The DOI matches its Crossref record; 155 of the 156 references it cites were found in a registry or an index.
Molecular and cellular insights into T cell exhaustion
Open accessAbstract
In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called 'exhaustion'. Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with inefficient control of persisting infections and tumours, but revitalization of exhausted T cells can reinvigorate immunity. Here, we review recent advances that provide a clearer molecular understanding of T cell exhaustion and reveal new therapeutic targets for persisting infections and cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Other situations of chronic antigen stimulation, such as cancer or chronic viral infections, result in T cell exhaustion, characterized by the progressive loss of cytokine expression, proliferative potential, and upregulation of inhibitory receptors (immune checkpoints).”
From Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases (2024) · cites this paper as [32]
The cited source says what the claim attributes to it.
In the citing paper
“Exhaustion can be partially reversed by immune checkpoint inhibitors, providing the basis for successful therapies against cancer. 32,33”
From Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases (2024) · cites this paper as [32]
The cited source says what the claim attributes to it.
In the citing paper
“In TME, prolonged antigen exposure leads to T cell exhaustion, marked by losing effector functions.”
From Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer (2025) · cites this paper as [24]
In the citing paper
“cells with an exhaustion signature (denoted exhausted, fig. S3B) overexpressing the Lag3, Tbc1d4, Sostdc1, and Tnfsf8 genes (22, 31)”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838
Nivolumab plus Ipilimumab in Advanced Melanoma
Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Self-citationRestoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057
Self-citationRegulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680
Self-citationControl of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
Self-citation
Flagged first, then by citations
1 of the 156 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 701–800 of 1,019
The Human Gut Microbiome in Health and Disease
Jovel, J., Dieleman, L. A., Kao, D. H., Mason, A. L., & Wine, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-102268-9.00010-0 · Cited by 83
Machicote, A., Belén, S., Baz, P., Billordo, L. A., & Fainboim, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02788 · Cited by 81
The clinical potential of gene editing as a tool to engineer cell‐based therapeutics
Ashmore‐Harris, C., & Fruhwirth, G. O. (2020) · Clinical and Translational Medicine · doi:10.1186/s40169-020-0268-z · Cited by 79
Bai, Y., Hu, M., Chen, Z., Wei, J., & Du, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767070 · Cited by 74
Brightman, S. E., Becker, A., Thota, R. R., Naradikian, M. S., Chihab, L. Y., Zavala, K. S., Premlal, A. L. R., Griswold, R. Q., Dolina, J. S., Cohen, E. E. W., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01543-9 · Cited by 79
Roider, T., Baertsch, M., Fitzgerald, D., Vöhringer, H. S., Brinkmann, B. J., Czernilofsky, F., Knoll, M., Cid, L. L., Mathioudaki, A., Faßbender, B., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01358-2 · Cited by 81
Inducible down-regulation of MHC class I results in natural killer cell tolerance
Bern, M. D., Parikh, B. A., Yang, L., Beckman, D. L., Poursine‐Laurent, J., & Yokoyama, W. M. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181076 · Cited by 78
Kim, J. H., Ghosh, A., Ayithan, N., Romani, S., Khanam, A., Park, J., Rijnbrand, R. C. A., Tang, L., Sofia, M. J., Kottilil, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58870-2 · Cited by 78
Han, H. S., Jeong, S., Kim, H., Kim, H., Kim, A. R., Kwon, M., Park, S., Woo, C. G., Kim, H. K., Lee, K. H., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.035 · Cited by 82
Involvement of cytotoxic Eomes-expressing CD4 + T cells in secondary progressive multiple sclerosis
Raveney, B. J. E., Sato, W., Takewaki, D., Zhang, C., Kanazawa, T., Lin, Y., Okamoto, T., Araki, M., Kimura, Y., Sato, N., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021818118 · Cited by 85
Immune Aging and Immunotherapy in Cancer
Kaiser, M., Semeraro, M. D., Herrmann, M., Absenger, G., Gerger, A., & Renner, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137016 · Cited by 79
Hematopoietic responses to SARS-CoV-2 infection
Elahi, S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04220-6 · Cited by 79
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
Lamarche, C., Ward‐Hartstonge, K. A., Tian, M., Lin, D. T. S., Huang, Q. B., Brown, A., Edwards, K., Novakovsky, G., Qi, C. N., Kobor, M. S., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219086120 · Cited by 87
CD8+ T cell exhaustion in the tumor microenvironment of breast cancer
Xie, H., Xi, X., Lei, T., Liu, H., & Xia, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1507283 · Cited by 79
Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer
Singh, N., Shi, J., June, C. H., & Ruella, M. (2017) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-017-0417-7 · Cited by 80
Zheng, F., Dang, J., Zhang, H., Xu, F., Ba, D., Zhang, B., Cheng, F., Chang, A. E., Wicha, M. S., & Li, Q. (2018) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000242 · Cited by 77
Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer
Grywalska, E., Pasiarski, M., Góźdź, S. S., & Roliński, J. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s150817 · Cited by 82
Miyamoto, C., Kojo, S., Yamashita, M., Moro, K., Lacaud, G., Shiroguchi, K., Taniuchi, I., & Ebihara, T. (2019) · Nature Communications · doi:10.1038/s41467-019-08365-0 · Cited by 76
Galectin-3 modulation of T-cell activation: mechanisms of membrane remodelling
Gilson, R. C., Gunasinghe, S. D., Johannes, L., & Gaus, K. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.101010 · Cited by 74
TIGIT limits immune pathology during viral infections
Schorer, M., Rakebrandt, N., Lambert, K., Hunziker, A., Pallmer, K., Oxenius, A., Kipar, A., Stertz, S., & Joller, N. (2020) · Nature Communications · doi:10.1038/s41467-020-15025-1 · Cited by 76
A Longitudinal Study of Immune Cells in Severe COVID-19 Patients
Payen, D. M., Cravat, M., Maadadi, H., Didelot, C., Prosic, L., Dupuis, C., Losser, M.-R., & Bittencourt, M. D. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.580250 · Cited by 77
Battistello, E., Hixon, K., Comstock, D. E., Collings, C. K., Chen, X., Rodriguez-Hernaez, J., Lee, S., Cervantes, K. S., Hinkley, M. M., Ntatsoulis, K., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.02.026 · Cited by 78
Mitochondrial immune regulation and anti-tumor immunotherapy strategies targeting mitochondria
Bai, R., & Cui, J. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216223 · Cited by 83
Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease
Chao, Z., Mei, Q., Yang, C., Luo, J., Liu, P., Peng, H., Guo, X., Yin, Z., Li, L., & Wang, Z. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02332-6 · Cited by 96
Current State and Future Prospects of Immunotherapy for Glioma
Kamran, N., Alghamri, M. S., Núñez, F. J., Shah, D., Asad, A. S., Candolfi, M., Altshuler, D. B., Lowenstein, P. R., & Castro, M. G. (2018) · Immunotherapy · doi:10.2217/imt-2017-0122 · Cited by 77
Zhao, M., Svensson, M. N. D., Venken, K., Chawla, A., Liang, S. Y., Engel, I., Mydel, P. M., Day, J., Elewaut, D. S., Bottini, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05095-7 · Cited by 75
Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M. M., Hakanen, H. H. E., Ala-Hongisto, H., Savelius, M., Balboa, D., von Eyß, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08541-2 · Cited by 73
SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection
Lü, Y., Zhong, M., Qian, J., Calderon, V., Tleugabulova, M. C., Mallevaey, T., & Veillette, A. (2019) · Nature Immunology · doi:10.1038/s41590-019-0334-0 · Cited by 75
Insights in the immunobiology of glioblastoma
Strepkos, D., Markouli, M., Κλώνου, Α., Piperi, C., & Papavassiliou, A. G. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01835-4 · Cited by 75
New Insights into Mechanisms of Immune Checkpoint Inhibitor-Induced Cardiovascular Toxicity
Khunger, A., Battel, L., Wadhawan, A., More, A., Kapoor, A., & Agrawal, N. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-00925-8 · Cited by 77
Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies
Mhaidly, R., & Verhoeyen, E. (2020) · Cancers · doi:10.3390/cancers12071915 · Cited by 76
Woods, D. M., Woan, K. V., Cheng, F., Sodré, A. L., Wang, D., Wu, Y., Wang, Z., Chen, J., Powers, J., Pinilla-Ibarz, J., et al. (2017) · Blood · doi:10.1182/blood-2016-08-731505 · Cited by 74
Karnell, F. G., Lin, D. Y., Motley, S., Duhen, T., Lim, N., Campbell, D., Turka, L. A., Maecker, H. T., & Harris, K. M. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.12985 · Cited by 75
Obesity induced T cell dysfunction and implications for cancer immunotherapy
Aguilar, E. G., & Murphy, W. J. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.012 · Cited by 77
The senescence journey in cancer immunoediting
Zingoni, A., Antonangeli, F., Sozzani, S., Santoni, A., Cippitelli, M., & Soriani, A. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01973-5 · Cited by 77
Zhang, B., Liu, J., Mo, Y., Zhang, K., Huang, B., & Shang, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1476904 · Cited by 84
Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma
Park, J., Kim, C. G., Shim, J., Kim, J. H., Lee, H., Lee, J. E., Kim, M. H., Haam, K., Jung, I., Park, S., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1525243 · Cited by 73
Kang, H. J., Oh, J., Chun, S., Kim, D., Ryu, Y., Hwang, H. S., Kim, S., An, J., Cho, E. J., Lee, H., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.018 · Cited by 73
Is There a Place for Immunotherapy for Metastatic Microsatellite Stable Colorectal Cancer?
Ghiringhelli, F., & Fumet, J.-D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01816 · Cited by 78
Immune Response Against Head and Neck Cancer: Biological Mechanisms and Implication on Therapy
Perri, F., Ionna, F., Longo, F., Scarpati, G. D. V., Angelis, C. D., Ottaiano, A., Botti, G., & Caponigro, F. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.11.008 · Cited by 73
Maintenance of PD‐1 on brain‐resident memory CD8 T cells is antigen independent
Shwetank, Abdelsamed, H. A., Frost, E. L., Schmitz, H. M., Mockus, T. E., Youngblood, B., & Lukacher, A. E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.62 · Cited by 73
Sundahl, N., Seremet, T., Dorpe, J. V., Neyns, B., Ferdinande, L., Meireson, A., Brochez, L., Krüse, V., & Ost, P. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.03.041 · Cited by 73
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion
Olesch, C., Sirait‐Fischer, E., Berkefeld, M., Fink, A. F., Susen, R. M., Ritter, B., Michels, B. E., Steinhilber, D., Greten, F. R., Savai, R., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136928 · Cited by 71
Naseem, S., Hussain, T., & Manzoor, S. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.01.002 · Cited by 72
Immune profiles in primary squamous cell carcinoma of the head and neck
Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I. V., Zhavoronkov, A. A., Sidransky, D., Bedi, A., Hoque, M. O., et al. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2019.06.032 · Cited by 73
Galectin-9 and VISTA Expression Define Terminally Exhausted T Cells in HIV-1 Infection
Shahbaz, S., Dunsmore, G., Koleva, P. T., Xu, L., Houston, S. C., & Elahi, S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901481 · Cited by 73
ASGR1 and its enigmatic relative, CLEC10A
Hoober, J. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144818 · Cited by 74
Mimura, K., Kua, L., Xiao, J.-F., Asuncion, B. R., Nakayama, Y., Syn, N. L. X., Fazreen, Z., Soong, R. C. T., Kono, K., & Yong, W. P. (2021) · Gastric Cancer · doi:10.1007/s10120-020-01151-8 · Cited by 75
Wang, J., Li, R., Cao, Y., Gu, Y., Fang, H., Fei, Y., Lv, K., He, X., Lin, C., Liu, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23356-w · Cited by 71
Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement
Chin, A. L., Jiang, S., Jang, E., Niu, L., Li, L., Jia, X., & Tong, R. (2021) · Nature Communications · doi:10.1038/s41467-021-25391-z · Cited by 71
Metabolic plasticity and regulation of T cell exhaustion
Li, F., Liu, H., Zhang, D., Ma, Y., & Zhu, B. (2022) · Immunology · doi:10.1111/imm.13575 · Cited by 73
A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1)
Li, F., Tian, J., Zhang, L., He, H., & Song, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117225 · Cited by 72
Beltra, J., Bourbonnais, S., Bédard, N., Charpentier, T., Boulangé, M., Michaud, E., Boufaied, I., Bruneau, J., Shoukry, N. H., Lamarre, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604256113 · Cited by 72
Close, H. J., Stead, L. F., Nsengimana, J., Reilly, K., Droop, A., Wurdak, H., Mathew, R. K., Corns, R. A., Newton‐Bishop, J., Melcher, A. A., et al. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13403 · Cited by 76
IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection
Huang, Z., Žák, J., Pratumchai, I., Shaabani, N., Vartabedian, V. F., Nguyen, N., Wu, T., Xiao, C., & Teijaro, J. R. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190173 · Cited by 71
Clinical application of immune checkpoints in targeted immunotherapy of prostate cancer
Jafari, S., Molavi, O., Kahroba, H., Hejazi, M. S., Maleki‐Dizaji, N., Barghi, S., Kiaie, S. H., & Jadidi‐Niaragh, F. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03459-1 · Cited by 72
The spleen: “epicenter” in malaria infection and immunity
Ghosh, D., & Stumhofer, J. S. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ri1020-713r · Cited by 71
Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
Xie, Y., Xie, F., Zhang, L., Zhou, X., Huang, J., Wang, F., Jin, J., Zhang, L., Zeng, L., & Zhou, F. (2021) · Advanced Science · doi:10.1002/advs.202101672 · Cited by 72
Tumor accomplice: T cell exhaustion induced by chronic inflammation
Fang, L., Liu, K., Liu, C., Wang, X., Ma, W., Xu, W., Wu, J., & Sun, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.979116 · Cited by 72
Pathogenesis ofTaenia soliumtaeniasis and cysticercosis
Gonzáles, I., Rivera, J., Garcia, H. H., & for The Cysticercosis Working Group in Peru (2016) · Parasite Immunology · doi:10.1111/pim.12307 · Cited by 71
Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis
Gorini, F., Azzimonti, L., Delfanti, G., Scarfò, L., Scielzo, C., Bertilaccio, M. T. S., Ranghetti, P., Gulino, A., Doglioni, C., Napoli, A. D., et al. (2017) · Blood · doi:10.1182/blood-2016-11-751065 · Cited by 71
Immune checkpoint inhibitor-related myocarditis
Tajiri, K., Aonuma, K., & Sekine, I. (2017) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyx154 · Cited by 71
Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Shenoy, G. N., Loyall, J. L., Maguire, O., Iyer, V., Kelleher, R. J., Minderman, H., Wallace, P. K., Odunsi, K. O., Balu‐Iyer, S. V., & Bankert, R. B. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0113 · Cited by 72
Analysis of CAR-Mediated Tonic Signaling
Calderón, H., Mamonkin, M., & Guedan, S. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0146-4_17 · Cited by 76
Cytokine-Mediated Regulation of CD8 T-Cell Responses During Acute and Chronic Viral InfectionPreprint
Hashimoto, M., Im, S. J., Araki, K., & Ahmed, R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028464 · Cited by 78
The PD-1:PD-L1 axis in Inflammatory Arthritis
Canavan, M., Floudas, A., Veale, D. J., & Fearon, U. (2021) · BMC Rheumatology · doi:10.1186/s41927-020-00171-2 · Cited by 73
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes
Martins, C. P., New, L. A., O’Connor, E. C., Previte, D. M., Cargill, K. R., Tse, I., Sims‐Lucas, S., & Piganelli, J. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669456 · Cited by 70
PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
Srour, N., Villarreal, O. D., Hardikar, S., Yu, Z., Preston, S. E. J., Miller, W. H., Szewczyk, M. M., Baršytė-Lovejoy, D., Xu, H., Chen, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110582 · Cited by 70
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
Blaeschke, F., Chen, Y. Y., Apathy, R., Dániel, B., Chen, A. Y., Chen, P. A., Sándor, K., Zhang, W., Li, Z., Mowery, C. T., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.013 · Cited by 71
Huang, M., Yu, X., Wang, Q., Jiang, Z., Li, X., Chen, W., & Song, C. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01455-z · Cited by 71
Arruda, L. C. M., de Azevedo, J. T. C., de Oliveira, G. L. V., Scortegagna, G. T., Rodrigues, E. S., Palma, P. V. B., Brum, D. G., Guerreiro, C. T., Marques, V. D., Barreira, A. A., et al. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.06.005 · Cited by 71
Correia, M. P., Stojanovic, A., Bauer, K., Juraeva, D., Tykocinski, L., Lorenz, H., Brors, B., & Cerwenka, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720564115 · Cited by 69
Rådestad, E., Klynning, C., Stikvoort, A., Mogensen, O. E., Nava, S., Magalhaes, I., & Uhlin, M. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1535730 · Cited by 71
Brain Metastasis OrganotropismPreprint
Yuzhalin, A. E., & Yu, D. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037242 · Cited by 71
Okuma, A., Hanyu, A., Watanabe, S., & Hara, E. (2017) · Nature Communications · doi:10.1038/s41467-017-02281-x · Cited by 69
Tremblay-LeMay, R., Rastgoo, N., & Chang, H. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0589-1 · Cited by 69
Lin, S. X. W., & Balthasar, J. P. (2018) · Antibodies · doi:10.3390/antib7010005 · Cited by 68
Oft, M. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101325 · Cited by 71
Exhausted T cells and epigenetic status
Zeng, Z., Wei, F., & Ren, X. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0338 · Cited by 73
Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice
Kalia, V., Yuzefpolskiy, Y., Vegaraju, A., Xiao, H., Baumann, F. M., Jatav, S., Church, C. D., Prlic, M., Jha, A., Nghiem, P., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba6006 · Cited by 71
Zhang, T., Liu, H., Jiao, L., Zhang, Z., He, J., Li, L., Qiu, L., Qian, Z., Zhou, S., Gong, W., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004114 · Cited by 69
CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas
Niborski, L. L., Gueguen, P., Ye, M., Thiolat, A., Ramos, R. N., Caudana, P., Denizeau, J., Colombeau, L., Rodriguez, R., Goudot, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31504-z · Cited by 70
Diversity of immune checkpoints in cancer immunotherapy
Guo, Z., Zhang, R., Yang, A., & Zheng, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1121285 · Cited by 73
Tick-TOX, it’s time for T cell exhaustion
Mann, T. H., & Kaech, S. M. (2019) · Nature Immunology · doi:10.1038/s41590-019-0478-y · Cited by 70
Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER export
Chen, F., Li, Z., Ma, D., & Yu, Q. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1831153 · Cited by 68
T Cell Exhaustion and CAR‐T Immunotherapy in Hematological Malignancies
Tang, L., Zhang, Y., Hu, Y., & Mei, H. (2021) · BioMed Research International · doi:10.1155/2021/6616391 · Cited by 72
Immunotherapy Treatment for Triple Negative Breast Cancer
Berger, E. R., Park, T. S., Saridakis, A., Golshan, M. A., Greenup, R. A., & Ahuja, N. (2021) · Pharmaceuticals · doi:10.3390/ph14080763 · Cited by 72
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
Bulbiankova, D., Díaz‐Puertas, R., Álvarez‐Martínez, F. J., Herranz‐López, M., Barrajón‐Catalán, E., & Micol, V. (2023) · Antioxidants · doi:10.3390/antiox12020444 · Cited by 72
Monoclonal Antibodies for the Treatment of Melanoma: Present and Future Strategies
Bhandaru, M., & Rotte, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8958-4_4 · Cited by 68
Wan, P. K.-T., Ryan, A. J., & Seymour, L. W. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.04.015 · Cited by 67
Single-Cell Analysis of the Pan-Cancer Immune Microenvironment and scTIME Portal
Hong, F., Meng, Q., Zhang, W., Zheng, R., Li, X., Cheng, T., Hu, D., & Gao, X. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-1026 · Cited by 67
Preclinical Evaluation of CAR T Cell Function: In Vitro and In Vivo Models
Si, X., Xiao, L., Brown, C. E., & Wang, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063154 · Cited by 70
Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy
Czajka‐Francuz, P., Prendes, M. J., Mankan, A. K., Quintana, Á., Pabla, S., Ramkissoon, S. H., Jensen, T. J., Peiró, S., Severson, E. A., Achyut, B. R., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1200646 · Cited by 73
Ouyang, W., Jin, S., Xu, N., Liu, W.-Y., Zhao, H. Q., Zhang, L., Kang, L., Tao, Y., Liu, Y., Wang, Y., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008429 · Cited by 71
Attenuated effector T cells are linked to control of chronic HBV infection
Heim, K., Sagar, Sogukpinar, Ö., Llewellyn‐Lacey, S., Price, D. A., Emmerich, F., Kraft, A. R. M., Cornberg, M., Kielbassa, S., Knolle, P. A., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01928-4 · Cited by 72
Lakshmikanth, T., Olin, A., Chen, Y., Mikeš, J., Fredlund, E., Remberger, M., Omazic, B., & Brodin, P. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.021 · Cited by 64
Park, J., Kwon, M., Kim, K. H., Kim, T.-S., Hong, S.-H., Kim, C. G., Kang, S., Moon, J. H., Kim, E. H., Park, S., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2564 · Cited by 68
Lau, S. P., van Montfoort, N., Kinderman, P., Lukkes, M. M., Klaase, L., van Nimwegen, M., van Gulijk, M., Dumas, J., Mustafa, D. A. M., Lievense, S., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000772 · Cited by 70
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression
Myers, L. M., Tal, M. C., Torrez Dulgeroff, L. B., Carmody, A. B., Messer, R. J., Gulati, G., Yiu, Y. Y., Staron, M. M., Angel, C. L., Sinha, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08637-9 · Cited by 66
Bilen, M. A., Martini, D. J., Liu, Y., Shabto, J. M., Brown, J. T., Williams, M., Khan, A. I., Speak, A., Lewis, C. M., Collins, H., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2019-0751 · Cited by 67
Metadata
- Authors
- Wherry, E. J., & Kurachi, M.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Wherry, E. John
- Kurachi, Makoto
- Venue
- Nature Reviews Immunology
- Published
- 2015-07-24
- Volume
- 15
- Issue
- 8
- Pages
- 486-499
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4889009
- OpenAlex
- W1910012553
- Cited by
- 4,652
- References
- 156
- Citations by year
- 2026: 563 · 2025: 494 · 2024: 518 · 2023: 508 · 2022: 517 · 2021: 551 · 2020: 441 · 2019: 381 · 2018: 306 · 2017: 227 · 2016: 129 · 2015: 12
- FWCI
- 21.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (HHSN266200500030C)
- National Institute of Allergy and Infectious Diseases (HHSN266200500030C, AI 082630, R01AI105343, AI095608, AI105343, AI112521, P01AI112521, U01AI095608, U19AI082630)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- T cell exhaustion, chronic viral infection, cancer immunotherapy, inhibitory receptors, persistent antigen, inflammatory signals, transcriptional programs, therapeutic target
- MeSH terms
- Bacterial Infections, Gene Expression Regulation, Humans, Immunologic Memory, Lymphocyte Activation, Neoplasms, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Virus Diseases, Signal Transduction, Cytokines, Clonal Anergy, CD57 Antigens, T-Lymphocytes, Regulatory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
