Cited by 4,652T-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction

The DOI matches its Crossref record; 155 of the 156 references it cites were found in a registry or an index.

Molecular and cellular insights into T cell exhaustion

Open access

Wherry, E. John, Kurachi, Makoto·2015·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called 'exhaustion'. Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with inefficient control of persisting infections and tumours, but revitalization of exhausted T cells can reinvigorate immunity. Here, we review recent advances that provide a clearer molecular understanding of T cell exhaustion and reveal new therapeutic targets for persisting infections and cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri3862

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838
Nivolumab plus Ipilimumab in Advanced Melanoma
Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230
T cell exhaustion
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Self-citation
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057
Self-citation
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680
Self-citation
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
Self-citation

Flagged first, then by citations

Show all 156 references

1 of the 156 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 1,019

A spatially resolved single-cell genomic atlas of the adult human breast
Kumar, T., Nee, K., Wei, R., He, S., Nguyen, Q., Bai, S., Blake, K., Pein, M., Gong, Y., Sei, E., et al. (2023) · Nature · doi:10.1038/s41586-023-06252-9 · Cited by 260
Regulation of immunity during visceral Leishmania infection
Rodrigues, V., Cordeiro‐da‐Silva, A., Laforge, M., Silvestre, R., & Estaquier, J. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1412-x · Cited by 253
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients
Naing, A., Infante, J. R., Papadopoulos, K. P., Chan, I. H., Shen, C., Ratti, N. P., Rojo, B., Autio, K. A., Wong, D. J. L., Patel, M. R., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.10.007 · Cited by 258
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
Yates, K. B., Tonnerre, P., Martin, G. E., Gerdemann, U., Abosy, R. A., Comstock, D. E., Weiss, S. A., Wolski, D., Tully, D. C., Chung, R. T., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00979-1 · Cited by 257
Nanomaterials in tumor immunotherapy: new strategies and challenges
Zhu, X., & Li, S. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01797-9 · Cited by 263
Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment
Acharya, N., Madi, A., Zhang, H., Klapholz, M., Escobar, G., Dulberg, S., Christian, E., Ferreira, M., Dixon, K. O., Fell, G. G., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.005 · Cited by 257
Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy
Lee, N., Zakka, L. R., Mihm, M. C., & Schatton, T. (2016) · Pathology · doi:10.1016/j.pathol.2015.12.006 · Cited by 250
Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes
Long, S. A., Thorpe, J., DeBerg, H. A., Gersuk, V., Eddy, J. A., Harris, K. M., Ehlers, M., Herold, K. C., Nepom, G. T., & Linsley, P. S. (2016) · Science Immunology · doi:10.1126/sciimmunol.aai7793 · Cited by 250
Cutaneous Manifestations of Human and Murine Leishmaniasis
Scorza, B. M., Carvalho, E. M., & Wilson, M. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061296 · Cited by 241
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response
Cunha, L. L., Perazzio, S. F., Azzi, J., Cravedi, P., & Riella, L. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01748 · Cited by 245
Liver-Mediated Adaptive Immune Tolerance
Zheng, M., & Tian, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02525 · Cited by 262
Strategies to Address Chimeric Antigen Receptor Tonic Signaling
Ajina, A., & Maher, J. F. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1097 · Cited by 251
Immune checkpoints in the tumor microenvironment
Toor, S. M., Nair, V. S., Decock, J. V., & Elkord, E. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.021 · Cited by 242
Hallmarks of response to immune checkpoint blockade
Cogdill, A. P., Andrews, M. C., & Wargo, J. A. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.136 · Cited by 251
Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
Hung, M., Lee, J. S., Ma, C., Diggs, L. P., Heinrich, S., Chang, C.-W., Ma, L., Forgues, M., Budhu, A., Chaisaingmongkol, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21804-1 · Cited by 246
CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?
Hoyt-Miggelbrink, A. M., Jackson, J. D., Lorrey, S., Srinivasan, E. S., Polania, J. W., Wilkinson, D. S., & Fecci, P. E. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-0206 · Cited by 258
Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
Wang, Y., Tong, C., Dai, H., Wu, Z., Han, X., Guo, Y., Chen, D., Wei, J., Ti, D., Liu, Z. Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20696-x · Cited by 241
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
Ramakrishnan, R. K., Kashour, T., Hamid, Q. A., Halwani, R., & Tleyjeh, I. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686029 · Cited by 246
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity
Wang, D., Aguilar, B., Starr, R., Alizadeh, D., Brito, A., Sarkissian, A., Ostberg, J. R., Forman, S. J., & Brown, C. E. (2018) · JCI Insight · doi:10.1172/jci.insight.99048 · Cited by 233
Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes
Moro‐García, M. A., Mayo, J. C., Sainz, R. M., & Alonso‐Arias, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00339 · Cited by 241
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology
Selby, M., Engelhardt, J., Johnston, R. J., Lu, L.-S., Han, M., Thudium, K. B., Yao, D., Quigley, M. M., Valle, J., Wang, C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161779 · Cited by 236
TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy
Chiang, E. Y., & Mellman, I. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004711 · Cited by 235
Memory T cell, exhaustion, and tumor immunity
Ando, M., Ito, M., Srirat, T., Kondo, T., & Yoshimura, A. (2019) · Immunological Medicine · doi:10.1080/25785826.2019.1698261 · Cited by 233
Memory CD4+ T Cells in Immunity and Autoimmune Diseases
Raphael, I., Robinson, R. R., & Forsthuber, T. G. (2020) · Cells · doi:10.3390/cells9030531 · Cited by 241
ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma
Sheng, H., Huang, Y., Xiao, Y., Zhu, Z., Shen, M., Zhou, P., Guo, Z., Wang, J., Wang, H., Dai, W., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000340 · Cited by 228
PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19
Rha, M., Jeong, H. W., Ko, J. H., Choi, S. J., Seo, I., Lee, J. S., Sa, M., Kim, A. R., Joo, E., Ahn, J. Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.12.002 · Cited by 227
Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
Liu, X., Mo, W., Ye, J., Li, L., Zhang, Y., Hsueh, E. C., Hoft, D. F., & Peng, G. (2018) · Nature Communications · doi:10.1038/s41467-017-02689-5 · Cited by 224
T cell Allorecognition Pathways in Solid Organ Transplantation
Siu, J. H. Y., Surendrakumar, V., Richards, J. A., & Pettigrew, G. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02548 · Cited by 223
High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells
Li, J., He, Y., Hao, J., Ni, L., & Dong, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02981 · Cited by 229
Cellular architecture of human brain metastases
Velozo, H. G., Mei, W., Robles, I., Hagerling, C., Allen, B. M., Okholm, T. L. H., Nanjaraj, A., Verbeek, T. C. A. I., Kalavacherla, S., van Gogh, M., et al. (2022) · Cell · doi:10.1016/j.cell.2021.12.043 · Cited by 224
Human Inflammaging
Fülöp, T., Larbi, A., & Witkowski, J. M. (2019) · Gerontology · doi:10.1159/000497375 · Cited by 221
Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Chu, X., Tian, W., Wang, Z., Zhang, J., & Zhou, R. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01800-3 · Cited by 232
The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome
Caswell, D. R., & Swanton, C. (2017) · BMC Medicine · doi:10.1186/s12916-017-0900-y · Cited by 225
The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology
Wienke, J., Dierselhuis, M. P., Tytgat, G. A. M., Künkele, A., Nierkens, S., & Molenaar, J. J. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.11.014 · Cited by 221
The Evolving Role of CD8+CD28− Immunosenescent T Cells in Cancer Immunology
Huff, W. X., Kwon, J. H., Henriquez, M., Fetcko, K., & Dey, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112810 · Cited by 217
Advancing to the era of cancer immunotherapy
Wang, Y., Wang, M., Wu, H., & Xu, R. (2021) · 癌症：英文版 · doi:10.1002/cac2.12178 · Cited by 221
Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions
Brauning, A., Rae, M., Zhu, G., Fulton, E., Admasu, T. D., Stolzing, A., & Sharma, A. (2022) · Cells · doi:10.3390/cells11061017 · Cited by 215
Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma
Granier, C., Dariane, C., Combe, P., Verkarre, V., Urien, S., Badoual, C., Roussel, H., Mandavit, M., Ravel, P., Sibony, M., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0274 · Cited by 224
Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy
Knaus, H. A., Berglund, S., Hackl, H., Blackford, A. L., Zeidner, J. F., Montiel-Esparza, R., Mukhopadhyay, R., Vanura, K., Blazar, B. R., Karp, J. E., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120974 · Cited by 220
Immunotherapy of multiple myeloma
Minnie, S. A., & Hill, G. R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129205 · Cited by 220
CAR T‐Cell‐Based gene therapy for cancers: new perspectives, challenges, and clinical developments
Jogalekar, M. P., Rajendran, R. L., Khan, F., Dmello, C., Gangadaran, P., & Ahn, B.-C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.925985 · Cited by 214
De novo design of protein logic gates
Chen, Z., Kibler, R. D., Hunt, A. C., Büsch, F., Pearl, J. R., Jia, M., VanAernum, Z. L., Wicky, B. I. M., Dods, G., Liao, H., et al. (2020) · Science · doi:10.1126/science.aay2790 · Cited by 211
Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level
Rao, M., Wang, X., Guo, G., Wang, L., Chen, S., Yin, P., Chen, K., Chen, L., Zhang, Z., Chen, X., et al. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00897-1 · Cited by 217
Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1 + Macrophages and Fibroblasts
Sathe, A., Mason, K., Grimes, S. M., Zhou, Z., Lau, B. T., Bai, X., Su, A., Tan, X., Lee, H., Suarez, C. J., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2041 · Cited by 225
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells
Minervina, A. A., Pogorelyy, M. V., Kirk, A. M., Crawford, J. C., Allen, E. K., Chou, C., Mettelman, R. C., Allison, K., Lin, C.-Y., Brice, D. C., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01184-4 · Cited by 221
The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment
Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D., & Gajewski, T. F. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160485 · Cited by 213
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells
Li, J., Lee, Y., Li, Y., Jiang, Y. Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.018 · Cited by 213
Tissue-resident CD4 + T helper cells assist the development of protective respiratory B and CD8 + T cell memory responses
Son, Y. M., Cheon, I. S., Wu, Y., Li, C., Wang, Z., Gao, X., Chen, Y., Takahashi, Y., Fu, Y., Dent, A. L., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abb6852 · Cited by 218
Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial
Hong, D. S., Tine, B. A. V., Biswas, S., McAlpine, C., Johnson, M. L., Olszanski, A. J., Clarke, J. M., Araujo, D. M., Blumenschein, G. R., Kebriaei, P., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02128-z · Cited by 218
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
Si, J., Shi, X., Sun, S., Zou, B., Li, Y., An, D., Lin, X., Gao, Y., Long, F., Pang, B., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.08.001 · Cited by 209
Chimeric antigen receptor T cell persistence and memory cell formation
McLellan, A. D., & Rad, S. M. A. H. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12254 · Cited by 211
Cellular senescence: the sought or the unwanted?
Sun, Y., Coppé, J.-P., & Lam, E. W.-F. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.08.002 · Cited by 208
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Chen, Z., Arai, E., Khan, O., Zhang, Z., Ngiow, S. F., He, Y. M., Huang, H., Manne, S., Cao, Z., Baxter, A. E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.019 · Cited by 210
Self-citation
Can we predict T cell specificity with digital biology and machine learning?
Hudson, D., Fernandes, R. A., Basham, M., Ogg, G. S., & Koohy, H. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00835-3 · Cited by 209
Regulation of the T Cell Response by CD39
Takenaka, M. C., Robson, S. C., & Quintana, F. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.009 · Cited by 211
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Dagar, G., Gupta, A., Masoodi, T., Nisar, S., Merhi, M., Hashem, S., Chauhan, R., Dagar, M., Mirza, S., Bagga, P., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04292-3 · Cited by 229
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments
Yu, J. W., Bhattacharya, S., Yanamandra, N., Kilian, D., Shi, H., Yadavilli, S., Katlinskaya, Y. V., Kaczynski, H., Conner, M., Benson, W., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206223 · Cited by 204
Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy
Emran, A. A., Chatterjee, A., Rodger, E. J., Tiffen, J. C., Gallagher, S. J., Eccles, M. R., & Hersey, P. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.004 · Cited by 207
Intratumoral CXCL13 + CD8 + T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma
Dai, S., Zeng, H., Liu, Z., Jin, K., Jiang, W., Wang, Z., Lin, Z., Xiong, Y., Wang, J., Chang, Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001823 · Cited by 216
Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead
Kirtane, K., Elmariah, H., Chung, C. H., & Abate‐Daga, D. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002723 · Cited by 205
JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma
Žák, J., Pratumchai, I., Marro, B. S., Marquardt, K., Zavareh, R. B., Lairson, L. L., Oldstone, M. B. A., Varner, J. A., Hegerova, L. T., Cao, Q., et al. (2024) · Science · doi:10.1126/science.ade8520 · Cited by 208
Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors
Siemers, N. O., Holloway, J. L., Han, C., Chasalow, S. D., Ross‐Macdonald, P., Voliva, C. F., & Szustakowski, J. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179726 · Cited by 204
Memory of Inflammation in Regulatory T Cells
van der Veeken, J., González, Á., Cho, H., Arvey, A. J., Hemmers, S., Leslie, C. S., & Rudensky, A. Y. (2016) · Cell · doi:10.1016/j.cell.2016.07.006 · Cited by 203
Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence
Judge, S. J., Murphy, W. J., & Canter, R. J. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00049 · Cited by 216
Immunotherapy for glioblastoma: the promise of combination strategies
Bausart, M., Véronique Préat, A., & Malfanti, A. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02251-2 · Cited by 205
The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
Cohen, M., Giladi, A., Barboy, O., Hamon, P., Li, B., Zada, M., Gurevich‐Shapiro, A., Beccaría, C. G., David, E., Maier, B. B., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00338-5 · Cited by 204
Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases
Osborn, M. J., Webber, B. R., Knipping, F., Lonetree, C.-L., Tennis, N., DeFeo, A. P., McElroy, A. N., Starker, C. G., Lee, C., Merkel, S., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2015.197 · Cited by 201
T cell exhaustion: from pathophysiological basics to tumor immunotherapy
Catakovic, K., Klieser, E., Neureiter, D., & Geisberger, R. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-016-0160-z · Cited by 207
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Franzin, R., Netti, G. S., Spadaccino, F., Porta, C., Gesualdo, L., Stallone, G., Castellano, G., & Ranieri, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574271 · Cited by 208
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade
Berry, S., Giraldo, N. A., Green, B., Cottrell, T. R., Stein, J. E., Engle, E. L., Xu, H., Ogurtsova, A., Roberts, C. A., Wang, D., et al. (2021) · Science · doi:10.1126/science.aba2609 · Cited by 202
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers
Hanada, K.-I., Zhao, C., Gil-Hoyos, R., Gartner, J. J., Chow-Parmer, C., Lowery, F. J., Krishna, S., Prickett, T. D., Kivitz, S., Parkhurst, M. R., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.03.012 · Cited by 200
Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy
Zhao, Y., Shuen, T. W. H., Toh, T. B., Chan, X. Y., Liu, M., Tan, S. Y., Fan, Y., Yang, H., Lyer, S. G., Bonney, G. K., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315201 · Cited by 200
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
Noviello, M., Manfredi, F., Ruggiero, E., Perini, T., Oliveira, G., Cortesi, F., Simone, P. D., Toffalori, C., Gambacorta, V., Greco, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08871-1 · Cited by 203
ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation
Vendetti, F. P., Karukonda, P., Clump, D. A., Teo, T., Lalonde, R., Nugent, K., Ballew, M., Kiesel, B. F., Beumer, J. H., Sarkar, S. N., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96519 · Cited by 198
Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?
Seebach, E., & Kubatzky, K. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01724 · Cited by 197
Opposing Roles of Type I Interferons in Cancer Immunity
Boukhaled, G. M., Harding, S. M., & Brooks, D. G. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-031920-093932 · Cited by 208
Metabolism in tumor microenvironment: Implications for cancer immunotherapy
Shi, R., Tang, Y., & Miao, H. (2020) · MedComm · doi:10.1002/mco2.6 · Cited by 210
Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma
Makkouk, A., Yang, X., Barca, T., Lucas, A., Turkoz, M., Wong, J. T. S., Nishimoto, K. P., Brodey, M. M., Tabrizizad, M., Gundurao, S. R. Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003441 · Cited by 199
Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer
Wan, C., Keany, M. P., Dong, H., Al-Alem, L., Pandya, U. M., Lazo, S., Boehnke, K., Lynch, K. N., Xu, R., Zarrella, D. T., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1674 · Cited by 201
Activation or exhaustion of CD8+ T cells in patients with COVID-19
Rha, M., & Shin, E. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00750-4 · Cited by 201
Emerging concepts in PD-1 checkpoint biology
Pauken, K. E., Torchia, J. A., Chaudhri, A., Sharpe, A. H., & Freeman, G. J. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101480 · Cited by 203
Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells
Gorchs, L., Moro, C. F., Bankhead, P., Kern, K. P., Sadeak, I., Meng, Q., Rangelova, E. B., & Kaipe, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00847 · Cited by 197
Molecular approaches for classifying endometrial carcinoma
Piulats, J. M., Guerra, E., Gil-Martín, M., Roman‐Canal, B., Gatius, S., Pamplona, R. S., Velasco, A., Vidal, A., & Matías‐Guiu, X. (2016) · Gynecologic Oncology · doi:10.1016/j.ygyno.2016.12.015 · Cited by 197
The interplay of immunology and cachexia in infection and cancer
Baazim, H., Antonio-Herrera, L., & Bergthaler, A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00624-w · Cited by 192
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
Dumauthioz, N., Tschumi, B., Wenes, M., Marti, B., Wang, H., Franco, F., Li, W., López‐Mejía, I. C., Fajas, L., Ho, P., et al. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0365-3 · Cited by 199
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability
Guedan, S., Madar, A., Casado‐Medrano, V., Shaw, C. E., Wing, A., Liu, F., Young, R. M., June, C. H., & Posey, A. D. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133215 · Cited by 190
High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE
Vahid, M. R., Brown, E. L., Steen, C. B., Zhang, W., Jeon, H. S., Kang, M., Gentles, A. J., & Newman, A. M. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01697-9 · Cited by 187
Targeting type I interferon–mediated activation restores immune function in chronic HIV infection
Zhen, A., Rezek, V. K., Youn, C., Lam, B. B., Chang, N. Y., Rick, J. W., Carrillo, M. A., Martin, H. A., Kasparian, S., Syed, P., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci89488 · Cited by 189
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 192
The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade
Li, H. Y., McSharry, M. V., Bullock, B., Nguyen, T. T., Kwak, J., Poczobutt, J. M., Sippel, T. R., Heasley, L. E., Weiser-Evans, M. C. M., Clambey, E. T., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0365 · Cited by 193
Metabolism‐associated molecular classification of hepatocellular carcinoma
Yang, C. G., Huang, X., Liu, Z., Qin, W., & Wang, C. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12639 · Cited by 192
Calcium–NFAT transcriptional signalling in T cell activation and T cell exhaustion
Hogan, P. G. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.01.014 · Cited by 188
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
Wang, D., Prager, B. C., Gimple, R. C., Aguilar, B., Alizadeh, D., Tang, H., Lv, D., Starr, R., Brito, A., Wu, Q., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1243 · Cited by 185
Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection
Riou, C., Bruyn, E. D., Stek, C. J., Daroowala, R., Goliath, R. T., Abrahams, F., Said-Hartley, Q., Allwood, B., Hsiao, M., Wilkinson, K. A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149125 · Cited by 207
Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor–Redirected T Cells Against Multiple Myeloma
Wang, X., Walter, M., Urak, R. Z., Weng, L., Huynh, C., Lim, L., Wong, C. W., Chang, W.-C., Thomas, S. H., Sanchez, J. F., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0344 · Cited by 183
Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders
Duarte, L. F., Farías, M. A., Álvarez, D. M., Bueno, S. M., Riedel, C. A., & González, P. A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00046 · Cited by 192
The function and dysfunction of memory CD 8+ T cells in tumor immunity
Reading, J. L., Gálvez‐Cancino, F., Swanton, C., Lladser, Á., Peggs, K. S., & Quezada, S. A. (2018) · Immunological Reviews · doi:10.1111/imr.12657 · Cited by 186
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection
Chen, Y., Zander, R., Wu, X., Schauder, D., Kasmani, M. Y., Shen, J., Zheng, S., Burns, R., Taparowsky, E. J., & Cui, W. (2021) · Nature Immunology · doi:10.1038/s41590-021-00965-7 · Cited by 183
Molecular assessment of disease states in kidney transplant biopsy samples
Halloran, P. F., Famulski, K. S., & REEVE, J. P. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.85 · Cited by 185
Lack of immunoediting in murine pancreatic cancer reversed with neoantigen
Evans, R. A., Diamond, M. S., Rech, A. J., Chao, T., Richardson, M. W., Lin, J., Bajor, D. L., Byrne, K. T., Stanger, B. Z., Riley, J. L., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88328 · Cited by 181

Authors: Wherry, E. J., & Kurachi, M.
Affiliations: University of Pennsylvania (US)
Corresponding author: Wherry, E. John
Kurachi, Makoto
ORCID: Wherry, E. John
Kurachi, Makoto
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-07-24
Volume: 15
Issue: 8
Pages: 486-499
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3862
PMC: PMC4889009
OpenAlex: W1910012553
Cited by: 4,652
References: 156
Citations by year: 2026: 563 · 2025: 494 · 2024: 518 · 2023: 508 · 2022: 517 · 2021: 551 · 2020: 441 · 2019: 381 · 2018: 306 · 2017: 227 · 2016: 129 · 2015: 12
FWCI: 21.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (HHSN266200500030C)
National Institute of Allergy and Infectious Diseases (HHSN266200500030C, AI 082630, R01AI105343, AI095608, AI105343, AI112521, P01AI112521, U01AI095608, U19AI082630)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Keywords: T cell exhaustion, chronic viral infection, cancer immunotherapy, inhibitory receptors, persistent antigen, inflammatory signals, transcriptional programs, therapeutic target
MeSH terms: Bacterial Infections, Gene Expression Regulation, Humans, Immunologic Memory, Lymphocyte Activation, Neoplasms, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Virus Diseases, Signal Transduction, Cytokines, Clonal Anergy, CD57 Antigens, T-Lymphocytes, Regulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular and cellular insights into T cell exhaustion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks