Molecular and cellular insights into T cell exhaustion

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320

The blockade of immune checkpoints in cancer immunotherapy

Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838

Nivolumab plus Ipilimumab in Advanced Melanoma

Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057

Regulation of type I interferon responses

Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes

Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103

Cancer Immunosurveillance by T Cells

Rao, S., Gharib, K., & Han, A. S. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.08.001 · Cited by 60

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer

Looney, T. J., Topacio-Hall, D., Lowman, G., Conroy, J. M., Morrison, C., Oh, D. Y., Fong, L. H., & Zhang, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02985 · Cited by 58

Impact of chronic obstructive pulmonary disease on immune checkpoint inhibitor efficacy in advanced lung cancer and the potential prognostic factors

Zhou, J., Chao, Y., Yao, D., Ding, N., Li, J., Gao, L., Zhang, Y., Xu, X., Zhou, J., Halmos, B., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-214 · Cited by 58

Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

Wu, S.-Y., Liao, P., Yan, L.-Y., Zhao, Q.-Y., Xie, Z., Dong, J., & Sun, H. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01984-2 · Cited by 60

Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Costa, P. A. C., da Silva, W. N., Prazeres, P. H. D. M., Picoli, C. C., Guardia, G. D. A., Costa, A. C., Oliveira, M. D. A., Guimarães, P. P. G., Gonçalves, R., Pinto, M. C. X., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01273-9 · Cited by 59

TCR-sequencing in cancer and autoimmunity: barcodes and beyond

Pauken, K. E., Lagattuta, K. A., Lu, B. Y., Lucca, L. E., DAUD, A. I., Hafler, D. A., Kluger, H. M., Raychaudhuri, S., & Sharpe, A. H. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.01.002 · Cited by 60

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

Kaneko, N., Boucau, J., Kuo, H.-H., Perugino, C. A., Mahajan, V. S., Farmer, J. R., Liu, H., Diefenbach, T. J., Trocha, A. K., Lefteri, K., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.108991 · Cited by 58

Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies

Ta, T. M., Malik, S., Anderson, E. M., Jones, A. D., Perchik, J., Freylikh, M., Sardo, L., Klase, Z. A., & Izumi, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.862270 · Cited by 61

Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells

Meng, X., Layhadi, J. A., Keane, S. T., Cartwright, N., Durham, S. R., & Shamji, M. H. (2023) · Asia Pacific Allergy · doi:10.5415/apallergy.0000000000000128 · Cited by 70

Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model

Waugh, K. A., Leach, S. M., Moore, B. L., Bruno, T. C., Buhrman, J. D., & Slansky, J. E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600589 · Cited by 59

Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model

Dyck, L., Wilk, M. M., Raverdeau, M., Misiak, A., Boon, L., & Mills, K. H. G. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1906-6 · Cited by 60

Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer

Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G., Ilyas, M., & Eremin, O. (2016) · Journal of Immunology Research · doi:10.1155/2016/4757405 · Cited by 60

Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival

Markowitz, G. J., Havel, L. S., Crowley, M. J. P., Ban, Y., Lee, S. B., Thalappillil, J. S., Narula, N., Bhinder, B., Elemento, O., Wong, S. T. C., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.96836 · Cited by 59

Molecular phenotype of kidney transplant indication biopsies with inflammation in scarred areas

Halloran, P. F., Matas, A. J., Kasiske, B. L., Madill-Thomsen, K. S., Mackova, M., & Famulski, K. S. (2018) · American Journal of Transplantation · doi:10.1111/ajt.15178 · Cited by 58

CAR T cells and checkpoint inhibition for the treatment of glioblastoma

Shen, S. H., Woroniecka, K. I., Barbour, A. B., Fecci, P. E., Sanchez-Perez, L. A., & Sampson, J. H. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1727436 · Cited by 62

Combination Strategies for Immune-Checkpoint Blockade and Response Prediction by Artificial Intelligence

Huemer, F., Leisch, M., Geisberger, R., Melchardt, T., Rinnerthaler, G., Zaborsky, N., & Greil, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082856 · Cited by 60

Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway

Li, N., Tang, N., Cheng, C., Hu, T., Wei, X., Han, W., & Wang, H. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1824643 · Cited by 58

Targeting immunometabolism in host defence against Mycobacterium tuberculosis

Sheedy, F. J., & Divangahi, M. (2020) · Immunology · doi:10.1111/imm.13276 · Cited by 62

Tumor immune microenvironment-based classifications of bladder cancer for enhancing the response rate of immunotherapy

Meng, J., Lu, X., Zhou, Y., Zhang, M., Ge, Q., Zhou, J., Hao, Z., Gao, S., Yan, F., & Liang, C. Y. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.02.001 · Cited by 57

Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

Huaux, F., de Bousies, V. D., Parent, M.-A., Orsi, M., Uwambayinema, F., Devosse, R., Ibouraadaten, S., Yakoub, Y., Panin, N., Palmai‐Pallag, M., et al. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0158-0 · Cited by 59

Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma

Liu, F., Liu, W., Zhou, S. Y., Yang, C., Tian, M., Jia, G., Wang, H., Zhu, B., Feng, M., Lü, Y., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000501 · Cited by 58

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

Soon, M. S. F., Lee, H. J., Engel, J. A., Straube, J., Thomas, B. S., Pernold, C. P. S., Clarke, L. S., Laohamonthonkul, P., Haldar, R., Williams, C. G., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0800-8 · Cited by 56

Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing

Wang, P., Jin, X., Zhou, W., Luo, M., Xu, Z., Xu, C., Li, Y., Ma, K., Cao, H., Huang, Y., et al. (2020) · Genomics · doi:10.1016/j.ygeno.2020.12.036 · Cited by 57

The therapeutic landscape of hepatocellular carcinoma

Gallage, S., Beccaria, M. G., Szydlowska, M., Rahbari, M., Mohr, R. U., Tacke, F., & Heikenwälder, M. F. (2021) · Med · doi:10.1016/j.medj.2021.03.002 · Cited by 61

CD4+ T-cell epitope-based heterologous prime-boost vaccination potentiates anti-tumor immunity and PD-1/PD-L1 immunotherapy

Xiao, M., Xie, L., Cao, G., Lei, S., Wang, P., Wei, Z., Luo, Y., Fang, J., Yang, X., Huang, Q., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004022 · Cited by 59

Tissue‐resident memory T cells and lung immunopathology

Cheon, I. S., Son, Y. M., & Sun, J. (2023) · Immunological Reviews · doi:10.1111/imr.13201 · Cited by 64

Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta

O’Connor, R. A., Martinez, B. R., Koppensteiner, L., Mathieson, L., & Akram, A. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1221532 · Cited by 63

Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells

Provine, N. M., Larocca, R. A., Aïd, M., Penaloza‐MacMaster, P., Badamchi-Zadeh, A., Borducchi, E. N., Yates, K. B., Abbink, P., Kirilova, M., Ng’ang’a, D., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600591 · Cited by 58

Spatiotemporal Dynamics of Virus Infection Spreading in Tissues

Bocharov, G. A., Meyerhans, A., Bessonov, N., Trofimchuk, S. I., & Volpert, V. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168576 · Cited by 57

NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

Srirat, T., Hayakawa, T., Mise-Omata, S., Nakagawara, K., Ando, M., Shichino, S., Ito, M., & Yoshimura, A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113898 · Cited by 56

Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma

Keller, H. R., Zhang, X., Li, L., Schaider, H., & Wells, J. W. (2017) · Oncotarget · doi:10.18632/oncotarget.18523 · Cited by 55

The tumor microenvironment shapes the molecular characteristics of exhausted CD8+ T cells

Cheng, H., Ma, K., Zhang, L., & Li, G. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.02.013 · Cited by 60

Clinical Impact of Immune Cells and Their Spatial Interactions in Diffuse Large B-Cell Lymphoma Microenvironment

Autio, M. I., Leivonen, S., Brück, O. E., Karjalainen‐Lindsberg, M., Pellinen, T. S., & Leppä, S. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3140 · Cited by 59

Knowns and Unknowns about CAR-T Cell Dysfunction

Titov, A., Kaminskiy, Y., Ganeeva, I., Zmievskaya, E., Valiullina, A., Rakhmatullina, A., Petukhov, A., Рифкатовна, М. Р., Rizvanov, A. A., & Bulatov, E. (2022) · Cancers · doi:10.3390/cancers14041078 · Cited by 56

Novel Immunotherapies for Osteosarcoma

Lu, Y., Zhang, J., Chen, Y., Kang, Y., Liao, Z., He, Y., & Zhang, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.830546 · Cited by 58

Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade

Jiang, Y., Yang, Y., Hu, Y., Yang, R., Huang, J., Liu, Y. F., Wu, Y., Li, S., Ma, C., Humphries, F., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111553 · Cited by 55

Effect of Cancer-Related Cachexia and Associated Changes in Nutritional Status, Inflammatory Status, and Muscle Mass on Immunotherapy Efficacy and Survival in Patients with Advanced Non-Small Cell Lung Cancer

Madeddu, C., Busquets, S., Donisi, C., Lai, E., Pretta, A., López-Soriano, F. J., Argilés, J. M. A., Scartozzi, M., & Macciò, A. (2023) · Cancers · doi:10.3390/cancers15041076 · Cited by 60

Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells

Kallemeijn, M. J., Boots, A. M. H., van der Klift, M. Y., Brouwer, E., Abdulahad, W. H., Verhaar, J. A. N., van Dongen, J. J. M., & Langerak, A. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-05849-1 · Cited by 57

Combination Immune Checkpoint Blockade to Reverse HIV Latency

van der Sluis, R. M., Kumar, N., Pascoe, R. D., Zerbato, J. M., Evans, V. A., Dantanarayana, A., Anderson, J. L., Sékaly, R., Fromentin, R., Chomont, N., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901191 · Cited by 56

The glucocorticoids prednisone and dexamethasone differentially modulate T cell function in response to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade

Okoye, I., Xu, L., Walker, J. W. T., & Elahi, S. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02555-2 · Cited by 57

Immune checkpoint inhibitors associated cardiovascular immune-related adverse events

Jo, W., Won, T., Daoud, A., & Čiháková, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1340373 · Cited by 55

PD-1-PD-L1 immune-checkpoint blockade in malignant lymphomas

Wang, Y., Wu, L., Tian, C., & Zhang, Y. (2017) · Annals of Hematology · doi:10.1007/s00277-017-3176-6 · Cited by 56

CRISPR/Cas9 Gene-Editing in Cancer Immunotherapy: Promoting the Present Revolution in Cancer Therapy and Exploring More

Ou, X., Ma, Q., Yin, W., Ma, X., & He, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.674467 · Cited by 58

Natural killer cell dysfunction in cancer and new strategies to utilize NK cell potential for cancer immunotherapy

Zhang, W., Zhao, Z., & Li, F. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.02.015 · Cited by 57

Natural products and their derivatives as immune check point inhibitors: Targeting cytokine/chemokine signalling in cancer

Gupta, M., Chandan, K., & Sarwat, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.06.009 · Cited by 56

Patterns of immune evasion in triple-negative breast cancer and new potential therapeutic targets: a review

Serrano-García, L., Jávega, B., Llombart‐Cussac, A., Gión, M., Pérez-García, J. M., Cortés, J., & Fernández-Murga, M. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1513421 · Cited by 57

Elevated T cell activation score is associated with improved survival of breast cancer

Lu, L., Bai, Y., & Wang, Z. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4281-x · Cited by 55

Context-Dependent Pharmacological Effects of Metformin on the Immune System

Marcucci, F., Romeo, E. L., Caserta, C. A., Rumio, C., & Lefoulon, F. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.01.003 · Cited by 57

Axitinib plus avelumab in the treatment of recurrent glioblastoma: a stratified, open-label, single-center phase 2 clinical trial (GliAvAx)

Awada, G., Salama, L. B., Cremer, J., Schwarze, J. K., Fischbuch, L., Seynaeve, L., Four, S. D., Vanbinst, A., Michotte, A., Everaert, H., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001146 · Cited by 56

CD8+ T Cell Responses during HCV Infection and HCC

Hofmann, M., Tauber, C., Hensel, N., & Thimme, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10050991 · Cited by 58

Aging and Options to Halt Declining Immunity to Virus Infections

Palacios-Pedrero, M. Á., Osterhaus, A. D. M. E., Becker, T., Elbahesh, H., Rimmelzwaan, G. F., & Saletti, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681449 · Cited by 55

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer

Hu, J., Han, C., Zhong, J., Liu, H., Liu, R., Luo, W., Chen, P., & Ling, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.691142 · Cited by 56

Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection

Dunsmore, G., Rosero, E. P., Shahbaz, S., Santer, D. M., Jovel, J., Lacy, P., Houston, S. C., & Elahi, S. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001387 · Cited by 54

Focus on immune checkpoint PD-1/PD-L1 pathway: New advances of polyphenol phytochemicals in tumor immunotherapy

Liu, K., Sun, Q., Liu, Q., Li, H., Zhang, W., & Sun, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113618 · Cited by 57

Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response

Cruz, A. S., Mendes‐Frias, A., Azarias-da-Silva, M., André, S., Oliveira, A. I., Pires, O., Mendes, M., Oliveira, B., Braga, M., Lopes, J. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37368-1 · Cited by 54

Single-Cell Transcriptomics Reveals Crucial Cell Subsets and Functional Heterogeneity Associated With Carotid Atherosclerosis and Cerebrovascular Events

Tan, J., Liang, Y., Zhou, Y., He, Q., Tong, J., Deng, Y., Guo, W., Liang, K., Tang, J., Shi, W., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318974 · Cited by 57

Chiral polypeptide hydrogels regulating local immune microenvironment and anti-tumor immune response

Ding, J., Wang, T., Lin, Z., Li, Z., Yang, J., Li, F., Rong, Y., Chen, X., & He, C. (2025) · Nature Communications · doi:10.1038/s41467-025-56137-w · Cited by 60

Immune Exhaustion and Transplantation

Fueyo, A. S., & Markmann, J. F. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13702 · Cited by 54

Varicella-Zoster Virus–Specific Cellular Immune Responses to the Live Attenuated Zoster Vaccine in Young and Older Adults

Weinberg, A., Canniff, J. D., Rouphael, N., Mehta, A. K., Mulligan, M. J., Whitaker, J. A., & Levin, M. J. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700290 · Cited by 54

Nutrients, Infectious and Inflammatory Diseases

Oz, H. S. (2017) · Nutrients · doi:10.3390/nu9101085 · Cited by 54

T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma

Lucas, F. M., Pennell, M. L., Huang, Y., Benson, D. M., Efebera, Y. A., Chaudhry, M., Hughes, T. L., Woyach, J. A., Byrd, J. C., Zhang, S., et al. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.08.009 · Cited by 55

Harnessing the Effects of BTKi on T Cells for Effective Immunotherapy against CLL

Mhibik, M., Wiestner, A. U., & Sun, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010068 · Cited by 57

The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction

Quan, H., Shan, Z., Liu, Z., Liu, S., Yang, L., Fang, X., Li, K., Wang, B., Deng, Z., Hu, Y., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02479-x · Cited by 55

Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells

Bowyer, G., Sharpe, H., Venkatraman, N., Ndiaye, P. B., Wade, D., Brenner, N., Mentzer, A. J., Mair, C., Waterboer, T., Lambe, T., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200004 · Cited by 52

Forest Bathing Always Makes Sense: Blood Pressure-Lowering and Immune System-Balancing Effects in Late Spring and Winter in Central Europe

Péterfalvi, Á., Meggyes, M., Makszin, L., Farkas, N., Mikó, É., Miseta, A., & Szereday, L. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18042067 · Cited by 61

The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

Niesel, K., Schulz, M., Anthes, J., Alekseeva, T., Macas, J., Salamero‐Boix, A., Möckl, A., Oberwahrenbrock, T., Lolies, M., Stein, S., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013412 · Cited by 56

The Role of Diverse Liver Cells in Liver Transplantation Tolerance

Jiang, Y., Que, W., Zhu, P., & Li, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01203 · Cited by 56

Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Crosby, E. J., Acharya, C. R., Haddad, A.-F., Rabiola, C. A., Lei, G., Wei, J.-P., Yang, X., Wang, T., Liu, C.-X., Wagner, K., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0389 · Cited by 53

Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch

Yuan, B., Clark, C. A., Wu, B., Yang, J., Drerup, J. M., Li, T., Jin, V. X., Hu, Y., Curiel, T. J., & Li, R. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001932 · Cited by 57

Early systemic immune biomarkers predict bone regeneration after trauma

Cheng, A., Vantucci, C. E., Krishnan, L., Ruehle, M. A., Kotanchek, T., Wood, L. B., Roy, K., & Guldberg, R. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017889118 · Cited by 53

PD‐1‐induced T cell exhaustion is controlled by a Drp1‐dependent mechanism

Simula, L., Antonucci, Y., Scarpelli, G., Cancila, V., Colamatteo, A., Manni, S., Angelis, B. D., Quintarelli, C., Procaccini, C., Matarese, G., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13103 · Cited by 53

Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy

Gavali, S., Liu, J., Li, X., & Paolino, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910800 · Cited by 53

Breast cancer microenvironment and obesity: challenges for therapy

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A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19)

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