Luxembourg
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: TNF-α, cell survival, apoptosis, regulated necrosis, inflammatory diseases, autoimmune disease, arthritis, inflammatory bowel disease, inflammatory cytokines
MeSH terms: Animals, Autoimmune Diseases, Cell Communication, Homeostasis, Humans, Inflammation, Tumor Necrosis Factor-alpha, NF-kappa B, Apoptosis, Membrane Microdomains, Ubiquitination, Activation, Metabolic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of tumour necrosis factor signalling: live or let die

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks